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11. 发明申请

WO2011075677A2 METHODS FOR PRODUCING POLYPEPTIDES IN PROTEASE-DEFICIENT MUTANTS OF TRICHODERMA 审中-公开
标题翻译：用于在TRICHODERMA的蛋白酶缺陷型突变体中生产多肽的方法
公开(公告)号：WO2011075677A2
公开(公告)日：2011-06-23
申请号：PCT/US2010/061105
申请日：2010-12-17
申请人： NOVOZYMES, INC. , MAIYURAN, Suchindra , JANG, Abigall , BROWN, Kimberly , MERINO, Sandra , SHASKY, Jeffrey , ABBATE, Eric
发明人： MAIYURAN, Suchindra , JANG, Abigall , BROWN, Kimberly , MERINO, Sandra , SHASKY, Jeffrey , ABBATE, Eric
IPC分类号： C12N1/14 , C12N9/58 , C12N15/57 , C12N15/80 , C12P21/02
CPC分类号： C12P21/00 , C12N9/58 , C12N15/80 , C12P21/02
摘要： The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin-like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
摘要翻译：本发明涉及亲本木霉属菌株的突变体，其包含编码多肽的多核苷酸和选自以下的一种或多种（几种）基因：第一枯草杆菌蛋白酶 - 丝氨酸蛋白酶基因，第一天冬氨酸蛋白酶基因，胰蛋白酶样丝氨酸蛋白酶基因，第二枯草杆菌蛋白酶样丝氨酸蛋白酶基因和第二天冬氨酸蛋白酶基因，其中所述一个或多个（几个）基因被修饰使得所述突变体选自第一枯草杆菌蛋白酶样丝氨酸蛋白酶，第一天冬氨酸蛋白酶，胰蛋白酶样丝氨酸蛋白酶，第二枯草杆菌蛋白酶样丝氨酸蛋白酶和第二枯草杆菌蛋白酶样丝氨酸蛋白酶的一种或多种（几种）酶产生缺陷的菌株当在相同条件下培养时，与亲本木霉属菌株相比，它们分别与天冬氨酸蛋白酶相比。本发明还涉及在这种突变体中生产多肽的方法和生产这种突变体的方法。

12. 发明公开

EP3074513A1 ENZYME COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： ENZYMZUSAMMENSETZUNGEN UND VERWENDUNGEN DAVON
公开(公告)号：EP3074513A1
公开(公告)日：2016-10-05
申请号：EP14812377.1
申请日：2014-11-25
申请人： Novozymes A/S
发明人： HARRIS, Paul , MAIYURAN, Suchindra , MCBRAYER, Brett , MUZZI-ERICHSEN, Gloria
IPC分类号： C12N9/24 , C12N9/42 , C12P19/14
CPC分类号： C12P19/14 , C12N9/2402 , C12N9/2437 , C12N9/2445 , C12N9/248 , C12N9/2482 , C12P19/02 , C12P21/02 , C12P2203/00 , C12Y302/01004 , C12Y302/01008 , C12Y302/01021 , C12Y302/01037 , C12Y302/01091
摘要： The present invention relates to enzyme compositions and methods of producing and using the compositions for the saccharification of lignocellulosic material.
摘要翻译：本发明涉及酶组合物和生产和使用用于木质纤维素材料糖化的组合物的方法。

13. 发明公开

EP2195424A1 POLYPEPTIDES HAVING CELLOBIOHYDROLASE II ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：多糖微生物蛋白溶解酶II-AKTIVITÄTUNDDAFÜRCODIERENDE POLYNUKLEOTIDE
公开(公告)号：EP2195424A1
公开(公告)日：2010-06-16
申请号：EP08833449.5
申请日：2008-09-26
申请人： Novozymes A/S
发明人： MAIYURAN, Suchindra , HARRIS, Paul , DING, Hanshu , BROWN, Kimberly
IPC分类号： C12N9/42 , C11D3/386 , C12N15/56 , C12N5/10
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01091
摘要： The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维二糖水解酶活性的分离的多肽和编码多肽的分离的多核苷酸。本发明还涉及包含多核苷酸的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

14. 发明申请

WO2019046703A1 METHODS FOR IMPROVING GENOME EDITING IN FUNGI 审中-公开
公开(公告)号：WO2019046703A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/049066
申请日：2018-08-31
申请人： NOVOZYMES A/S , SHASKY, Jeffrey
发明人： SHASKY, Jeffrey , MAIYURAN, Suchindra , LEHMBECK, Jan
IPC分类号： C12N15/01 , C12N15/63 , C12N15/80 , C12N15/90
CPC分类号： C12N15/80 , C12N15/01 , C12N15/102 , C12N15/63 , C12N15/902
摘要： The present disclosure relates to methods for modifying the genome of a fungal cell, comprising: (A) introducing into the fungal cell: (i) a first nucleic acid construct comprising a polynucleotide encoding an RNA-guided DNA endonuclease; (ii) a second nucleic acid construct comprising (a) a U6 promoter sequence operably linked to (1) a transfer RNA encoding sequence, (2) a single guide RNA encoding sequence, and (b) a U6 terminator sequence; and optionally (iii) a third nucleic acid construct comprising a donor DNA for modifying the genome; and (B) selecting a transformant of the fungal cell, wherein the genome is modified.

15. 发明申请

WO2005056772A1 METHODS FOR ELIMINATING OR REDUCING THE EXPRESSION OF GENES IN FILAMENTOUS FUNGAL STRAINS 审中-公开
标题翻译：消除或减少真菌真菌菌株中基因表达的方法
公开(公告)号：WO2005056772A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/041510
申请日：2004-12-09
申请人： NOVOZYMES INC. , NOVOZYMES A/S
发明人： MAIYURAN, Suchindra , UDAGAWA, Hiroaki , BRODY, Howard
IPC分类号： C12N1/15
CPC分类号： C12P1/02 , C12N15/113 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to methods for reducing or eliminating the expression of a target gene in a filamentous fungal strain, comprising: (a) inserting into the genome of the strain a double-stranded transcribable nucleic acid construct comprising a first nucleotide sequence comprising a promoter operably linked to a homologous coding region of the target gene and a second nucleotide sequence comprising the homologous coding region, or a portion thereof, of the target gene, wherein first and second nucleotide sequences are complementary to each other and the second nucleotide sequence is in reverse orientation relative to the first nucleotide sequence; and (b) inducing production of an interfering RNA encoded by the double-stranded transcribable nucleic acid construct by cultivating the under conditions conducive for production of the interfering RNA; wherein the interfering RNA interacts with RNA transcripts of the target gene to reduce or eliminate expression of the target gene.
摘要翻译：本发明涉及用于减少或消除丝状真菌菌株中靶基因表达的方法，其包括：（a）在菌株的基因组中插入双链可转录核酸构建体，其包含第一核苷酸序列，其包含启动子可操作地连接到靶基因的同源编码区和包含靶基因的同源编码区或其部分的第二核苷酸序列，其中第一和第二核苷酸序列彼此互补，第二个核苷酸序列在相对于第一核苷酸序列的反向取向; 和（b）通过培养有利于产生干扰RNA的条件，诱导由双链可转录核酸构建体编码的干扰RNA的产生; 其中所述干扰RNA与所述靶基因的RNA转录物相互作用以减少或消除所述靶基因的表达。

16. 发明公开

EP3894565A1 METHODS FOR INCREASING THE PRODUCTIVITY OF A FILAMENTOUS FUNGAL CELL IN THE PRODUCTION OF A POLYPEPTIDE 审中-实审
公开(公告)号：EP3894565A1
公开(公告)日：2021-10-20
申请号：EP19836744.3
申请日：2019-12-12
申请人： Novozymes A/S
发明人： LOPEZ DE LEON, Alfredo , SHASKY, Jeffrey , MAIYURAN, Suchindra
IPC分类号： C12N15/80 , C07K14/37

17. 发明公开

EP2245050A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有纤维素分解增强活性的多肽和编码该多肽的多核苷酸
公开(公告)号：EP2245050A2
公开(公告)日：2010-11-03
申请号：EP08867611.9
申请日：2008-12-17
申请人： Novozymes A/S
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/39 , C12N9/42
CPC分类号： C07K14/37 , C12N9/2434
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
摘要翻译：本发明涉及具有纤维素分解增强活性的分离的多肽和编码所述多肽的分离的多核苷酸。本发明还涉及包含所述多核苷酸的核酸构建体，载体和宿主细胞以及生产和使用所述多肽的方法。

18. 发明公开

EP2235049A2 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有增强纤维素降解效果的多肽的确保两编码多核苷酸
公开(公告)号：EP2235049A2
公开(公告)日：2010-10-06
申请号：EP08868796.7
申请日：2008-12-17
申请人： Novozymes A/S
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/39 , C12N9/42
CPC分类号： C12N9/2434 , C07K14/37 , C12P19/14
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

19. 发明公开

EP2235048A1 POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
公开(公告)号：EP2235048A1
公开(公告)日：2010-10-06
申请号：EP08867623.4
申请日：2008-12-17
申请人： Novozymes A/S
发明人： HARRIS, Paul , MAIYURAN, Suchindra , BROWN, Kimberly
IPC分类号： C07K14/37 , C12N9/42 , C12N15/74 , C11D3/386
CPC分类号： C12N9/2434 , C07K14/37 , C11D3/38645
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

20. 发明公开

EP3887391A1 IMPROVED FILAMENTOUS FUNGAL HOST CELLS 审中-实审
公开(公告)号：EP3887391A1
公开(公告)日：2021-10-06
申请号：EP19824219.0
申请日：2019-11-26
申请人： Novozymes A/S
发明人： MCFARLAND, Sarah , MAIYURAN, Suchindra
IPC分类号： C07K14/37 , C12N15/80

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