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11. 发明公开

EP2509492A4 DIAGNOSTIC AND THERAPEUTIC MAGNETIC PROPULSION CAPSULE AND METHOD FOR USING THE SAME 审中-公开
标题翻译：磁力驱动诊断和治疗胶囊AND METHOD FOR USE
公开(公告)号：EP2509492A4
公开(公告)日：2015-04-15
申请号：EP10836642
申请日：2010-12-08
申请人： SHACHAR YEHOSHUA , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN , WU WINSTON , MAGNETECS CORP
发明人： SHACHAR YEHOSHUA , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN , WU WINSTON
IPC分类号： A61B5/05 , A61B1/00 , A61B1/04 , A61B5/00
CPC分类号： A61B5/073 , A61B1/00036 , A61B1/00158 , A61B1/041 , A61B5/062 , A61B5/14539 , A61B2034/732

12. 发明申请

WO2011072060A3 DIAGNOSTIC AND THERAPEUTIC MAGNETIC PROPULSION CAPSULE AND METHOD FOR USING THE SAME 审中-公开
标题翻译：诊断和治疗磁力推进胶囊及其使用方法
公开(公告)号：WO2011072060A3
公开(公告)日：2011-10-13
申请号：PCT/US2010059546
申请日：2010-12-08
申请人： SHACHAR YEHOSHUA , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN , WU WINSTON , MAGNETECS CORP
发明人： SHACHAR YEHOSHUA , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN , WU WINSTON
IPC分类号： A61B5/05
CPC分类号： A61B5/073 , A61B1/00036 , A61B1/00158 , A61B1/041 , A61B5/062 , A61B5/14539 , A61B2034/732
摘要： A guided medical propulsion capsule driven by strong electro-magnetic interaction between an external AC/DC magnetic gradient-lobe generator and a set of uniquely magnetized ferrous-conductive elements contained within the capsule. The capsule is navigated through the lumens and cavities of the human body wirelessly and without any physical contact for medical diagnostic, drug delivery, or other procedures with the magnetically guiding field generator external to the human body. The capsule is equipped with at least two sets of magnetic rings, disks and/or plates each possessing anisotropic magnetic properties. The external magnetic gradient fields provide the gradient forces and rotational torques on the internal conductive and magnetic elements needed to make the capsule move, tilt, and rotate in the body lumens and cavities according to the commands of an operator.
摘要翻译：由外部AC / DC磁梯度发生器和包含在胶囊内的一组独特的磁化铁导电元件之间的强电磁相互作用驱动的导向医疗推进胶囊。通过人体外部的导磁场发生器无缝地导航胶囊，并且没有任何物理接触用于医疗诊断，药物递送或其他过程。该胶囊配备有至少两组各具有各向异性磁性的磁环，磁盘和/或板组。外部磁梯度场根据操作员的命令，在使得胶囊沿着体腔和空腔移动，倾斜和旋转所需的内部导电和磁性元件上提供梯度力和旋转扭矩。

13. 发明申请

WO2009155614A3 A MAGNETIC BREATHER PUMP AND A METHOD FOR TREATING A BRAIN TUMOR USING THE SAME 审中-公开
标题翻译：一种磁性呼吸泵和一种使用该方法治疗脑肿瘤的方法
公开(公告)号：WO2009155614A3
公开(公告)日：2010-05-14
申请号：PCT/US2009048189
申请日：2009-06-22
申请人： SHACHAR YEHOSHUA , CHEN THOMAS C , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LAZLO , PHARMACO KINESIS CORP
发明人： SHACHAR YEHOSHUA , CHEN THOMAS C , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LAZLO
IPC分类号： A61M37/00 , A61M1/10 , A61M5/142 , A61P35/00
CPC分类号： A61M5/16827 , A61M5/14276 , A61M2210/0693
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.
摘要翻译：将磁力控制的泵植入患者的脑中，并以对应于患者的特定需要的受控速率递送多个治疗剂。本发明包括由两层聚合物形成的柔性双壁袋。该小袋由磁性螺线管交替地膨胀和收缩。当收缩时，通过多根针将药剂从袋中推出。当袋膨胀时，将周围的脑液吸入小袋的双壁之间的空间，通过导管将其从拉伸到分析器。分析从患者抽取的脑液。基于这些测量，该装置的操作以及因此的处理被远程控制并通过外部控制器显示。

14. 发明申请

WO2012077107A2 MAGNETICALLY MANEUVERABLE IN-VIVO DEVICE 审中-公开
标题翻译：磁性可移动内部设备
公开(公告)号：WO2012077107A2
公开(公告)日：2012-06-14
申请号：PCT/IL2011000930
申请日：2011-12-08
申请人： GIVEN IMAGING LTD , KHAIT SEMION , GILAD ZVIKA , SCHACHAR JOSH , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN , MAGNETECS CORP
发明人： KHAIT SEMION , GILAD ZVIKA , SCHACHAR JOSH , FARKAS LASZLO , MARX BRUCE , JOHNSON DAVID , HAKIM SHAWN
IPC分类号： A61B1/04 , A61B1/00
CPC分类号： A61B1/00158 , A61B1/041 , A61B5/062 , A61B34/73
摘要： An in-vivo device includes a magnetic steering unit (MSU) to maneuver it by an external electromagnetic field. The MSU may include a permanent magnets assembly to produce a magnetic force for navigating the device. The MSU may include a magnets carrying assembly (MCA) to accommodate the permanent magnet(s). The MCA may be designed to generate eddy currents, in response to AC magnetic field, to apply a repelling force. The in-vivo device may also include a multilayered imaging and sensing printed circuit board (MISP) to capture and transmit images. The MISP may include a sensing coil assembly (SCA) to sense electromagnetic fields to determine a location/orientation/angular position of the in-vivo device. Data representing location/orientation/angular position of the device may be used by a maneuvering system to generate a steering magnetic field to steer the in-vivo device from one location or state to another location or state.
摘要翻译：体内装置包括用于通过外部电磁场操纵它的磁转向单元（MSU）。 MSU可以包括永磁体组件以产生用于导航该装置的磁力。 MSU可以包括用于容纳永磁体的磁体承载组件（MCA）。 MCA可以被设计成响应于AC磁场产生涡流以施加排斥力。体内装置还可以包括用于捕获和发射图像的多层成像和感测印刷电路板（MISP）。 MISP可以包括感测线圈组件（SCA），用于感测电磁场以确定体内装置的位置/取向/角位置。表示设备的位置/方向/角度位置的数据可以由操纵系统使用以产生转向磁场以将体内装置从一个位置或状态转移到另一个位置或状态。

15. 发明专利

AU2009259842B2 A magnetic breather pump and a method for treating a brain tumor using the same 未知
公开(公告)号：AU2009259842B2
公开(公告)日：2013-02-14
申请号：AU2009259842
申请日：2009-06-22
申请人： PHARMACO KINESIS CORP , SHACHAR YEHOSHUA
发明人： CHEN THOMAS C , MARX BRUCE , FARKAS LAZLO , SHACHAR YEHOSHUA , FARKAS LESLIE , JOHNSON DAVID
IPC分类号： A61M37/00 , A61M1/10 , A61M5/142 , A61P35/00
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

16. 发明专利

CA2716894C A MAGNETIC BREATHER PUMP AND A METHOD FOR TREATING A BRAIN TUMOR USING THE SAME 未知
公开(公告)号：CA2716894C
公开(公告)日：2012-11-20
申请号：CA2716894
申请日：2009-06-22
申请人： PHARMACO KINESIS CORP , SHACHAR YEHOSHUA
发明人： SHACHAR YEHOSHUA , CHEN THOMAS C , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LAZLO
IPC分类号： A61M37/00 , A61M1/10 , A61M5/142 , A61P35/00
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicat-ing agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexi-ble double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The oper-ation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

17. 发明专利

AU2009259842A1 A magnetic breather pump and a method for treating a brain tumor using the same 未知
公开(公告)号：AU2009259842A1
公开(公告)日：2009-12-23
申请号：AU2009259842
申请日：2009-06-22
申请人： PHARMACO KINESIS CORP , SHACHAR YEHOSHUA
发明人： FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , SHACHAR YEHOSHUA , CHEN THOMAS C , FARKAS LAZLO
IPC分类号： A61M37/00 , A61M1/10 , A61M5/142 , A61P35/00
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

18. 发明公开

EP2288406A4 A MAGNETIC BREATHER PUMP AND A METHOD FOR TREATING A BRAIN TUMOR USING THE SAME 有权
标题翻译：磁排气泵和方法治疗脑瘤
公开(公告)号：EP2288406A4
公开(公告)日：2013-11-20
申请号：EP09767921
申请日：2009-06-22
申请人： SHACHAR YEHOSHUA , PHARMACO KINESIS CORP
发明人： CHEN THOMAS C , FARKAS LESLIE , MARX BRUCE , JOHNSON DAVID , FARKAS LAZLO , SHACHAR YEHOSHUA
IPC分类号： A61M37/00 , A61M1/10 , A61M5/142 , A61P35/00
CPC分类号： A61M5/16827 , A61M5/14276 , A61M2210/0693
摘要： A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

19. 发明申请

WO2008124234A3 METHOD AND APPARATUS FOR CONTROLLING CATHETER POSITIONING AND ORIENTATION 审中-公开
标题翻译：用于控制导管定位和定向的方法和装置
公开(公告)号：WO2008124234A3
公开(公告)日：2008-12-31
申请号：PCT/US2008056277
申请日：2008-03-07
申请人： MAGNETECS INC
发明人： FARKAS LESLIE , SHACHAR YEHOSHUA , MARX BRUCE
IPC分类号： A61B5/06
CPC分类号： A61B5/06 , A61B5/062 , A61B5/7285 , A61B34/20 , A61B34/25 , A61B34/76 , A61B90/36 , A61B2017/00703 , A61B2034/102 , A61B2034/105 , A61B2034/107 , A61B2034/2051
摘要： A method and apparatus for detecting position and orientation of catheter distal magnetic element end while moving in a patient's heart is described. The apparatus includes magnetic sensors for to detect the magnetic field of a generated by the catheter tip. Each sensor transmits the field magnitude and direction to a detection unit, which filters the signals and removes other field sources, such as generated by CGCI coils and external medical hardware. The method allows the measurements of magnitude corresponding to the catheter tip distance from the sensor and the orientation of the field showing the magnetic tip orientation. Since the tip's magnetic field is not necessarily symmetric, the position and orientation computation technique are not independent of each other. Hence, an iterative calculation is used to converge to a solution. The method of determining tip position is calculated by triangulation from each sensor. In one embodiment, the tip orientation is calculated by an intersecting-planes algorithm. The orientation is used to adjust the distances from each sensor, and the process is repeated until convergence for both position and orientation is achieved. The resultant value provides the actual catheter tip position and orientation (AP). The actual position is further filtered by synchronizing the AP measurements with the QRS signal of the heart, allowing the operator and CGCI controller to view the organ as a static object.
摘要翻译：描述了用于在患者心脏中移动时检测导管末端磁性元件端的位置和取向的方法和设备。该设备包括用于检测由导管尖端产生的磁场的磁性传感器。每个传感器将场幅度和方向传输到检测单元，该单元过滤信号并移除其他场源，例如由CGCI线圈和外部医疗硬件产生的场源。该方法允许测量与来自传感器的导管末端距离相对应的量值以及显示磁性末端取向的场的取向。由于尖端的磁场不一定是对称的，所以位置和方向计算技术不是彼此独立的。因此，迭代计算用于收敛到解决方案。通过来自每个传感器的三角测量来计算确定尖端位置的方法。在一个实施例中，尖端取向由相交平面算法计算。方向用于调整每个传感器的距离，重复该过程直到达到位置和方向的收敛。结果值提供了实际的导管尖端位置和方向（AP）。通过将AP测量结果与心脏的QRS信号同步来进一步过滤实际位置，使操作员和CGCI控制器可以将器官视为静态对象。

20. 发明申请

WO2011049814A3 METHOD FOR ACQUIRING HIGH DENSITY MAPPING DATA WITH A CATHETER GUIDANCE SYSTEM 审中-公开
标题翻译：用导管指导系统获取高密度映射数据的方法
公开(公告)号：WO2011049814A3
公开(公告)日：2014-03-27
申请号：PCT/US2010052696
申请日：2010-10-14
申请人： MAGNETECS INC
发明人： SHACHAR YEHOSHUA , MARX BRUCE , JOHNSON DAVID , FARKAS LESLIE , KIM STEVEN
IPC分类号： A61B1/01
CPC分类号： A61B5/0422 , A61B5/06 , A61B5/062
摘要： The present invention is directed to a method of rotating a catheter while it is manually guided in order to increase the volume of space it passes through during a geometric mapping procedure as to provide a higher and more uniform location data point cloud density in a volumetric mapping system.
摘要翻译：本发明涉及一种旋转导管，同时手动引导导管，以便在几何测绘过程期间增加其通过的空间体积，以便在体积映射中提供更高和更均匀的位置数据点云密度系统。

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