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11. 发明授权

US08744579B2 LV threshold measurement and capture management 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US08744579B2
公开(公告)日：2014-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

12. 发明申请

US20100137935A1 LV THRESHOLD MEASUREMENT AND CAPTURE MANAGEMENT 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US20100137935A1
公开(公告)日：2010-06-03
申请号：US12700454
申请日：2010-02-04
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

13. 发明授权

US07684863B2 LV threshold measurement and capture management 有权
标题翻译： LV阈值测量和捕获管理
公开(公告)号：US07684863B2
公开(公告)日：2010-03-23
申请号：US11311984
申请日：2005-12-20
申请人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
发明人： Purvee P. Parikh , John C. Stroebel , Todd J. Sheldon , Karen J. Kleckner
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/371
摘要： The invention provides methods and apparatus for determining in a non-tracking pacing mode (e.g., DDI/R, VVI/R) whether a ventricular pacing stimulus is capturing a paced ventricle, including some or all of the following aspects. For example, increasing a ventricular pacing rate a nominal amount to an overdrive pacing rate higher than a most recent heart rate and evaluating a conduction interval from a first pacing ventricle to a second sensing ventricle and then continuing to monitor the underlying rate to ensure that a threshold testing pacing rate will not exceed a predetermined minimum interval and providing pacing stimulation to the first ventricle and sensing the second ventricle to determine whether the pacing stimulation to the first ventricle was one of sub-threshold and supra-threshold. The methods and apparatus are especially useful in conjunction with ensuring actual delivery of a ventricular pacing regime (e.g., cardiac resynchronization therapy or “CRT”).
摘要翻译：本发明提供了用于在非跟踪起搏模式（例如，DDI / R，VVI / R）中确定心室起搏刺激是否捕获节奏心室的方法和装置，包括以下方面中的一些或全部。例如，将心室起搏速率提高到高于最近心率的超速起搏速率的标称值，并评估从第一起搏心室到第二感测心室的传导间隔，然后继续监测潜在速率，以确保阈值测试起搏速率不会超过预定的最小间隔，并且向第一脑室提供起搏刺激并且感测第二脑室以确定对第一脑室的起搏刺激是否是子阈值和超阈值之一。所述方法和装置与确保心室起搏方案（例如，心脏再同步治疗或“CRT”）的实际递送相结合特别有用。

14. 发明授权

US07869872B2 System and method for determining intrinsic AV interval timing 有权
公开(公告)号：US07869872B2
公开(公告)日：2011-01-11
申请号：US11424395
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle is truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.

15. 发明申请

US20070293899A1 System and Method for Ventricular Interval Smoothing Following a Premature Ventricular Contraction 有权
标题翻译：心室收缩后心室间隔平滑的系统和方法
公开(公告)号：US20070293899A1
公开(公告)日：2007-12-20
申请号：US11424405
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3621
摘要： An implantable medical device includes cardiac pacing functions. In order to reduce ventricular pacing, various modes are employed that tolerate missed ventricular beats, provide backup pacing and maintain overall AV synchrony. Upon the occurrence of a PVC, A-A timing is modified so that resultant V-V intervals are appropriate and ventricular pacing is avoided.
摘要翻译：可植入医疗装置包括心脏起搏功能。为了减少心室起搏，采用各种模式，允许心跳失败，提供后备起搏和维持整体AV同步。发生PVC时，修改A-A定时，以便得到合适的V-V间隔，避免心室起搏。

16. 发明授权

US07856269B2 System and method for determining phsyiologic events during pacing mode operation 有权
标题翻译：用于在起搏模式操作期间确定phsyiologic事件的系统和方法
公开(公告)号：US07856269B2
公开(公告)日：2010-12-21
申请号：US11461162
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

17. 发明申请

US20080027494A1 System and Method for Determining Phsyiologic Events During Pacing Mode Operation 有权
标题翻译：在起搏模式运行期间确定病理学事件的系统和方法
公开(公告)号：US20080027494A1
公开(公告)日：2008-01-31
申请号：US11461162
申请日：2006-07-31
申请人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
发明人： Todd J. Sheldon , Scott R. Stanslaski , Michael O. Sweeney , Robert A. Betzold , Douglas A. Hettrick
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

18. 发明申请

US20110112596A1 SYSTEM AND METHOD FOR DETERMINING INTRINSIC AV INTERVAL TIMING 有权
标题翻译：用于确定内部AV间隔时序的系统和方法
公开(公告)号：US20110112596A1
公开(公告)日：2011-05-12
申请号：US13004510
申请日：2011-01-11
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle is truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

19. 发明授权

US07894898B2 System and method for ventricular interval smoothing following a premature ventricular contraction 有权
标题翻译：室性早搏后心室间隔平滑的系统和方法
公开(公告)号：US07894898B2
公开(公告)日：2011-02-22
申请号：US11424405
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3621
摘要： An implantable medical device includes cardiac pacing functions. In order to reduce ventricular pacing, various modes are employed that tolerate missed ventricular beats, provide backup pacing and maintain overall AV synchrony. Upon the occurrence of a PVC, A-A timing is modified so that resultant V-V intervals are appropriate and ventricular pacing is avoided.
摘要翻译：可植入医疗装置包括心脏起搏功能。为了减少心室起搏，采用各种模式，允许心跳失败，提供后备起搏和维持整体AV同步。发生PVC时，修改A-A定时，以便得到合适的V-V间隔，避免心室起搏。

20. 发明授权

US07565196B2 System and method for promoting intrinsic conduction through atrial timing 有权
标题翻译：通过心房定时促进内在传导的系统和方法
公开(公告)号：US07565196B2
公开(公告)日：2009-07-21
申请号：US11424410
申请日：2006-06-15
申请人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
发明人： Todd J. Sheldon , Paul A. Belk , Michael O. Sweeney
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61F2002/30677 , A61F2002/3068 , A61F2002/444 , A61F2002/4666 , A61F2250/0067 , A61F2250/0068 , A61K9/0024 , A61M31/002 , A61N1/3627 , A61N1/3682
摘要： An atrial based pacing protocol promotes intrinsic conduction. An entire cardiac cycle is monitored for ventricular activity and permitted to lapse with ventricular activity. Ventricular pacing is available in a cardiac cycle immediately subsequent to such a skipped beat. When monitoring for intrinsic ventricular events, an event is expected within a given window. If no such event is detected, the cardiac cycle in truncated, leading to a shorter cycle that is devoid of ventricular activity. The subsequent cycle has a high likelihood of a ventricular sensed event and a greater than normal AV interval is provided prior to pacing.
摘要翻译：基于心房的起搏方案促进内在传导。监测整个心动周期的心室活动，并允许心室活动失效。在这种跳过的搏动之后，心室起搏可以在心脏周期中使用。在监测内部心室事件时，预期在给定的窗口内会发生事件。如果没有检测到这样的事件，心脏周期被截断，导致没有心室活动的更短的周期。随后的周期具有心室感测事件的高可能性，并且在起搏之前提供大于正常的AV间隔。

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