会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 11. 发明申请
    • Reagens for the Detection of Protein Acetylation Signaling Pathways
    • 用于检测蛋白质乙酰化信号通路的试剂
    • US20090124023A1
    • 2009-05-14
    • US12227321
    • 2007-05-11
    • Ailan GuoTing-Lei GuJeffrey MitchellPeter Hornbeck
    • Ailan GuoTing-Lei GuJeffrey MitchellPeter Hornbeck
    • G01N33/566C07K16/18
    • G01N33/68C07K16/18C07K16/44G01N33/6842
    • The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases.
    • 本发明公开了在信号转导蛋白中鉴定的432个新的乙酰化位点和基于人蛋白质乙酰化信号通路的途径,并提供乙酰化位点特异性抗体和重同位素标记肽(AQUA肽),用于选择性检测和定量这些乙酰化位点/蛋白质 ,以及使用试剂用于此目的的方法。 确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点:乙酰转移酶,适配器/支架蛋白,肌动蛋白结合蛋白,粘附蛋白,细胞凋亡蛋白,钙结合蛋白,细胞周期调节蛋白,细胞表面蛋白,DNA结合蛋白,DNA 复制蛋白,通道蛋白,伴侣蛋白,细胞代谢酶,细胞骨架蛋白,DNA修复蛋白,内质网蛋白,酶蛋白,G蛋白和GTP酶活化蛋白,鸟嘌呤核苷酸交换因子,Helicase蛋白,异构酶蛋白,Extracelluar基质蛋白,水解酶 ,连接酶蛋白,脂质激酶,抑制蛋白,脂质结合蛋白和裂解酶。
    • 16. 发明授权
    • Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
    • 用于检测EGFR-信号通路中蛋白质磷酸化的试剂
    • US07807789B2
    • 2010-10-05
    • US11821130
    • 2007-06-21
    • Ailan GuoKimberly LeeKlarisa RikovaCharles FarnsworthAlbrecht MoritzYu LiRobert Polakiewicz
    • Ailan GuoKimberly LeeKlarisa RikovaCharles FarnsworthAlbrecht MoritzYu LiRobert Polakiewicz
    • C12P21/08C07K16/28
    • C07K16/2863C07B59/008C07K2317/34
    • The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.
    • 本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径,并提供磷酸化位点特异性抗体和重同位素标记肽(AQUA肽),用于选择性检测和定量这些磷酸化位点 /蛋白质,以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是以下蛋白质类型发生的位点:肌动蛋白结合蛋白,衔接/支架蛋白,钙结合蛋白,细胞周期调节蛋白,细胞骨架蛋白,DNA结合和复制蛋白,GTP酶激活蛋白,鸟嘌呤核苷酸交换因子 蛋白质,脂质激酶,受体酪氨酸激酶,受体酪氨酸激酶配体,蛋白激酶,受体和蛋白磷酸酶,转录因子蛋白,肿瘤抑制蛋白和囊泡蛋白。