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11. 发明申请

US20220062830A1 Bilayer Polyamide Desalination Membrane 有权
公开(公告)号：US20220062830A1
公开(公告)日：2022-03-03
申请号：US16948137
申请日：2020-09-03
申请人： John F. Thompson , Lars Kohler , Qun Song , Jane C. Li
发明人： John F. Thompson , Lars Kohler , Qun Song , Jane C. Li
IPC分类号： B01D69/12 , B01D61/02 , B01D71/56 , C02F1/44
摘要： A composite reverse osmosis membrane having a semipermeable bilayer polyamide composition comprising a base layer containing a rigid crosslinked aromatic polyamide and a top layer containing a flexible aliphatic polyamide is disclosed, the two layers in combination providing reduced salt passage in reverse osmosis desalination of brackish waters and of seawater.

12. 发明申请

US20110301042A1 METHODS OF SAMPLE ENCODING FOR MULTIPLEX ANALYSIS OF SAMPLES BY SINGLE MOLECULE SEQUENCING 审中-公开
标题翻译：通过单分子序列对样品进行多重分析的样本编码方法
公开(公告)号：US20110301042A1
公开(公告)日：2011-12-08
申请号：US13127669
申请日：2009-11-11
申请人： Kathleen Steinmann , Elaine Joseph , Marie Causey , John F. Thompson
发明人： Kathleen Steinmann , Elaine Joseph , Marie Causey , John F. Thompson
IPC分类号： C40B20/04 , C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2525/155 , C12Q2535/101 , C12Q2563/185
摘要： The invention generally relates to methods for sequencing a plurality of nucleic acids from different samples. In certain embodiments, methods of the invention provide contacting a nucleic acid duplex including a primer nucleic acid hybridized to a template nucleic acid with a polymerase enzyme in the presence of a first detectably labeled nucleotide under conditions that permit the polymerase to add nucleotides to the primer in a template-dependent manner, in which a unique oligonucleotide sequence is attached to the template nucleic acid so that the template nucleic acid may be differentiated from other template nucleic acid molecules, detecting a signal from the incorporated labeled nucleotide, and sequentially repeating the contacting and detecting steps at least once, wherein sequential detection of incorporated labeled nucleotide determines the sequence of the nucleic acid.
摘要翻译：本发明一般涉及从不同样品测序多个核酸的方法。在某些实施方案中，本发明的方法提供了在允许聚合酶向引物添加核苷酸的条件下，使含有与模板核酸杂交的引物核酸的核酸双链在聚合酶存在下在第一可检测标记的核苷酸存在下接触以模板依赖的方式，其中独特的寡核苷酸序列连接到模板核酸，使得模板核酸可以与其他模板核酸分子区分，检测来自掺入的标记核苷酸的信号，并依次重复接触和检测步骤至少一次，其中并入的标记核苷酸的顺序检测确定核酸的序列。

13. 发明授权

US4071949A Apparatus for securing a spherical body to a supporting member 失效
标题翻译：用于将球体固定到支撑构件的装置
公开(公告)号：US4071949A
公开(公告)日：1978-02-07
申请号：US748792
申请日：1976-12-09
申请人： Cecil J. Ross , John F. Thompson
发明人： Cecil J. Ross , John F. Thompson
IPC分类号： B21K25/00 , B23Q7/10
CPC分类号： B21K25/00 , B23Q7/106 , Y10T29/49837 , Y10T29/49908 , Y10T29/49915 , Y10T29/5343 , Y10T29/53522 , Y10T29/53996
摘要： A method and apparatus for securing spherical bodies to a supporting member by staking. The spheres are fed one by one into a bore of a setting apparatus where they are picked up by the front end of a staking punch which reciprocates in the bore. The punch advances the sphere to the supporting member and imbeds the sphere in the surface of the supporting member while at the same time forming integral tangs from the supporting member which partially encircle the sphere and hold it in place. The punch then withdraws to pick up a fresh sphere and a new supporting member is moved into place to receive the fresh sphere.
摘要翻译：一种用于通过铆接将球体固定到支撑构件的方法和装置。球体一个接一个地进入设置装置的孔中，在该孔中它们被在孔中往复运动的打桩冲头的前端拾起。冲头将球体推进到支撑构件并且将支撑构件的表面中的球嵌入，同时从支撑构件形成整体的柄脚，该支撑构件部分地环绕球体并将其保持在适当的位置。然后，冲头撤回来拿起一个新鲜的球体，一个新的支撑构件移动到位以接收新的球体。

14. 发明授权

US11684895B2 Bilayer polyamide desalination membrane 有权
公开(公告)号：US11684895B2
公开(公告)日：2023-06-27
申请号：US16948137
申请日：2020-09-03
申请人： John F. Thompson , Lars Kohler , Qun Song , Jane C. Li
发明人： John F. Thompson , Lars Kohler , Qun Song , Jane C. Li
IPC分类号： B01D69/12 , B01D61/02 , C02F1/44 , B01D71/56 , C02F103/08
CPC分类号： B01D69/125 , B01D61/025 , B01D71/56 , C02F1/441 , C02F2103/08
摘要： A composite reverse osmosis membrane having a semipermeable bilayer polyamide composition comprising a base layer containing a rigid crosslinked aromatic polyamide and a top layer containing a flexible aliphatic polyamide is disclosed, the two layers in combination providing reduced salt passage in reverse osmosis desalination of brackish waters and of seawater.

15. 发明申请

US20100159533A1 SIMPLIFIED SAMPLE PREPARATION FOR RNA ANALYSIS 审中-公开
标题翻译： RNA分析的简化样品制备
公开(公告)号：US20100159533A1
公开(公告)日：2010-06-24
申请号：US12625115
申请日：2009-11-24
申请人： Doron Lipson , Tal Raz , John F. Thompson
发明人： Doron Lipson , Tal Raz , John F. Thompson
IPC分类号： C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2525/179 , C12Q2525/204 , C12Q2521/107
摘要： Methods and kits for selective preparing cDNA relatively free of sequences found in rRNA and subcellular RNAs are disclosed. The methods and kits utilize approximately 200 hexamer sequences which target messenger RNA. The methods and kits are useful in preparing samples for sequencing analysis, especially when performing single molecule sequencing by synthesis.
摘要翻译：公开了用于选择性制备相对不含在rRNA和亚细胞RNA中发现的序列的cDNA的方法和试剂盒。该方法和试剂盒利用约200个靶向信使RNA的六聚体序列。方法和试剂盒可用于制备样品进行测序分析，特别是通过合成进行单分子测序时。

16. 发明申请

US20090233303A1 METHODS FOR ASSESSING BREAKDOWN PRODUCTS AND STABILITY OF SIRNA AND OTHER TARGET OLIGONUCLEOTIDES 审中-公开
标题翻译：评估SIRNA和其他目标寡核苷酸的突破性产品和稳定性的方法
公开(公告)号：US20090233303A1
公开(公告)日：2009-09-17
申请号：US12403597
申请日：2009-03-13
申请人： John F. Thompson
发明人： John F. Thompson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2525/313 , C12Q2525/207 , C12Q2521/501
摘要： The disclosure provides methods and compositions for assessing by sequencing the type and quantity of in vivo or in vitro breakdown products and stability of nucleic acids such as small interfering RNA (siRNA) and other target oligonucleotides. In general, the disclosed methods involve the use of tester oligonucleotides that comprise a double-stranded region, an optional loop (in the case of hairpin testers), and a single-stranded 3′ overhang that is complementary to the full-length and a shortened target oligonucleotide. A tester is designed so that the 3′ end of a respective target oligonucleotide anneals to the overhang immediately adjacent to the 5′ end of the tester. The juxtaposed ends of the tester and target at adjacent positions allow for a ligase to ligate the chain if there is a match between a tester and its respective target. By sequencing the ligated product in the region of the ligation site, one may determine the sequence of the 3′ end of the target oligonucleotide or of the entire target and its relative amount in the sample.
摘要翻译：本公开提供了通过测序体内或体外分解产物的类型和数量以及核酸例如小干扰RNA（siRNA）和其它靶寡核苷酸的稳定性进行评估的方法和组合物。通常，所公开的方法包括使用包含双链区域，任选环（在发夹测试仪的情况下）的测试者寡核苷酸和与全长互补的单链3'突出端缩短目标寡核苷酸。设计一种测试仪，使得各个靶寡核苷酸的3'末端与紧邻测试仪5'端的突出部分退火。如果测试仪和其各自的目标之间存在匹配，则测试仪和目标位置在相邻位置处并置的端部允许连接酶连接链条。通过对连接位点的连接产物进行测序，可以确定靶寡核苷酸的3'末端或整个靶标的序列及其在样品中的相对量。

17. 发明授权

US06951510B1 Chemical mechanical polishing pad with grooves alternating between a larger groove size and a smaller groove size 失效
标题翻译：化学机械抛光垫，槽间距较大，沟槽尺寸较小
公开(公告)号：US06951510B1
公开(公告)日：2005-10-04
申请号：US10799279
申请日：2004-03-12
申请人： Jose Omar Rodriguez , Charles A. Storey , John F. Thompson
发明人： Jose Omar Rodriguez , Charles A. Storey , John F. Thompson
IPC分类号： B24B1/00
CPC分类号： B24B37/26
摘要： A chemical mechanical polishing (CMP) pad is provided. The CMP pad includes a groove pattern disposed on a polishing surface of the pad. The groove pattern is formed of an alternating sequence of spaced apart grooves. The alternating sequence of grooves comprises a groove of a first size and a groove of a second size, wherein the first and second groove sizes are different relative to one another.
摘要翻译：提供化学机械抛光（CMP）垫。 CMP垫包括设置在垫的抛光表面上的凹槽图案。凹槽图案由间隔开的凹槽的交替顺序形成。槽的交替顺序包括第一尺寸的凹槽和第二尺寸的凹槽，其中第一和第二凹槽尺寸彼此不同。

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