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11. 发明授权

US08638256B2 Accuracy and performance of a hybrid positioning system 有权
标题翻译：混合定位系统的精度和性能
公开(公告)号：US08638256B2
公开(公告)日：2014-01-28
申请号：US12569106
申请日：2009-09-29
申请人： Farshid Alizadeh-Shabdiz , Mohammad A. Heidaran
发明人： Farshid Alizadeh-Shabdiz , Mohammad A. Heidaran
IPC分类号： G01S19/48
CPC分类号： G01S19/13 , G01S19/48
摘要： The present disclosure relates to a method for determining the position of a WLAN positioning system (WPS) and satellite positioning system (SPS) enabled device. The method can include determining an initial WPS position of the device using WPS, calculating an error region around the initial WPS position of the device, dividing the error region into a plurality of points, obtaining satellite measurements from at least two satellites in view of the device, determining a variation in a receiver clock bias for each point within the error region based on the satellite measurements from at least two satellites, selecting the point with the lowest variation in the receiver clock bias, and determining whether or not to use the point with the lowest variation in receiver clock bias to refine the initial WPS position of the device.
摘要翻译：本公开涉及一种用于确定WLAN定位系统（WPS）和卫星定位系统（SPS）使能设备的位置的方法。该方法可以包括使用WPS确定设备的初始WPS位置，计算设备的初始WPS位置周围的误差区域，将误差区域划分为多个点，从至少两个卫星获得卫星测量设备，基于来自至少两颗卫星的卫星测量确定误差区域内的每个点的接收机时钟偏差的变化，选择接收机时钟偏差中具有最低变化的点，以及确定是否使用该点接收机时钟偏差的变化最小，以改善器件的初始WPS位置。

12. 发明申请

US20100047214A1 Methods and Compositions for Treatment of Bone Defects with Placental Cell Populations 有权
标题翻译：用胎盘细胞群治疗骨缺损的方法和组合
公开(公告)号：US20100047214A1
公开(公告)日：2010-02-25
申请号：US12546556
申请日：2009-08-24
申请人： Sascha D. Abramson , Marian Guelakis , Mohammad A. Heidaran , Kristen Labazzo , Shmuel Yaccoby
发明人： Sascha D. Abramson , Marian Guelakis , Mohammad A. Heidaran , Kristen Labazzo , Shmuel Yaccoby
IPC分类号： A61K35/50 , C12N5/071
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.
摘要翻译：本文提供了成骨胎盘贴壁细胞（OPAC），使用OPAC和OPAC群体的方法，以及培养，增殖，扩增或分化OPAC的方法。本文还提供了使用OPAC来配制适于给予受试者的可植入或可注射组合物的方法。本文还提供了用OPAC和包含OPAC的组合物治疗骨缺损的方法。本文还提供了在多发性骨髓瘤的治疗和管理中使用OPAC的方法，例如减少多发性骨髓瘤个体中多发性骨髓瘤的一种或多种症状的进展，停止进展或改善多发性骨髓瘤的一种或多种症状的方法，包括施用多个的OPACs给个人。

13. 发明申请

US20080200345A1 HIGH THROUGHPUT METHOD TO IDENTIFY LIGANDS FOR CELL ATTACHMENT 审中-公开
标题翻译：识别细胞附着配体的高通量方法
公开(公告)号：US20080200345A1
公开(公告)日：2008-08-21
申请号：US12015233
申请日：2008-01-16
申请人： Andrea Liebmann-Vinson , Jonathan A. Rowley , Chris H. Bodily , Mohammad A. Heidaran
发明人： Andrea Liebmann-Vinson , Jonathan A. Rowley , Chris H. Bodily , Mohammad A. Heidaran
IPC分类号： C40B30/06
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5029 , G01N33/54393
摘要： A high throughput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are effective in producing the desired biological response in the contacted cells.
摘要翻译：提供了一种高通量方法，用于鉴定能够在全细胞中产生所需生物反应的试剂。该方法包括提供具有培养表面的容器的步骤; 根据统计设计将单一试剂的不同混合物置于选择性容器中; 并将单一试剂的混合物固定到培养表面。该方法还包括使固定化的试剂与整个细胞接触; 并且获取指示所接触细胞中所需生物反应的数据。该方法还包括使用获取的数据的统计建模来确定单个试剂的哪些混合物和/或这些混合物中的哪一种试剂在接触的细胞中产生所需的生物反应是有效的。

14. 发明授权

US06932977B2 Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4 失效
标题翻译：用BMP-4细胞外基质诱导或增强软骨形成的方法
公开(公告)号：US06932977B2
公开(公告)日：2005-08-23
申请号：US09805816
申请日：2001-03-13
申请人： Mohammad A. Heidaran , Robin Daverman
发明人： Mohammad A. Heidaran , Robin Daverman
IPC分类号： A61K9/00 , A61K9/16 , A61K31/715 , A61K35/12 , A61K38/18 , A61K38/39 , C12N5/00 , C12N5/077 , A61F2/02
CPC分类号： A61K9/0024 , A61K9/1652 , A61K9/1658 , A61K31/715 , A61K35/12 , A61K38/1875 , A61K38/39 , C12N5/0068 , C12N5/0655 , C12N2501/155 , C12N2501/19 , C12N2533/54 , C12N2533/70 , A61K2300/00
摘要： A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing BMP-4 or a combination of BMP-4 and GDF-5.
摘要翻译：提供用于在体内或体外诱导或增强软骨形成的方法和组合物。该方法通过将体外或体内细胞暴露于包含I型胶原，II型胶原或I型胶原或II型胶原和透明质酸盐的混合物并进一步含有BMP-4或BMP的组合的细胞外基质 -4和GDF-5。

15. 发明授权

US06645945B1 Method of treating diseased, injured or abnormal cartilage with hyaluronic acid and growth factors 有权
标题翻译：用透明质酸和生长因子治疗患病，损伤或异常软骨的方法
公开(公告)号：US06645945B1
公开(公告)日：2003-11-11
申请号：US09298539
申请日：1999-04-22
申请人： Michael Radomsky , Mohammad A. Heidaran
发明人： Michael Radomsky , Mohammad A. Heidaran
IPC分类号： A61K31715
CPC分类号： A61K31/728 , A61K31/715 , A61K38/1825 , A61K38/30 , A61K2300/00
摘要： A composition is provided for treating diseased, injured or diseased cartilage comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site for a period of time sufficient to alleviate the symptoms of the disease, injury or abnormality. Preferably hyaluronic acid is used in a composition range of 0.01-4% by weight and the preferred growth factor is IGF-I, present in a concentration range of about 10−6 to 100 mg/ml.
摘要翻译：提供了组合物，用于治疗包含透明质酸和生长因子的患病，受伤或患病的软骨。该组合物具有足够的粘度和生物降解性，足以在该部位持续足以减轻疾病症状，损伤或异常的时间。透明质酸优选使用的组成范围为0.01-4重量％，优选的生长因子是IGF-I，其浓度范围约为10 -6至100mg / ml。

16. 发明授权

US08728805B2 Methods and compositions for treatment of bone defects with placental cell populations 有权
标题翻译：用于治疗胎盘细胞群体骨缺损的方法和组合物
公开(公告)号：US08728805B2
公开(公告)日：2014-05-20
申请号：US12546556
申请日：2009-08-24
申请人： Sascha D. Abramson , Marian Guelakis , Mohammad A. Heidaran , Kristen Labazzo , Shmuel Yaccoby
发明人： Sascha D. Abramson , Marian Guelakis , Mohammad A. Heidaran , Kristen Labazzo , Shmuel Yaccoby
IPC分类号： C12N5/07
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Provided herein are osteogenic placental adherent cells (OPACs), methods of using OPACs and OPAC populations, and methods of culturing, proliferating, expanding, or differentiating the OPACs. Further provided herein are methods of using the OPACs to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are methods for treating bone defects with OPACs and compositions comprising OPACs. Also provided herein are methods of using OPACs in the treatment and management of multiple myeloma, e.g., reducing the progression of, halting the progression of, or improving, one or more symptoms of multiple myeloma in an individual having multiple myeloma, comprising administering a plurality of OPACs to the individual.
摘要翻译：本文提供了成骨胎盘贴壁细胞（OPAC），使用OPAC和OPAC群体的方法，以及培养，增殖，扩增或分化OPAC的方法。本文还提供了使用OPAC来配制适于给予受试者的可植入或可注射组合物的方法。本文还提供了用OPAC和包含OPAC的组合物治疗骨缺损的方法。本文还提供了在多发性骨髓瘤的治疗和管理中使用OPAC的方法，例如减少多发性骨髓瘤个体中多发性骨髓瘤的一种或多种症状的进展，停止进展或改善多发性骨髓瘤的一种或多种症状的方法，包括施用多个的OPACs给个人。

17. 发明授权

US07399630B2 Peptides for enhanced cell attachment and growth 有权
标题翻译：用于增强细胞附着和生长的肽
公开(公告)号：US07399630B2
公开(公告)日：2008-07-15
申请号：US11604530
申请日：2006-11-27
申请人： Richard David Guarino , Bryce Nelson Chaney , Andrea Liebmann-Vinson , Mohammad A. Heidaran
发明人： Richard David Guarino , Bryce Nelson Chaney , Andrea Liebmann-Vinson , Mohammad A. Heidaran
IPC分类号： C12M3/00 , C12N5/00 , C12N5/02 , C12N5/06 , C07K17/08
CPC分类号： C07K7/06 , B33Y70/00 , B33Y80/00 , C07K5/0806 , C07K5/1008 , C07K5/1019
摘要： The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
摘要翻译：本发明涉及促进细胞附着或细胞粘附到培养物表面的细胞粘附促进（“CAP”）肽组合，否则细胞粘附抗性“CAR”。本发明提供了肽的组合，当共价偶联到CAR层（例如在聚苯乙烯表面上产生的透明质酸）共价偶联时，促进细胞附着，生长分化以及在培养中执行其它所需的细胞功能。

18. 发明授权

US06967086B2 Method for determining the presence or absence of respiring cells on a three-dimensional scaffold 有权
标题翻译：用于确定在三维支架上存在或不存在呼吸细胞的方法
公开(公告)号：US06967086B2
公开(公告)日：2005-11-22
申请号：US10109475
申请日：2002-03-28
申请人： Richard David Guarino , John Jacob Hemperly , Catherine A. Spargo , Andrea Liebmann-Vinson , Mohammad A. Heidaran
发明人： Richard David Guarino , John Jacob Hemperly , Catherine A. Spargo , Andrea Liebmann-Vinson , Mohammad A. Heidaran
IPC分类号： C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/04 , B33Y80/00 , C12Q1/18 , C12Q2304/44
摘要： The invention provides a method and apparatus for determining the presence or absence of respiring cells, involving combining a three-dimensional biomimetic scaffold and cells onto a sensor composition.
摘要翻译：本发明提供了一种用于确定呼吸细胞的存在或不存在的方法和装置，其涉及将三维仿生支架和细胞组合到传感器组合物上。

19. 发明授权

US06586406B2 Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5 有权
标题翻译：用含有GDF-5的细胞外基质诱导或增强软骨形成的方法
公开(公告)号：US06586406B2
公开(公告)日：2003-07-01
申请号：US09418689
申请日：1999-10-14
申请人： Mohammad A. Heidaran , Robert C. Spiro , Robin Daverman , LinShu Liu
发明人： Mohammad A. Heidaran , Robert C. Spiro , Robin Daverman , LinShu Liu
IPC分类号： A61K3800
CPC分类号： A61K38/1875 , A61K38/39 , C12N5/0068 , C12N5/0655 , C12N2501/19 , C12N2533/54 , C12N2533/70 , A61K2300/00
摘要： A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.
摘要翻译：提供用于在体内或体外诱导或增强软骨形成的方法和组合物。该方法通过将体外或体内细胞暴露于包含I型胶原，II型胶原或I型胶原或II型胶原和透明质酸盐的混合物并进一步含有GDF-5的细胞外基质进行。

20. 发明申请

US20100172830A1 Extraembryonic Tissue cells and method of use thereof 审中-公开
标题翻译：胚胎组织细胞及其使用方法
公开(公告)号：US20100172830A1
公开(公告)日：2010-07-08
申请号：US12028756
申请日：2008-02-08
申请人： Mohammad A. Heidaran
发明人： Mohammad A. Heidaran
IPC分类号： A61K51/00 , C12N5/00 , C12N5/02 , A61K35/12 , A61K49/00
CPC分类号： A61K49/1896 , A61K35/12 , A61K51/1203 , C12N5/0605 , C12N2533/74
摘要： The present invention provides Pre-term Placenta Extra-embryonic Tissue Cell (PPETC) populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of using such cells for therapeutic and diagnostic applications. The present invention provides a method for isolation of extra-embryonic cell population will which are to be obtained preferably from premature discarded placenta by a process of non-enzymatic digestion or mechanical disruption. The isolated cells are cultured in semi-solid glycosaminoglycan-based three-dimensional milieu supplemented with autologous umbilical cord-derived serum. The isolated cells which are expanded in semi-solid media will be formulated for intravenous injections to patients having end stage cystic fibrosis. A preferred method of formulating cells for intravenous injection and optimal cell number are described herein. The PPETC may also used to diagnose diseased organs and elicit a robust immune response to stem cell markers commonly found in certain type of cancer stem cells.
摘要翻译：本发明提供了前期胎盘超胚胎组织细胞（PPETC）群体及其培养，增殖和扩增的方法。本发明还提供了使用这种细胞用于治疗和诊断应用的方法。本发明提供了一种通过非酶消化或机械破坏的方法从胚胎早熟获得的胚胎间细胞群的分离方法。分离的细胞在补充有自体脐带血清的半固体基于糖胺聚糖的三维环境中培养。在半固体培养基中扩增的分离的细胞将被配制用于具有末期囊性纤维化的患者的静脉内注射。本文描述了配制用于静脉内注射的细胞和最佳细胞数量的优选方法。 PPETC还可以用于诊断患病的器官，并且对通常在某些类型的癌症干细胞中发现的干细胞标记物产生强大的免疫应答。

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