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11. 发明申请

WO2009024160A1 PREDICTION OF NON-FATAL AND FATAL ATHEROTHROMBOTIC EVENTS 审中-公开
标题翻译：非致命性和致命性自身免疫性事件的预测
公开(公告)号：WO2009024160A1
公开(公告)日：2009-02-26
申请号：PCT/EP2007/007286
申请日：2007-08-17
申请人： SIEMENS HEALTHCARE DIAGNOSTICS GMBH , GEHRMANN, Mathias , STASCH, Johannes-Peter
发明人： GEHRMANN, Mathias , STASCH, Johannes-Peter
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/70575 , G01N2800/323 , G01N2800/324 , G01N2800/347
摘要： The present invention relates to methods and systems for the prediction of atherothrombotic events in human subjects. Preferably the human subjects are afflicted with a cardiovascular disease, such as end-stage renal disease. Methods and systems of the invention are particularly suited to predict atherothrombotic events in patients on hemodialysis.
摘要翻译：本发明涉及用于预测人类受试者中动脉粥样硬化血栓形成事件的方法和系统。优选地，人类受试者患有心血管疾病，例如终末期肾病。本发明的方法和系统特别适用于预测血液透析患者的动脉粥样硬化血栓形成事件。

12. 发明申请

WO2013014296A1 METHOD FOR PREDICTING THE RESPONSE TO CHEMOTHERAPY IN A PATIENT SUFFERING FROM OR AT RISK OF DEVELOPING RECURRENT BREAST CANCER 审中-公开
标题翻译：预防患者发生反应性乳腺癌风险的患者反应的方法
公开(公告)号：WO2013014296A1
公开(公告)日：2013-01-31
申请号：PCT/EP2012/064865
申请日：2012-07-30
申请人： SIVIDON DIAGNOSTICS GMBH , GEHRMANN, Mathias , WEBER, Karsten , KRONENWETT, Ralf , PETRY, Christoph , BRASE, Jan
发明人： GEHRMANN, Mathias , WEBER, Karsten , KRONENWETT, Ralf , PETRY, Christoph , BRASE, Jan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： A method for predicting a response to and/or benefit of chemotherapy, including neoadjuvant chemotherapy, in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprising the steps of: (a) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, RACGAP1, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP, indicative of a response to chemotherapy for a tumor, or (b) determining in a tumor sample from said patient the RNA expression levels of the following 8 genes: UBE2C, BIRC5, DHCR7, STC2, AZGP1, RBBP8, IL6ST, and MGP; indicative of a response to chemotherapy for a tumor (c) mathematically combining expression level values for the genes of the said set which values were determined in the tumor sample to yield a combined score, wherein said combined score is predicting said response and/or benefit of chemotherapy.
摘要翻译：一种在患有或有发生复发性肿瘤疾病，特别是乳腺癌风险的患者中预测化疗（包括新辅助化疗）的反应和/或益处的方法，所述方法包括以下步骤：（a）在来自所述患者的肿瘤样品包括以下8个基因的RNA表达水平：UBE2C，RACGAP1，DHCR7，STC2，AZGP1，RBBP8，IL6ST和MGP，指示对肿瘤的化学疗法的反应，或（b）在肿瘤中测定来自所述患者的样品来自以下8个基因的RNA表达水平：UBE2C，BIRC5，DHCR7，STC2，AZGP1，RBBP8，IL6ST和MGP; 指示对肿瘤的化学疗法的反应（c）在数学上组合所述组的基因的表达水平值，所述基因在肿瘤样品中测定以产生组合评分，其中所述组合评分预测所述应答和/或益处的化疗。

13. 发明申请

WO2006009702A3 LIVER DISEASE-RELATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：WO2006009702A3
公开(公告)日：2006-01-26
申请号：PCT/US2005/021002
申请日：2005-06-15
申请人： BAYER HEALTHCARE LLC , VOLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef , THIEL, Robert, P. , PETRY, Christoph , ROSENBERG, William
发明人： VOLKER, Michael , BECKA, Michael , KROLL, Werner , KNORR, Andreas , UNGER, Sylvia , GEHRMANN, Mathias , HENNIG, Guido , BURCHARDT, Elmar-Reinhold , ARTHUR, Michael, J. , BURT, Alastair, D. , PINZANI, Massimo , SCHUPPAN, Detlef , THIEL, Robert, P. , PETRY, Christoph , ROSENBERG, William
IPC分类号： A01N1/02 , A61K31/765 , C12M1/00 , G01N31/00 , G01N33/53 , G01N35/00
摘要： The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related computer-readable media, that use blood marker values, including serum and plasma marker values: (1) to screen for active ingredients useful in the treatment of a liver disease; (2) to aid in the selection of treatment regimens for patients that are predisposed to, or suffer from, liver disease; and (3) to aid in the design of clinical programs useful in monitoring the status or progress of liver disease in one or more patients.

14. 发明申请

WO2007107254A1 PREDICTION OF BREAST CANCER RESPONSE TO CHEMOTHERAPY 审中-公开
标题翻译：乳腺癌预防化疗反应
公开(公告)号：WO2007107254A1
公开(公告)日：2007-09-27
申请号：PCT/EP2007/002063
申请日：2007-03-09
申请人： BAYER HEALTHCARE AG , GEHRMANN, Mathias
发明人： GEHRMANN, Mathias
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： Method for the prediction of the response to epirubicin/cyclophosphamide-based chemotherapy of a breast cancer in a patient, from a tumour sample of said patient, comprising steps of determining the expression level of a group of marker genes consisting of (i) a first marker gene selected from the group consisting of MLPH, SPDEF, and AKR7A3; and (ii) a pair of second marker genes selected from the group of pairs consisting of (H2BFS and UBE2S), (BGN and ZBTB16), (ZBTB16 and EMP1), (LGALS8 and UBE2S) and (OLFML2B and ZBTB16); and (iii) a third marker gene selected from the group consisting of CYBA, ACP5, a gene specifically binding to Affymetrix probe set ID 210915 x at, LCK, GSTM3; classifying said sample as belonging to one of several breast cancer response classes from the expression levels determined; predicting the response of said breast cancer in said patient to chemotherapy from previously known characteristic properties of tumours of said one of several breast cancer response classes.
摘要翻译：用于预测来自所述患者的肿瘤样品的患者的乳腺癌对表柔比星/环磷酰胺类化疗的反应的方法，包括确定一组标记基因的表达水平的步骤，所述标记基因组由以下组成：（i）第一标记基因，其选自MLPH，SPDEF和AKR7A3; 和（ii）选自由（H2BFS和UBE2S），（BGN和ZBTB16），（ZBTB16和EMP1），（LGALS8和UBE2S）和（OLFML2B和ZBTB16）组成的组中的一对第二标记基因; 和（iii）选自CYBA，ACP5，特异性结合Affymetrix探针组ID 210915 x at LCK，GSTM3的基因的第三标记基因; 将所述样品从所确定的表达水平分类为几种乳腺癌反应类别之一; 从所述几种乳腺癌反应类别的肿瘤的先前已知的特征性质预测所述患者中的所述乳腺癌对化学疗法的反应。

15. 发明申请

WO2007062777A1 METHODS AND KITS FOR BREAST CANCER PROGNOSIS 审中-公开
标题翻译：乳腺癌预防的方法和工具
公开(公告)号：WO2007062777A1
公开(公告)日：2007-06-07
申请号：PCT/EP2006/011230
申请日：2006-11-23
申请人： BAYER HEALTHCARE AG , GEHRMANN, Mathias
发明人： GEHRMANN, Mathias
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , G01N2333/91215
摘要： The present invention relates to the field of prognosis of a proliferative disease in a patient. More specifically, the present invention relates to methods for the identification of the likely outcome of breast cancer in a breast cancer patient. The invention also relates to methods for the identification of the likely outcome of breast cancer in a patient on the basis of the ERBB2 status of the patient and expression levels of immune genes in tumour tissue of said patient.
摘要翻译：本发明涉及患者中增殖性疾病的预后领域。更具体地，本发明涉及用于鉴定乳腺癌患者乳腺癌的可能结果的方法。本发明还涉及基于患者的ERBB2状态和所述患者的肿瘤组织中的免疫基因的表达水平来鉴定患者中乳腺癌的可能结果的方法。

16. 发明申请

WO2003044225A3 PROFILING OF THE IMMUNE GENE REPERTOIRE 审中-公开
公开(公告)号：WO2003044225A3
公开(公告)日：2003-05-30
申请号：PCT/EP2002/012822
申请日：2002-11-15
申请人： BAYER AKTIENGESELLSCHAFT , GEHRMANN, Mathias , SCHWERS, Stephan , WEIDLER, Marcus
发明人： GEHRMANN, Mathias , SCHWERS, Stephan , WEIDLER, Marcus
IPC分类号： C12Q1/68
摘要： The present invention relates to a method for the profiling of the antibody and T-cell receptor mRNA repertoire of an organism. Profiles that are generated describe the current immune status. This knowledge is useful for the diagnosis and prediction of disorders and for the identification of therapeutic drugs and proteins.

17. 发明申请

WO2003031650A3 GENES AND PROTEINS FOR PREVENTION, PREDICTION, PROGNOSIS AND THERAPY OF CARDIOVASCULAR DISEASE 审中-公开
公开(公告)号：WO2003031650A3
公开(公告)日：2003-04-17
申请号：PCT/EP2002/011034
申请日：2002-10-02
申请人： BAYER HEALTHCARE AG , MUNNES, Marc , GEHRMANN, Mathias , WICK, Maresa , SCHMITZ, Gerd
发明人： MUNNES, Marc , GEHRMANN, Mathias , WICK, Maresa , SCHMITZ, Gerd
IPC分类号： C12Q1/68
摘要： Genes that are differentially expressed in blood vessels of cardiovascular disease patients versus blood vessels of normal people are disclosed. The genes provide novel methods, uses and compositions for the prediction, prevention, diagnosis, prognosis and treatment of cardiovascular disease.

18. 发明申请

WO2003031650A2 GENES AND PROTEINS FOR PREVENTION, PREDICTION, PROGNOSIS AND THERAPY OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：预防，预防，预防和治疗心血管疾病的基因和蛋白质
公开(公告)号：WO2003031650A2
公开(公告)日：2003-04-17
申请号：PCT/EP2002/011034
申请日：2002-10-02
申请人： BAYER AKTIENGESELLSCHAFT , MUNNES, Marc , GEHRMANN, Mathias , WICK, Maresa , SCHMITZ, Gerd
发明人： MUNNES, Marc , GEHRMANN, Mathias , WICK, Maresa , SCHMITZ, Gerd
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6883 , C12Q2600/158
摘要： Genes that are differentially expressed in blood vessels of cardiovascular disease patients versus blood vessels of normal people are disclosed. The genes provide novel methods, uses and compositions for the prediction, prevention, diagnosis, prognosis and treatment of cardiovascular disease.
摘要翻译：披露了心血管疾病患者血管与正常人血管差异表达的基因。该基因为心血管疾病的预测，预防，诊断，预后和治疗提供了新的方法，用途和组成。

19. 发明申请

WO2002097127A2 GENES AND PROTEINS FOR PREVENTION, PREDICTION, DIAGNOSIS, PROGNOSIS AND TREATMENT OF CHRONIC LUNG DISEASE 审中-公开
标题翻译：预防，预防，诊断，预防和治疗慢性肺疾病的基因和蛋白质
公开(公告)号：WO2002097127A2
公开(公告)日：2002-12-05
申请号：PCT/EP2002/005835
申请日：2002-05-28
申请人： BAYER AKTIENGESELLSCHAFT , OELLERS, Nadja , GEHRMANN, Mathias , KALLABIS, Harald , HALL, Roderick , SCHULZE, Thomas , KROEGEL, Claus
发明人： OELLERS, Nadja , GEHRMANN, Mathias , KALLABIS, Harald , HALL, Roderick , SCHULZE, Thomas , KROEGEL, Claus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： Genes that are differentially expressed in lung tissue of COPD patients versus lungs of normal people are disclosed. The genes provide novel methods for the prevention, prediction, diagnosis, prognosis and treatment of chronic lung disease.
摘要翻译：公开了在COPD患者的肺组织中与正常人的肺部差异表达的基因。这些基因为慢性肺部疾病的预防，预测，诊断，预后和治疗提供了新的方法。

20. 发明申请

WO2009071655A2 METHODS FOR BREAST CANCER PROGNOSIS 审中-公开
标题翻译：乳腺癌预防方法
公开(公告)号：WO2009071655A2
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066868
申请日：2008-12-05
申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC. , GEHRMANN, Mathias
发明人： GEHRMANN, Mathias
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides a method to assess the risk of recurrence of a node positive and hormone receptor positive breast cancer patient when treated with tamoxifen. The method is based on quantitative det ermination of RNA species isolated from the tumor in order to obtain expression values and subsequent bioinformatic analysis of said determined expression values. First, steroid hormone receptor (SR) status is determined. Then, one or more RNA species coding for proliferation associated genes are determined. Then a combination of genes indicating the presence of T-lymphocyte infiltration is used to classify a tumor as low, intermediate or high risk tumor.
摘要翻译：本发明提供了当用他莫昔芬治疗时评估淋巴结阳性和激素受体阳性乳腺癌患者复发风险的方法。该方法基于从肿瘤分离的RNA物种的定量检测，以获得所述确定的表达值的表达值和随后的生物信息学分析。首先，确定类固醇激素受体（SR）状态。然后，确定编码增殖相关基因的一种或多种RNA物质。然后使用指示存在T淋巴细胞浸润的基因的组合来将肿瘤分类为低，中等或高危肿瘤。

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