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    • 17. 发明授权
    • Hard medicinal capsule
    • 硬药胶囊
    • US4917885A
    • 1990-04-17
    • US946119
    • 1986-12-23
    • Tohru ChibaHiroaki MutoSoji TaniokaYuichi NishiyamaNoboru HoshiYoshiro Onda
    • Tohru ChibaHiroaki MutoSoji TaniokaYuichi NishiyamaNoboru HoshiYoshiro Onda
    • A61K9/48C08L1/28
    • A61K9/4816C08L1/28
    • In place of gelatin conventionally used as a material for shaping hard medicinal capsules, the invention proposes a hard capsule for medicinal use shaped of a polymer blend of a water-soluble cellulose ether, e.g., alkyl cellulose, hydroxyalkyl cellulose and alkyl hydroxyalkyl cellulose, and a polyvinyl alcohol in a weight ratio of 70:30 to 98:2. The inventive hard medicinal capsules have remarkably low permeability to oxygen and moisture with little influences on the medicament contained therein along with sufficiently high mechanical strengths and are much more stable than conventional gelatin-made capsules against the influences of the ambient conditions, such as, the crack formation unavoidable in a gelatin-made hard capsule when it is kept under an extremely low humidity.
    • 本发明代替通常用作形成硬药胶囊的材料的明胶,而提出了一种用于医用的硬胶囊,其形式为水溶性纤维素醚,例如烷基纤维素,羟烷基纤维素和烷基羟烷基纤维素的聚合物共混物,以及 聚乙烯醇,重量比为70:30至98:2。 本发明的硬药物胶囊具有非常低的氧气和水分渗透性,对其中所含的药物几乎没有影响,同时具有足够高的机械强度,并且比常规明胶制成的胶囊比环境条件的影响更稳定,例如 当明胶制成的硬胶囊保持在极低的湿度下时,不可避免的裂缝形成。