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11. 发明申请

US20110201638A1 PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT 有权
标题翻译：苯并噻唑类化合物和含有其作为活性成分的NFkB抑制剂
公开(公告)号：US20110201638A1
公开(公告)日：2011-08-18
申请号：US13125698
申请日：2009-10-23
申请人： Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
发明人： Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , C07D491/147
摘要： A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atom; R2 represents a hydroxyl group, or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).
摘要翻译：提供了具有优异的NF＆Kgr B抑制效果的新化合物，具体公开了下式（1）表示的化合物或其盐：其中，R1表示氢原子，低级烷基，低级烷氧基，或卤素原子; R2表示羟基或低级烷氧基; R3表示氢原子，低级烷基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子，低级烷氧基，卤素原子，羟基或亚甲二氧基; R6表示与R5一起形成的氢原子，低级烷氧基或亚甲二氧基，或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; 并且R 8表示氢原子，羟基，氨基或低级烷基羰基氧基（R 1，R 3，R 4和R 7为氢原子的情况除外，R 2和R 8为羟基，R 5和R 6为甲氧基）。

12. 发明申请

US20110201637A1 PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT 有权
标题翻译：苯并呋喃衍生物和含有其作为活性成分的NFκB抑制剂
公开(公告)号：US20110201637A1
公开(公告)日：2011-08-18
申请号：US13124554
申请日：2009-10-23
申请人： Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
发明人： Takashi Ikeda , Seigo Sawada , Takashi Yaegashi , Takeshi Matsuzaki , Shusuke Hashimoto , Ryuta Yamazaki
IPC分类号： A61K31/437 , C07D221/18 , A61P35/00
CPC分类号： C07D471/04
摘要： A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof: wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like; R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like; R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6; R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.
摘要翻译：提供了具有优异NF＆Kgr B抑制作用的新型化合物。具体公开的是由下式（1）表示的化合物或其盐：其中，R1表示氢原子，低级烷基等; R2表示氢原子，低级烷基，卤素原子等; R3表示氢原子，低级烷基，羟基或卤素原子; R4表示氢原子或低级烷氧基; R5表示与R6一起形成的与R6或异丙烯二氧基一起形成的氢原子，低级烷氧基，卤素原子，羟基或亚甲二氧基; R6表示与R5一起形成的氢原子，低级烷氧基或亚甲二氧基，或与R5形成的异丙烯二氧基; R7表示氢原子或低级烷基; R8表示氢原子，羟基，氨基，低级烷基羰基氧基或卤素原子。

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