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11. 发明专利

ES2284770T3 PROTEINA ESTIMULANTE DE DISOCIACION DE GDP, PROTEINA DE ENSAMBLAJE DE NUCLEOSOMA ESPECIFICA DE CEREBRO, ENZIMA CONJUGANTE DE UBIQUITINA ESPECIFICA DE MUSCULO ESQUELETICO, PROTEINA DE PROLIFERACION CELULAR, FOSFATIDILINOSITOLQUINASA, PROTEINAS RELACIONADAS CON NEL. 未知
公开(公告)号：ES2284770T3
公开(公告)日：2007-11-16
申请号：ES02026841
申请日：1997-03-19
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO
IPC分类号： C12N15/09 , C12N15/12 , A61K38/00 , A61K38/17 , A61K38/45 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
摘要： Nuevo gen humano NPIK que comprende una secuencia nucleotídica que codifica la secuencia de aminoácidos mostrada como SEC. ID. nº: 28.

12. 发明专利

DE69737740D1 未知
公开(公告)号：DE69737740D1
公开(公告)日：2007-06-28
申请号：DE69737740
申请日：1997-03-19
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO
IPC分类号： C12N15/09 , C12N15/12 , A61K38/00 , A61K38/17 , A61K38/45 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

13. 发明专利

AT362536T 未知
公开(公告)号：AT362536T
公开(公告)日：2007-06-15
申请号：AT02026841
申请日：1997-03-19
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO
IPC分类号： C12N15/09 , C12N15/12 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
摘要： The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.

14. 发明专利

JPH10117782A HUMAN MAD-ASSOCIATING PROTEIN GENE 失效
公开(公告)号：JPH10117782A
公开(公告)日：1998-05-12
申请号：JP28358996
申请日：1996-10-25
申请人： OTSUKA PHARMA CO LTD
发明人： WATANABE TAKESHI , SUZUKI MIKIO
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07H21/04 , C12P21/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To obtain a human Mad-associating protein gene having an analogue with a gene of a bacterium, a yeast, a nematode, a mouse, a human, etc., in the human gene included in Escherichia coil clone containing various human genes, useful for elucidation of morbid state, diagnosis, treatment, etc., of genepathy, cancer, etc. SOLUTION: This human Mad-associating protein gene is the new one containing a base sequence coding an amino acid sequence of formulas I and II. The new gene having an analogue with a gene of a bacterium, a yeast, a nematode, a mouse, etc., in the human gene is found by synthesizing cDNA from mDNA extracted from human fetal encephalon, adult blood vessel and placenta, forming Escherichia coil clone containing various kinds of human genes by transforming the cDNA using a library and by registering the clone, performing elongation by a deoxy terminator method using a cDNA obtained by culturing the each of clones thereof as templates, and determining a sequence of about 400 based from 5' termianl of the human gene included in the registered each clone. The gene is produced by performing an immunologic screening, etc., from the human cDNA library.

15. 发明专利

JPH09182587A HUMAN TCTEX-1 GENE 失效
公开(公告)号：JPH09182587A
公开(公告)日：1997-07-15
申请号：JP24596
申请日：1996-01-05
申请人： OTSUKA PHARMA CO LTD
发明人： WATANABE TAKESHI , KUGA YOSHIAKI , TAKAICHI TSUGIKO
IPC分类号： G01N33/50 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/21 , C12N5/10 , C12N15/09 , C12R1/19 , G01N33/53 , G01N33/531 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene coding for a human tctex-1 protein having a specific amino acid sequence, capable of utilizing for expression and detection of the protein and useful for diagnosis and elucidation of condition of retinal degeneration, etc., and development, etc., of preventing and treating medicines for male infertility. SOLUTION: This new gene codes for human tctex-1 protein having an amino acid sequence represented by the formula and is utilizable for expression and detection of human tctex-1 protein and is useful for diagnosis and elucidation of condition of various kinds of diseases such as retina degeneration, diagnosis of male infertility and screening, evaluation, etc., of medicines for treating and preventing diseases based on the retinal dysplasia and male infertility related to the protein. The gene is obtained by carrying out immunological screening of human fetal brain and placenta cDNA library using an antibody specific to human tctex-1 or screening, etc., of the cDNA library due to hybridization using a probe comprising a part of human tctex-1 gene to select a positive clone and then recovering the DNA.

16. 发明专利

JPH10215872A HUMAN RHO-RELATED PROTEIN HP1 GENE 失效
公开(公告)号：JPH10215872A
公开(公告)日：1998-08-18
申请号：JP2129397
申请日：1997-02-04
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU FUMIO , FUJIWARA TSUTOMU , WATANABE TAKESHI
IPC分类号： C12N15/09 , C07H21/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene comprising a human Rho-related protein HP1 gene containing a base sequence coding a specific amino acid sequence and useful for elucidation of morbid state of genepathy, cancer, etc., in which the gene participates and diagnosis, treatment, etc., thereof. SOLUTION: This new human Rho-related protein HP1 gene comprises a base sequence coding an amino acid sequence represented by the formula and is useful for detection of expression of the gene in various tissues, analysis of the structure and function, genetically-engineered production of a human Rho-related protein, elucidation of morbid state of genepathy, cancer, etc., in which the gene participates and diagnosis, treatment, etc., thereof. The gene is obtained by synthesizing cDNA from mRNA extracted from human placenta, assembling cDNA library by using the cDNA and then, cloning cDNA according to a cycle sequence method obtained by adding PCR method to dideoxy terminator method by using a synthetic oligomer nucleotide primer comprising a part of the Rho-related protein HP1 gene.

17. 发明专利

JPH1014577A HUMAN M6 GENE 失效
公开(公告)号：JPH1014577A
公开(公告)日：1998-01-20
申请号：JP17128896
申请日：1996-07-01
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU FUMIO , WATANABE TAKESHI , FUJIWARA TSUTOMU , TAKAHASHI EIICHI
IPC分类号： C12N15/09 , A61K48/00 , C07H21/04 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene, a gene coding a specific amino acid sequence, useful for detecting expression in brain tissue, analyzing the structure and function of an expressed product, producing human protein, and diagnosing/ treating genepathy, brain diseases and neuropathy, etc., through analyzing the expressed product. SOLUTION: This gene, which is a new human M6 gene containing a base sequence coding an amino acid sequence of the formula, is useful for detecting expression in brain tissue, analyzing the structure and function of an expressed product, producing human protein coded thereby base on the genetic engineering, and the morbid state elucidation, diagnoses and treatments of involved diseases (e.g. genetic diseases, cancer, brain diseases and neuropathy such as dementia). This gene is obtained by the following process: using a mRNA extracted from human fetal brain tissue, a cDNA library is constructed by conventional means; and using a DNA sequence chemically synthesized based on the information about the gene as probe, the cDNA library is screened.

18. 发明专利

JPH09308492A HUMAN GENE 失效
公开(公告)号：JPH09308492A
公开(公告)日：1997-12-02
申请号：JP6916397
申请日：1997-03-05
申请人： OTSUKA PHARMA CO LTD
发明人： FUJIWARA TSUTOMU , WATANABE TAKESHI , HORIE MASATO , KATAGIRI TOYOMASA
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C12N9/00 , C12N9/12 , C12N9/64 , C12N15/12 , C12N15/54 , C12N15/55 , C12P21/02 , C12Q1/68 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To obtain a new human gene coding a GDP dissociation promoting protein, capable of detecting expression in a human tissue, elucidating the state of a disease related to a genetic disease, a cancer, etc., diagnosing and treating the diseases, and producing a human protein by a genetic engineering method. SOLUTION: This new DOP dissociation promoting protein gene contains a base sequence coding an amino acid sequence of the formula and is useful for detecting expression in various human tissues, analyzing the structure and the function of the expression, producing a human protein by a genetic engineering method, elucidating the state of a disease related to a genetic disease, a cancer, etc., and diagnosing and treating the disease. The human gene is obtained by extracting an mRNA from tissues of human fetal brain, adult blood vessel and placenta, synthesizing a cDNA by using the mRNA, preparing a cDNA library by a conventional method and cloning the library by using a primer composed of a part of a GDP dissociation promoting gene by a PCR method.

19. 发明专利

JPH099975A HUMAN UBIQUITIN-CONJUGATING ENZYME GENE 失效
公开(公告)号：JPH099975A
公开(公告)日：1997-01-14
申请号：JP287496
申请日：1996-01-11
申请人： OTSUKA PHARMA CO LTD
发明人： WATANABE TAKESHI , SHIMADA YOSHIKAZU , NAGATA MASAMI
IPC分类号： C12N15/09 , A61K48/00 , A61P35/00 , C07H21/04 , C12N9/88 , C12Q1/68 , C12R1/19
摘要： PROBLEM TO BE SOLVED: To obtain the subject new enzyme gene coding for a human ubiquitin- conjugating enzyme having a specific amino acid sequence, and to be used for e.g. producing enzymes useful for diagnosing various diseases such as cancer and metastasis and screening the therapeutic agents and preventives therefor. SOLUTION: This new gene contains a base sequence coding for an amino acid sequence of the formula, being useful for e.g. manifesting and detecting the human ubiquitin-conjugating enzyme protein valuable for diagnosing various diseases involving human ubiquitin-conjugating enzyme, morbid state elucidation of these diseases, e.g. diagnosis cancer and metastasis, and for screening or evaluation of the therapeutic agents and preventives for cancer and metastasis. This gene is obtained by the following process: a reverse transcriptase is made to act on a human fetus brain poly(A)+RNA to synthesize cDNA, which is, in turn, amplified by PCR process using a pair of primers consisting of a fragment of this gene followed by conducting a cloning.

20. 发明专利

JPS6024182A HUMAN B CELL LINE 失效
公开(公告)号：JPS6024182A
公开(公告)日：1985-02-06
申请号：JP13306683
申请日：1983-07-20
申请人： OTSUKA PHARMA CO LTD
发明人： NAKAI SATORU , KATOU KAORU , WATANABE TAKESHI , HIRAI YOSHIKATSU
IPC分类号： C12N15/02 , C12N5/00 , C12N5/10 , C12N15/00 , C12P21/08 , C12R1/91
摘要： PURPOSE:To obtain a human B cell deficient in hypoxanthine-guanine-phosphoribosyltransferase, by cultivating human B cell varied with a virus in a medium containing 8-azaguanine. CONSTITUTION:Human B cell varied with a virus, such as CESS, is cultivated in a medium containing 2muM 8-azaguanine and 10wt% FCS for about one week, and then in a medium containing 16muM 8-azaguanine. It is then successively cultivated in a medium having 8-azaguanine concentration of twice as much as the former concentration, and finally cultivated in a medium having 100muM 8- azaguanine concentration, to give a cell strain resistant to 8-azaguanine. The cell is deficient in hypoxanthine-guanine-phosphoribosyltransferas (HGPRT).

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