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11. 发明申请

US20050277649A1 Aryl sulfonamide compounds and uses related thereto 失效
标题翻译：芳基磺酰胺化合物及其用途
公开(公告)号：US20050277649A1
公开(公告)日：2005-12-15
申请号：US11018401
申请日：2004-12-20
申请人： Michael DeGraffenreid , Xiao He , Jay Powers , Daqing Sun , Xuelei Yan
发明人： Michael DeGraffenreid , Xiao He , Jay Powers , Daqing Sun , Xuelei Yan
IPC分类号： A61K31/495 , A61K31/496 , C07D213/38 , C07D213/61 , C07D213/81 , C07D233/54 , C07D241/04 , C07D295/26 , C07D401/06 , C07D401/08 , C07D403/06 , C07D403/08 , C07D43/02
CPC分类号： C07D213/38 , C07D213/61 , C07D213/81 , C07D233/54 , C07D241/04 , C07D295/26 , C07D401/06 , C07D403/06
摘要： The present invention provides Aryl Sulfonamide Compounds having the formula: and prodrugs or pharmaceutically acceptable salts or prodrugs thereof. The Aryl Sulfonamide Compounds are useful for treating diabetes, obesity, and other diseases and disorders.
摘要翻译：本发明提供具有下式的芳基磺酰胺化合物及其前药或药学上可接受的盐或前药。芳基磺酰胺化合物可用于治疗糖尿病，肥胖症和其他疾病和障碍。

12. 发明申请

US20070021502A1 Aniline sulfonamide derivatives and their uses 失效
标题翻译：苯胺磺酰胺衍生物及其用途
公开(公告)号：US20070021502A1
公开(公告)日：2007-01-25
申请号：US11490143
申请日：2006-07-21
申请人： Jay Powers , Xiao He , Dustin McMinn , Yosup Rew
发明人： Jay Powers , Xiao He , Dustin McMinn , Yosup Rew
IPC分类号： A61K31/277 , A61K31/18 , C07C311/20
CPC分类号： C07C311/21 , C07C311/44 , C07C2601/02 , C07C2601/04
摘要： Aniline sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R1, R2, R3, R4, R5, R6, and L are set forth in the description.
摘要翻译：根据式I的苯胺磺酰胺衍生物具有治疗效用，特别是治疗糖尿病，肥胖症及相关病症和病症：其中R 1，R 2，R 2， 3，R 4，R 5，R 6和L在说明书中列出。

13. 发明授权

US07176314B2 Inflammation modulators 有权
标题翻译：炎症调节剂
公开(公告)号：US07176314B2
公开(公告)日：2007-02-13
申请号：US10314428
申请日：2002-12-04
申请人： Timothy D. Cushing , Xiao He , Marie-Louise Smith , Michael R. DeGraffenreid , Jay Powers , Craig S. Tomooka , David L. Clark , Xiaolin Hao , Juan C. Jaen , Marc Labelle , Nigel P. C. Walker , Adrian L. Gill , Francisco X. Talamas , Sharada Labadie
发明人： Timothy D. Cushing , Xiao He , Marie-Louise Smith , Michael R. DeGraffenreid , Jay Powers , Craig S. Tomooka , David L. Clark , Xiaolin Hao , Juan C. Jaen , Marc Labelle , Nigel P. C. Walker , Adrian L. Gill , Francisco X. Talamas , Sharada Labadie
IPC分类号： C07D215/00 , C09B25/00
CPC分类号： C07D401/04 , A61K31/4709 , C07D401/14 , C07D405/14 , A61K2300/00
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain quinoline or quinazoline rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有喹啉或喹唑啉环。

14. 发明授权

US06846834B2 Antiinflammation agents 失效
标题翻译：抗炎剂
公开(公告)号：US06846834B2
公开(公告)日：2005-01-25
申请号：US10004287
申请日：2001-10-23
申请人： Michelle F. Browner , David L. Clark , Timothy D. Cushing , Xiaolin Hao , Ronald C. Hawley , Xiao He , Juan C. Jaen , Sharada S. Labadie , Marie-Louise Smith , Francisco X. Talamas , Nigel P. C. Walker , Marc Labelle
发明人： Michelle F. Browner , David L. Clark , Timothy D. Cushing , Xiaolin Hao , Ronald C. Hawley , Xiao He , Juan C. Jaen , Sharada S. Labadie , Marie-Louise Smith , Francisco X. Talamas , Nigel P. C. Walker , Marc Labelle
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , C07C281/08 , A61K31/175 , C07D215/02 , A81P19/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有稠合的碳环或杂环。

15. 发明申请

US20070135464A1 Antiinflammation agents 审中-公开
公开(公告)号：US20070135464A1
公开(公告)日：2007-06-14
申请号：US11650268
申请日：2007-01-05
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/519 , A61K31/4709 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

16. 发明授权

US07186841B2 Antiinflammation agents 失效
标题翻译：抗炎剂
公开(公告)号：US07186841B2
公开(公告)日：2007-03-06
申请号：US10928784
申请日：2004-08-26
申请人： Michelle F. Browner , David L. Clark , Timothy D. Cushing , Xiaolin Hao , Ronald C. Hawley , Xiao He , Juan C. Jaen , Sharada S. Labadie , Marie-Louise Smith , Francisco X. Talamas , Nigel P. C. Walker , Marc Labelle
发明人： Michelle F. Browner , David L. Clark , Timothy D. Cushing , Xiaolin Hao , Ronald C. Hawley , Xiao He , Juan C. Jaen , Sharada S. Labadie , Marie-Louise Smith , Francisco X. Talamas , Nigel P. C. Walker , Marc Labelle
IPC分类号： C07D401/04 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.
摘要翻译：本文提供了可用于治疗炎症，免疫调节，代谢和细胞增殖性病症或疾病的化合物，组合物和方法。特别地，本发明提供调节参与炎症，代谢和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物含有稠合的碳环或杂环。

17. 发明申请

US20050043330A1 Antiinflammation agents 失效
公开(公告)号：US20050043330A1
公开(公告)日：2005-02-24
申请号：US10928784
申请日：2004-08-26
申请人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
发明人： Michelle Browner , David Clark , Timothy Cushing , Xiaolin Hao , Ronald Hawley , Xiao He , Juan Jaen , Sharada Labadie , Marie-Louise Smith , Francisco Talamas , Nigel Walker , Marc Labelle
IPC分类号： A61K31/4709 , A61K31/4745 , A61K31/5377 , A61P3/10 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14 , C07D417/04 , C07D471/04 , C12N15/25 , C12N15/28 , A61K31/519 , A61K31/517 , C07D487/02 , C07D43/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

18. 发明授权

US08692789B2 Establishing an authenticated wireless connection between short-range wireless terminals more conveniently 失效
标题翻译：在短距离无线终端之间更方便地建立经过身份验证的无线连接
公开(公告)号：US08692789B2
公开(公告)日：2014-04-08
申请号：US13276930
申请日：2011-10-19
申请人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
发明人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
IPC分类号： G06F3/041
CPC分类号： H04M1/7253 , G06F3/04883 , H04L63/0492 , H04L63/08 , H04M2250/22 , H04W12/06
摘要： A system and computer program product for establishing a wireless connection based on a touch screen of a wireless device. The wireless device includes a slide-out processing section for determining, in response to a slide-out from an edge of the touch screen, a first slide-out parameter for determining by the other wireless device an object to be connected, and broadcasting the first slide-out parameter. The wireless device further includes a slide-in processing section for determining a slide-in parameter in response to a slide-in from the edge of the touch screen and reception of a second slide-out parameter directionally transmitted from the other wireless device. Furthermore, if the determined slide-in parameter matches the second slide-out parameter, then the slide-in processing section establishes a wireless connection between the wireless device and the other wireless device. As a result, an authenticated wireless connection between short-range wireless terminals can be established more conveniently.
摘要翻译：一种用于基于无线设备的触摸屏建立无线连接的系统和计算机程序产品。无线装置包括滑出处理部分，用于响应于从触摸屏的边缘滑出来确定用于由另一无线设备确定要连接的对象的第一滑出参数，并且广播第一个滑出参数。无线设备还包括滑入式处理部分，用于响应于从触摸屏的边缘的滑入以及从另一无线设备定向发送的第二滑出参数的接收来确定滑入参数。此外，如果所确定的滑入参数与第二滑出参数匹配，则滑入式处理部分在无线设备与另一无线设备之间建立无线连接。结果，可以更方便地建立短距离无线终端之间的认证无线连接。

19. 发明申请

US20120105346A1 ESTABLISHING AN AUTHENTICATED WIRELESS CONNECTION BETWEEN SHORT-RANGE WIRELESS TERMINALS MORE CONVENIENTLY 失效
标题翻译：在短距离无线终端之间建立认证无线连接更为方便
公开(公告)号：US20120105346A1
公开(公告)日：2012-05-03
申请号：US13276930
申请日：2011-10-19
申请人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
发明人： Yan Chen , Xiao He , Kuang Hu , Guo Jun Zhang
IPC分类号： G06F3/041
CPC分类号： H04M1/7253 , G06F3/04883 , H04L63/0492 , H04L63/08 , H04M2250/22 , H04W12/06
摘要： A method, system and computer program product for establishing a wireless connection based on a touch screen of a wireless device. The wireless device includes a slide-out processing section for determining, in response to a slide-out from an edge of the touch screen, a first slide-out parameter for determining by the other wireless device an object to be connected, and broadcasting the first slide-out parameter. The wireless device further includes a slide-in processing section for determining a slide-in parameter in response to a slide-in from the edge of the touch screen and reception of a second slide-out parameter directionally transmitted from the other wireless device. Furthermore, if the determined slide-in parameter matches the second slide-out parameter, then the slide-in processing section establishes a wireless connection between the wireless device and the other wireless device. As a result, an authenticated wireless connection between short-range wireless terminals can be established more conveniently.
摘要翻译：一种用于基于无线设备的触摸屏建立无线连接的方法，系统和计算机程序产品。无线装置包括滑出处理部分，用于响应于从触摸屏的边缘滑出来确定用于由另一无线设备确定要连接的对象的第一滑出参数，并且广播第一个滑出参数。无线设备还包括滑入式处理部分，用于响应于从触摸屏的边缘的滑入以及从另一无线设备定向发送的第二滑出参数的接收来确定滑入参数。此外，如果所确定的滑入参数与第二滑出参数匹配，则滑入式处理部分在无线设备与另一无线设备之间建立无线连接。结果，可以更方便地建立短距离无线终端之间的认证无线连接。

20. 发明申请

US20100179177A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：US20100179177A1
公开(公告)日：2010-07-15
申请号：US12713360
申请日：2010-02-26
申请人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
发明人： Yi Chen , Timothy D. Cushing , Xiaolin Hao , Xiao He , Andreas Reichelt , Robert M. Rzasa , Jennifer Seganish , Youngsook Shin , Dawei Zhang
IPC分类号： A61K31/506 , C07D239/42 , C07D215/36 , A61K31/4709 , C07D215/12 , A61P19/02 , A61P19/00 , A61P29/00 , A61P37/00 , A61P27/02 , A61P13/10 , A61P17/00 , A61P1/00 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

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