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11. 发明申请

US20070203100A1 Immunosuppressant Compounds and Compositions 失效
标题翻译：免疫抑制剂化合物和组合物
公开(公告)号：US20070203100A1
公开(公告)日：2007-08-30
申请号：US10590618
申请日：2005-02-24
申请人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
发明人： Shifeng Pan , Thomas Marsilje , Wenshuo Lu , Gao Wenqi , Nathanael Gray , Yun He , Yahua Liu , Yuan Mi , Yongping Xie
IPC分类号： A61K31/675 , A61K31/495 , A61K31/454 , A61K31/453 , A61K31/40
CPC分类号： C07D401/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D213/74 , C07D237/22 , C07D239/46 , C07D295/108 , C07D295/15 , C07D401/06 , C07D403/04 , C07D403/06 , C07D409/04 , C07D409/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要翻译：本发明涉及免疫抑制剂，其生产方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG受体介导的信号转导相关的疾病。

12. 发明授权

US09048999B2 Unequalized clock data recovery for serial I/O receiver 有权
标题翻译：用于串行I / O接收器的无与伦比的时钟数据恢复
公开(公告)号：US09048999B2
公开(公告)日：2015-06-02
申请号：US13976189
申请日：2012-04-19
申请人： Yun He , Sanjib Sarkar , Fei Deng , Senthil Arun Singaravelu , Narender Nagulapally , Pranali Shah
发明人： Yun He , Sanjib Sarkar , Fei Deng , Senthil Arun Singaravelu , Narender Nagulapally , Pranali Shah
IPC分类号： H04L7/00 , H04L25/03 , G06F13/40 , H04L7/033
CPC分类号： H04L25/03057 , G06F13/4072 , H04L7/0062 , H04L7/0079 , H04L7/0087 , H04L7/0276 , H04L7/033 , H04L7/0332 , H04L25/03949
摘要： A serial input/output method and receiver include an receiver portion to receive an analog differential serial input and sample the input to provide data and error signals, an equalization feedback loop responsive to the data and error signals to adjust the receiver portion, a phase feedback mechanism separate from the equalization feedback loop to provide a phase error, and a clock data recovery block coupled to receive the phase error to perform timing recovery for the receiver portion independent of the equalization feedback to adjust the sampling.
摘要翻译：串行输入/输出方法和接收器包括接收模拟差分串行输入并对输入进行采样以提供数据和误差信号的接收器部分，响应于数据和误差信号的均衡反馈回路以调整接收器部分，相位反馈与均衡反馈环路分离以提供相位误差，以及时钟数据恢复块，其耦合以接收相位误差，以独立于均衡反馈来执行接收器部分的定时恢复以调整采样。

13. 发明授权

US08354443B2 Cyclopropane indolinone derivatives 失效
标题翻译：环丙烷二氢吲哚酮衍生物
公开(公告)号：US08354443B2
公开(公告)日：2013-01-15
申请号：US12959408
申请日：2010-12-03
申请人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
发明人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
IPC分类号： A61K31/404 , C07D209/96
CPC分类号： C07D209/96 , C07D209/34 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D413/12 , C07D491/107
摘要： The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R1至R4具有权利要求1中给出的含义。该化合物可用于例如治疗或预防肥胖症，高血糖症，血脂异常和1型或2型糖尿病。

14. 发明授权

US08268870B2 Aminotetrahydroindazoloacetic acids 失效
公开(公告)号：US08268870B2
公开(公告)日：2012-09-18
申请号：US13324650
申请日：2011-12-13
申请人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D231/56 , C07D401/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

15. 发明授权

US08138208B2 Aminotetrahydroindazoloacetic acids 失效
标题翻译：氨基四氢吲唑并乙酸
公开(公告)号：US08138208B2
公开(公告)日：2012-03-20
申请号：US12497807
申请日：2009-07-06
申请人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人： Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号： A61K31/4439 , A61K31/416 , C07D231/54 , C07D401/02
CPC分类号： C07D231/56 , C07D401/12 , C07D413/12
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中Q，W，X，R 1 -R 5和n在详细描述和权利要求书中定义。此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。

16. 发明申请

US20110144106A1 NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES 失效
标题翻译：新型环丙基吲哚啉酮衍生物
公开(公告)号：US20110144106A1
公开(公告)日：2011-06-16
申请号：US12959408
申请日：2010-12-03
申请人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
发明人： Li Chen , Lichun Feng , Yun He , Mengwei Huang , Hongying Yun
IPC分类号： A61K31/5377 , C07D209/96 , C07D401/08 , C07D403/10 , C07D413/10 , C07D401/14 , C07D403/12 , C07D401/06 , C07D405/06 , C07D413/06 , C07D403/06 , C07D403/04 , A61K31/403 , A61K31/4439 , A61K31/496 , A61K31/4155 , A61K31/4178 , A61K31/422
CPC分类号： C07D209/96 , C07D209/34 , C07D401/06 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D413/06 , C07D413/10 , C07D413/12 , C07D491/107
摘要： The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes,
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，其中R1至R4具有权利要求1中给出的含义。该化合物可用于例如治疗或预防肥胖症，高血糖症，血脂异常和1型或2型糖尿病，

17. 发明申请

US20090247517A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 失效
标题翻译：化合物和组合物作为CANNABINOID受体1活性的抑制剂
公开(公告)号：US20090247517A1
公开(公告)日：2009-10-01
申请号：US11718016
申请日：2005-10-26
申请人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
发明人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
IPC分类号： A61K31/5377 , C07D487/02 , A61K31/519 , C07D471/02 , A61K31/437 , C07D473/30 , A61K31/522 , C07D413/14 , A61K31/496 , C07D413/02 , A61P3/04
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D498/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译：本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。

18. 发明申请

US20090203681A1 NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES 失效
标题翻译：新型N-（2-氨基苯基）酰胺衍生物
公开(公告)号：US20090203681A1
公开(公告)日：2009-08-13
申请号：US12358348
申请日：2009-01-23
申请人： Li Chen , Yun He , Jason Christopher Wong
发明人： Li Chen , Yun He , Jason Christopher Wong
IPC分类号： A61K31/54 , A61K31/535 , A61K31/235 , C07D279/12 , C07D265/36 , C07D295/12 , C07C269/00
CPC分类号： C07C309/66 , C07C237/20 , C07C255/60 , C07C271/28 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07D205/04 , C07D207/09 , C07D213/36 , C07D213/74 , C07D215/38 , C07D231/08 , C07D249/18 , C07D265/30 , C07D295/13 , C07D295/15 , C07D295/185 , C07D307/52 , C07D309/04 , C07D333/20 , C07D409/12 , C07D491/08
摘要： The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The compounds of the present invention show anti-proliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion. The invention also covers the use of such compounds for the treatment of diseases such as cancer and for the manufacture of corresponding medicaments.
摘要翻译：本发明提供了通式（I）的新化合物及其药学上可接受的盐，这些新化合物的制备方法和含有这些化合物的药物。本发明化合物显示抗增殖和分化诱导活性，其导致肿瘤细胞增殖的抑制，凋亡诱导和抑制侵袭。本发明还涉及这些化合物用于治疗诸如癌症的疾病和用于制造相应药物的用途。

19. 发明授权

US07564384B2 Binarizing method and device thereof 有权
标题翻译：二价法及其装置
公开(公告)号：US07564384B2
公开(公告)日：2009-07-21
申请号：US12132959
申请日：2008-06-04
申请人： Yun He , Ping Yang , Wei Yu , Xinjian Meng , Jianhua Zheng
发明人： Yun He , Ping Yang , Wei Yu , Xinjian Meng , Jianhua Zheng
IPC分类号： H03M7/00
CPC分类号： H04N19/517 , H04N19/139 , H04N19/50 , H04N19/91
摘要： A binary coding and decoding method and apparatus for MVD (Motion Vector Difference) absolute values, includes: dividing symbols for MVD absolute values to be coded into a plurality of subsets according to probability distribution properties; assigning a binary codeword for each subset; assigning a binary codeword for each symbol in each subset; concatenating and outputting the binary codeword for each subset and the binary codeword for each symbol in the subset, as the binary coding result. At the decoding side, decoding operations are performed by using a principle corresponding to that at the coding side. In this manner, the invention makes full use of the source properties on one hand, and effectively prevents the codeword length from being too long on the other hand. It has been experimentally testified that a better compression effect may be achieved during arithmetic coding process and thus the image coding performance may be improved effectively.
摘要翻译：用于MVD（运动矢量差）绝对值的二进制编码和解码方法和装置包括：根据概率分布特性将要编码的MVD绝对值的符号划分成多个子集; 为每个子集分配二进制码字; 为每个子集中的每个符号分配二进制码字; 作为二进制编码结果，连接并输出每个子集的二进制码字和子集中每个符号的二进制码字。在解码侧，通过使用与编码侧对应的原理进行解码操作。以这种方式，本发明一方面充分利用了源特性，另一方面有效地防止了码字长度过长。已经通过实验证明，在算术编码过程中可以获得更好的压缩效果，因此可以有效地提高图像编码性能。

20. 发明授权

US07495016B2 Pyrrolidones with anti-HIV activity 失效
标题翻译：具有抗HIV活性的吡咯烷酮
公开(公告)号：US07495016B2
公开(公告)日：2009-02-24
申请号：US10690873
申请日：2003-10-21
申请人： Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
发明人： Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
IPC分类号： A61K31/443 , A61K31/402 , C07D401/04 , C07D207/08
CPC分类号： C07D207/26 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
摘要翻译：本发明涉及使用吡咯烷酮和与吡咯烷酮有关的化合物来抑制病毒，例如HIV。本发明还涉及用于鉴定和使用试剂的方法，包括抑制细胞中HIV的小分子化学组合物; 以及与艾滋病毒感染和相关疾病状态如艾滋病相关的预防和治疗方法。

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