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11. 发明授权

US07147362B2 Method of mixing by intermittent centrifugal force 失效
标题翻译：通过间歇离心力混合的方法
公开(公告)号：US07147362B2
公开(公告)日：2006-12-12
申请号：US10687276
申请日：2003-10-15
申请人： Michael P. Caren , Carol T. Schembri
发明人： Michael P. Caren , Carol T. Schembri
IPC分类号： B01F5/06
CPC分类号： B01F15/0201 , B01F5/061 , B01F13/0059 , B01F15/0233 , B01F2005/0621 , B01F2005/0636 , B01F2215/0431 , B01J2219/00326 , B01J2219/0052 , B01J2219/00657 , B01J2219/00702 , B01L3/50273 , B01L2200/10 , B01L2300/0636 , B01L2300/0806 , B01L2300/0867 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , C40B60/14 , G01N2035/00237 , G01N2035/0449 , Y10S366/01 , Y10S366/03
摘要： An apparatus for mixing fluids comprises a housing having at least a portion of its interior, for example, a channel, with capillary dimensions and at least one structural member in the interior adjacent an end of the channel. The dimensions of and placement of the structural member are sufficient such that intermittent application of centrifugal force to the interior of the housing causes movement of the fluid therein. The housing may comprise a mixing chamber or area that is in fluid communication with the interior. The apparatus may comprise a mechanism adapted to generate centrifugal force within the housing to cause movement of fluid in the interior of the housing without exit of fluid therefrom.
摘要翻译：用于混合流体的装置包括壳体，其具有其内部的至少一部分，例如具有毛细管尺寸的通道，并且在内部中的至少一个结构构件邻近通道的端部。结构构件的尺寸和放置是足够的，使得将离心力间歇地施加到壳体内部导致其中的流体的移动。壳体可以包括与内部流体连通的混合室或区域。该装置可以包括适于在壳体内产生离心力的机构，以引起流体在壳体内部的移动而不从其流出流体。

12. 发明授权

US06872359B2 Pressure variation in array fabrication 失效
标题翻译：阵列制造中的压力变化
公开(公告)号：US06872359B2
公开(公告)日：2005-03-29
申请号：US10691223
申请日：2003-10-21
申请人： Michael P. Caren , Peter G. Webb , Carol T. Schembri
发明人： Michael P. Caren , Peter G. Webb , Carol T. Schembri
IPC分类号： B01L3/02 , C40B40/06 , C40B60/14
CPC分类号： B01L3/0268 , B01J2219/00378 , B01J2219/00529 , B01J2219/00608 , B01J2219/00662 , B01J2219/00689 , B01J2219/00722 , B01L2200/14 , B01L2400/0439 , B01L2400/0442 , C40B40/06 , C40B60/14 , Y10T436/2575
摘要： A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into which the fluid is loaded and an orifice communicating with the chamber from which the fluid is dispensed. The method includes, when the chamber is loaded, applying a prime pressure to the fluid which varies over a range sufficient to move fluid within the drop dispenser but insufficient to cause fluid to be dispensed from the orifice. Drops are dispensed from the dispenser to the substrate so as to form the array.
摘要翻译：一种用于在衬底上制造生物聚合物阵列的方法，装置和计算机程序产品。该方法使用生物聚合物或生物共聚物流体和具有腔室的液滴分配器，流体被加载到该腔室中，以及与腔室连通的孔口，流体从该腔室分配。该方法包括，当腔室被装载时，向在液滴分配器内足以移动流体的范围内变化的流体施加主压力，但不足以使流体从孔口分配。从分配器将液滴分配到基底以形成阵列。

13. 发明授权

US06656740B1 Pressure variation in array fabrication 失效
标题翻译：阵列制造中的压力变化
公开(公告)号：US06656740B1
公开(公告)日：2003-12-02
申请号：US09703303
申请日：2000-10-31
申请人： Michael P. Caren , Peter G. Webb , Carol T. Schembri
发明人： Michael P. Caren , Peter G. Webb , Carol T. Schembri
IPC分类号： B01L302
CPC分类号： B01L3/0268 , B01J2219/00378 , B01J2219/00529 , B01J2219/00608 , B01J2219/00662 , B01J2219/00689 , B01J2219/00722 , B01L2200/14 , B01L2400/0439 , B01L2400/0442 , C40B40/06 , C40B60/14 , Y10T436/2575
摘要： A method, apparatus and computer program product, for fabricating an array of biopolymers on a substrate. The method uses a biopolymer or biomonomer fluid and a drop dispenser having a chamber into which the fluid is loaded and an orifice communicating with the chamber from which the fluid is dispensed. The method includes, when the chamber is loaded, applying a prime pressure to the fluid which varies over a range sufficient to move fluid within the drop dispenser but insufficient to cause fluid to be dispensed from the orifice. Drops are dispensed from the dispenser to the substrate so as to form the array.
摘要翻译：一种用于在衬底上制造生物聚合物阵列的方法，装置和计算机程序产品。该方法使用生物聚合物或生物共聚物流体和具有腔室的液滴分配器，流体被加载到该腔室中，以及与腔室连通的孔口，流体从该腔室分配。该方法包括，当腔室被装载时，向在液滴分配器内足以移动流体的范围内变化的流体施加主压力，但不足以使流体从孔口分配。从分配器将液滴分配到基底以形成阵列。

14. 发明授权

US06323043B1 Fabricating biopolymer arrays 失效
标题翻译：制造生物聚合物阵列
公开(公告)号：US06323043B1
公开(公告)日：2001-11-27
申请号：US09302922
申请日：1999-04-30
申请人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
发明人： Michael P. Caren , Carol T. Schembri , Peter G. Webb
IPC分类号： G01N33543
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.
摘要翻译：一种使用生物聚合物或生物共聚物流体以及使用分配头在衬底上制造生物聚合物阵列的方法和装置。头部具有储存室和至少一个可将液滴分配到基底上的射流。喷射器包括与储存室连通的毛细管输送室，该输送室具有孔口。射流还包括喷射器，其在被激活时使得液滴从孔口喷出。该方法包括通过将头部与孔相邻并且面向生物体或生物聚合物流体的位置来装载头部，并向贮存室提供负载压力。负载压力足够负，使得流体通过孔口和输送室被吸入储存室，同时不足以在头部已经被加载并且没有另外的流体是通过孔口导致环境大气通过孔口进入输送室面对并邻近孔口。头部定位成孔口面向衬底，并且从头部孔口分配多个液滴，以便在衬底上形成液滴阵列。

15. 发明授权

US06309828B1 Method and apparatus for fabricating replicate arrays of nucleic acid molecules 失效
标题翻译：用于制造核酸分子重复阵列的方法和装置
公开(公告)号：US06309828B1
公开(公告)日：2001-10-30
申请号：US09195421
申请日：1998-11-18
申请人： Arthur Schleifer , Michael P. Caren , Leslie A. Leonard , Charles Z. Hotz , Michel G. M. Perbost
发明人： Arthur Schleifer , Michael P. Caren , Leslie A. Leonard , Charles Z. Hotz , Michel G. M. Perbost
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00286 , B01J2219/00313 , B01J2219/00315 , B01J2219/00351 , B01J2219/00369 , B01J2219/00423 , B01J2219/00452 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00722 , B01L3/0258 , B01L3/0262 , B01L3/0275 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2400/0439 , C40B40/06 , C40B60/14
摘要： A method and apparatus for fabricating replicate arrays of nucleic acid molecules include the preparation of the molecules and the application the molecules onto a substrate in an ordered array. The apparatus comprises a synthesis unit and a plurality of outlets. The synthesis unit comprises a plurality of synthesis chambers that are spatially arranged relative to each other to provide an array suitable for conducting parallel nucleic acid syntheses. The chambers are suitable for containing discrete compositions of nucleic acid molecules. Each outlet of the plurality of outlets communicates with a single synthesis chamber. The plurality of outlets are configured such that nucleic acid molecules can be removed from the chambers through the outlet and deposited onto the substrate in an ordered array that corresponds to the spatial arrangement of the synthesis chambers.
摘要翻译：用于制造核酸分子的重复阵列的方法和装置包括分子的制备和以有序阵列将分子施加到基底上。该装置包括合成单元和多个出口。合成单元包括相对于彼此空间布置的多个合成室，以提供适于进行平行核酸合成的阵列。这些室适合含有离散的核酸分子组合物。多个出口的每个出口与单个合成室连通。多个出口被配置成使得核酸分子可以通过出口从室中除去并以对应于合成室的空间布置的有序阵列沉积到基板上。

16. 发明申请

US20120030602A1 METHODS AND SYSTEM FOR VIEWING GENOMIC DATA 审中-公开
标题翻译：用于查看基因数据的方法和系统
公开(公告)号：US20120030602A1
公开(公告)日：2012-02-02
申请号：US13198578
申请日：2011-08-04
申请人： Michael T. Barrett , Michael P. Caren
发明人： Michael T. Barrett , Michael P. Caren
IPC分类号： G06F3/048
CPC分类号： G16B45/00
摘要： A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.
摘要翻译：提供了一种用于查看实验数据的计算机实现方法。在某些实施方案中，该方法包括：a）将基因组阵列数据和细胞遗传学数据输入到计算机存储器中; 以及b）产生图形用户界面，其包括：i）所述基因组阵列数据的染色体图，其包括指示染色体图上的位置的第一位置指示符; 和ii）细胞遗传学数据的细胞遗传学图谱，其包括指示细胞遗传学图谱上的位置的第二位置指示剂。

17. 发明申请

US20070238104A1 Competitive oligonucleotides 审中-公开
标题翻译：竞争性寡核苷酸
公开(公告)号：US20070238104A1
公开(公告)日：2007-10-11
申请号：US11400475
申请日：2006-04-07
申请人： Michael Thomas Barrett , Michael P. Caren
发明人： Michael Thomas Barrett , Michael P. Caren
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6816 , C12Q2525/186
摘要： The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.
摘要翻译：本发明一般涉及竞争性寡核苷酸，在一些实施方案中涉及用于比较基因组杂交（CGH）和相关技术的竞争性寡核苷酸。一个方面通常涉及构建和排列用于核酸测定中的阻断组合物。封闭组合物可以包含寡核苷酸，其包含选择用于与测定中使用的核酸杂交的序列。另一方面通常涉及在不存在Cot-1级分的情况下对基因组DNA进行CGH测定和类似技术，使得基因组DNA基本上不交叉杂交。本发明的其它方面涉及用于制备或使用竞争性寡核苷酸的装置或试剂盒，促进这种竞争性寡核苷酸的方法等。

18. 发明授权

US07078505B2 Manufacture of arrays with varying deposition parameters 失效
标题翻译：制造具有不同沉积参数的阵列
公开(公告)号：US07078505B2
公开(公告)日：2006-07-18
申请号：US10165783
申请日：2002-06-06
申请人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
发明人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
IPC分类号： C07H21/04 , C12Q1/68 , C12M1/36
CPC分类号： C03C17/32 , B01J2219/00286 , B01J2219/00378 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01L3/0241 , C03C17/002 , C40B40/06 , C40B60/14
摘要： Methods are disclosed for synthesizing a plurality of compounds on the surface of supports. The synthesis comprises a series of cycles of steps in which reagents for conducting the synthesis are deposited on the surface of the support to form the chemical compounds. At least one physical parameter of the deposition varies between cycles The method comprises conducting the synthesis in at least two sets of cycles, arbitrarily designated as a first set and a second set. Each cycle comprises at least one step of depositing reagents on a surface by means of droplet dispensing elements that traverse the surface of the support. At least one, and desirably all, of the following deposition parameters are employed as indicated: The number of times of repetition for a step of depositing reagents in at least one cycle of the second set is less than the number of times of repetition for a corresponding step in at least one cycle of the first set. The rate of deposition in at least one cycle of the second set is slower than or equal to the rate of deposition in at least one cycle of the first set. The rate of traversal of the dispensing elements over the surface of the support in at least one cycle of the second set is greater than such rate of traversal in at least one cycle of the first set.
摘要翻译：公开了在载体表面上合成多种化合物的方法。该合成包括一系列循环的步骤，其中用于进行合成的试剂沉积在载体的表面上以形成化合物。沉积物的至少一个物理参数在循环之间变化。该方法包括以任意指定为第一组和第二组的至少两组循环进行合成。每个循环包括至少一个步骤，其通过穿过载体表面的液滴分配元件在表面上沉积试剂。如下所示使用以下沉积参数中的至少一个，期望地全部以下沉积参数：在第二组的至少一个循环中沉积试剂的步骤的重复次数小于第二组的重复次数在第一组的至少一个循环中的对应步骤。在第二组的至少一个循环中的沉积速率慢于或等于第一组的至少一个循环中的沉积速率。在第二组的至少一个循环中，分配元件在支撑体表面上的遍历速率大于在第一组的至少一个循环中的穿过速率。

19. 发明授权

US08027823B2 Methods and system for viewing genomic data 有权
标题翻译：观察基因组数据的方法和系统
公开(公告)号：US08027823B2
公开(公告)日：2011-09-27
申请号：US11473869
申请日：2006-06-23
申请人： Michael T. Barrett , Michael P. Caren
发明人： Michael T. Barrett , Michael P. Caren
IPC分类号： G06G7/58 , G06F7/60 , G01N33/48 , C12Q1/68
CPC分类号： G06F19/26
摘要： A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.
摘要翻译：提供了一种用于查看实验数据的计算机实现方法。在某些实施方案中，该方法包括：a）将基因组阵列数据和细胞遗传学数据输入到计算机存储器中; 以及b）产生图形用户界面，其包括：i）所述基因组阵列数据的染色体图，其包括指示染色体图上的位置的第一位置指示符; 和ii）细胞遗传学数据的细胞遗传学图谱，其包括指示细胞遗传学图谱上的位置的第二位置指示剂。

20. 发明授权

US5736998A Inkjet cartridge design for facilitating the adhesive sealing of a printhead to an ink reservoir 失效
标题翻译：喷墨墨盒设计，用于促进打印头与墨水容器的粘合密封
公开(公告)号：US5736998A
公开(公告)日：1998-04-07
申请号：US398849
申请日：1995-03-06
申请人： Michael P. Caren , Max Stephen Gunther , John C. Nadworny
发明人： Michael P. Caren , Max Stephen Gunther , John C. Nadworny
IPC分类号： B41J2/14 , B41J2/16 , B41J2/135
CPC分类号： B41J2/1631 , B41J2/14024 , B41J2/1603 , B41J2/1623 , B41J2/1625 , B41J2/1628 , B41J2/1634 , B41J2002/14362
摘要： This disclosure describes an improved ink seal between a print cartridge body and an inkjet printhead. In a preferred embodiment, a nozzle member containing an array of orifices has a substrate, having heater elements formed thereon, affixed to a back surface of the nozzle member. Each orifice in the nozzle member is associated with a single heating element formed on the substrate. The back surface of the nozzle member extends beyond the outer edges of the substrate. Ink is supplied from an ink reservoir to the orifices by a fluid channel within a barrier layer between the nozzle member and the substrate. The fluid channel in the barrier layer may receive ink fl owing around two or more outer edges of the substrate or may receive ink which flows through a hole in the center of the substrate. The nozzle member is adhesively sealed with respect to the ink reservoir body by forming an ink seal circumscribing the substrate, between the back surface of the nozzle member and the headland area of the print cartridge. This method and structure for a print cartridge headland for providing a seal directly between a nozzle member and an ink reservoir body has many advantages over other methods of providing a seal between a printhead and the ink reservoir body. One advantage is that such a structure reduces the occurrence of clogged nozzles during the adhesive sealing process. Another advantage is that there is a reduced occurrence of adhesive voids where the adhesive seal acts to encapsulate and protect the traces near the substrate which may come in contact with ink. A further advantage is that it is easier to control adhesive flow and bulges due to varying amounts and placement of adhesive. The above advantages provide reduced yield losses, and thus lower manufacturing costs, when manufacturing thermal inkjet print cartridges.
摘要翻译：本公开描述了在打印盒本体和喷墨打印头之间改进的墨水密封。在优选实施例中，包含孔阵列的喷嘴构件具有固定到喷嘴构件的后表面上的在其上形成有加热元件的基板。喷嘴构件中的每个孔与形成在基底上的单个加热元件相关联。喷嘴构件的后表面延伸超过衬底的外边缘。油墨通过喷嘴构件和基底之间的阻挡层内的流体通道从油墨储存器供应到孔口。阻挡层中的流体通道可以在基底的两个或更多个外边缘处接收墨水，或者可以接收流经基板中心的孔的墨。喷嘴构件通过在喷嘴构件的后表面和打印碳粉盒的岬角区域之间形成限定衬底的油墨密封而相对于储墨体粘合地密封。用于在喷嘴构件和墨水储存器本体之间直接提供密封的打印墨盒头岬的这种方法和结构具有优于在打印头和墨水储存器本体之间提供密封的其它方法的优点。一个优点是这种结构减少了在粘合剂密封过程中喷嘴堵塞的发生。另一个优点是粘合剂空隙的发生减少，其中粘合剂密封件用于封装和保护靠近基底的迹线，该迹线可能与墨接触。另一个优点是，由于粘合剂的量的变化和放置，控制粘合剂流动和膨胀更容易。上述优点在制造热喷墨打印墨盒时提供降低的产量损失，并因此降低制造成本。

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