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11. 发明专利

JP2000229846A RELEASE CONTROL TYPE DOSAGE FORM 失效
公开(公告)号：JP2000229846A
公开(公告)日：2000-08-22
申请号：JP2000033132
申请日：2000-02-10
申请人： PFIZER PROD INC
发明人： REA ELIZABETH APPEL , CURATOLO WILLIAM JOHN , HERBIG SCOTT MAX , JAMES ALAN SHRIVER NIGHTINGALE , THOMBRE AVINASH GOVIND
IPC分类号： A61K9/22 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/26 , A61K9/50 , A61K9/52 , A61K31/135 , A61K31/137 , A61K31/17 , A61K31/36 , A61K31/404 , A61K31/44 , A61K31/497 , A61K31/505 , A61K31/517 , A61K31/522 , A61K47/32 , A61K47/34 , A61K47/38
摘要： PROBLEM TO BE SOLVED: To obtain a release control type dosage form having respectively specific core and coating to provide improved medicine bioavailability to deliver a medicine having poor solubility and short half-life of exclusion. SOLUTION: This dosage form comprises a core 12 composed of a penetrating agent and a poor soluble medicine, and a coating 18 around the core 12 having substantial water permeability. In the core 12, the medicine is in the form of a solid dispersed matter in a dispersed polymer, and at least most of the medicine is noncrystalline. The coating 18 contains at least one delivery boat 19 and controls the water inflow from an aqueous use environment to the core 12 to push out at least part of the core 12 to the above environment through the boat 19. During release of the above-mentioned medicine, the coating 18 has insolubility and non-erodibility.

12. 发明专利

JP2005162733A Azithromycin preparation form exhibiting only few adverse effect 有权
标题翻译： AZITHROMYCIN制剂形式只展现不良影响
公开(公告)号：JP2005162733A
公开(公告)日：2005-06-23
申请号：JP2004228455
申请日：2004-08-04
申请人： Pfizer Prod Inc , ファイザー・プロダクツ・インク
发明人： HAGEN TIMOTHY A , HERBIG SCOTT MAX , LO JULIAN BELKNAP , THOMBRE AVINASH GOVIND , APPEL LEAH E , CREW MARSHALL D , DWAYNE THOMAS FREESEN , LYON DAVID K , MCCRAY SCOTT B , WEST JAMES B
IPC分类号： C07H17/00 , A61K9/00 , A61K9/16 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： PROBLEM TO BE SOLVED: To provide an azithromycin preparation form having a bioavailability resembling to that of an instantaneous releasing type azithromycin of the same dose and less gastrointestinal adverse effects. SOLUTION: This azithromycin oral preparation contains an effective amount of an alkalizing agent and azithromycin multiple particles. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供具有类似于相同剂量的瞬时释放型阿奇霉素的生物利用度的阿奇霉素制剂形式和较少的胃肠道不良作用。解决方案：这种阿奇霉素口服制剂含有有效量的碱化剂和阿奇霉素多重颗粒。版权所有（C）2005，JPO＆NCIPI

13. 发明专利

JP2010132700A Azithromycin dosage form with reduced side effect 审中-公开
标题翻译： AZITHROMYCIN剂量形式具有减少的副作用
公开(公告)号：JP2010132700A
公开(公告)日：2010-06-17
申请号：JP2010044743
申请日：2010-03-01
申请人： Pfizer Prod Inc , ファイザー・プロダクツ・インク
发明人： HAGEN TIMOTHY A , HERBIG SCOTT MAX , LO JULIAN BELKNAP , THOMBRE AVINASH GOVIND , APPEL LEAH E , CREW MARSHALL D , DWAYNE THOMAS FREESEN , LYON DAVID K , MCCRAY SCOTT B , WEST JAMES B
IPC分类号： A61K31/7052 , C07H17/00 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/34 , A61K47/44 , A61P31/04 , A61P33/00
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： PROBLEM TO BE SOLVED: To provide an azithromycin dosage form which has bioavailability analogical to an instantly dischargeable azithromycin with the same dose and has gastrointestinal side effect smaller than the bioavailability. SOLUTION: The azithromycin dosage form includes azithromycin multiparticles and an effective amount of an alkalizing agent. Preferably, the alkalizing agent includes an aluminum salt, a magnesium salt, a calcium salt, a bicarbonate, a phosphate, a metal hydroxide, a metal oxide, N-methylglucamine, arginine, an arginine salt, an amine, or a combination thereof. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有类似于具有相同剂量的立即可释放的阿奇霉素的生物利用度的阿奇霉素剂型，并且具有小于生物利用度的胃肠道副作用。解决方案：阿奇霉素剂型包括阿奇霉素多颗粒和有效量的碱化剂。优选地，碱化剂包括铝盐，镁盐，钙盐，碳酸氢盐，磷酸盐，金属氢氧化物，金属氧化物，N-甲基葡糖胺，精氨酸，精氨酸盐，胺或其组合。版权所有（C）2010，JPO＆INPIT

14. 发明专利

JP2002255858A DELICIOUS MEDICINAL COMPOSITION FOR COMPANION ANIMAL 审中-公开
公开(公告)号：JP2002255858A
公开(公告)日：2002-09-11
申请号：JP2002047380
申请日：2002-02-25
申请人： PFIZER PROD INC
发明人： KASRAIAN KASRA , THOMBRE AVINASH GOVIND
IPC分类号： A61K47/46 , A23K1/16 , A23K1/18 , A61K9/00 , A61K9/20
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition enabling excellent treating compliance and convenience and larger satisfaction of pet owner. SOLUTION: In this delicious medicinal composition for orally administering to companion animals, comprising a pharmaceutically active substance combined with a palatability-improving agent and a pharmaceutically permissible carrier in a pharmaceutically effective amount, the palatability-improving agent is derived from non-meat and non-fish and the medicinal composition exists in enough amount to make the medicinal composition delicious for companion animal, with the proviso that when the palatability-improving agent is yeast, the agent exists in an amount of about 2 to about 25 wt.% based on the delicious medicinal composition.

15. 发明专利

JP2001206841A QUICKLY DISINTEGRATING AND QUICKLY DISSOLVING SOLID PREPARATION FORM 失效
公开(公告)号：JP2001206841A
公开(公告)日：2001-07-31
申请号：JP2001011348
申请日：2001-01-19
申请人： PFIZER PROD INC
发明人： THOMBRE AVINASH GOVIND , WIGMAN LARRY STEVEN
IPC分类号： A61K9/00 , A61K9/02 , A61K9/20 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42
摘要： PROBLEM TO BE SOLVED: To provide a solid preparation dissolving in the palate, especially useful for a subject necessary or desirable to take a drug by oral administration and difficult to swallow a standard oral administration drug such as tablet or for the subject having vomiting tendency and useful also as a vaginal or rectal suppository for quick drug delivery or as an animal drug for peroral drug delivery. SOLUTION: The quickly disintegrating and quickly dissolving non-crushable solid preparation is produced from a pharmacologically permissible steam- extrusion polymer.

16. 发明专利

JP2005320354A Matrix control release device 有权
标题翻译：矩阵控制释放装置
公开(公告)号：JP2005320354A
公开(公告)日：2005-11-17
申请号：JP2005226695
申请日：2005-08-04
申请人： Pfizer Prod Inc , ファイザー・プロダクツ・インク
发明人： REA ELIZABETH APPEL , CURATOLO WILLIAM JOHN , DWAYNE THOMAS FREESEN , JAMES ALAN SHRIVER NIGHTINGALE , THOMBRE AVINASH GOVIND
IPC分类号： A61K47/38 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/26 , A61K9/48 , A61K31/138 , A61K31/155 , A61K31/405 , A61K31/4409 , A61K31/455 , A61K31/496 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/64 , A61K45/00 , A61K47/14 , A61K47/24 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K47/42 , A61P1/12 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/26 , A61P5/40 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/14 , A61P13/00 , A61P15/10 , A61P23/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/06 , A61P37/08
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/2054 , A61K9/2077
摘要： PROBLEM TO BE SOLVED: To obtain improved bioavailability of a drug by providing a matrix control release device that is a controlled release dosage form for delivering a low-solubility drug having a short half-time for extinction. SOLUTION: A dosage composition has the controlled release dosage form for the low-solubility drug. The dosage composition is a solid amorphous dispersion of the drug in a spray-dried or spray-coated ionic cellulose polymer matrix and is obtained by formulating the solid amorphous dispersion into a second erosive polymer matrix. The method for treating disease or trouble involves administering such the dosage form. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过提供一种基质控制释放装置来获得药物的改善的生物利用度，所述基质控制释放装置是用于递送具有短的半衰期的低溶解度药物的控制释放剂型。解决方案：剂量组合物具有用于低溶解度药物的控释剂型。剂量组合物是药物在喷雾干燥或喷雾的离子纤维素聚合物基质中的固体无定形分散体，并且通过将固体无定形分散体配制成第二侵蚀性聚合物基质而获得。用于治疗疾病或麻烦的方法包括给予这种剂型。版权所有（C）2006，JPO＆NCIPI

17. 发明专利

JP2000229888A MATRIX CONTROL RELEASE DEVICE 失效
公开(公告)号：JP2000229888A
公开(公告)日：2000-08-22
申请号：JP2000033446
申请日：2000-02-10
申请人： PFIZER PROD INC
发明人： REA ELIZABETH APPEL , CURATOLO WILLIAM JOHN , DWAYNE THOMAS FREESEN , JAMES ALAN SHRIVER NIGHTINGALE , THOMBRE AVINASH GOVIND
IPC分类号： A61K47/38 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/26 , A61K9/48 , A61K31/138 , A61K31/155 , A61K31/405 , A61K31/4409 , A61K31/455 , A61K31/496 , A61K31/497 , A61K31/517 , A61K31/519 , A61K31/64 , A61K45/00 , A61K47/14 , A61K47/24 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/40 , A61K47/42 , A61P1/12 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/26 , A61P5/40 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/14 , A61P13/00 , A61P15/10 , A61P23/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/06 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To obtain a controlled release administration composition useful in the administration form for providing controlled release of a medicine having low solubility by a corrosive or diffusing mechanism by making the composition include a specific solid dispersion and a specified cellulose polymer matrix. SOLUTION: This controlled release administration composition comprises (A) a solid dispersion containing a medicine having a low solubility dispersed into a cellulose polymer in which most of the medicine is amorphous and (B) a water-soluble cellulose polymer matrix mixed with the component A in it. The medicine being a medicine having low solubility means a medicine having

18. 发明专利

CY1108486T1 ΜΟΡΦΕΣ ΔΟΣΟΛΟΓΙΑΣ ΑΖΙΘΡΟΜΥΚΙΝΗΣ ΜΕ ΜΕΙΩΜΕΝΕΣ ΠΑΡΕΝΕΡΓΕΙΕΣ 未知
公开(公告)号：CY1108486T1
公开(公告)日：2014-04-09
申请号：CY081101264
申请日：2008-11-06
申请人： PFIZER PROD INC
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , HAGEN TIMOTHY ARTHUR , HERBIG SCOTT MAX , LO JULIAN BELKNAP , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , THOMBRE AVINASH GOVIND , WEST JAMES BLAIR
IPC分类号： A61K9/16 , C07H17/00 , A61K9/00 , A61K9/20 , A61K31/7052 , A61K47/02 , A61K47/14 , A61K47/18 , A61K47/44 , A61P31/04
摘要： Μίαμορφήδοσολογίαςδιατουστόματοςπεριλαμβάνουσααζιθρομυκίνηκαιμίααποτελεσματικήποσότηταενόςπαράγοντααλκαλοποιήσεως. Κατάπροτίμηση, ηενλόγωμορφήδοσολογίαςδιατουστόματοςπεριλαμβάνειμίααποτελεσματικήποσότηταενόςπαράγοντααλκαλοποιήσεωςκαιμίαπολυσωματιδιακήαζιθρομυκίνηόπουταενλόγωπολυσωματίδιαπεριλαμβάνουναζιθρομυκίνη, έναμίγμαμονοβεχενικούγλυκερυλίου, διβεχενικούγλυκερυλίουκαιτριβεχενικούγλυκερυλίουκαιέναπολοξαμερές. Τυπικά, ημορφήδοσολογίαςδιατουστόματοςπεριλαμβάνειοποιοδήποτεκατάλληλομέσοχορηγήσεωςδιατουστόματοςόπωςκόνηγιαστοματικόεναιώρημα, έναπακέτοή φακελίσκομοναδιαίαςδόσεως, έναδισκίοή μίακάψουλα. Αποκαλύπτεταιεπίπλέονέναστοματικόεναιώρημαπεριλαμβάνοναζιθρομυκίνη, μίααποτελεσματικήποσότηταενόςπαράγοντααλκαλοποιήσεωςκαιέναόχημα. Κατάπροτίμηση, ηαζιθρομυκίνηείναισεπολυσωματιδιακήμορφήόπουη ενλόγωπολυσωματιδιακήσύνθεσηπεριλαμβάνειαζιθρομυκίνη, έναμίγμαμονοβεχενικούγλυκερυλίου, διβεχενικούγλυκερυλίουκαιτριβεχενικούγλυκερυλίουκαιέναπολοξαμερές. Αποκαλύπτεταιεπίσηςμίαμέθοδοςμειώσεωςτωνγαστρεντερικώνπαρενεργειώνπουσυνδέονταιμετηχορήγησηαζιθρομυκίνηςσεέναθηλαστικό, περιλαμβάνουσατηγειτονικήχορήγησηαζιθρομυκίνηςκαιμίαςαποτελεσματικήςποσότηταςενόςπαράγοντααλκαλοποιήσεωςστοενλόγωθηλαστικόόπουη συχνότητατωνγαστρεντερικώνπαρενεργειώνείναιχαμηλότερηαπόεκείνηπουπαρουσιάζεταιδιαχορηγήσεωςμίαςίσηςδόσεωςαζιθρομυκίνηςχωρίςτονενλόγωπαράγοντααλκαλοποιήσεως. Αποκαλύπτεταιπεραιτέρωμίαμέθοδοςαγωγήςμίαςβακτηριακήςή πρωτοζωικήςλοιμώξεως

19. 发明专利

CA2395333C HYDROGEL-DRIVEN DRUG DOSAGE FORM 未知
公开(公告)号：CA2395333C
公开(公告)日：2009-01-13
申请号：CA2395333
申请日：2000-12-20
申请人： PFIZER PROD INC
发明人： CURATOLO WILLIAM JOHN , FRIESEN DWAYNE THOMAS , SMITH KELLY LINCOLN , CHIDLAW MARK BRIAN , THOMBRE AVINASH GOVIND , BEYERINCK RONALD ARTHUR , APPEL LEAH ELIZABETH
IPC分类号： A61K9/22 , A61K9/36 , A61K9/00 , A61K9/28 , A61K31/519 , A61K47/36 , A61K47/38 , A61P15/10
摘要： A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific dr ug release profiles are disclosed.

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