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11. 发明申请

US20060264395A1 Modulation of apolipoprotein c-III expression 有权
标题翻译：载脂蛋白c-III表达的调节
公开(公告)号：US20060264395A1
公开(公告)日：2006-11-23
申请号：US10553722
申请日：2004-04-15
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译：提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。

12. 发明申请

US20060009410A1 Effects of apolipoprotein B inhibition on gene expression profiles in animals 审中-公开
标题翻译：载脂蛋白B抑制对动物基因表达谱的影响
公开(公告)号：US20060009410A1
公开(公告)日：2006-01-12
申请号：US11123656
申请日：2005-05-05
申请人： Rosanne Crooke , Mark Graham
发明人： Rosanne Crooke , Mark Graham
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Methods are provided for modulating the expression of genes involved in lipid metabolism, useful in the treatment of conditions associated with cardiovascular risk. Antisense oligonucleotides targeted to apolipoprotein B reduce the level of apolipoprotein B mRNA, lower serum cholesterol and shift liver gene expression profiles from those of an obese animal towards those of a lean animal. Further provided are methods for improving the cardiovascular risk of a subject through antisense inhibition of apolipoprotein B. Also provided are methods for employing antisense oligonucleotides targeted to apolipoprotein B to modulate a cellular pathway or metabolic process.
摘要翻译：提供了用于调节参与脂质代谢的基因的表达的方法，其可用于治疗与心血管风险相关的病症。靶向载脂蛋白B的反义寡核苷酸降低载脂蛋白B mRNA的水平，降低血清胆固醇，并将肥胖动物的肝脏基因表达谱从精子动物转移到肝脏基因表达谱。还提供了通过载脂蛋白B的反义抑制来改善受试者的心血管风险的方法。还提供了使用靶向载脂蛋白B的反义寡核苷酸调节细胞途径或代谢过程的方法。

13. 发明申请

US20050181376A1 Antisense modulation of microsomal triglyceride transfer protein expression 审中-公开
标题翻译：微粒体甘油三酯转移蛋白表达的反义调制
公开(公告)号：US20050181376A1
公开(公告)日：2005-08-18
申请号：US10759618
申请日：2004-01-16
申请人： Rosanne Crooke , Mark Graham
发明人： Rosanne Crooke , Mark Graham
IPC分类号： A61K38/00 , C12N15/113 , A61K48/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of microsomal triglyceride transfer protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding microsomal triglyceride transfer protein. Methods of using these compounds for modulation of microsomal triglyceride transfer protein expression and for treatment of diseases associated with expression of microsomal triglyceride transfer protein are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节微粒体甘油三酯转运蛋白的表达。组合物包含靶向编码微粒体甘油三酸转移蛋白的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节微粒体甘油三酯转移蛋白表达和治疗与微粒体甘油三酯转运蛋白表达有关的疾病的方法。

14. 发明申请

US20050014257A1 Modulation of C-reactive protein expression 失效
标题翻译： C反应蛋白表达调控
公开(公告)号：US20050014257A1
公开(公告)日：2005-01-20
申请号：US10858500
申请日：2004-06-01
申请人： Rosanne Crooke , Mark Graham
发明人： Rosanne Crooke , Mark Graham
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04 , C12N20060101 , C12N15/113 , C12Q1/68
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译：提供化合物，组合物和方法用于调节C-反应蛋白的表达。组合物包含针对编码C反应蛋白的核酸的寡核苷酸。提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。

15. 发明授权

US09145238B2 Lid for beverage container and beverage container including same 有权
标题翻译：用于饮料容器和包含其的饮料容器的盖子
公开(公告)号：US09145238B2
公开(公告)日：2015-09-29
申请号：US13491765
申请日：2012-06-08
申请人： Aldo J. Barreto , David K. Mackenzie , John Dugan , Mark Graham , Bryan Keller , Thomas B. Remm
发明人： Aldo J. Barreto , David K. Mackenzie , John Dugan , Mark Graham , Bryan Keller , Thomas B. Remm
IPC分类号： B65D51/18 , A47G19/22 , B65D43/12 , B65D43/02 , B65D47/28 , B65D47/32 , B65D81/38
CPC分类号： B65D43/12 , A47G19/2205 , A47G19/2272 , B65D43/022 , B65D47/286 , B65D47/32 , B65D81/3869 , B65D2205/02 , B65D2543/00046 , B65D2543/00092 , B65D2543/00296 , B65D2543/00314 , B65D2543/00518 , B65D2543/00546 , B65D2543/00564
摘要： A beverage container having a slidably openable lid assembly is disclosed. The lid assembly basically comprises a base member and a cover member. The base member includes a wall portion releasably securing the lid assembly to the container and an opening in fluid communication with a beverage holding chamber in the container. The cover member is slidably coupled to the base member to slide from a closed position to an open position and vice versa. When the cover member is in the closed position it isolates the opening and the contiguous portions of the base member from the ambient surroundings. When the cover member is in the open position it exposes the opening to enable a user to drink the beverage via the opening. The cover includes an elastomeric member arranged to engage and seal the opening in the base member when the cover member is in the closed position.
摘要翻译：公开了一种具有可滑动打开的盖组件的饮料容器。盖组件基本上包括基部构件和盖构件。底座部件包括壁部分，该壁部分将盖组件可释放地固定到容器上，开口与容器中的饮料容纳室流体连通。盖构件可滑动地联接到基座构件以从关闭位置滑动到打开位置，反之亦然。当盖构件处于关闭位置时，其将基部构件的开口和邻接部分与周围环境隔离。当盖构件处于打开位置时，它暴露开口以使使用者能够经由开口饮用饮料。所述盖包括弹性体构件，所述弹性构件布置成当所述盖构件处于所述关闭位置时接合并密封所述基座构件中的所述开口。

16. 发明授权

US08783861B2 Frame design for electronic spectacles 有权
标题翻译：电子眼镜框架设计
公开(公告)号：US08783861B2
公开(公告)日：2014-07-22
申请号：US13175633
申请日：2011-07-01
申请人： Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C5/22
CPC分类号： G02C11/10 , G02C5/146 , G02C7/081 , G02C7/101
摘要： A first device is provided that comprises a frame. The frame further comprises a lens housing adapted to support a first lens and a second lens, a first temple movable coupled to the lens housing, and a second temple movably coupled to the lens housing. The first device further comprises a first spring mechanism coupled to the first temple and the lens housing. A first conductive path is provided from the first temple to the lens housing for at least one position of the first temple relative to the frame.
摘要翻译：提供了包括框架的第一装置。框架还包括适于支撑第一透镜和第二透镜的透镜壳体，可移动地联接到透镜壳体的第一光阑以及可移动地联接到透镜壳体的第二光阑。第一装置还包括联接到第一镜腿和镜片壳体的第一弹簧机构。第一导电路径从第一镜腿提供到透镜外壳，用于第一镜腿相对于镜框的至少一个位置。

17. 发明申请

US20130092748A1 HOSE ATTACHMENT PARTICULATE SPREADER 审中-公开
标题翻译：软管接头颗粒挤出机
公开(公告)号：US20130092748A1
公开(公告)日：2013-04-18
申请号：US13690949
申请日：2012-11-30
申请人： Thomas Waggoner , Mario Restive , Tom Remms , Mark Graham , Steve Domik
发明人： Thomas Waggoner , Mario Restive , Tom Remms , Mark Graham , Steve Domik
IPC分类号： B05B7/14
CPC分类号： B05B7/149 , A01C15/02
摘要： A hose attachment particulate spreader device is provided that includes a housing having a particulate egress aperture. A first funnel channel is provided for conveying dry flowable particulate. A selector controls a first gate in communication with the first funnel channel. The first gate meters dry flowable particulate within the first funnel channel. A water inlet is also provided for engaging a water supply hose. A water trigger is included for simultaneously opening a second gate in communication with the first gate and the egress aperture, as well as applying a water spray to exhaust a content from the funnel hose out the egress aperture. A process for field spreading is provided that includes attaching a bottle to such a device, the bottle containing a content of a dry flowable particulate or a slurry. The device is coupled to a water supply hose and by exhausting a water spray from the water supply hose through the device to exhaust a portion of the content while the content remaining in the bottle does not contact the water spray and remains in an unchanged form.
摘要翻译：提供了一种软管附件颗粒撒布机装置，其包括具有颗粒出口孔的壳体。提供用于输送干燥可流动颗粒的第一漏斗通道。选择器控制与第一漏斗通道通信的第一门。第一个门在第一个漏斗通道内可以流动干燥的颗粒。还提供进水口用于接合供水软管。包括水触发器，用于同时打开与第一门和出口孔连通的第二门，以及施加喷水以从漏斗管排出出口出口的内容物。提供了一种用于现场扩散的方法，其包括将瓶附接到这种装置，该瓶含有干燥可流动颗粒或浆料的内容物。该装置连接到供水软管，并且通过装置从供水软管排出喷水，以排出一部分内容物，同时保留在瓶中的内容物不接触水喷雾并保持不变的形式。

18. 发明申请

US20130010256A1 ELECTRO-ACTIVE SPECTACLE FRAMES 有权
标题翻译：电活动框架
公开(公告)号：US20130010256A1
公开(公告)日：2013-01-10
申请号：US13179219
申请日：2011-07-08
申请人： Joshua N. Haddock , Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Joshua N. Haddock , Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C7/06 , G02C11/00
CPC分类号： G02C11/10 , G02C5/2272
摘要： A first device is provided. The first device includes a lens comprising at least a first electrical contact and a lens housing holding the lens. The lens housing includes at least a second electrical contact. The first device further comprises a compliant conductive element disposed between the first and the second electrical contact. The compliant conductive element electrically connects the first and second electrical contacts.
摘要翻译：提供第一个设备。第一装置包括至少包括第一电触头和保持透镜的透镜壳体的透镜。透镜壳体至少包括第二电触点。第一装置还包括设置在第一和第二电触点之间的柔性导电元件。柔性导电元件电连接第一和第二电触点。

19. 发明申请

US20120127420A1 ELECTRONIC SPECTACLE FRAMES 有权
标题翻译：电子麦克风框架
公开(公告)号：US20120127420A1
公开(公告)日：2012-05-24
申请号：US13298992
申请日：2011-11-17
申请人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C5/16 , B23P11/00
CPC分类号： G02C7/101 , G02C1/10 , G02C5/146 , G02C5/2236 , G02C7/081 , G02C11/10 , Y10T29/49826
摘要： Embodiments may provide a first device that includes a frame having a first temple and a second temple. The frame may also comprise a housing module coupled (e.g. attached) to a structural member. The first device may further include a first lens and a second lens coupled to the frame and an electronics module that may be located within the housing module. The electronics module may include at least any two of: a power source; a controller; and/or a sensing mechanism.
摘要翻译：实施例可以提供第一装置，其包括具有第一神庙和第二神殿的框架。框架还可以包括耦合（例如附接）到结构构件的壳体模块。第一装置还可以包括耦合到框架的第一透镜和第二透镜以及可以位于壳体模块内的电子模块。电子模块可以包括以下至少任意两个：电源; 控制器和/或感测机构。

20. 发明申请

US20070179706A1 VEHICLE EMAIL NOTIFICATION USING TEMPLATES 有权
标题翻译：车辆电子邮件通知使用模板
公开(公告)号：US20070179706A1
公开(公告)日：2007-08-02
申请号：US11618210
申请日：2006-12-29
申请人： Shane McCutchen , Mark Graham
发明人： Shane McCutchen , Mark Graham
IPC分类号： G01C21/00
CPC分类号： G07C5/008 , G06Q10/00 , G06Q10/06 , G06Q10/107 , G06Q30/02 , G06Q30/0278 , G06Q50/30 , G07C5/085 , Y10S370/908
摘要： A vehicle email notification system and method in which templates are used to automatically generate email messages that provide the recipient with diverse types of dynamic vehicle information. The email notifications are triggered by different events, some of which are independent of the vehicle (e.g., a monthly trigger), and others of which occur at the vehicle, such as a mileage or low oil life trigger. The notification system selects an appropriate template based on the type of trigger and uses that template to build and send to the subscriber an email message that contains the dynamic vehicle information and identifies any detected vehicle condition for which action is needed. In addition to trigger type, different templates can be defined for each combination of vehicle type (e.g., make of vehicle), trigger type, and a language preference (e.g., English, Spanish).
摘要翻译：一种车辆电子邮件通知系统和方法，其中使用模板来自动生成向接收者提供不同类型的动态车辆信息的电子邮件消息。电子邮件通知由不同的事件触发，其中一些事件是独立于车辆（例如，每月触发器），其他事件发生在车辆上，例如里程或低油寿命触发。通知系统基于触发器的类型选择适当的模板，并使用该模板来构建并向用户发送包含动态车辆信息的电子邮件，并且识别需要动作的任何检测到的车辆状况。除了触发类型之外，可以为车辆类型（例如，车辆形式），触发类型和语言偏好（例如，英语，西班牙语）的每个组合定义不同的模板。

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