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    • 11. 发明专利
    • Method for separating and purifying higher aliphatic alcohol
    • 分离和纯化高级醇类的方法
    • JP2008063264A
    • 2008-03-21
    • JP2006241472
    • 2006-09-06
    • Nof Corp日油株式会社
    • TANIMIZU KOICHITSUSHIMA SAWAEABE TAKAMIKI
    • C07C29/86A61K31/045A61P3/06A61P15/00B01J20/281B01J20/34C07C31/02C07C31/20G01N30/26G01N30/88
    • PROBLEM TO BE SOLVED: To provide a method for separating and purifying 20 to 40 C higher aliphatic alcohols contained in a natural wax by a liquid chromatography, and to provide a method for analyzing the higher aliphatic alcohols.
      SOLUTION: This method for separating and purifying the higher aliphatic alcohols contained in a natural wax comprises hydrolyzing the components of the natural wax, extracting the higher aliphatic alcohols with a fat-soluble solvent, purifying the extracted higher aliphatic alcohols to reduce the content of fatty acids contained in the higher aliphatic alcohols to ≤10 mass% and the content of 35C to 49C triglycerides to ≤5 mass%, and then separating the purified higher aliphatic alcohols by a liquid chromatography using a methanol/tetrahydrofuran solvent mixture as an eluent and also using ODS silica as a filler.
      COPYRIGHT: (C)2008,JPO&INPIT
    • 待解决的问题:提供通过液相色谱法分离和纯化天然蜡中所含的20至40℃的高级脂族醇的方法,并提供分析高级脂族醇的方法。 解决方案:用于分离和纯化天然蜡中所含的高级脂族醇的方法包括水解天然蜡的组分,用脂溶性溶剂萃取高级脂族醇,纯化萃取的高级脂族醇以减少 高脂肪醇中含有的脂肪酸含量≤10质量%,35℃〜49℃甘油三酯含量≤5质量%,然后使用甲醇/四氢呋喃溶剂混合物进行液相色谱分离纯化的高级脂族醇,为 洗脱液,也使用ODS二氧化硅作为填料。 版权所有(C)2008,JPO&INPIT
    • 12. 发明专利
    • Coating and granulating agent for tableting
    • 涂料和造粒剂
    • JP2010013402A
    • 2010-01-21
    • JP2008175302
    • 2008-07-04
    • Nof Corp日油株式会社
    • TANIMIZU KOICHISATO TOSHIHIRO
    • A61K47/42A61K9/16
    • PROBLEM TO BE SOLVED: To provide a gelatine having functions for improving tableting trouble such as sticking in a coating and granulating processing before tableting, and to provide a coated granule having improved tabletability in the coating granulation by using the gelatine.
      SOLUTION: The coating and granulating agent for the tableting is a crosslinked gelatine prepared by crosslinking the gelatine having 50,000-200,000 weight average molecular weight with a transglutaminase, and providing a 5 mass% aqueous solution having 10-50 mPa s viscosity at 40°C. The crosslinked gelatine-coated granule is coated with the coating and granulating agent for the tableting.
      COPYRIGHT: (C)2010,JPO&INPIT
    • 解决的问题:提供具有改善压片麻烦的功能的明胶,例如粘贴在包衣和制粒前的造粒处理中,并提供通过使用明胶在涂布造粒中具有改进的可压片性的包衣颗粒。 解决方案:用于压片的涂布和造粒剂是通过用转谷氨酰胺酶交联具有50,000-200,000重均分子量的明胶制备的交联明胶,并且提供具有10-50mPa·s粘度的5质量%水溶液 40℃。 交联的明胶包被的颗粒用用于压片的包衣和造粒剂包衣。 版权所有(C)2010,JPO&INPIT