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11. 发明授权

US06390967B1 Radiation for inhibiting hyperplasia after intravascular intervention 有权
标题翻译：用于抑制血管内干预后增生的辐射
公开(公告)号：US06390967B1
公开(公告)日：2002-05-21
申请号：US09661438
申请日：2000-09-14
申请人： Michael R. Forman , Paul A. Lovoi , Tom W. Rusch
发明人： Michael R. Forman , Paul A. Lovoi , Tom W. Rusch
IPC分类号： A61N500
CPC分类号： A61N5/1002 , A61N2005/1003 , A61N2005/1021
摘要： Apparatus and methods are provided for applying a radially uniform radiation dose to an intravascular treatment region to inhibit hyperplanes, and specifically to reduce “candy-wrapper” ends, following intravascular intervention. An embodiment of the apparatus comprises a catheter body having a proximal end and a distal end, a pair of axially spaced apart radiation shields on the catheter body, and a radiation source. The radiation source applies a radiation dose which is substantially uniform in a radial direction over an entire distance between the axially spaced apart shields.
摘要翻译：提供了设备和方法，用于将径向均匀的辐射剂量施加到血管内治疗区域以抑制超平面，并且具体地减少血管内干预后的“糖果包裹物”端。该装置的实施例包括具有近端和远端的导管主体，导管主体上的一对轴向隔开的辐射屏蔽和辐射源。辐射源施加辐射剂量，其在轴向间隔开的屏蔽之间的整个距离处在径向方向上基本均匀。

12. 发明授权

US5672083A Fabrication of flat panel device having backplate that includes ceramic layer 失效
标题翻译：具有包括陶瓷层的背板的平板装置的制造
公开(公告)号：US5672083A
公开(公告)日：1997-09-30
申请号：US483221
申请日：1995-06-07
申请人： Christopher J. Curtin , Anthony P. Schmid , Paul A. Lovoi
发明人： Christopher J. Curtin , Anthony P. Schmid , Paul A. Lovoi
IPC分类号： G02F1/133 , G02F1/1333 , G02F1/13357 , G02F1/1362 , H01J5/04 , H01J9/24 , H01J29/86 , H01J61/30 , H01J63/00 , H01J63/06 , H01J9/26
CPC分类号： G02F1/1333 , G02F1/133617 , G02F1/1362 , H01J29/863 , H01J5/04 , H01J61/302 , H01J63/00 , H01J63/06 , H01J9/241 , G02F2001/133302 , G02F2001/133374 , H01J2329/00
摘要： A flat panel display manufacturing process entails forming a laminated structure (90x) by combining a plurality of layers (90 and 90a-90e), including a ceramic layer (90). The laminated structure is fired to convert the layers into an integrated backplate structure, at least part of which constitutes a backplate (93b, 16, or 201). A flat panel device that contains the backplate, a faceplate (91a, 12, or 202) connected to the baseplate to form a sealed enclosure (203), a mechanism (22 and 93) for producing light, and a mechanism (20 or 204) for controlling the light-producing mechanism is then fabricated. The ceramic may be of the zero shrinkage tolerance type. Glazing material can be formed over the backplate. Cooling channels (1101a) can be incorporated in the backplate. A field emission cathode (243) can be formed in openings (241a) in the backplate.
摘要翻译：平板显示器制造工艺需要通过组合包括陶瓷层（90）的多个层（90和90a-90e）来形成层压结构（90x）。层压结构被烧制以将层转化成整体的背板结构，其中至少一部分构成背板（93b，16或201）。一种平板装置，其包含背板，连接到基板以形成密封外壳（203）的面板（91a，12或202），用于产生光的机构（22和93）和机构（20或204 ）用于控制发光机构。陶瓷可以是零收缩容差型。玻璃材料可以形成在背板上。冷却通道（1101a）可以并入背板中。场致发射阴极（243）可以形成在背板中的开口（241a）中。

13. 发明授权

US5614781A Structure and operation of high voltage supports 失效
标题翻译：高压支架的结构和运行
公开(公告)号：US5614781A
公开(公告)日：1997-03-25
申请号：US505841
申请日：1995-07-20
申请人： Christopher J. Spindt , David L. Morris , Theodore S. Fahlen , Anthony P. Schmid , Paul A. Lovoi
发明人： Christopher J. Spindt , David L. Morris , Theodore S. Fahlen , Anthony P. Schmid , Paul A. Lovoi
IPC分类号： H01J9/18 , H01J9/24 , H01J17/49 , H01J29/02 , H01J29/08 , H01J29/46 , H01J29/86 , H01J31/12 , H01J61/30 , H01J19/44
CPC分类号： H01J61/30 , H01J29/028 , H01J29/085 , H01J29/467 , H01J29/864 , H01J31/127 , H01J9/185 , H01J9/242 , H01J2329/863 , H01J2329/864 , H01J2329/8645 , H01J2329/8655
摘要： According to the invention, a flat panel device includes a spacer for providing internal support. In one embodiment, the spacer is made of ceramic, glass-ceramic, ceramic reinforced glass, devitrified glass, metal with electrically insulative coating or high-temperature vacuum-compatible polyimide, and can be a spacer wall, a spacer structure including a plurality of holes, or some combination of a spacer wall, spacer walls, and spacer structure. Spacer surfaces are treated to reduce secondary emissions and prevent charging of the spacer surfaces. The flat panel device can include a thermionic cathode or a field emitter cathode, and the faceplate and backplate can both be straight or both be curved. The flat panel device can include an addressing grid.
摘要翻译：根据本发明，平板装置包括用于提供内部支撑的间隔件。在一个实施例中，间隔件由陶瓷，玻璃陶瓷，陶瓷增强玻璃，失透玻璃，具有电绝缘涂层的金属或高温真空兼容的聚酰亚胺制成，并且可以是间隔壁，间隔结构，包括多个孔或间隔壁，间隔壁和间隔结构的某种组合。处理间隔表面以减少二次排放并防止间隔件表面的充电。平板装置可以包括热离子阴极或场发射体阴极，并且面板和背板都可以是直的或两者都是弯曲的。平板设备可以包括寻址网格。

14. 发明授权

US5477105A Structure of light-emitting device with raised black matrix for use in optical devices such as flat-panel cathode-ray tubes 失效
标题翻译：具有用于诸如平板阴极射线管的光学装置的具有凸起黑矩阵的发光装置的结构
公开(公告)号：US5477105A
公开(公告)日：1995-12-19
申请号：US188856
申请日：1994-01-31
申请人： Christopher J. Curtin , Ronald S. Nowicki , Theodore S. Fahlen , Robert M. Duboc, Jr. , Paul A. Lovoi
发明人： Christopher J. Curtin , Ronald S. Nowicki , Theodore S. Fahlen , Robert M. Duboc, Jr. , Paul A. Lovoi
IPC分类号： H01J9/18 , H01J17/49 , H01J29/02 , H01J29/08 , H01J29/32 , H01J29/46 , H01J31/12 , H01J61/30 , H01J29/18
CPC分类号： H01J9/185 , H01J17/49 , H01J29/028 , H01J29/085 , H01J29/327 , H01J29/467 , H01J31/123 , H01J31/126 , H01J61/30 , H01J9/14 , H01J2329/08 , H01J2329/28 , H01J2329/323 , H01J2329/8625 , H01J2329/863 , H01J2329/864 , H01J2329/8645
摘要： A light-emitting structure (306) contains a main section (302), a pattern of ridges (314) situated along the main section, and a plurality of light-emissive regions (313) situated in spaces between the ridges. The light-emissive regions produce light of various colors upon being hit by electrons. The ridges, which extend further away from the main section than the light-emissive regions, are substantially non-emissive of light when hit by electrons. Each ridge includes a dark region. The ridges thereby form a raised black matrix that improves contrast and color purity. The dark region of each ridge may be formed with metal, ceramic, semiconductor, or carbide. Each ridge may include an additional region (314b) of different chemical composition than the dark region.
摘要翻译：发光结构（306）包含主要部分（302），沿着主要部分设置的脊部（314）的图案以及位于脊部之间的空间中的多个发光区域（313）。发光区域在被电子击中时产生各种颜色的光。与光发射区相比远离主区延伸的脊在被电子击中时基本上不发光。每个脊包括一个暗区。因此，脊形成提高对比度和色纯度的凸起黑矩阵。每个脊的暗区可以由金属，陶瓷，半导体或碳化物形成。每个脊可以包括与暗区不同的化学成分的附加区域（314b）。

15. 发明授权

US09055972B2 Proportional attenuation of radiation in brachytheraphy treatment 有权
标题翻译：近距离治疗辐射的比例衰减
公开(公告)号：US09055972B2
公开(公告)日：2015-06-16
申请号：US13291854
申请日：2011-11-08
申请人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
发明人： Steve Axelrod , Robert R. Burnside , Paul A. Lovoi
IPC分类号： A61N5/10 , A61B19/00
CPC分类号： A61B19/40 , A61B90/04 , A61B2090/0436 , A61N5/1001 , A61N2005/1094
摘要： Attenuating masks for selective attenuation of radiation, particularly from an x-ray source in brachytherapy, employ materials having atomic number in a specific range, so as to attenuate radiation dose intensity generally proportionally through a range of distance from the source. Some preferred attenuation materials are silver and molybdenum. A set of small masks can be provided for a particular design of catheter that holds a radiation source, each mask having a size and shape to define a different solid angle of masking, so that in a brachytherapy procedure, sensitive tissue such as bone or skin can be protected by proper selection of and positioning of the attenuating mask, to reduce the dose intensity to that tissue.
摘要翻译：用于选择性衰减辐射的衰减掩模，特别是来自近距离放射治疗中的X射线源，使用具有特定范围内的原子序数的材料，以便通过成比例的方式衰减辐射剂量强度，从而远离源的距离。一些优选的衰减材料是银和钼。可以为保持辐射源的导管的特定设计提供一组小的掩模，每个掩模具有尺寸和形状以限定不同的立体角度掩蔽，使得在近程放射治疗程序中，诸如骨骼或皮肤的敏感组织可以通过适当选择和定位衰减掩模来保护，以减少对该组织的剂量强度。

16. 发明申请

US20130041447A1 DURABLE FINE WIRE LEAD FOR THERAPEUTIC ELECTROSTIMULATION AND SENSING 审中-公开
标题翻译：耐用的精细电线，用于治疗电感和感觉
公开(公告)号：US20130041447A1
公开(公告)日：2013-02-14
申请号：US13648840
申请日：2012-10-10
申请人： John L. Erb , Kimberly Anderson , Paul A. Lovoi
发明人： John L. Erb , Kimberly Anderson , Paul A. Lovoi
IPC分类号： A61N1/05 , B05D5/12 , H01R43/16
CPC分类号： A61N1/056 , Y10T29/49204
摘要： A cardiac pacemaker, other CRT device or neurostimulator has one or more fine wire leads. Formed of a glass, silica, sapphire or crystalline quartz fiber with a metal buffer cladding, a unipolar lead can have an outer diameter as small as about 300 microns or even smaller. The buffered fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar leads can include several conductors side by side within a glass/silica fiber, or can be concentric metal coatings in a structure including several fiber layers. An outer protective sheath of a flexible polymer material can be included.
摘要翻译：心脏起搏器，其他CRT装置或神经刺激器具有一根或多根细线。由具有金属缓冲包层的玻璃，二氧化硅，蓝宝石或结晶石英纤维形成，单极引线可以具有小至约300微米甚至更小的外径。缓冲的纤维是非常耐用的，可以弯曲通过小的半径，即使从数百万次的弯曲迭代也不会疲劳。双极引线可以在玻璃/二氧化硅纤维内并排包括多个导体，或者可以是包括几个纤维层的结构的同心金属涂层。可以包括柔性聚合物材料的外护套。

17. 发明授权

US07744521B2 Customized gynecological brachytherapy applicator and method 有权
标题翻译：定制妇科近距离放射治疗仪及方法
公开(公告)号：US07744521B2
公开(公告)日：2010-06-29
申请号：US11805065
申请日：2007-05-21
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.
摘要翻译：通过将固定在手柄上的模制气囊放置在阴道腔中，然后用可固定的液体材料填充模具球，形成定制的妇科近距离放射治疗仪。当通过化学作用，温度变化，氧化，诸如光或其它固化方式的固化手段设定时，该材料可以是膨胀泡沫体或任何其它形式的可固化材料，其变得固体，刚性或柔韧性。取决于施用器将其外表面与阴道轮廓相一致的程度，模具气囊可以是弹性的或非弹性的。提供了一个或多个灯泡以在接收辐射源的集合填充材料中，其中另外的腔可以任选地提供用于治疗剂的排出或施用。在治疗期间，施用器可以被取出并重新插入阴道，并且根据辐射处方照射与施用器相邻的选定组织。

18. 发明授权

US07513861B2 Real time verification in radiation treatment 失效
标题翻译：放射治疗实时验证
公开(公告)号：US07513861B2
公开(公告)日：2009-04-07
申请号：US11394640
申请日：2006-03-31
申请人： Michael Klein , Paul A. Lovoi
发明人： Michael Klein , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/1048 , A61N5/1067
摘要： A radiation therapy system and method, especially for brachytherapy, monitors and verifies dose delivered at a plurality of points at or near the region to be irradiated, integrating verification with radiation delivery. In one procedure, mapping is used to determine the shape and location of the region to be irradiated. A treatment plan is developed using the mapping information and a dose prescription. As radiation is delivered to the target region internally, preferably using an electronic radiation source, the dose received at plural points is monitored and continually fed to a central processor. As needed based on feedback, the system modifies the treatment plan and delivery of radiation accordingly, to arrive substantially at the prescribed dose at all locations in the region. In a modified procedure the treatment is done according to a prescription dose but without a treatment plan by multiple iterations of source pullback and feedback and analysis of dose received in the tissue. Source radiation levels and/or pattern and dwell are modified for each successive iteration and preferably for different dwell points in an iteration.
摘要翻译：放射治疗系统和方法，特别是近距离放射治疗，监测和验证在待照射区域处或附近的多个点递送的剂量，将验证与放射递送集成。在一个过程中，使用映射来确定要照射的区域的形状和位置。使用映射信息和剂量处方开发治疗计划。随着辐射在内部，优选地使用电子辐射源被传送到目标区域，在多个点处接收的剂量被监测并且连续地馈送到中央处理器。根据反馈要求，系统相应地修改治疗计划和辐射传播，以达到该地区所有地点的规定剂量。在修改的程序中，根据处方剂量进行治疗，但是通过多次重复的来源回退和反馈以及组织中接收的剂量的分析来进行治疗计划。源辐射水平和/或图案和驻留对于每个连续的迭代进行修改，优选地对于迭代中的不同驻留点进行修改。

19. 发明申请

US20090030258A1 Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures 有权
标题翻译：用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
公开(公告)号：US20090030258A1
公开(公告)日：2009-01-29
申请号：US11881835
申请日：2007-07-28
申请人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
发明人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
IPC分类号： A61M36/06
CPC分类号： A61M25/1011 , A61B2017/22069 , A61M25/1002 , A61M2025/1061 , A61N5/1015
摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue, such as skin or bone, farther away from a radiation source within a source guide inside the balloon. In one case a secondary balloon or secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber, primarily of inelastic or fairly rigidly elastic wall material, but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape (which may be approximately spherical), and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
摘要翻译：气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。这对于将敏感组织（例如皮肤或骨骼）移动离气囊内的源引导件内的辐射源更远是有用的。在一种情况下，次级球囊或次级隔室形成在主气囊上，并且可分开地充气，以便在需要时根据需要允许起泡。在另一种形式中，气囊包括主要为非弹性或相当刚性弹性的壁材料的单个腔室，但具有球囊壁具有弹性或比主气囊壁基本上更有弹性的“窗口”或区域，从而使气球直到某一点形成基本上规则的气球形状（其可以近似为球形），并且增加进一步的压力将使弹性区域起泡以增加轴和敏感组织之间的距离，气球。

20. 发明申请

US20080300445A1 Customized gynecological brachytherapy applicator and method 有权
公开(公告)号：US20080300445A1
公开(公告)日：2008-12-04
申请号：US11809836
申请日：2007-05-31
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.

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