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    • 11. 发明申请
    • SURFACE-ACTIVE COLLAGEN BARRIER MEMBRANE TO WHICH A PEPTIDE IS BOUND
    • 表面活性胶原蛋白膜对于肽是有害的
    • WO2012144778A3
    • 2013-01-17
    • PCT/KR2012002895
    • 2012-04-17
    • NANO INTELLIGENT BIOMED ENGCHUNG CHONG-PYOUNGPARK YOON-JEONGLEE JUE-YEONSHIM IN KYONGPARK HYUN JUNG
    • CHUNG CHONG-PYOUNGPARK YOON-JEONGLEE JUE-YEONSHIM IN KYONGPARK HYUN JUNG
    • C07K19/00A61K38/39A61L27/24C07K14/78
    • C07K14/51A61K38/00A61L27/227A61L27/54A61L2300/25A61L2300/412C07K14/4723C07K14/485C07K14/49C07K14/78C07K2319/00
    • The present invention relates to a barrier membrane to which a peptide, which binds to collagen and which is capable of regenerating bone tissue, is bound. More particularly, the present invention relates to a collagen barrier membrane in which a fusion peptide consisting of a collagen-bound peptide and a functional bone-tissue-regenerating peptide is fixed to the surface of collagen. According to the present invention, the surface-active collagen barrier membrane, in which a fusion peptide is coupled to the surface of collagen, can stably bind to the body due to increased local retention, and promote the transport, proliferation, and differentiation of cells, to thereby ultimately maximize bone-tissue-regenerating capacity when implanted in the body. Therefore, the barrier membrane of the present invention is useful in the development of guided bone-regeneration technology. In addition, a fusion peptide can be applied to implants made of collagen having other shapes, and a collagen-bound peptide, which constitutes the fusion peptide, can be bound to and synthesized with a peptide having effects in regenerating other tissue, and therefore can be useful in tissue-regenerating biomaterials for other purposes, e.g. for regenerating skin.
    • 本发明涉及一种与胶原结合且能够再生骨组织的肽结合的阻隔膜。 更具体地说,本发明涉及胶原屏障膜,其中由胶原结合肽和功能性骨组织再生肽组成的融合肽固定在胶原蛋白表面。 根据本发明,融合肽与胶原表面偶联的表面活性胶原屏障膜可以由于局部保留的增加而稳定地结合身体,促进细胞的转运,增殖和分化 ,从而最终使植入体内的骨组织再生能力最大化。 因此,本发明的阻隔膜可用于引导骨再生技术的开发。 此外,融合肽可以应用于具有其他形状的胶原的植入物,并且构成融合肽的胶原结合肽可以与具有再生其他组织的作用的肽结合并合成,因此可以 用于组织再生生物材料用于其他目的,例如 用于再生皮肤。
    • 15. 发明专利
    • BRPI0706921A2
    • 2011-04-12
    • BRPI0706921
    • 2007-01-19
    • SEOUL NAT UNIV IND FOUNDATION
    • PARK YOON-JEONGCHUNG CHONG-PYOUNGLEE SEUNG-JINLEE JUE-YEON
    • A61L27/10
    • The present invention relates to a pharmaceutical composition comprising a bone graft material, a scaffold for tissue engineering applications and type I collagen Binding Peptides which have bone calcification-promoting peptides immobilized on the surface, and more particularly, to a bone graft material and a scaffold for tissue engineering applications (hereinafter, referred to as scaffold), which have peptides specifically binding with type I collagen immobilized on the surface, and pharmaceutical composition for recovering tissue regeneration containing type I collagen binding-inducing peptide. In the inventive bone graft material and scaffold for tissue engineering applications, the cells related to regeneration by collagen binding-inducing peptide adhered to the surface, promote an adhesion of type I collagen binding-inducing peptide (main ingredients of extracellular matrix) to increase differentiation rate into bone tissues, and promote a calcification which is last step of bone regeneration to maximize a tissue regeneration finally.