专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07977462B2 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US07977462B2
公开(公告)日：2011-07-12
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

12. 发明申请

US20090305297A1 Tyrosine phosphorylation sites 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090305297A1
公开(公告)日：2009-12-10
申请号：US12157179
申请日：2008-06-06
申请人： Peter Hornbeck , Francesco Boccalatte , Charles Farnsworth , Valerie Goss , Ting-Lei Gu , Ailan Guo , Yu Li , Albrecht Moritz , Klarisa Rikova , Erik Spek , Matthew Stokes , Jian Yu
发明人： Peter Hornbeck , Francesco Boccalatte , Charles Farnsworth , Valerie Goss , Ting-Lei Gu , Ailan Guo , Yu Li , Albrecht Moritz , Klarisa Rikova , Erik Spek , Matthew Stokes , Jian Yu
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： G01N33/573 , C07K16/40 , C12Q1/485 , G01N33/574 , G01N33/57426
摘要： The invention discloses 397 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的397个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

13. 发明申请

US20090099340A1 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20090099340A1
公开(公告)日：2009-04-16
申请号：US11974480
申请日：2007-10-12
申请人： Ailan Guo , Klarisa Rikova , Albrecht Moritz , Yu Li , Charles Farnsworth , Kimberly Lee , Roberto Polakiewicz
发明人： Ailan Guo , Klarisa Rikova , Albrecht Moritz , Yu Li , Charles Farnsworth , Kimberly Lee , Roberto Polakiewicz
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/574 , G01N33/6842
摘要： The invention discloses 214 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho-diesterases/Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的214个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质作为使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：适配器/支架蛋白，细胞骨架蛋白，GTP信号蛋白，激酶，代谢蛋白，磷酸酶/磷酸二酯酶/蛋白酶，受体蛋白，RNA加工蛋白，转录蛋白，翻译蛋白质，转运蛋白和Ubitquitin蛋白质，以及其他蛋白质类型。

14. 发明申请

US20110105732A1 Reagents for the Detection of Protein Phosphorylation in Carcinoma Signaling Pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20110105732A1
公开(公告)日：2011-05-05
申请号：US12985879
申请日：2011-01-06
申请人： Ailan Guo , Roberto Polakiewicz , Charles Farnsworth , Klarisa Rikova , Albrecht Moritz , Kimberly Lee , Yu Li
发明人： Ailan Guo , Roberto Polakiewicz , Charles Farnsworth , Klarisa Rikova , Albrecht Moritz , Kimberly Lee , Yu Li
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/574 , G01N33/6842
摘要： The invention discloses 214 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho-diesterases/Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的214个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质作为使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：适配器/支架蛋白，细胞骨架蛋白，GTP信号蛋白，激酶，代谢蛋白，磷酸酶/磷酸二酯酶/蛋白酶，受体蛋白，RNA加工蛋白，转录蛋白，翻译蛋白质，转运蛋白和Ubitquitin蛋白质，以及其他蛋白质类型。

15. 发明申请

US20080108795A1 Reagents for the detection of protein phosphorylation in EGFR-signaling pathways 有权
标题翻译：用于检测EGFR-信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20080108795A1
公开(公告)日：2008-05-08
申请号：US11821130
申请日：2007-06-21
申请人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
发明人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , C07B59/008 , C07K2317/34
摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。

16. 发明申请

US20110130547A1 Reagents For The Detection Of Protein Phosphorylation In EGFR Signaling Pathways 审中-公开
标题翻译：用于检测EGFR信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20110130547A1
公开(公告)日：2011-06-02
申请号：US12897363
申请日：2010-10-04
申请人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Roberto Polakiewicz
发明人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Roberto Polakiewicz
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , C07B59/008 , C07K2317/34
摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。

17. 发明授权

US07807789B2 Reagents for the detection of protein phosphorylation in EGFR-signaling pathways 有权
标题翻译：用于检测EGFR-信号通路中蛋白质磷酸化的试剂
公开(公告)号：US07807789B2
公开(公告)日：2010-10-05
申请号：US11821130
申请日：2007-06-21
申请人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
发明人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
IPC分类号： C12P21/08 , C07K16/28
CPC分类号： C07K16/2863 , C07B59/008 , C07K2317/34
摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。

18. 发明申请

US20100173322A1 Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways 审中-公开
标题翻译：用于检测间变性大细胞淋巴瘤信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20100173322A1
公开(公告)日：2010-07-08
申请号：US12074876
申请日：2008-03-06
申请人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Kimberly Lee , Erik Spek , Charles Farnsworth , Francesco Boccalatte
发明人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Kimberly Lee , Erik Spek , Charles Farnsworth , Francesco Boccalatte
IPC分类号： G01N33/53 , C07K16/18 , G01N33/566
CPC分类号： C07K16/3061 , C07K2317/34 , G01N33/6842 , G01N33/6848
摘要： The invention discloses nearly 219 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the NPM-ALK translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的近219个新的磷酸化位点和涉及NPM-ALK易位/融合的间变性大细胞淋巴瘤（ALCL）的途径，并且提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于这些磷酸化位点/蛋白质的选择性检测和定量，以及用于这些目的的试剂的方法。

19. 发明申请

US20100304406A1 Protein Phosphorylation by Serine/Threonine Kinases in Insulin Signaling Pathways 审中-公开
标题翻译：胰岛素信号途径中丝氨酸/苏氨酸激酶的蛋白质磷酸化
公开(公告)号：US20100304406A1
公开(公告)日：2010-12-02
申请号：US12586088
申请日：2009-09-17
申请人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Jing Zhou , John Rush , Klarisa Rikova , Matthew Stokes , Valerie Goss , Yu Li
发明人： Ailan Guo , Albrecht Moritz , Anthony Possemato , Charles Farnsworth , Hong Ren , Jing Zhou , John Rush , Klarisa Rikova , Matthew Stokes , Valerie Goss , Yu Li
IPC分类号： G01N33/567 , C07K16/18 , G01N33/68
CPC分类号： G01N33/6842 , C07K16/18 , C07K2317/34 , G01N33/6851
摘要： The invention discloses 137 novel phosphorylation sites identified in insulin signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在胰岛素信号通路中鉴定的137个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体以及上述的诊断和治疗用途。

20. 发明申请

US20110143368A1 Tyrosine phosphorylation sites 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20110143368A1
公开(公告)日：2011-06-16
申请号：US12806766
申请日：2010-08-20
申请人： Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
发明人： Ting-Lei Gu , Anthony Possemato , Klarisa Rikova , Jian Yu , Valerie Goss , Corinne Michaud , Charles Farnsworth , Ailan Guo , Albrecht Moritz , Yu Li
IPC分类号： G01N33/68 , C07K16/40 , C07K16/30 , C07K16/18
CPC分类号： C07K16/44 , C07K16/30 , C07K2317/34 , G01N33/6842
摘要： The invention discloses 142 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了142个在癌中鉴定的新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式