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11. 发明授权

US07989642B2 Process for producing powdered compositions containing highly unsaturated fatty acid esters of ascorbic acid and powdered compositions containing the esters 有权
标题翻译：制备含有抗坏血酸的高度不饱和脂肪酸酯的粉末状组合物和含有酯的粉末状组合物的方法
公开(公告)号：US07989642B2
公开(公告)日：2011-08-02
申请号：US10547259
申请日：2004-02-27
申请人： Harukazu Fukami
发明人： Harukazu Fukami
IPC分类号： C07D307/62 , C08K2/16
CPC分类号： C11C3/04 , A23D9/05
摘要： The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a simple and easy means; highly unsaturated fatty acid esters of ascorbic acid which are improved in stability by powdering; and compositions containing the powdered highly unsaturated fatty acid esters of ascorbic acid. Specifically, a process for powdering a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I): RCO-A [wherein RCO— is acyl derived from a highly unsaturated fatty acid; and A is an ascorbic acid residue bonded through an —O— linkage resulting from an hydroxyl group of ascorbic acid], characterized by mixing a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I) with an aqueous solution of a water-soluble filler to form an emulsion and dehydrating and drying the emulsion by a spray drying method.
摘要翻译：本发明提供了一种通过简单方便的方法粉化糊状的高度不饱和脂肪酸的抗坏血酸和物理性质问题的方法; 通过粉化提高稳定性的抗坏血酸的高度不饱和脂肪酸酯; 以及含有抗坏血酸的粉末状高度不饱和脂肪酸酯的组合物。具体而言，是将通式（I）表示的抗坏血酸高度不饱和脂肪酸酯粉末化的方法：RCO-A [其中，RCO-为高度不饱和脂肪酸衍生的酰基， A是通过由抗坏血酸的羟基产生的-O-键连接的抗坏血酸残基]，其特征在于将由通式（I）表示的抗坏血酸的高度不饱和脂肪酸酯与水溶性填料以形成乳液，并通过喷雾干燥方法使乳液脱水和干燥。

12. 发明申请

US20080058409A1 Esterified Catechins, Processes for Producing the Same, and Foods and Beverages as well as Cosmetics Containing Such Esterified Catechins 审中-公开
标题翻译：酯化儿茶素，其制备方法，食品和饮料以及含有这种酯化儿茶素的化妆品
公开(公告)号：US20080058409A1
公开(公告)日：2008-03-06
申请号：US11795959
申请日：2006-01-25
申请人： Harukazu Fukami , Masahiro Nakao , Koshi Namikawa , Mitsuru Maeda
发明人： Harukazu Fukami , Masahiro Nakao , Koshi Namikawa , Mitsuru Maeda
IPC分类号： A61K31/352 , A61P31/04 , C07D311/04 , C12P17/06
CPC分类号： C12P17/06 , A01N43/16 , A23L3/3472 , A23L3/3517 , A61K8/498 , A61Q17/005 , C07D311/62
摘要： The present invention provides substances having sufficiently antibacterial activity against heat-resistant spore-forming bacteria that they can be used to improve the shelf life of beverages and processed foods, as well as to control the growth of microorganisms in cosmetics. The present invention provides a catechin ester in which at least one of the hydroxyl groups of a catechin is esterified with a medium-chain fatty acid. This medium-chain fatty acid ester of a catechin, which may be used either alone or as a composition, shows a strong growth suppressing effect on heat-resistant spore-forming bacteria and, if added to foods or beverages, can prevent them from rotting or deterioration and, if added to cosmetics, can prevent their rotting or deterioration.
摘要翻译：本发明提供对耐热孢子形成细菌具有足够抗菌活性的物质，它们可用于改善饮料和加工食品的保质期，以及控制化妆品中微生物的生长。本发明提供一种儿茶素酯，其中儿茶素的至少一个羟基与中链脂肪酸酯化。可以单独或作为组合物使用的儿茶素的该中链脂肪酸酯对耐热孢子形成细菌具有强烈的生长抑制作用，如果添加到食品或饮料中，可以防止它们的腐烂或变质，如果添加到化妆品中，可以防止其腐烂或变质。

13. 发明授权

US06867214B1 Quinazoline derivatives and pharmaceutical applications thereof 失效
标题翻译：喹唑啉衍生物及其药物应用
公开(公告)号：US06867214B1
公开(公告)日：2005-03-15
申请号：US09763213
申请日：1999-08-20
申请人： Harukazu Fukami , Akiko Ito , Seiichi Imajo
发明人： Harukazu Fukami , Akiko Ito , Seiichi Imajo
IPC分类号： A61K31/517 , A61K31/538 , A61P7/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/12 , A61P17/00 , A61P19/02 , A61P29/00 , A61P37/08 , A61P43/00 , C07C311/60 , C07D239/96 , C07D401/12 , C07D413/12
CPC分类号： C07D401/12 , C07C311/60 , C07D239/96 , C07D413/12
摘要： A quinazoline derivative having formula (1) and a pharmaceutically acceptable salt thereof: wherein the ring A represents an aryl group, which derivative has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase, and a pharmaceutical composition containing the same as an essential ingredient. These compounds are useful for treatment of allergic diseases, rheumatic diseases, and cardiac and circulatory system diseases which are due to the abnormal exacerbation of Angiotensin II production.
摘要翻译：具有式（1）的喹唑啉衍生物及其药学上可接受的盐：其中环A表示芳基，该衍生物具有糜酶抑制活性，并抑制由胃促胰酶诱导的血管通透性恶化，以及含有一个必不可少的成分。这些化合物可用于治疗由于血管紧张素II产生异常恶化而引起的过敏性疾病，风湿性疾病以及心脏和循环系统疾病。

14. 发明授权

US06583296B2 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and &agr;-1-blocking action 失效
标题翻译：具有5-羟色胺受体拮抗作用和α-1-阻断作用的吡罗噻嗪和吡咯并噻吩类化合物
公开(公告)号：US06583296B2
公开(公告)日：2003-06-24
申请号：US09939829
申请日：2001-08-28
申请人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Harukazu Fukami , Norio Inomata
发明人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Harukazu Fukami , Norio Inomata
IPC分类号： C07D20736
CPC分类号： C07D513/04 , C07D207/36
摘要： A pyrrolesulfonamide compound having the following formula (I): wherein the ring P represented by is a pyrrole ring having the following structure: wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; l stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl. The compound (1) has been improved in potency, selectivity to receptors other than serotonin-2 receptors, toxicity, side effects and/or the like over medicines reported to date and equipped with &agr;1-blocking action and serotonin-2 receptor antagonistic action in combination.
摘要翻译：具有下式（I）的吡咯磺酰胺化合物：其中由具有以下结构的吡咯环表示的环P：其中A表示亚烷基，亚烯基或亚炔基; Y表示W表示CH，C =或N的基团; 当W为CH或N时，m代表0或1，当W为C =时，m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基; l代表0或1; 虚线表示存在或不存在键; 当存在键时，Z 2不存在，Z1表示H，但当不存在键时，Z1表示H，Z2表示OH或Z1，Z2组合在一起表示O或NOR5基团，其中R5表示 H或烷基，芳烷基或芳基; R代表H，烷基，环烷基，环烷基 - 烷基或芳烷基。化合物（1）对迄今为止报道的并且具有α1-阻断作用和5-羟色胺-2受体拮抗作用的药物的效力，对5-羟色胺2受体以外的受体的选择性，毒性，副作用等改善组合。

15. 发明授权

US4684739A Alkylenedioxybenzene derivatives and acid addition salts thereof 失效
标题翻译：亚烷基二氧基苯衍生物及其酸加成盐
公开(公告)号：US4684739A
公开(公告)日：1987-08-04
申请号：US326417
申请日：1981-12-01
申请人： Ryoji Kikumoto , Harukazu Fukami , Kenichiro Nakao , Mamoru Sugano
发明人： Ryoji Kikumoto , Harukazu Fukami , Kenichiro Nakao , Mamoru Sugano
IPC分类号： C07D317/64 , C07D319/20 , C07D407/12 , C07D321/10
CPC分类号： C07D407/12 , C07D317/64 , C07D319/20
摘要： Alkylenedioxybenzene derivatives are prepared and found to be useful as pharmaceutical agents, particularly as hypotensives.
摘要翻译：制备了亚烷基二氧基苯衍生物，发现其可用作药剂，特别是作为低渗剂。

16. 发明授权

US08383384B2 Polypeptide having glycosylation activity on a flavonoid 失效
标题翻译：对黄酮具有糖基化活性的多肽
公开(公告)号：US08383384B2
公开(公告)日：2013-02-26
申请号：US13530914
申请日：2012-06-22
申请人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
发明人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
IPC分类号： C12N9/28
CPC分类号： C12N9/1048
摘要： The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.
摘要翻译：本发明提供了由Ascomycetoto丝状真菌（优选属于木霉属，更优选绿色木霉）的物质以及编码它们的基因产生的新的糖基转移酶蛋白质。在本发明提供的新型酶蛋白中，特别优选从绿色木霉菌株IAM5141的培养物上清液获得的酶蛋白质。本发明的新型酶可以使类黄酮化合物进行糖基化从而提高其水溶性。

17. 发明授权

US08278088B2 Polynucleotide encoding a polypeptide having glycosylation activity on a flavonoid 有权
标题翻译：编码具有对类黄酮具有糖基化活性的多肽的多核苷酸
公开(公告)号：US08278088B2
公开(公告)日：2012-10-02
申请号：US12523068
申请日：2008-01-18
申请人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
发明人： Misa Ochiai , Harukazu Fukami , Masahiro Nakao , Akio Noguchi
IPC分类号： C12N1/20 , C12N1/00 , C12N1/12 , C12N5/04 , C12N5/00 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1048
摘要： The present invention provides novel glycosyltransferase proteins produced by ascomycetous filamentous fungi (preferably species belonging to the genus Trichoderma, more preferably Trichoderma viride), as well as genes encoding the same. Among novel enzyme proteins provided by the present invention, particularly preferred is an enzyme protein obtained from the culture supernatant of Trichoderma viride strain IAM5141. The novel enzymes of the present invention allow glycosylation of flavonoid compounds to thereby improve their water solubility.
摘要翻译：本发明提供了由Ascomycetoto丝状真菌（优选属于木霉属，更优选绿色木霉）的物质以及编码它们的基因产生的新的糖基转移酶蛋白质。在本发明提供的新型酶蛋白中，特别优选从绿色木霉菌株IAM5141的培养物上清液获得的酶蛋白质。本发明的新型酶可以使类黄酮化合物进行糖基化从而提高其水溶性。

18. 发明申请

US20110217768A1 NOVEL LIPASE 有权
标题翻译：新手
公开(公告)号：US20110217768A1
公开(公告)日：2011-09-08
申请号：US12981929
申请日：2010-12-30
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C12N5/10 , C12N15/63 , C07H21/04 , C12N1/00 , C07H21/00
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供一种分子量约40kDa的新型脂肪酶，其由属于四孢属属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

19. 发明申请

US20100075380A1 Novel Lipase 有权
标题翻译：新型脂肪酶
公开(公告)号：US20100075380A1
公开(公告)日：2010-03-25
申请号：US12096574
申请日：2006-12-08
申请人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
发明人： Masahiro Nakao , Masaki Kanamori , Harukazu Fukami , Hiroaki Kasai , Misa Ochiai
IPC分类号： C07H21/04 , C12N15/63 , C12N1/21 , C07K14/195 , C12N9/20 , C12P7/64 , C12P21/00 , C12N5/10 , C12N1/19
CPC分类号： C12N9/20 , C12P7/6409 , C12P7/6436 , C12R1/01
摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of digestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.
摘要翻译：本发明提供了一种分子量约32kDa的新型脂肪酶，其由属于四联属属的菌株产生，以及编码该脂肪酶的基因。该脂肪酶具有识别中链脂肪酸作为底物的能力。本发明还提供一种分子量约40kDa的新型脂肪酶，其由属于四孢属属的菌株产生，并且具有将中链脂肪酸和长链脂肪酸同时识别为底物的能力，以及编码该多核苷酸的多核苷酸。本发明进一步提供了Tetrasphaera sp。菌株NITE P-154。本发明的脂肪酶可以用作固定化酶，可用于生产消化剂和/或调味剂，生产临床实验室试剂，洗涤剂和/或脂肪等领域，以及生产光学活性中间体农药和药物制剂。

20. 发明申请

US20070065380A1 2-O-(beta-D-glucopyranosyl) ascorbic acid, process for its production, and foods cosmetics containing compositions comprising it 有权
标题翻译： 2-O-（β-D-吡喃葡萄糖基）抗坏血酸，其生产方法，以及含有组合物的食品化妆品
公开(公告)号：US20070065380A1
公开(公告)日：2007-03-22
申请号：US11501074
申请日：2006-08-09
申请人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
发明人： Mitsuru Maeda , Masahiro Nakao , Harukazu Fukami
IPC分类号： A61K31/7048 , A61K8/49
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：与常规已知的2-O-（α-D-吡喃葡萄糖基）抗坏血酸相比，本发明提供了一种新型抗坏血酸衍生物作为维生素C，其具有改善的身体稳定性和延长的身体寿命。含有新化合物2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物已经从宁夏枸杞子和/或枸杞子等植物中提取出来。包含2-O-（β-D-吡喃葡萄糖基）抗坏血酸的组合物可以使用β-D-葡糖基转移酶酶促合成。可以从这样的组合物制备纯的2-O-（β-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（β-D-吡喃葡萄糖基）抗坏血酸。与相应的α-D-吡喃葡萄糖基衍生物相比，2-O-（β-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C 用于化妆品和食品。

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