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11. 发明授权

US5648238A Human protein kinase C inhibitor homolog 失效
标题翻译：人蛋白激酶C抑制剂同源物
公开(公告)号：US5648238A
公开(公告)日：1997-07-15
申请号：US666798
申请日：1996-06-18
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/55 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C12N15/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention provides a polynucleotide (ipkc) which identifies and encodes a novel human protein kinase C inhibitor homolog (IPKC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding IPKC.
摘要翻译：本发明提供鉴定和编码新的人蛋白激酶C抑制物同源物（IPKC）的多核苷酸（ipkc）。本发明提供了包含编码IPKC的核酸序列的遗传工程表达载体和宿主细胞。

12. 发明授权

US6113904A Human glycoprotein 失效
标题翻译：人类糖蛋白
公开(公告)号：US6113904A
公开(公告)日：2000-09-05
申请号：US63869
申请日：1998-04-20
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N1/21 , C12N15/12 , A61K39/00 , C07K1/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人糖蛋白（SC2H）的多核苷酸。本发明提供了包含编码SC2H的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质中用于治疗与SC2H表达相关的疾病的基本纯化的SC2H及其激动剂的用途。另外，本发明提供了用于治疗与SC2H表达相关的疾病的SC2H反义分子的用途。本发明还描述了利用包含与编码SC2H的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

13. 发明授权

US6015788A Human nucleic acid binding protein 失效
标题翻译：人核酸结合蛋白
公开(公告)号：US6015788A
公开(公告)日：2000-01-18
申请号：US195855
申请日：1998-11-19
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.
摘要翻译：本发明提供鉴定和编码新的人核酸结合蛋白（NABP）的多核苷酸。本发明提供了包含编码NABP的核酸序列的基因工程表达载体和宿主细胞。本发明还提供在药物组合物中用于治疗与NABP表达相关的疾病的基本纯化的NABP或其拮抗剂的用途。另外，本发明提供了用于治疗与NABP表达相关的疾病的药物组合物中NABP的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与编码特异性结合NABP的NABP或抗NABP抗体的多核苷酸的基因组序列或转录物杂交。

14. 发明授权

US5856128A Human nucleic acid binding protein 失效
公开(公告)号：US5856128A
公开(公告)日：1999-01-05
申请号：US698407
申请日：1996-08-15
申请人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Olga Bandman , Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nucleic acid binding protein (NABP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NABP. The invention also provides for the use of substantially purified NABP or its antagonists, in pharmaceutical compositions for the treatment of diseases associated with the expression of NABP. Additionally, the invention provides for the use of antisense molecules to NABP in pharmaceutical compositions for treatment of diseases associated with the expression of NABP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NABP or anti-NABP antibodies which specifically bind to NABP.

15. 发明授权

US5747319A Human mRNA editing enzyme 失效
标题翻译：人类mRNA编辑酶
公开(公告)号：US5747319A
公开(公告)日：1998-05-05
申请号：US687895
申请日：1996-07-25
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K38/00 , A61K38/43 , A61K48/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/28 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/22 , C07H21/04 , C12N5/00 , C12N15/63
CPC分类号： C12N9/00 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human mRNA editing enzyme (REE). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding REE. The invention also provides for the use of substantially purified REE and its agonists, antagonists, or inhibitors in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of REE. Additionally, the invention provides for the use of antisense molecules to REE in pharmaceutical compositions for treatment of diseases associated with the expression of REE. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding REE or anti-REE antibodies which specifically bind to REE.
摘要翻译：本发明提供鉴定和编码新的人mRNA编辑酶（REE）的多核苷酸。本发明提供了包含编码REE的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质和用于治疗与REE表达有关的疾病的药物组合物中使用基本上纯化的REE及其激动剂，拮抗剂或抑制剂。此外，本发明提供了用于治疗与REE表达相关的疾病的药物组合物中REE的反义分子的用途。本发明还描述了使用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与编码特异性结合REE的REE或抗REE抗体的多核苷酸的基因组序列或转录物杂交。

16. 发明授权

US6080841A Human induced tumor protein 失效
标题翻译：人诱导的肿瘤蛋白
公开(公告)号：US6080841A
公开(公告)日：2000-06-27
申请号：US58376
申请日：1998-04-09
申请人： Janice Au-Young , Phillip R. Hawkins
发明人： Janice Au-Young , Phillip R. Hawkins
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K48/00 , A61P1/00 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/574 , C07K14/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.
摘要翻译：本发明提供鉴定和编码新型人诱导肿瘤蛋白（HITP）的多核苷酸。本发明提供了包含编码HITP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本上纯化的HITP以强制分化并停止癌细胞中的细胞分裂。本发明还描述了利用多核苷酸与编码HITP的转录物和特异性结合HITP的抗HITP抗体杂交的诊断测定法。

17. 发明授权

US5863780A Human Protein Kinases 失效
标题翻译：人类蛋白激酶
公开(公告)号：US5863780A
公开(公告)日：1999-01-26
申请号：US712709
申请日：1996-09-12
申请人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
发明人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
IPC分类号： C12N15/00 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/48 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
摘要翻译：本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

18. 发明授权

US5846778A Human map kinase homolog 失效
标题翻译：人地图激酶同源物
公开(公告)号：US5846778A
公开(公告)日：1998-12-08
申请号：US920296
申请日：1997-08-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K38/00 , C12N9/12 , C12N15/00 , C07H21/04 , C07K14/435
CPC分类号： C12N9/1205 , C12N9/12 , A61K38/00 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

19. 发明授权

US06232077B1 Human protein kinases 失效
标题翻译：人类蛋白激酶
公开(公告)号：US06232077B1
公开(公告)日：2001-05-15
申请号：US09541228
申请日：2000-04-03
申请人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
发明人： Janice Au-Young , Karl J. Guegler , Phillip R. Hawkins
IPC分类号： C07H2104
CPC分类号： C12N9/1205 , A61K38/00
摘要： The present invention provides novel human protein kinases (HPK) and polynucleotides which identify and encode HPK. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPK. The invention also provides for pharmaceutical compositions comprising HPK or antagonists of HPK, and antibodies which specifically bind HPK. Additionally, the invention provides antisense molecules to HPK for treatment or prevention of diseases associated with abnormal expression of HPK.
摘要翻译：本发明提供了鉴定和编码HPK的新型人蛋白激酶（HPK）和多核苷酸。本发明提供了包含编码HPK的核酸序列的基因工程表达载体和宿主细胞。本发明还提供包含HPK或HPK拮抗剂的药物组合物，以及特异性结合HPK的抗体。此外，本发明提供了用于治疗或预防与HPK异常表达相关的疾病的HPK的反义分子。

20. 发明授权

US5663313A Human map kinase homolog 失效
标题翻译：人地图激酶同源物
公开(公告)号：US5663313A
公开(公告)日：1997-09-02
申请号：US674612
申请日：1996-06-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K38/00 , C12N9/12 , C07H21/04 , C12N5/10 , C12Q1/68
CPC分类号： C12N9/1205 , C12N9/12 , A61K38/00 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

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