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11. 发明授权

US08488485B2 Packet latency estimation 有权
标题翻译：分组延迟估计
公开(公告)号：US08488485B2
公开(公告)日：2013-07-16
申请号：US12994332
申请日：2008-05-23
申请人： Roland Carlsson , Aare Mällo
发明人： Roland Carlsson , Aare Mällo
IPC分类号： H04L12/26
CPC分类号： H04L43/16 , H04L43/0852 , H04L2001/0097
摘要： An intermediary node is adapted for receiving a sequence of packets from a server, wherein the intermediary node comprises a time estimator adapted for performing the following steps—resolving the sequence number (k) and time of arrival to the intermediary node for at least a plurality (q) of incoming packets; establishing the frame period of the incoming packets (T); establishing a sequence of normalized packet arrival times (ek) as corresponding to the established frame period (T); calculating the relative arrival time (rtrec, k) of the plurality (q) of incoming packets in relation to the normalized packet arrival times; creating a cumulative density function (CDF) for a given sequence of packets; and establishing the threshold value for the relative arrival time (rtPL) yielding the predefined packet loss (PL) based on the cumulative density function (CDF).
摘要翻译：中间节点适于从服务器接收分组序列，其中中间节点包括适于执行以下步骤的时间估计器 - 将至少多个节点的序列号（k）和到达中间节点的时间解析（q）传入分组; 建立传入分组（T）的帧周期; 建立与建立的帧周期（T）相对应的归一化分组到达时间（ek）的序列; 计算相对于归一化分组到达时间的多个（q）输入分组的相对到达时间（rtrec，k）为给定的包序列创建累积密度函数（CDF）; 以及基于累积密度函数（CDF）建立产生预定义分组丢失（PL）的相对到达时间（rtPL）的阈值。

12. 发明授权

US08114966B2 Peptide-based passive immunization therapy for treatment of atherosclerosis 有权
标题翻译：基于肽的被动免疫治疗动脉粥样硬化
公开(公告)号：US08114966B2
公开(公告)日：2012-02-14
申请号：US12258745
申请日：2008-10-27
申请人： Jan Nilsson , Roland Carlsson , Jenny Bengtsson , Leif Strandberg
发明人： Jan Nilsson , Roland Carlsson , Jenny Bengtsson , Leif Strandberg
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , A61K39/00 , C07K1/00
CPC分类号： C07K14/775 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical or prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.
摘要翻译：本发明涉及用于治疗或预防动脉粥样硬化的被动免疫，其使用针对至少一种载脂蛋白B的氧化片段的分离的人抗体制造用于通过被动免疫治疗或预防性治疗动脉粥样硬化的药物组合物，以及制备这种抗体的方法，以及使用这种抗体治疗哺乳动物，优选人的方法以提供被动免疫。

13. 发明申请

US20110262461A1 BIOLOGICAL MATERIALS AND USES THEREOF 有权
标题翻译：生物材料及其用途
公开(公告)号：US20110262461A1
公开(公告)日：2011-10-27
申请号：US13053846
申请日：2011-03-22
申请人： Björn Frendéus , Roland Carlsson , Anne-Christine Carlsson
发明人： Björn Frendéus , Roland Carlsson , Anne-Christine Carlsson
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N5/078 , A61P31/18 , A61P35/00 , A61P35/02 , A61P29/00 , A61P37/06 , A61P31/00 , C12N5/071 , C12N5/0781
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.
摘要翻译：本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞凋亡。还提供了用于凋亡诱导的方法和药物组合物及其用途。

14. 发明申请

US20090208503A1 IMMUNOTHERAPEUTIC TREATMENT 审中-公开
标题翻译：免疫治疗
公开(公告)号：US20090208503A1
公开(公告)日：2009-08-20
申请号：US12065413
申请日：2006-09-04
申请人： Roland Carlsson , Anne-Christine Carlsson , Jan Nilsson
发明人： Roland Carlsson , Anne-Christine Carlsson , Jan Nilsson
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , A01K67/027 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0012 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/30 , C07K2317/622 , Y02A50/407
摘要： The use of immunotherapy against oxidised LDL to induce regression of pre-existing atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.
摘要翻译：使用针对氧化LDL的免疫治疗来诱导个体中先前存在的动脉粥样硬化病变的消退。免疫治疗可以是使用与氧化的LDL上存在的表位结合的抗体的免疫治疗，或使用疫苗组合物的活性免疫治疗来诱导针对氧化的LDL上存在的表位的免疫应答。

15. 发明授权

US07563578B2 Method for in vitro molecular evolution of protein function 有权
标题翻译：蛋白质功能体外分子进化的方法
公开(公告)号：US07563578B2
公开(公告)日：2009-07-21
申请号：US11858429
申请日：2007-09-20
申请人： Roland Carlsson , Ann-Christin Malmborg Hager , Christina Furebring , Carl Borrebaeck
发明人： Roland Carlsson , Ann-Christin Malmborg Hager , Christina Furebring , Carl Borrebaeck
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12N15/10 , C12N15/1027
摘要： The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3′ and 5′ ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
摘要翻译：本发明提供了从编码一种或多种蛋白质基序的母体单链多核苷酸序列产生多核苷酸序列或序列群的方法，包括以下步骤：a）提供构成母体多核苷酸序列的正负链的单链DNA; b）用不同于DNase I的核酸酶消化单链多核苷酸序列以产生单链片段群; c）将由正链产生的所述片段与由负链产生的片段接触，并任选地加入在退火条件下退火至少一种母体多核苷酸的3'和5'末端的引物序列; d）与由所述亲本多核苷酸编码的一种或多种蛋白质基序相比，扩增彼此退火的片段以产生编码一种或多种具有改变的特征的蛋白质基序的至少一个多核苷酸序列。

16. 发明授权

US07563437B2 Methods and compositions for impairing multiplication of HIV-1 失效
标题翻译：减少HIV-1增殖的方法和组合物
公开(公告)号：US07563437B2
公开(公告)日：2009-07-21
申请号：US11353293
申请日：2006-02-13
申请人： Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
发明人： Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
IPC分类号： A61K39/395
CPC分类号： C07K16/1072 , C07K2317/92
摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.
摘要翻译：单个分离的抗体或其抗体片段结合HIV-1多重菌株和亚型中显示的HIV-1 Tat蛋白的表位内的多个变体序列。这种“泛表位”抗体可用于HIV-1感染的治疗和预防组合物和治疗，不管应变如何。该泛表位抗体可用于基于生物样品中Tat蛋白量的测量来检测HIV-1水平的测定中。

17. 发明授权

US07542722B2 Method and arrangement for minimizing intracell interference in a data transmission system 有权
标题翻译：用于最小化数据传输系统中的小区干扰的方法和装置
公开(公告)号：US07542722B2
公开(公告)日：2009-06-02
申请号：US10583456
申请日：2003-12-19
申请人： Roland Carlsson
发明人： Roland Carlsson
IPC分类号： H04B3/10 , H04B7/212 , H04B1/00 , H04J3/12 , H04J11/00 , H04J3/00 , H04J4/00 , H04Q7/20 , H04Q7/00 , G01S3/02
CPC分类号： H04W72/082 , H04W16/02 , H04W16/10 , H04W16/24 , H04W64/00 , H04W72/0413 , H04W72/0446
摘要： An arrangement and a method for minimizing intracell and/or intercell interference for a data transmission system comprises a scheduler (2). A first base station (BS) receives information from user equipments (UE1-UE4) in a first cell (1) by means of a first antenna system (Rx, Tx). The scheduler (2) identifies the position of each user and allots a first time slot (TS1) to at least one user equipment (UE1) in a first cell segment (CS1) in the first cell (1). The scheduler (2) also allots the first time slot to at least one user (UE3) equipment in a second cell segment (CS2) in the first cell (1). The antenna system (Rx, Tx) then sends information from the base station (BS) simultaneously to all user equipments (UE1, UE3) allotted to the first time slot.
摘要翻译：用于最小化数据传输系统的小区内和/或小区间干扰的装置和方法包括调度器（2）。第一基站（BS）借助于第一天线系统（Rx，Tx）从第一小区（1）中的用户设备（UE1-UE4）接收信息。调度器（2）识别每个用户的位置，并将第一时隙（TS1）分配给第一小区（1）中的第一小区段（CS1）中的至少一个用户设备（UE1）。调度器（2）还向第一小区（1）中的第二小区段（CS2）中的至少一个用户（UE3）设备分配第一时隙。然后，天线系统（Rx，Tx）同时向基站（BS）发送分配给第一时隙的所有用户设备（UE1，UE3）的信息。

18. 发明申请

US20070111745A1 Power control for high speed packet data transmission 有权
标题翻译：用于高速分组数据传输的功率控制
公开(公告)号：US20070111745A1
公开(公告)日：2007-05-17
申请号：US10596730
申请日：2003-12-22
申请人： Roland Carlsson , Torbjorn Karlsson
发明人： Roland Carlsson , Torbjorn Karlsson
IPC分类号： H04B7/00 , H04B1/04 , H04B1/00
CPC分类号： H04W52/60 , H04W52/262 , H04W52/286 , H04W52/34 , H04W52/367
摘要： A transmitting unit comprising a first unit (CM_SCHDR) receiving scheduled first data (DATA2, DATA3) for transmission on at least a first channel, a power control unit (PWR_CTRL) for the first channel responsive to a respective closed loop power regulation signal (TCP_CMD), under which at least the transmit power rate of change is limited to a predetermined value per time unit, a packet data scheduler (HS_SCHDR) scheduling second data packets (DATA1), such as HSPDA data, for transmission on at least a second channel at an actual power level (P_H(t)), and a power amplifier (POWER_AMP) amplifying and outputting the scheduled first and second data, whereby the outputted first and second channels are subject to interference from one another, is shown. A possible power (P_POS(t)) is determined at a given instance as the maximum value of either the actual power (P_HS(t−1)) at a previous instance or the possible power determined at a previous instance (P_POS(t−1)), decreasing the maximum value by a predetermined value (d). Moreover, a permitted power (P_PERM(t)) at a given instance as the maximum value of either the actual power of a previous instance (P_HS(t−1)) added with the predetermined value (d) or the determined possible power (P_POS(t)). Finally, the scheduling is performed within these limits.
摘要翻译：一种发送单元，包括接收用于在至少第一信道上传输的调度的第一数据（DATA2，DATA3）的第一单元（CM_SCHDR），用于响应于各自的闭环功率调节信号的第一通道的功率控制单元（PWR_CTRL）（TCP_CMD），至少将发送功率变化率限制在每个时间单位的预定值，分组数据调度器（HS_SCHDR）至少调度第二数据分组（DATA 1），例如HSDPA数据，用于至少传输示出了实际功率电平（P_H（t））的第二信道和放大并输出调度的第一和第二数据的功率放大器（POWER_AMP），由此输出的第一和第二信道彼此受到干扰。在给定情况下确定可能的功率（P_POS（t））作为先前情况下的实际功率（P_H（t-1））或先前实例确定的可能功率的最大值（P_POS（t- 1）），将最大值减小预定值（d）。此外，在给定实例处的允许功率（P_PERM（t））作为加上预定值（d）的前一个实例（P_H（t-1））的实际功率的最大值或所确定的可能功率 P_POS（t））。最后，在这些限制内进行调度。

19. 发明授权

US06958213B2 Method for in vitro molecular evolution of protein function 失效
标题翻译：蛋白质功能体外分子进化的方法
公开(公告)号：US06958213B2
公开(公告)日：2005-10-25
申请号：US09734801
申请日：2000-12-12
申请人： Roland Carlsson , Ann-Christin Malmborg Hager , Christina Furebring , Carl Borrebaeck
发明人： Roland Carlsson , Ann-Christin Malmborg Hager , Christina Furebring , Carl Borrebaeck
IPC分类号： C12N15/10 , C12Q1/68 , C07H21/04 , C12P21/06
CPC分类号： C12N15/10 , C12N15/1027
摘要： The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; (b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3′ and 5′ ends of at least one of the parent polynucleotides under annealing conditions; (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
摘要翻译：本发明提供了从编码一种或多种蛋白质基序的母体单链多核苷酸序列产生多核苷酸序列或序列群的方法，其包括以下步骤：（a）提供构成母体多核苷酸序列的正负链的单链DNA; （b）用除DNA酶I以外的核酸酶消化单链多核苷酸序列以产生单链片段群; （c）将由正链产生的所述片段与由负链产生的片段接触，并任选地加入在退火条件下与至少一种母体多核苷酸的3'和5'末端退火的引物序列; （d）与由所述亲本多核苷酸编码的一种或多种蛋白质基序相比，扩增彼此退火的片段以产生编码一种或多种具有改变特征的蛋白质基序的至少一个多核苷酸序列。

20. 发明授权

US08238361B2 Scheduling and queue management with adaptive queue latency 有权
标题翻译：具有自适应队列延迟的调度和队列管理
公开(公告)号：US08238361B2
公开(公告)日：2012-08-07
申请号：US12520021
申请日：2006-12-18
申请人： Roland Carlsson
发明人： Roland Carlsson
IPC分类号： H04L12/54 , H04L12/28 , G01R31/08
CPC分类号： H04L47/10 , H04L47/14 , H04L47/193 , H04L47/22 , H04L47/25 , H04L47/37 , H04L49/90
摘要： The invention relates to a scheduler for a TCP/IP based data communication system and a method for the scheduler. The communication system comprises a TCP/IP transmitter and a receiving unit (UE). The scheduler is associated with a Node comprising a rate measuring device for measuring a TCP/IP data rate from the TCP/IP transmitter and a queue buffer device for buffering data segments from the TCP/IP transmitter. The scheduler is arranged to receive information from the rate measuring device regarding the TCP/IP data rate and is arranged to adapt the permitted queue latency to a minimum value when the TCP/IP transmitter is in a slow start mode and to increase the permitted queue latency when the TCP/IP rate has reached a threshold value.
摘要翻译：本发明涉及一种用于基于TCP / IP的数据通信系统的调度器和一种调度器的方法。通信系统包括TCP / IP发射机和接收单元（UE）。调度器与包括用于从TCP / IP发送器测量TCP / IP数据速率的速率测量设备的节点和用于从TCP / IP发送器缓冲数据段的队列缓冲器设备相关联。调度器被布置为从速率测量设备接收关于TCP / IP数据速率的信息，并且被布置为当TCP / IP发射机处于慢启动模式时将允许的队列等待时间调整到最小值，并且增加允许的队列 TCP / IP速率达到阈值时的延迟。

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