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11. 发明申请

US20090005381A1 METHODS OF TREATING SEROTONIN-MEDIATED DISEASES AND DISORDERS 审中-公开
标题翻译：治疗丝氨酸蛋白酶介导的疾病和疾病的方法
公开(公告)号：US20090005381A1
公开(公告)日：2009-01-01
申请号：US12144821
申请日：2008-06-24
申请人： Philip Manton Brown , Qingyun Liu , Brian Zambrowicz
发明人： Philip Manton Brown , Qingyun Liu , Brian Zambrowicz
IPC分类号： A61K31/5377 , A61K31/53 , A61K31/505 , A61P9/00 , A61P29/00 , A61K31/4192 , A61K31/4965
CPC分类号： A61K31/416 , A61K31/4192 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Methods are disclosed for treating serotonin-mediated diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
摘要翻译：公开了用于治疗血清素介导的疾病和病症的方法，其包括在有需要的患者中抑制色氨酸羟化酶（TPH）。

12. 发明授权

US07001742B1 Human uncoupling protein 3 失效
标题翻译：人解偶联蛋白3
公开(公告)号：US07001742B1
公开(公告)日：2006-02-21
申请号：US09081737
申请日：1998-05-19
申请人： Qingyun Liu , Fang Chen
发明人： Qingyun Liu , Fang Chen
IPC分类号： C12P21/06 , C07H17/00 , C07K14/00
CPC分类号： C07K14/47
摘要： An isolated nucleic acid molecule is disclosed which encodes a novel human uncoupling protein (UCP3), and related recombinant expression vectors, recombinant host cells and substantially purified forms of the UCP3 protein. The isolated nucleic acid and proteins disclosed herein will be useful in methods associated with identifying compounds which modulate energy expenditure and body weight regulation, as well as effecting diseases such as obesity and diabetes as well as mitochondria-associated hypermetabolism. Additionally, the isolated nucleic acids of the present ivention are candidates for gene therapy of a mammalian host, including humans.
摘要翻译：公开了分离的核酸分子，其编码新的人解偶联蛋白（UCP3）和相关的重组表达载体，重组宿主细胞和基本纯化的UCP3蛋白形式。本文公开的分离的核酸和蛋白质可用于鉴定调节能量消耗和体重调节以及影响疾病如肥胖和糖尿病以及线粒体相关高代谢的化合物相关的方法。另外，本发明的分离的核酸是包括人在内的哺乳动物宿主的基因治疗的候选物。

13. 发明申请

US20110263601A1 METHODS OF TREATING ULCERATIVE COLITIS 审中-公开
标题翻译：治疗精神分裂症的方法
公开(公告)号：US20110263601A1
公开(公告)日：2011-10-27
申请号：US12911011
申请日：2010-10-25
申请人： Philip Manton Brown , Qingyun Liu , Brian Zambrowicz
发明人： Philip Manton Brown , Qingyun Liu , Brian Zambrowicz
IPC分类号： A61K31/53 , A61K31/505 , A61K31/4965 , A61K31/497 , A61P1/04 , A61K31/405 , A61K31/4192 , A61K31/426 , A61K31/415 , A61K31/341 , A61K31/5377 , A61K31/44
CPC分类号： A61K31/416 , A61K31/4192 , A61K31/4965 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/5377
摘要： Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
摘要翻译：公开了用于治疗溃疡性结肠炎和相关疾病和病症的方法，其包括在有需要的患者中抑制色氨酸羟化酶（TPH）。

14. 发明申请

US20090029993A1 METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN 审中-公开
标题翻译：影响胃肠道传递和胃排空的方法及其有效的化合物
公开(公告)号：US20090029993A1
公开(公告)日：2009-01-29
申请号：US12174741
申请日：2008-07-17
申请人： Qingyun Liu , Brian Zambrowicz
发明人： Qingyun Liu , Brian Zambrowicz
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/4192 , A61K31/4965 , A61P1/00 , A61K31/53 , A61K31/44
CPC分类号： A61K31/4965 , A61K31/506 , A61K31/53
摘要： Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
摘要翻译：公开了用于影响胃肠运动性和胃排空的方法和化合物，其包括在有需要的患者中抑制色氨酸羟化酶（TPH）。

15. 发明授权

US07163799B2 Neuromedin U receptor NMUR2 and nucleotides encoding it 失效
标题翻译：神经介肽U受体NMUR2和编码它的核苷酸
公开(公告)号：US07163799B2
公开(公告)日：2007-01-16
申请号：US10258423
申请日：2001-04-25
申请人： Qingyun Liu , Kevin R. Lynch , Andrew D. Howard , Theodore N. Mellin , Alison Strack , Leonardus H. T. Van Der Ploeg , Ruiping Wang , Qingping Jiang , David Williams
发明人： Qingyun Liu , Kevin R. Lynch , Andrew D. Howard , Theodore N. Mellin , Alison Strack , Leonardus H. T. Van Der Ploeg , Ruiping Wang , Qingping Jiang , David Williams
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K14/70571 , C07K14/72 , C07K2319/00 , G01N33/6893 , G01N33/74 , G01N2500/00
摘要： A new neuromedin U receptor, designated NMUR2 has been found, which is involved in modulation of feeding behavior in mammals. Ligands of this receptor are able to modulate eating, and weight gain. Amino acid sequences of the human and rat forms, as well as their nucleic acid sequences are given.
摘要翻译：已经发现了一种称为NMUR2的新型神经介肽U受体，其涉及哺乳动物饲养行为的调节。该受体的配体能够调节饮食和体重增加。给出了人和大鼠形式的氨基酸序列，以及它们的核酸序列。

16. 发明授权

US08093291B2 Methods of using and compositions comprising tryptophan hydroxylase inhibitors 有权
标题翻译：使用方法和包含色氨酸羟化酶抑制剂的组合物
公开(公告)号：US08093291B2
公开(公告)日：2012-01-10
申请号：US12144953
申请日：2008-06-24
申请人： Philip Manton Brown , Qingyun Liu
发明人： Philip Manton Brown , Qingyun Liu
IPC分类号： A01N37/00 , A61K31/215 , C07C229/00
CPC分类号： A61K31/404 , A61K31/4192 , A61K31/4965 , A61K31/505 , A61K31/53 , A61K31/5377 , A61K45/06
摘要： Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some drugs.
摘要翻译：公开了包含色氨酸羟化酶抑制剂的方法和组合物。特别的方法是减少或避免与一些药物相关的5-羟色胺介导的不良反应。

17. 发明申请

US20100317664A1 METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN 审中-公开
标题翻译：影响胃肠道传递和胃排空的方法及其有效的化合物
公开(公告)号：US20100317664A1
公开(公告)日：2010-12-16
申请号：US12754284
申请日：2010-04-05
申请人： Qingyun Liu , Brian Zambrowicz
发明人： Qingyun Liu , Brian Zambrowicz
IPC分类号： A61K31/505 , A61K31/53 , A61K31/5377 , A61K31/513 , A61K31/197 , A61K31/4965 , A61P1/00
CPC分类号： A61K31/4965 , A61K31/506 , A61K31/53
摘要： Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof
摘要翻译：公开了用于影响胃肠蠕动和胃排空的方法和化合物，其包括在有需要的患者中抑制色氨酸羟化酶（TPH）

18. 发明申请

US20100202777A1 Mechanism to dectect an unstable wavelength channel and limit its impact on a ROADM network 有权
标题翻译：检测不稳定波长通道的机制，限制其对ROADM网络的影响
公开(公告)号：US20100202777A1
公开(公告)日：2010-08-12
申请号：US12322734
申请日：2009-02-06
申请人： Qingyun Liu , Philip Wisseman
发明人： Qingyun Liu , Philip Wisseman
IPC分类号： H04J14/02
CPC分类号： H04J14/0221 , H04J14/0204 , H04J14/0205 , H04J14/0212 , H04J14/0213
摘要： A system and method for limiting the impact of an unstable wavelength on other wavelengths in a reconfigurable optical add/drop multiplexer (ROADM) network are disclosed. The method generally comprises measuring optical channel power at prescribed time intervals; for each measurement of channel power falling outside a predefined threshold, recording a threshold crossing event; comparing the recorded threshold crossing events to stored criteria indicative of an unstable wavelength channel; and removing an unstable wavelength from the ROADM network if the threshold crossing events exceed the stored criteria.
摘要翻译：公开了一种用于限制可重构光分插复用器（ROADM）网络中不稳定波长对其他波长的影响的系统和方法。该方法通常包括以规定的时间间隔测量光信道功率; 对于每个测量的信道功率落在预定阈值之外，记录阈值交叉事件; 将记录的阈值交叉事件与指示不稳定波长信道的存储标准进行比较; 并且如果阈值跨越事件超过存储的标准，则从ROADM网络去除不稳定的波长。

19. 发明授权

US06599718B1 Growth hormone secretagogue related receptors and nucleic acids 失效
标题翻译：生长激素促分泌素相关受体和核酸
公开(公告)号：US06599718B1
公开(公告)日：2003-07-29
申请号：US09743742
申请日：2001-03-15
申请人： Qingyun Liu , Andrew D. Howard , Karen Kulju McKee
发明人： Qingyun Liu , Andrew D. Howard , Karen Kulju McKee
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release as well as other modulators of endocrine function.
摘要翻译：本发明涉及与生长激素促分泌素受体（GHS-R）和神经降压素受体（NT-R）两者呈现中度序列同一性的新家族受体，生长激素促分泌素相关受体。这些新鉴定的受体在多种组织中表达。本发明还涉及编码这些受体的核酸，以及这些受体用于鉴定调节生长激素释放的配体以及内分泌功能的其它调节剂的用途。

20. 发明授权

US06593108B1 Nucleic acid molecule encoding a melanin-concentrating hormone receptor 2 polypeptide 失效
标题翻译：编码黑色素浓缩激素受体2多肽的核酸分子
公开(公告)号：US06593108B1
公开(公告)日：2003-07-15
申请号：US09712368
申请日：2000-11-14
申请人： Qingyun Liu , Terrence P. McDonald , Andrew D. Howard
发明人： Qingyun Liu , Terrence P. McDonald , Andrew D. Howard
IPC分类号： C07H2104
CPC分类号： C07K14/723 , A61K38/00
摘要： The present invention features HG67 nucleic acids and HG67 polypeptides. HG67, also referred to herein as “MCH-R2”, is a G-protein coupled receptor having a high degree of sequence identity with MCH-R1. The amino acid sequence for HG67 is provided by SEQ. ID. NO. 1. The cDNA sequence of HG67 is provided by SEQ. ID. NO. 2.
摘要翻译：本发明的特征在于HG67核酸和HG67多肽。本文也称为“MCH-R2”的HG67是与MCH-R1具有高度序列同一性的G蛋白偶联受体。 HG67的氨基酸序列由SEQ。 ID。没有。 HG67的cDNA序列由SEQ。 ID。没有。 2。

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