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11. 发明专利

JPS6054959B2 失效
公开(公告)号：JPS6054959B2
公开(公告)日：1985-12-03
申请号：JP8781777
申请日：1977-07-20
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU TAKEFUMI , NAKAGAWA KAZUYUKI
IPC分类号： C07H17/02 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P1/04 , A61P11/08

12. 发明专利

JPS5116679A KARUBOKISHI HIDOROKISHI 3*44 JIHIDOROKARUBOSUCHIRIRUNO SEIZOHO 失效
公开(公告)号：JPS5116679A
公开(公告)日：1976-02-10
申请号：JP8736774
申请日：1974-07-29
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU TAKEFUMI , TAMURA YASUMITSU
IPC分类号： C07D215/48

13. 发明专利

JPS5116678A ASHIRU HIDOROKISHI 3*44 JIHIDOROKARUBOSUCHIRIRUJUDOTAINO SEIZOHO 失效
公开(公告)号：JPS5116678A
公开(公告)日：1976-02-10
申请号：JP8736674
申请日：1974-07-29
申请人： OTSUKA PHARMA CO LTD
发明人： SHIMIZU TAKEFUMI , TAMURA YASUMITSU
IPC分类号： C07D215/22 , C07D215/26

14. 发明专利

DE69128682D1 未知
公开(公告)号：DE69128682D1
公开(公告)日：1998-02-19
申请号：DE69128682
申请日：1991-03-27
申请人： OTSUKA PHARMA CO LTD
发明人： UCHIDA MINORU , MORITA SEIJI , OTSUBO KENJI , SHIMIZU TAKEFUMI , YAMASAKI KATSUYA
IPC分类号： A61K31/47 , A61P1/04 , C07D215/54
摘要： A quinoline derivative of general formula (I) and its salt, useful as an antiulcer drug, wherein R represents lower alkoxy, halogen, lower alkyl, lower alkylthio, lower alkanoyloxy-substituted lower alkyl, halogenated lower alkyl or hydroxylated lower alkyl; R and R may be the same or different from each other and each represents hydrogen, lower alkyl, halogenated lower alkyl, C3 to C8 cycloalkyl, cycloalkyl-substituted lower alkyl, lower alkenyloxy, lower alkenyl, lower alkoxy-substituted lower alkyl, phenyl-substituted lower alkyl, lower alkynyl, lower alkylphenyl or hydroxylated lower alkyl; R represents phenyl, tetrahydronaphthyl or naphthyl which may be each substituted with one or two members selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkanoyl, phenyl, cyano, lower alkynylsulfinyl, lower alkoxycarbonyl, lower alkenylthio, phenyl-substituted lower alkylthio, benzoyl, hydroxylated lower alkyl, lower alkanoyloxy-substituted lower alkyl, lower alkanoyloxy and hydroxyl; and n is 0, 1 or 2.

15. 发明专利

DK0480052T3 未知
公开(公告)号：DK0480052T3
公开(公告)日：1998-05-11
申请号：DK91906582
申请日：1991-03-27
申请人： OTSUKA PHARMA CO LTD
发明人： UCHIDA MINORU , MORITA SEIJI , OTSUBO KENJI , SHIMIZU TAKEFUMI , YAMASAKI KATSUYA
IPC分类号： A61K31/47 , A61P1/04 , C07D215/54
摘要： A quinoline derivative of general formula (I) and its salt, useful as an antiulcer drug, wherein R represents lower alkoxy, halogen, lower alkyl, lower alkylthio, lower alkanoyloxy-substituted lower alkyl, halogenated lower alkyl or hydroxylated lower alkyl; R and R may be the same or different from each other and each represents hydrogen, lower alkyl, halogenated lower alkyl, C3 to C8 cycloalkyl, cycloalkyl-substituted lower alkyl, lower alkenyloxy, lower alkenyl, lower alkoxy-substituted lower alkyl, phenyl-substituted lower alkyl, lower alkynyl, lower alkylphenyl or hydroxylated lower alkyl; R represents phenyl, tetrahydronaphthyl or naphthyl which may be each substituted with one or two members selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkanoyl, phenyl, cyano, lower alkynylsulfinyl, lower alkoxycarbonyl, lower alkenylthio, phenyl-substituted lower alkylthio, benzoyl, hydroxylated lower alkyl, lower alkanoyloxy-substituted lower alkyl, lower alkanoyloxy and hydroxyl; and n is 0, 1 or 2.

16. 发明专利

ES2112272T3 未知
公开(公告)号：ES2112272T3
公开(公告)日：1998-04-01
申请号：ES91906582
申请日：1991-03-27
申请人： OTSUKA PHARMA CO LTD
发明人： UCHIDA MINORU , MORITA SEIJI , OTSUBO KENJI , SHIMIZU TAKEFUMI , YAMASAKI KATSUYA
IPC分类号： A61K31/47 , A61P1/04 , C07D215/54
摘要： A quinoline derivative of general formula (I) and its salt, useful as an antiulcer drug, wherein R represents lower alkoxy, halogen, lower alkyl, lower alkylthio, lower alkanoyloxy-substituted lower alkyl, halogenated lower alkyl or hydroxylated lower alkyl; R and R may be the same or different from each other and each represents hydrogen, lower alkyl, halogenated lower alkyl, C3 to C8 cycloalkyl, cycloalkyl-substituted lower alkyl, lower alkenyloxy, lower alkenyl, lower alkoxy-substituted lower alkyl, phenyl-substituted lower alkyl, lower alkynyl, lower alkylphenyl or hydroxylated lower alkyl; R represents phenyl, tetrahydronaphthyl or naphthyl which may be each substituted with one or two members selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkanoyl, phenyl, cyano, lower alkynylsulfinyl, lower alkoxycarbonyl, lower alkenylthio, phenyl-substituted lower alkylthio, benzoyl, hydroxylated lower alkyl, lower alkanoyloxy-substituted lower alkyl, lower alkanoyloxy and hydroxyl; and n is 0, 1 or 2.

17. 发明专利

DE69128682T2 未知
公开(公告)号：DE69128682T2
公开(公告)日：1998-06-04
申请号：DE69128682
申请日：1991-03-27
申请人： OTSUKA PHARMA CO LTD
发明人： UCHIDA MINORU , MORITA SEIJI , OTSUBO KENJI , SHIMIZU TAKEFUMI , YAMASAKI KATSUYA
IPC分类号： A61K31/47 , A61P1/04 , C07D215/54
摘要： A quinoline derivative of general formula (I) and its salt, useful as an antiulcer drug, wherein R represents lower alkoxy, halogen, lower alkyl, lower alkylthio, lower alkanoyloxy-substituted lower alkyl, halogenated lower alkyl or hydroxylated lower alkyl; R and R may be the same or different from each other and each represents hydrogen, lower alkyl, halogenated lower alkyl, C3 to C8 cycloalkyl, cycloalkyl-substituted lower alkyl, lower alkenyloxy, lower alkenyl, lower alkoxy-substituted lower alkyl, phenyl-substituted lower alkyl, lower alkynyl, lower alkylphenyl or hydroxylated lower alkyl; R represents phenyl, tetrahydronaphthyl or naphthyl which may be each substituted with one or two members selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkanoyl, phenyl, cyano, lower alkynylsulfinyl, lower alkoxycarbonyl, lower alkenylthio, phenyl-substituted lower alkylthio, benzoyl, hydroxylated lower alkyl, lower alkanoyloxy-substituted lower alkyl, lower alkanoyloxy and hydroxyl; and n is 0, 1 or 2.

18. 发明专利

AU7548091A QUINOLINE DERIVATIVE, ANTIULCER DRUG CONTAINING THE SAME, AND PRODUCTION OF SAID DERIVATIVE 未知
公开(公告)号：AU7548091A
公开(公告)日：1991-10-21
申请号：AU7548091
申请日：1991-03-27
申请人： OTSUKA PHARMA CO LTD
发明人： UCHIDA MINORU , MORITA SEIJI , OTSUBO KENJI , SHIMIZU TAKEFUMI , YAMASAKI KATSUYA
IPC分类号： A61K31/47 , A61P1/04 , C07D215/54
摘要： A quinoline derivative of general formula (I) and its salt, useful as an antiulcer drug, wherein R represents lower alkoxy, halogen, lower alkyl, lower alkylthio, lower alkanoyloxy-substituted lower alkyl, halogenated lower alkyl or hydroxylated lower alkyl; R and R may be the same or different from each other and each represents hydrogen, lower alkyl, halogenated lower alkyl, C3 to C8 cycloalkyl, cycloalkyl-substituted lower alkyl, lower alkenyloxy, lower alkenyl, lower alkoxy-substituted lower alkyl, phenyl-substituted lower alkyl, lower alkynyl, lower alkylphenyl or hydroxylated lower alkyl; R represents phenyl, tetrahydronaphthyl or naphthyl which may be each substituted with one or two members selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, lower alkanoyl, phenyl, cyano, lower alkynylsulfinyl, lower alkoxycarbonyl, lower alkenylthio, phenyl-substituted lower alkylthio, benzoyl, hydroxylated lower alkyl, lower alkanoyloxy-substituted lower alkyl, lower alkanoyloxy and hydroxyl; and n is 0, 1 or 2.

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