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11. 发明授权

US5893999A Ultrafine inorganic phosphor, specifically binding material labeled with this phosphor, and detection method using this specific binding material 失效
标题翻译：超细无机磷光体，用该荧光体标记的特异性结合材料，以及使用该特异性结合材料的检测方法
公开(公告)号：US5893999A
公开(公告)日：1999-04-13
申请号：US304868
申请日：1994-09-13
申请人： Masaaki Tamatani , Hirotami Koike , Miwa Okumura , Keiko Albessard , Naotoshi Matsuda
发明人： Masaaki Tamatani , Hirotami Koike , Miwa Okumura , Keiko Albessard , Naotoshi Matsuda
IPC分类号： C09K11/08 , C09K11/59 , C09K11/67 , C09K11/77 , G01N33/533 , G01N33/543 , G01N33/58 , C09K11/54 , C09K11/55
CPC分类号： G01N33/587 , C09K11/0811 , C09K11/595 , C09K11/673 , C09K11/7734 , C09K11/7769 , C09K11/7771 , C09K11/7795 , G01N33/533 , G01N33/582
摘要： A specific binding material labeled with an ultrafine inorganic phosphor 1 to 100 nm in particle size is disclosed The composition of the ultrafine inorganic phosphor is one of Ln.sub.2 O.sub.3 :Re, Ln.sub.2 O.sub.2 S:Re, ZnO, CaWO.sub.4, MO.xAl.sub.2 O.sub.3 :Eu, Zn.sub.2 SiO.sub.4 :Mn, and LaPO.sub.4 :Ce,Tb, wherein Ln represents at least one element selected from La, Gd, Lu, and Y, Re represents at least one element selected from lanthanide elements, M represents at least one element selected from alkali earth metals, and x represents a value from 0.5 to 15. This ultrafine inorganic phosphor is prepared by one of the following processes a process of evaporation in a gas including an RF thermal plasma process, dc plasma thermal spraying, sputtering, glass crystallization, a sol-gel process, precipitation including hydrothermal synthesis, and a spraying process. An antibody which reacts specifically with an antigen to be measured is labeled with this ultrafine inorganic phosphor and reacted with a specimen, and the unreacted material is removed. The antibody bound to the specimen is detected by quantitatively observing fluorescence emitted by the phosphor.
摘要翻译：公开了以超细无机荧光体1〜100nm标记的特定结合材料。超细无机荧光体的组成为Ln 2 O 3：Re，Ln 2 O 2 S：Re，ZnO，CaWO 4，MO x Al 2 O 3：Eu，Zn 2 SiO 4：Mn 和LaPO 4：Ce，Tb，其中Ln表示选自La，Gd，Lu和Y中的至少一种元素，Re表示选自镧系元素中的至少一种元素，M表示选自碱土金属的至少一种元素，和 x表示0.5至15的值。该超细无机磷光体通过以下方法之一制备包括RF热等离子体工艺，直流等离子体喷涂，溅射，玻璃结晶，溶胶 - 凝胶法在内的气体中的蒸发过程，包括水热合成的沉淀和喷雾过程。用该超细无机荧光体标记与待测抗原特异性反应的抗体，并与样品反应，除去未反应物质。通过定量观察由荧光体发出的荧光来检测与样品结合的抗体。

12. 发明授权

US5640016A Rare-earth oxysulfide scintillators and X-ray detectors using rare-earth oxysulfide scintillators 失效
标题翻译：稀土氧硫化物闪烁体和使用稀土氧硫化物闪烁体的X射线探测器
公开(公告)号：US5640016A
公开(公告)日：1997-06-17
申请号：US594387
申请日：1996-01-31
申请人： Naotoshi Matsuda , Masaaki Tamatani , Miwa Okumura , Kazuto Yokota
发明人： Naotoshi Matsuda , Masaaki Tamatani , Miwa Okumura , Kazuto Yokota
IPC分类号： C09K11/00 , C09K11/77 , C09K11/84 , G01T1/20 , G01T1/202 , G21K4/00
CPC分类号： G01T1/20 , C04B35/547 , C04B35/6455 , C09K11/7771 , G21K4/00 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/3229 , C04B2235/656 , C04B2235/6562 , C04B2235/6565 , C04B2235/6567 , C04B2235/6584 , C04B2235/72 , G21K2004/06
摘要： A scintillator is disclosed that comprises a ceramic of a rare-earth oxysulfide activated with Pr, such as Gd.sub.2 O.sub.2 S:Pr, having: (1) a ratio of a peak value at about 270 K to that at about 140 K in a glow curve of about 0.01 or less, when the thermoluminescence intensity of the scintillator is measured at a rate of temperature increase of 15.+-.5 K/min after 20 minutes irradiation with ultraviolet rays having a wavelength of 254 nm and a power of 1 W/m.sup.2 at liquid nitrogen temperature, and (2) a ratio of a peak value at about 630 nm to that at about 512 nm of a thermoluminescence of about 410 K with about 2 nm resolution of about 1 or less.
摘要翻译：公开了一种闪烁体，其包含用Pr活化的稀土氧硫化物的陶瓷，例如Gd 2 O 2 S：Pr，其具有：（1）在约270K的峰值与约140K的峰值的比率在约为0.01以下，当用波长254nm，功率1W / m 2的紫外线照射20分钟后，以15±5K / min的升温速度测定闪烁体的热发光强度在液氮温度下，和（2）大约630nm的峰值与约512nm的峰值在大约410K的热释光下的约2nm分辨率约为1或更小。

13. 发明授权

US06384417B1 Ceramic scintillator, method for producing same, and x-ray detector and x-ray CT imaging equipment using same 有权
标题翻译：陶瓷闪烁体，其制造方法以及使用其的X射线检测器和X射线CT成像设备
公开(公告)号：US06384417B1
公开(公告)日：2002-05-07
申请号：US09407760
申请日：1999-09-29
申请人： Miwa Okumura , Masaaki Tamatani , Naotoshi Matsuda , Takeshi Takahara , Yukihiro Fukuta
发明人： Miwa Okumura , Masaaki Tamatani , Naotoshi Matsuda , Takeshi Takahara , Yukihiro Fukuta
IPC分类号： G01T100
CPC分类号： G01T1/20 , C04B35/50 , C04B35/5156 , C04B35/547 , C04B2235/3224 , C04B2235/446 , C04B2235/658 , C04B2235/663 , C04B2235/80 , C04B2235/963 , C04B2235/9653
摘要： A sintered body of a rare earth oxysulfide is heat-treated at a temperature of 900° C. to 1200° C. in an atmosphere of a mixture of sulfur and oxygen to form island-like rare earth oxide phases on the surface of the sintered body to produce a ceramic scintillator. Therefore, the ceramic scintillator comprises a sintered body of a rare earth oxysulfide, and a rare earth oxide phase formed on the surface of the sintered body, wherein a rare earth oxysulfide phase or the rare earth oxide phase is dispersed on the surface of the sintered body, so that the optical output characteristic of the ceramic scintillator is improved. According to this ceramic scintillator, it is possible to remove the pressure and distortion during sintering, the coloring caused by the deviation from the stoichiometric composition, and the coloring caused during processing such as saw-cutting and polishing.
摘要翻译：在硫和氧混合物的气氛中，将氧化硫化稀土的烧结体在900℃〜1200℃的温度下进行热处理，在烧结体的表面形成岛状稀土氧化物相，产生陶瓷闪烁体。因此，陶瓷闪烁体包括在烧结体表面形成的稀土氧硫化物的烧结体和稀土氧化物相，其中稀土氧硫化物相或稀土氧化物相分散在烧结体的表面上使得陶瓷闪烁体的光输出特性得到改善。根据该陶瓷闪烁体，可以消除烧结期间的压力和变形，由化学计量组成的偏离引起的着色以及在切割和抛光等加工过程中引起的着色

14. 发明授权

US08379792B2 X-ray CT apparatus 有权
标题翻译： X射线CT装置
公开(公告)号：US08379792B2
公开(公告)日：2013-02-19
申请号：US12542186
申请日：2009-08-17
申请人： Yasuo Saito , Miwa Okumura
发明人： Yasuo Saito , Miwa Okumura
IPC分类号： H05G1/62 , H05G1/10 , G01N23/083
CPC分类号： A61B6/032 , A61B5/113 , A61B6/027
摘要： According to the present invention, a subject is prompted to take breaths that are different at least in depth, and the subject's motion associated with respiration is captured. A timing when the subject is scanned is controlled according to the captured motion of the subject associated with respiration. A two-dimensional detector formed like a two-dimensional plane detects an X-ray beam having passed through the subject. Data is collected from the two-dimensional detector to acquire volume data on the subject.
摘要翻译：根据本发明，促使受试者至少进行深度不同的呼吸，并且捕获受试者与呼吸相关的动作。根据与呼吸相关的受试者的捕获的运动来控制被摄体被扫描的时间。形成为二维平面的二维检测器检测穿过被检体的X射线束。从二维检测器收集数据以获取关于受试者的体数据。

15. 发明申请

US20090028289A1 X-RAY CT APPARATUS 有权
标题翻译： X射线CT装置
公开(公告)号：US20090028289A1
公开(公告)日：2009-01-29
申请号：US12177262
申请日：2008-07-22
申请人： Masaharu TSUYUKI , Miwa Okumura , Yasuko Fujisawa
发明人： Masaharu TSUYUKI , Miwa Okumura , Yasuko Fujisawa
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/032 , A61B6/463 , A61B6/465 , A61B6/503 , A61B6/504 , A61B6/541
摘要： A CT value of an image within a region of interest is calculated with time. While the calculated CT value does not exceed a predetermined threshold value, a reconstruction mode used when an image is reconstructed from projection data is set to half reconstruction. On the other hand, while the calculated CT value exceeds a predetermined threshold value, the reconstruction mode is set to segment reconstruction.
摘要翻译：计算感兴趣区域内的图像的CT值。当计算的CT值不超过预定阈值时，将从投影数据重建图像时使用的重建模式设置为半重构。另一方面，当计算的CT值超过预定阈值时，将重建模式设置为分段重建。

16. 发明授权

US06947516B2 X-ray CT apparatus 有权
标题翻译： X射线CT装置
公开(公告)号：US06947516B2
公开(公告)日：2005-09-20
申请号：US10077819
申请日：2002-02-20
申请人： Miwa Okumura , Masahiko Yamazaki , Satoru Nakanishi , Toshihiro Rifu , Souji Miyashita
发明人： Miwa Okumura , Masahiko Yamazaki , Satoru Nakanishi , Toshihiro Rifu , Souji Miyashita
IPC分类号： G01T7/00 , A61B6/03 , G01T1/20 , G06T1/00 , A61B6/00
CPC分类号： A61B6/032 , A61B6/027
摘要： An X-ray apparatus including an X-ray source, a rotation mechanism which rotates the X-ray source about a rotational axis, and an X-ray detector having a plurality of detection elements. A blocking member defining a slit structure is provided between the X-ray source and the X-ray detector. The slits of the blocking member include two rows aligned in a channel direction of the detector elements, and two rows staggered in the channel direction, thereby to obtain a CT image with improved spatial resolution. Alternatively, instead of using a blocking member, some of the detection elements of at least one detection segment are staggered in the channel direction with respect to detection elements of another detection segment.
摘要翻译：一种X射线设备，包括X射线源，使X射线源围绕旋转轴线旋转的旋转机构和具有多个检测元件的X射线检测器。限定狭缝结构的阻挡构件设置在X射线源和X射线检测器之间。阻挡构件的狭缝包括在检测器元件的通道方向上排列的两列，并且在通道方向上交错排列的两列，从而获得具有改善的空间分辨率的CT图像。或者，代替使用阻挡构件，至少一个检测段的一些检测元件相对于另一个检测段的检测元件在通道方向上错开。

17. 发明授权

US06587538B2 Detector unit, X-ray computer tomographic photographing device, X-ray detector, and X-ray detector manufacturing method 有权
公开(公告)号：US06587538B2
公开(公告)日：2003-07-01
申请号：US09990335
申请日：2001-11-23
申请人： Kenji Igarashi , Hideki Ide , Kenji Ushimi , Yasuo Saito , Yuuzo Yoshida , Miwa Okumura
发明人： Kenji Igarashi , Hideki Ide , Kenji Ushimi , Yasuo Saito , Yuuzo Yoshida , Miwa Okumura
IPC分类号： A61B600
CPC分类号： H01L27/14658 , A61B6/06 , A61B6/4291
摘要： A detector unit for detecting X rays passed through a collimator having a plurality of collimator single plates, includes a substrate attached to a collimator support for supporting the collimator, a photodetecting device array including photodetecting devices mounted on the substrate, a scintillator block arranged corresponding to the photodetecting device array and provided on the photodetecting device array to convert the X rays into light, and an engaging component having an engaging portion provided on the collimator single plate side of the substrate, and engaged with the collimator single plate to regulate a position of the photodetecting device array or the scintillator block in a channel direction with respect to the collimator single plate.

18. 发明授权

US07920671B2 X-ray CT apparatus and control method of X-ray CT apparatus 有权
标题翻译： X射线CT装置及X射线CT装置的控制方法
公开(公告)号：US07920671B2
公开(公告)日：2011-04-05
申请号：US12566247
申请日：2009-09-24
申请人： Miwa Okumura , Satoru Nakanishi
发明人： Miwa Okumura , Satoru Nakanishi
IPC分类号： A61B6/00
CPC分类号： A61B6/4233 , A61B6/032 , A61B6/4085
摘要： An X-ray CT apparatus has a setting unit, a generating unit, a calculation unit, and a determination unit. The setting unit sets a required width of a group of X-ray detection elements in a row direction, which is relatively insusceptible to an influence of a cone angle of a cone-beam X-ray. The generating unit generates accumulation data by accumulating first projection data, based on first X-ray detection elements within the required width included in the group, with same channel in the row direction in preference to second projection data based on second X-ray detection elements outside the required width included in the group. The calculation unit obtains a motion amount for each heartbeat phase based on the accumulation data. The determination unit determines a specific heartbeat phase based on the motion amount for the each heartbeat phase.
摘要翻译： X射线CT装置具有设定部，生成部，计算部以及判定部。设置单元设置一组X射线检测元件在行方向上的所需宽度，这对于锥形束X射线的锥角的影响是相对不易察觉的。生成单元优先于基于第二X射线检测元件的第二投影数据，通过累积第一投影数据，基于组中包含的所需宽度内的第一X射线检测元件，在行方向上具有相同的通道，在组中包含的所需宽度之外。计算单元基于积累数据获得每个心跳相位的运动量。确定单元基于每个心跳阶段的运动量确定特定的心跳相位。

19. 发明申请

US20070145317A9 Image processing apparatus for reducing noise from image 有权
标题翻译：用于降低图像噪声的图像处理装置
公开(公告)号：US20070145317A9
公开(公告)日：2007-06-28
申请号：US10777681
申请日：2004-02-13
申请人： Tadaharu Kobayashi , Miwa Okumura
发明人： Tadaharu Kobayashi , Miwa Okumura
IPC分类号： F16K31/02
CPC分类号： F16K39/04 , F16K31/0613 , G06T5/002 , G06T2207/20012 , G06T2207/20192 , G06T2207/30004
摘要： An image processing apparatus is provided for reducing noise from an original image consisting of digital image data. The apparatus has an information calculator, smoothed image producer, weighting-factor calculator, and weighting adder. The information calculator calculates information in relation to a pixel-value change representing a degree that becomes larger with a spatial change in a pixel value averaged each predetermined area on the original image. The smoothed image producer produces a smoothed image by smoothing the original image. The weighting-factor calculator calculates a weighting factor depending on the calculated information in relation to the pixel-value change. The weighting adder mutually performing, using the weighting factor, weighting addition with either the original image or an image modulated from the original image and the produced smoothed image.
摘要翻译：提供一种用于减少由数字图像数据组成的原始图像的噪声的图像处理装置。该装置具有信息计算器，平滑图像生成器，加权因子计算器和加权加法器。信息计算器计算与代表原始图像上的每个预定区域平均的像素值的空间变化变大的像素值变化相关的信息。平滑的图像生成器通过平滑原始图像产生平滑的图像。加权因子计算器根据与像素值变化相关的计算的信息来计算加权因子。加权加法器使用加权因子与原始图像或从原始图像调制的图像和产生的平滑图像相加来进行加权相加。

20. 发明申请

US20060004279A1 Medical image processing apparatus and method of processing medical image 有权
标题翻译：医学图像处理设备及医学图像处理方法
公开(公告)号：US20060004279A1
公开(公告)日：2006-01-05
申请号：US11092899
申请日：2005-03-30
申请人： Yoshihiro Ikeda , Miwa Okumura , Kohsuke Kudo
发明人： Yoshihiro Ikeda , Miwa Okumura , Kohsuke Kudo
IPC分类号： A61B5/05
CPC分类号： G06T7/0012 , A61B6/507 , G06F19/00
摘要： According to a medical image processing apparatus, a data of a region of the blood vessel is removed from respectives of a plurality of sheets of original image data collected by scanning a subject injected with a contrast medium by a medical modality, thereafter, a pixel value of the region of the blood vessel is substituted for by pixel values of a plurality of pixels present at a surrounding of the region, the plurality of sheets of original image data including the substituted region of the blood vessel are subjected to a preprocessing including a noise removing processing and a pixel bundling processing, and circulation dynamic state information of perfusion of a substantial portion is analyzed from the plurality of sheets of original image data subjected to the preprocessing.
摘要翻译：根据医学图像处理装置，通过用医疗模式扫描注射了造影剂的被检体收集的多张原始图像数据的片段，从血管的区域的数据中除去数据，之后，将像素值通过存在于该区域的周围的多个像素的像素值代替血管区域，将包含血管的取代区域的多张原始图像数据片进行包括噪声的预处理从进行预处理的多张原始图像数据分析大量部分的灌注的循环动态状态信息，去除处理和像素束化处理。

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