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11. 发明专利

AU627628B2 HYDROPHILIC POLYMER-SILICATE MINERAL COMPOSITE AND ITS USE 未知
公开(公告)号：AU627628B2
公开(公告)日：1992-08-27
申请号：AU6532290
申请日：1990-10-19
申请人： SHISEIDO CO LTD
发明人： YANAKI TOSHIO , TAKAHASHI TADAHITO , NAGASAWA YOUKO , YAMAGUCHI MICHIHIRO
IPC分类号： A61K8/26 , A61K8/81 , A61K9/00 , A61K47/02 , A61K47/32 , A61Q1/02 , A61Q19/00 , A61Q19/10 , C01B33/44 , C08K3/34 , A61K7/00 , C01B33/21 , C09K3/00 , C09K3/18 , A61K31/78 , A61K47/04 , C08L101/08 , C08L33/02 , C08L33/10 , C08L1/10 , C08L5/04 , C08L5/00 , C08K3/36
摘要： A hydrophilic polymer/silicate mineral composite having an IR absorption at 1000-1300 cm-1 not assignable to the starting materials, consists of a carboxylated hydrophilic polymer and a water-swellable silicate mineral. The polymer is pref. poly(meth)acrylic acid, carboxymethylcellulose, hyaluronic acid, xanthan gum, gum arabic or alginic acid. The silicate is pref. a water-swellable micro-grain silica or a lamellar silicate. The gel strength of the composite is 15700-127000 dyne/cm2 for a polyacrylic acid/lamellar silicate composite, 9800-11800 dyne/cm2 for a polyacrylic acid/micrograin silica and 1960-58000 dyne/cm2 for a polysaccharide/lamellar silicate composite (as a 1wt.% gel in water). Also claimed is a gel perfume compsn. contg. the above composite (0.1-90% wt); perfume (1-99.0%); alcohol-based organic solvent (0-90%); non-ionic surfactant (0-40%) and the balance water.

12. 发明公开

EP1317915A4 HAIR NOURISHMENTS AND METHOD OF SCREENING THE SAME 审中-公开
标题翻译： FOR头发元素，AND METHOD FOR分流
公开(公告)号：EP1317915A4
公开(公告)日：2006-06-14
申请号：EP01963594
申请日：2001-09-11
申请人： SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TSUJI YUMIKO , SOMA TSUTOMU , DENDA SUMIKO , NAKANISHI JOTARO , TAKAHASHI TADAHITO , UMISHIO KENICHI , KOBAYASHI KOJI
IPC分类号： A61K8/49 , A61K8/64 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/18 , A61K38/55 , A61K45/06 , A61P1/16 , A61P13/12 , A61Q5/00 , A61Q7/00 , G01N33/15 , G01N33/50 , A61K7/06
CPC分类号： A61Q5/00 , A61K8/498 , A61K8/64 , A61K8/97 , A61K31/366 , A61K36/185 , A61K36/30 , A61K36/48 , A61K36/53 , A61K36/73 , A61K36/82 , A61K36/87 , A61K36/8994 , A61K38/06 , A61K38/55 , A61K45/06 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： There is provided a hair tonic comprising at least two of an inhibitor against 5 alpha reductase type 2, an inhibitor against transforming growth factor beta 2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5 alpha reductase type 2, inhibition against transforming growth factor beta 2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.

13. 发明公开

EP1234574A4 HAIR GROWTH STIMULANT 有权
标题翻译：头发成长基金
公开(公告)号：EP1234574A4
公开(公告)日：2005-12-21
申请号：EP01967782
申请日：2001-09-21
申请人： SHISEIDO CO LTD
发明人： HAMADA CHIKA , TAKAHASHI TADAHITO , TAJIMA MASAHIRO , NAKAMA YASUNARI , MAGARA TSUNAO
IPC分类号： C12P21/08 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/891 , A61K31/185 , A61K39/395 , A61P5/16 , A61P17/14 , A61P17/16 , A61P27/02 , A61P43/00 , A61Q7/00 , C07K16/28 , A61K7/00 , A61K7/075 , A61K7/08
CPC分类号： A61Q7/00 , A61K8/42 , A61K8/44 , A61K8/466 , A61K8/891 , A61K31/185
摘要： A hair growth stimulant and a hair growth shampoo which contain N-methyltaurine as the essential ingredient, have an effect of extending the hair growth stage and are capable of imparting tension and sturdiness to the hair thereby making the hair voluminous; and a hair tension/sturdiness improving agent and a cell activator to be added to hair care products.

14. 发明公开

EP1314417A4 HAIR GROWERS 审中-公开
标题翻译： HAARWUCHSMITTEL
公开(公告)号：EP1314417A4
公开(公告)日：2004-09-22
申请号：EP01963408
申请日：2001-08-31
申请人： SHISEIDO CO LTD
发明人： TAKAHASHI TADAHITO , NAKAZAWA YOSUKE , ARAI TAKAYUKI , IWABUCHI TOKURO , MAGARA TSUNAO , FUKUNISHI HIROTADA , KOBAYASHI KOJI , TAJIMA MASAHIRO , OHNO SHIGEO , HANDA HIROSHI
IPC分类号： A61K8/34 , A61K8/37 , A61K31/075 , A61K31/23 , A61P17/14 , A61Q7/00 , A61K7/06
CPC分类号： A61K31/075 , A61K8/34 , A61K8/345 , A61K8/375 , A61K31/23 , A61Q7/00
摘要： The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect. The hair promoting composition comprises, as an effective ingredient, a composition expressed by following Formula (I): wherein one of R to R is selected from a group of C14-22 alkyl, C14-22 alkoxy and C14-22 acyloxy groups, and the others are selected from a group of H, OH, C1-3 alkyl and C1-3 alkoxy groups; and when R is C14-22 alkoxy group and one of R and R is C1-3 alkoxy group, R is H, C1-3 alkyl or C1-3 alkoxy group; and when R is C14-22 acyloxy group, at least one of R to R is C1-3 alkoxy group.

15. 发明公开

EP0857174A4 UROKINASE PLASMINOGEN ACTIVATOR FRAGMENTS 失效
标题翻译： FRAGMENTE DES UROKINASE PLASMINOGEN -CHAVATORS
公开(公告)号：EP0857174A4
公开(公告)日：2000-05-31
申请号：EP95937394
申请日：1995-10-06
申请人： GEN HOSPITAL CORP , SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TAKAHASHI TADAHITO , HORII IZUMI , GOETINCK PAUL F , BACIU PETER C
IPC分类号： C12N5/06 , A61K31/00 , A61K31/195 , A61K38/00 , A61L27/00 , A61P17/00 , A61P17/02 , A61P43/00 , C07H21/04 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/745 , C12N5/10 , C12N9/72 , C12N15/09 , C12P21/02 , C12R1/91
CPC分类号： C12N9/6462 , A61K38/00 , C12Y304/21073

16. 发明公开

EP0692968A4 UROKINASE PLASMINOGEN ACTIVATOR FRAGMENTS 失效
标题翻译： UROKINASE PLASMINOGEN AKTIVATOR FRAGMENTE
公开(公告)号：EP0692968A4
公开(公告)日：1998-05-20
申请号：EP94911748
申请日：1994-03-30
申请人： GEN HOSPITAL CORP , SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TAKAHASHI TADAHITO , HORII IZUMI , GOETINCK PAUL F
IPC分类号： C12N5/06 , A61K31/00 , A61K31/195 , A61K38/00 , A61L27/00 , A61P17/00 , A61P17/02 , A61P43/00 , C07H21/04 , C07K5/103 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/745 , C12N5/10 , C12N9/72 , C12N15/09 , C12P21/02 , C12R1/91 , A61K35/12 , A61K38/43 , A61K39/395 , C07K7/00 , C07K7/04 , C12N5/00 , C12N5/02
CPC分类号： C12N9/6462 , A61K38/00 , C12Y304/21073

17. 发明专利

JP2000342296A EVALUATION OF SUBSTANCE ACTING ON TRANSFORMING GROWTH FACTOR-BETA 2 (TGF-BETA 2) 失效
公开(公告)号：JP2000342296A
公开(公告)日：2000-12-12
申请号：JP2000089551
申请日：2000-03-28
申请人： SHISEIDO CO LTD
发明人： SOMA TSUTOMU , HIBINO TOSHIHIKO , TAKAHASHI TADAHITO
IPC分类号： G01N33/50 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/53 , A61K36/73 , A61K36/75 , A61K45/00 , A61P1/16 , A61P13/12 , A61P17/14 , A61Q5/00 , A61Q7/00 , C12N5/07 , C12N5/09 , C12Q1/02 , C12R1/91 , G01N33/15 , G01N33/53 , A61K7/06 , A61K35/78 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To evaluate the subject action substance by proliferating a cell having an ability for producing a plasminogen activator-inhibiting factor-1(PAI-1) in the presence of a transforming growth factor-β2 and a test substance and then measuring PAI-1. SOLUTION: This method for evaluating a substance acting on a transforming growth factor-β2(TGF-β2) comprises proliferating a cell having an ability for producing a plasminogen activator-inhibiting factor-1(PAI-1), such as human hair papilla cell or human fibroblast, in the presence of the transforming growth factor-β2(TGF-β2) and a test substance and then measuring the plasminogen activator-inhibiting factor-1(PAI-1) contained in the culture medium. Thereby, the substance which acts on TGF-β2 and can be used for screening a TGF-β antagonist can simply be evaluated. The TGF-β antagonist is effective as a hair tonic, an agent for inhibiting the transfer of hair into its involutional period, a hepatocirrhosis medicine, a nephritis medicine and the like.

18. 发明专利

JPH10215881A OLIGONUCLEOTIDE PRIMER AND ITS USE 失效
公开(公告)号：JPH10215881A
公开(公告)日：1998-08-18
申请号：JP4014697
申请日：1997-02-07
申请人： SHISEIDO CO LTD
发明人： TAKEDA ATSUSHI , TAKAHASHI TADAHITO , OGO MASASHI , HIBINO TOSHIHIKO
IPC分类号： C12N15/09 , C07H21/04
摘要： PROBLEM TO BE SOLVED: To obtain a new primer for a polymerase chain reaction(PCR) capable of amplifying and detecting a human squamous cell carcinomarelated antigen gene, comprising an oligonucleotide fragment containing a specific nucleotide sequence at 3' or 5' end. SOLUTION: This new primer for a polymerase chain reaction(PCR) comprises an oligonucleotide fragment containing a nucleotide sequence of the formula GCAC, the formula GTGC, the formula CTGA or the formula TCAG at 3' or 5' end, is capable of amplifying a human squamous cell carcinoma-related antigen(SCCA) gene and distinguishing and detecting two types of squamous cell carcinoma antigens, SCCA1 and SCCA2 and is useful for diagnosing squamous cell carcinomas. The primer is obtained by forming various kinds of primers based on a base sequence encoding the amino acid sequence of squamous cell carcinoma antigen(SCCA), carrying out PCR using the primers and selecting a base sequence capable of selectively amplifying SCCA1 and SCCA2, respectively.

19. 发明专利

JP2002104938A PREVENTING OR TREATING COMPOSITION SUCH AS HAIR GROWING AGENT AND AGENT FOR SUPPRESSING TRANSITION TO HAIR RETREATING PERIOD 失效
公开(公告)号：JP2002104938A
公开(公告)日：2002-04-10
申请号：JP2000299341
申请日：2000-09-29
申请人： SHISEIDO CO LTD
发明人： HIBINO TOSHIHIKO , TSUJI YUMIKO , TAKAHASHI TADAHITO , UMISHIO KENICHI , KOBAYASHI KOJI
IPC分类号： A61K8/00 , A61K8/49 , A61K31/352 , A61P1/16 , A61P13/12 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To provide a hair growing agent, an agent for suppressing transition to the hair retreating period, a treating agent for hepatocirrhosis and a treating agent for nephritis, whose activity expressions are confirmed by the screening method found by the inventor of the present invention. SOLUTION: An isocoumarin, especially phyllodulcin (1) which is a component contained in an extract of sweet hydrangea leaf, is contained as an active ingredient.

20. 发明专利

JP2005237273A Method for evaluating hair grower 审中-公开
标题翻译：评估头发花洒的方法
公开(公告)号：JP2005237273A
公开(公告)日：2005-09-08
申请号：JP2004051168
申请日：2004-02-26
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： TAKAHASHI TADAHITO , TAJIMA MASAHIRO , EHAMA RITSUKO
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method and a kit for evaluating a hair grower, useful for diagnosing hair diseases, predicting alopecia, diagnosing a hair cycle, or the like. SOLUTION: The hair growth effect is known by using an oligonucleotide having a base sequence 5'-CCAAAACTGA AGCCGAGAAG-3' (sequence number 1) and an oligonucleotide having a base sequence 5'-ATCGATGCGG GTACAATGTG A-3'(sequence number 2) as a primer, amplifying a DNA from an insulin-like growth factor-1 receptor mRNA, assaying an amplification product and examining expression of an insulin-like growth factor-1 receptor gene. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于评估头发生长器的方法和试剂盒，其用于诊断头发疾病，预测脱发，诊断毛发循环等。解决方案：通过使用具有碱基序列5'-CCAAAACTGA AGCCGAGAAG-3'（序列号1）的寡核苷酸和具有碱基序列5'-ATCGATGCGG GTACAATGTG A-3'（序列号 2）作为引物，从胰岛素样生长因子-1受体mRNA扩增DNA，测定扩增产物并检查胰岛素样生长因子-1受体基因的表达。版权所有（C）2005，JPO＆NCIPI

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