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11. 发明申请

US20080171748A1 Substituted piperidines 失效
标题翻译：取代的哌啶
公开(公告)号：US20080171748A1
公开(公告)日：2008-07-17
申请号：US12076221
申请日：2008-03-14
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christiane Marti , Stefan Stutz , Stjepan Jelakovic , Zenon D. Konteatis , Jennifer L. Ludington , Michael Quirmbach , Aleksandar Stojanovic , Dirk Behnke , Frank Hollinger
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christiane Marti , Stefan Stutz , Stjepan Jelakovic , Zenon D. Konteatis , Jennifer L. Ludington , Michael Quirmbach , Aleksandar Stojanovic , Dirk Behnke , Frank Hollinger
IPC分类号： A61K31/50 , A61K31/4965
CPC分类号： C07D413/12 , C07D413/14
摘要： Substituted piperidines of formulae (I) and (II) with the substituent definitions as explained in the specification. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译：式（I）和（II）的取代的哌啶与说明书中所述的取代基定义相同。该化合物特别适合作为肾素抑制剂，并且是非常有效的。

12. 发明申请

US20100168145A1 FUSED IMIDAZOLE DERIVATIVES AND USE THEREOF AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
标题翻译：熔融咪唑衍生物及其作为阿糖胞苷合成酶抑制剂的用途
公开(公告)号：US20100168145A1
公开(公告)日：2010-07-01
申请号：US11921313
申请日：2006-05-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Nathalie Jotterand , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/438 , C07D471/10 , C07D471/20 , A61P5/42
CPC分类号： C07D471/04
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which A, R, R1, R2, X, Y, Z, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中A，R，R 1，R 2，X，Y，Z，n和p具有在说明书中更详细阐述的定义涉及制备方法它们以及这些化合物作为药物的使用，特别是作为醛固酮合酶抑制剂。

13. 发明申请

US20100029628A1 2,4,5-Substituted Piperidines as Renin Inhibitors 审中-公开
标题翻译： 2,4,5-取代哌啶酮作为肾素抑制剂
公开(公告)号：US20100029628A1
公开(公告)日：2010-02-04
申请号：US11887227
申请日：2006-03-30
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christiane Marti , Stefan Stutz , Stjepan Jelakovic , Zenon D. Konteatis , Jennifer L. Ludington , Michael Quirmbach , Aleksandar Stojanovic , Dirk Behnke , Frank Hollinger
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christiane Marti , Stefan Stutz , Stjepan Jelakovic , Zenon D. Konteatis , Jennifer L. Ludington , Michael Quirmbach , Aleksandar Stojanovic , Dirk Behnke , Frank Hollinger
IPC分类号： A61K31/538 , C07D413/02 , A61P9/00 , A61P13/00
CPC分类号： C07D413/12 , C07D413/14
摘要： SP-P2140 ATE-132—Abstract Novel substituted piperidines of the general formula (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译： SP-P2140ATE-132-摘要描述了通式（I）和（II）的具有取代基定义的新颖取代的哌啶，如在说明书中详细说明的。该化合物特别适合作为肾素抑制剂，并且是非常有效的。

14. 发明申请

US20090118281A1 Amino Alcohol Derivatives And Their Use As Renin Inhibitor 失效
标题翻译：氨基醇衍生物及其作为肾素抑制剂的用途
公开(公告)号：US20090118281A1
公开(公告)日：2009-05-07
申请号：US10587046
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： A61K31/5377 , C07D215/38 , A61K31/47 , C07D401/14 , A61P13/12 , A61P9/12 , A61K31/438 , C07D413/02
CPC分类号： C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/08 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和使用方法这些化合物作为药物，特别是作为肾素抑制剂。

15. 发明申请

US20070155743A1 Amino alcohol derivatives and their activity as renin inhibitors 失效
标题翻译：氨基醇衍生物及其作为肾素抑制剂的活性
公开(公告)号：US20070155743A1
公开(公告)日：2007-07-05
申请号：US10587150
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/5375 , A61K31/495 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D471/10 , C07C235/60 , C07C237/06 , C07C237/10 , C07C237/22 , C07C237/24 , C07C243/28 , C07C275/14 , C07C311/05 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/18 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/06 , C07C2602/22 , C07C2603/74 , C07D211/76 , C07D295/13 , C07D311/00
摘要： The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5,X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R 1，R 2，R 2，R 3，R 3， 4，R 5，X 1和X 2各自具有在说明书中详细说明的定义，涉及一种它们的制备和使用这些化合物作为药物，特别是作为肾素抑制剂。

16. 发明申请

US20110028512A1 BIS-HETEROCYCLIC IMIDAZOLYL COMPOUNDS 失效
标题翻译：双相异构体咪唑啉化合物
公开(公告)号：US20110028512A1
公开(公告)日：2011-02-03
申请号：US12900779
申请日：2010-10-08
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
IPC分类号： A61K31/437 , C07D487/04 , C07D471/04 , A61K31/4188 , A61P9/12 , A61P3/06 , A61P3/00 , A61P9/04
CPC分类号： C07D471/04
摘要： Heterocyclic compounds of the general formula (I) are provided in which R, R1, R2, R3, R4 and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldostereone synthase inhibitors,
摘要翻译：提供通式（I）的杂环化合物，其中R，R 1，R 2，R 3，R 4和n具有在说明书中更详细阐述的定义，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合成酶抑制剂，

17. 发明授权

US07851634B2 5-amino 4-hydroxy-7-(1H-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension 失效
标题翻译： 5-氨基-4-羟基-7-（1H-吲哚甲基）-8-甲基壬酰胺衍生物作为治疗高血压的肾素抑制剂
公开(公告)号：US07851634B2
公开(公告)日：2010-12-14
申请号：US10593460
申请日：2005-03-17
申请人： Peter Herold , Stefan Stutz , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Nathalie Jotterand , Michael Quirmbach , Dirk Behnke , Christiane Marti
发明人： Peter Herold , Stefan Stutz , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Nathalie Jotterand , Michael Quirmbach , Dirk Behnke , Christiane Marti
IPC分类号： C07D405/02 , A61K31/44
CPC分类号： C07C237/06 , C07C237/22 , C07D209/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The application relates to novel alkanamides of the general formula (I) where X is —CH2— or >CH—OH; (A) R1 is e.g. an optionally substituted heterocyclyl radical or an optionally substituted polycyclic, unsaturated hydrocarbon radical where X is hydroxymethylene; R2 is C1-C6-alkyl or C3-C6-cydoalkyl; R3 are each independently H, C1-C6-alkyl, C1-6-alkoxycarbonyl or C1-C6-alkanoyl; R4 is C1-C6-alkyl, C3-C6-cycloalkyl, C2-C6-alkenyl or unsubstituted or substituted arylC1-C6-alkyl; R5 is C1-C6-alkyl, C1-C6-hydroxyalkyl, C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkanoyloxy C1-C6-alkyl, C1-C6-aminoalkyl, C1-C6-alkylamino-C1-C6-alkyl, C1-C6-dialkylamino-C1-C6-alkyl, C1-C6-alkanoylamido-C1-C6-alkyl, HO(O)C—C1-C6-alkyl, C1-C6-alkyl-O—(O)C—C1-C6-alkyl, H2N—C(O)—C1-C6-alkyl, C1-C6-alkyl-HN—C(O)—C1-C6-alkyl, (C1,-C6-alkyl)2N—C(O)—C1-C6-alkyl, C2-C8-alkenyl, C2-C8-alkynyl, cyano-C1-C6-alkyl, halo-C1-C6-alkyl, optionally substituted aryl-Co-C6-alkyl, optionally substituted C3-C8-cycloalkyl-Co-C6-alkyl or optionally substituted heterocydyl-Co-C6-alkyl; to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors for the treatment of hypertension.
摘要翻译：本申请涉及通式（I）的新型烷酰胺，其中X为-CH 2 - 或> CH-OH; （A）R1是例如任选取代的杂环基或任选取代的多环不饱和烃基，其中X是羟基亚甲基; R2是C1-C6-烷基或C3-C6-环烷基; R 3各自独立地为H，C 1 -C 6 - 烷基，C 1-6 - 烷氧基羰基或C 1 -C 6 - 烷酰基; R4是C1-C6-烷基，C3-C6-环烷基，C2-C6-烯基或未取代或取代的芳基C1-C6-烷基; R5是C1-C6-烷基，C1-C6-羟基烷基，C1-C6-烷氧基-C1-C6-烷基，C1-C6-烷酰氧基C1-C6-烷基，C1-C6-氨基烷基，C1-C6烷基氨基-C1 C 1 -C 6 - 烷基，C 1 -C 6 - 二烷基氨基-C 1 -C 6 - 烷基，C 1 -C 6 - 烷酰基氨基-C 1 -C 6烷基，HO（O）C 1 -C 6 - 烷基，C 1 -C 6烷基-O-（ O）-C 1 -C 6烷基，H 2 N-C（O）-C 1 -C 6 - 烷基，C 1 -C 6烷基-NH-C（O）-C 1 -C 6 - 烷基，（C 1 -C 6 - 烷基） C 1 -C 6 - 烷基，C 2 -C 8 - 烯基，C 2 -C 8炔基，氰基-C 1 -C 6烷基，卤代-C 1 -C 6烷基，任选取代的芳基-C 0 -C 6 - 烷基，任选取代的C 3 -C 8 - 环烷基-C 0 -C 6 - 烷基或任选取代的杂环-Co-C 6 - 烷基; 其制备方法和这些化合物作为药物的使用，特别是用作治疗高血压的肾素抑制剂。

18. 发明授权

US07786307B2 Amino alcohol derivatives and their activity as renin inhibitors 失效
标题翻译：氨基醇衍生物及其作为肾素抑制剂的活性
公开(公告)号：US07786307B2
公开(公告)日：2010-08-31
申请号：US10587150
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： C07D211/26 , A61K31/445
CPC分类号： C07D471/10 , C07C235/60 , C07C237/06 , C07C237/10 , C07C237/22 , C07C237/24 , C07C243/28 , C07C275/14 , C07C311/05 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/18 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/06 , C07C2602/22 , C07C2603/74 , C07D211/76 , C07D295/13 , C07D311/00
摘要： The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5，X 1和X 2各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

19. 发明授权

US07718675B2 Diamino alcohols and their use as renin inhibitor 失效
标题翻译：二氨基醇及其作为肾素抑制剂的用途
公开(公告)号：US07718675B2
公开(公告)日：2010-05-18
申请号：US10586814
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D207/27 , C07C233/36 , C07C233/78 , C07C311/05 , C07D205/04 , C07D207/12 , C07D207/273 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/56 , C07D223/10 , C07D239/10 , C07D277/42 , C07D295/13 , C07D295/15 , C07D303/48 , C07D309/04 , C07D333/34 , C07D413/06 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

20. 发明申请

US20090197909A1 Bis-Heterocyclic Imidazolyl Compounds 有权
标题翻译：双杂环咪唑基化合物
公开(公告)号：US20090197909A1
公开(公告)日：2009-08-06
申请号：US12086193
申请日：2006-12-08
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
IPC分类号： A61K31/437 , C07D487/04 , C07D471/04 , A61K31/4188 , A61P5/42
CPC分类号： C07D471/04
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, R3, R4 and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these C compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中R，R 1，R 2，R 3，R 4和n具有在说明书中更详细阐述的定义，其制备方法和使用这些C化合物作为药物，特别是作为醛固酮合酶抑制剂。

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