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11. 发明专利

EA016567B1 ИНГИБИТОРЫ МАТРИКСНЫХ МЕТАЛЛОПРОТЕИНАЗ 未知
公开(公告)号：EA016567B1
公开(公告)日：2012-05-30
申请号：EA200970214
申请日：2007-08-21
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , RAUF ABDUL REHMAN ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D401/06
摘要： Настоящееизобретениеотноситсяк β-гидрокси- иаминозамещеннымкарбоновымкислотам, которыедействуютв качествеингибиторовматриксныхметаллопротеаз, конкретнок диастереомерночистымβ-гидроксикарбоновымкислотам, ксоответствующимспособамсинтезасоединенийпонастоящемуизобретениюи кфармацевтическимкомпозициям, содержащимданныесоединения. Соединенияпонастоящемуизобретениюявляютсяполезнымив леченииразличныхвоспалительных, аутоиммунныхи аллергическихзаболеваний, напримерв методикахлеченияастмы, ревматоидногоартрита, ХОЗЛ (хроническогообструктивногозаболеваниялегких), ринита, остеоартрита, псориатическогоартрита, псориаза, фиброзалегких, нарушенийзаживленияран, воспалениялегких, синдромаостройдыхательнойнедостаточности, периодонтита, рассеянногосклероза, гингивита, атеросклероза, неоинтимальнойпролиферации, котораяявляетсяпричинойвозникновениярестенозаи сердечнойнедостаточностиишемическойприроды, инсульта, пораженийпочек, метастазированияопухолейи другихвоспалительныхнарушений, характеризующихсяповышеннойэкспрессиейи повышеннойактивациейматрикснойметаллопротеиназы, сиспользованиемданныхсоединений.

12. 发明专利

UA95115C2 未知
公开(公告)号：UA95115C2
公开(公告)日：2011-07-11
申请号：UAA200902501
申请日：2007-08-21
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , RAUF ABDUL REHMAN ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D401/06
摘要： Изобретениекасаетсяβ-гидрокси- иаминозамещенныхкарбоновыхкислот, которыедействуюткакингибиторыматриксныхметаллопротеаз, конкретно - диастереомерночистыхβ-гидроксикарбоновыхкислот, соответствующихспособовсинтезасоединенийподанномуизобретениюи фармацевтическихкомпозиций, которыесодержатданныесоединения.Соединенияподанномуизобретениюпригодныдлялеченияразныхвоспалительных, аутоиммунныхи аллергическихзаболеваний, напримерв методикахлеченияастмы, ревматоидногоартрита, ХОЗЛ (хроническогообструктивногозаболеваниялегких), ринита, остеоартрит

13. 发明专利

HK1135684A1 PROCESS FOR PREPARING MATRIX METALLOPROTEINASE INHIBITORS AND CHIRAL AUXILIARY THEREFOR 未知
公开(公告)号：HK1135684A1
公开(公告)日：2010-06-11
申请号：HK09111893
申请日：2009-12-17
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , RAUF ABDUL REHMAN ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

14. 发明专利

CO6150172A2 INHIBIDORES DE LA METALOPROTEINASA MATRIZ 未知
公开(公告)号：CO6150172A2
公开(公告)日：2010-04-20
申请号：CO09017757
申请日：2009-02-23
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANAI JITENDRA , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , RAUF ADBUL REHMAN , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA , SRIVASTAVA PUNIT KUMAR
IPC分类号： A61K31/4035 , A61P29/00 , C07D209/48 , C07D401/06
摘要： 1.- Un compuesto de la Fórmula I:en donde: * representa un centro asimétrico estereogénico de configuración definida seleccionada de (R, R) , (S, S) (R, S) y (S,R) ; n es un entero de 1 a 5; R1 es hidrógeno, alquilo, alquenilo, alquinilo, cicloalquilo, arilo, heterociclilo, heteroarilo, aralquilo, alcoxi, ariloxi, alqueniloxi o alquiniloxi opcionalmente sustituido; R2 es heterociclilo, heteroarilo, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4, C(=Y)NR4R5, C(=O)OR6, en donde: Y es oxígeno o azufre, OR5, -OC(=O)NR4R5, O-acilo, S(O)mR4, -SO2N(R4)2, ciano, amidino o guanidino; Rx es R4 o -SO2N(R4)2;R6 es hidrógeno, alquilo, cicloalquilo, aralquilo, heteroarilalquilo, heterociclilalquilo o cicloalquilalquilo en donde:R4 es alquilo, alquenilo, alquinilo, cicloalquilo, arilo, heterociclilo, heteroarilo, aralquilo, heteroarilalquilo, heterociclilalquilo o cicloalquilalquilo; y m es un entero 0-2; R5 es hidrógeno o R4;R3 es hidrógeno, fluor, alquilo, cicloalquilalquilo o aralquilo; A es OH, OR4, -OC(=O)NR4R5, O-acilo, NH2, NR4R5, -NHC(=Y)R4, -NHC(=Y)NR5Rx, -NHC(=O)OR4, -NHSO2R4; Q es arilo o heteroarilo opcionalmente sustituido.

15. 发明专利

ZA200901427B Matrix metalloproteinase inhibitors 未知
公开(公告)号：ZA200901427B
公开(公告)日：2010-03-31
申请号：ZA200901427
申请日：2009-02-27
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , RAUF ABDUL REHMAN ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： A61K20100101 , A61P20100101 , C07D20100101
摘要： The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

16. 发明专利

CA2661299A1 MATRIX METALLOPROTEINASE INHIBITORS 未知
公开(公告)号：CA2661299A1
公开(公告)日：2008-02-28
申请号：CA2661299
申请日：2007-08-21
申请人： RANBAXY LAB LTD
发明人： TIWARI MANOJ KUMAR , PALLE VENKATA P , KHERA MANOJ KUMAR , SATTIGERI VISWAJANANI J , JOSEPH SONY , RAUF ABDUL REHMAN ABDUL , SONI AJAY , REDDY RANADHEER , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D401/06
摘要： The present invention relates to .beta.-hydroxy and amino substituted car boxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure .beta.-hydroxy carboxylic acids, corresponding proce sses for the synthesis of and pharmaceutical compositions containing the com pounds of the present invention. Compounds of the present invention are usef ul in the treatment of various inflammatory, autoimmune and allergic disease s, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound h ealing disorders, pulmonary inflammation, acute respiratory distress syndrom e, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke , renal diseases, tumor metastasis, and other inflammatory disorders charact erized by the over-expression and over- activation of a matrix metalloprotei nase using the compounds.

17. 发明专利

CR20140412A INHIBIDORES DE LA METALPROTEINASA MATRIZ 未知
公开(公告)号：CR20140412A
公开(公告)日：2014-10-22
申请号：CR20140412
申请日：2014-09-08
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , KHERA MANOJ KUMAR , REDDY RANADHEER , TOWARI MANOJ KUMAR , SONI AJAY , RAUF ABDUL REHNIAN ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA G , SRIVASTAVA PUNIT KUMAR
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D401/06
摘要： El presente invento se relacion con ácidos carboxílicos sustituidos mediante B-hidroxi y amino, que actúan como inhibidores de la metaloproteasa matriz, ácidos carboxílicos B-hidroxi diastereoméricamente puros, procesos correspondientes para la síntesis de composiciones farmacéuticas que contienen los compuestos del presente invento.

18. 发明专利

BRPI0715231A2 未知
公开(公告)号：BRPI0715231A2
公开(公告)日：2013-06-25
申请号：BRPI0715231
申请日：2007-08-21
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI J , PALLE VENKATA P , DASTIDAR SUNANDA G , KHERA MANOJ KUMAR , REDDY RANADHEER , TIWARI MANOJ KUMAR , SONI AJAY , REHMAN ABDUL , JOSEPH SONY , MUSIB ARPITA , SRIVASTAVA PUNIT KUMAR
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D401/06
摘要： The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

19. 发明专利

ES2397284T3 Proceso para preparar inhibidores de la metaloproteinasa de la matriz y auxiliares quirales para los mismos 未知
公开(公告)号：ES2397284T3
公开(公告)日：2013-03-06
申请号：ES07826082
申请日：2007-08-21
申请人： RANBAXY LAB LTD
发明人： SATTIGERI VISWAJANANI , PALLE VENKATA , KHERA MANOJ , REDDY RANADHEER , TIWARI MANOJ , SONI AJAY , RAUF ABDUL , JOSEPH SONY , MUSIB ARPITA , DASTIDAR SUNANDA , SRIVASTAVA PUNIT
IPC分类号： C07D209/48 , A61K31/4035 , A61P29/00 , C07D253/08 , C07D265/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10
摘要： Auxiliar quiral que es (4S)-4-bencil-1,3-tiazolidin-2-ona.

20. 发明专利

CU20090025A7 INHIBIDORES DE LA METALOPROTEINASA MATRIZ 未知
公开(公告)号：CU20090025A7
公开(公告)日：2011-07-11
申请号：CU20090025
申请日：2009-02-20
申请人： RANBAXY LAB LTD
发明人： SRIVASTAVA PUNIT KUMAR , MUSIB ARPITA , JOSEPH SONY , RAUF ABDUL REHMAN ABDUL , SONI AJAY , TIWARI MANOJ KUMAR , REDDY RANADHEER , PALLE VEKATA P , DASTIDAR SUNANDA G , KHERA MANOJ KUMAR , SATTIGERI VISWAJANANI JITENDRA
IPC分类号： C07D209/48
摘要： El presente invento se rerlaciona con ácidos carboxílicos sustituidos mediante B-hidroxi y amino, que actúan como inhibidores de la metaloproteasa matriz, ácidos carboxílicos B-hidroxi diastereoméricamente puros, procesos correspondientes para la síntesis de composiciones farmacéuticas que contienen los compuestos del presente invento. Los compuestos del presente invento son útiles en el tratamiento de diversas enfermedades inflamatorias, de autoinmunidad y alérgicas , como ser los métodos para tratar el asma, la artritis reumatoidea, COPD, rinitis, osteoartritis, artritis soriásica, psoriasis, fibrosis pulmonar, desórdenes en la cura de heridas, inflamación pulmonar, síndrome de perturbación respiratoria agudo, periodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neoíntima, que lleva a la restenosis y a la insuficiencia cardíaca isquémica, ataque apopléjico, enfermedades renales, metástasis tumoral y otros desódenes inflamatorios caracterizados por la hiperexpresión e hiper-activación de una metaloproteinasa matriz utilizando los compuestos.

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