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11. 发明专利

JP2000189173A EXPRESSION CLONING PROCESS FOR DISCOVERING, CHARACTERIZING AND ISOLATING GENE CODING FOR POLYPEPTIDE HAVING PREVIOUSLY DECIDED SPECIFIC CHARACTERISTIC 失效
公开(公告)号：JP2000189173A
公开(公告)日：2000-07-11
申请号：JP23622099
申请日：1999-08-23
申请人： CYTOS BIOTECHNOLOGY AG
发明人： BAILEY JAMES E , RENNER WOLFGANG A , ORBERGER GEORG H , KOLLER DANIEL
IPC分类号： C12N15/09 , C07K14/01 , C07K14/705 , C12N1/15 , C12N1/19 , C12N5/10 , C12N7/00 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To identify an objective recombinant nucleic acid by cultivating an eukaryote which has an expression system containing a plurality of different members that contain an extrinsic protein nucleic acid connected with a control element under conditions of expressing only extrinsic proteins. SOLUTION: This process is a method for identifying the recombinant nucleic acid that codes for an extrinsic protein having objective specific characteristics and consists of a process for providing a composition containing a plurality of eukaryote host cells. Here, the each host cells have an expression system containing different members and the respective members carry out a process which includes the recombinant nucleic acid coding for the extrinsic protein connected with a control element in the state capable of working, a process of cultivating the above eukaryote host cell under conditions by which the expression of an intrinsic protein in this eukaryote host cell is inhibited though the above extrinsic protein is expressed and a process of identifying the members containing the recombinant nucleic acid that codes for the extrinsic protein having the objective specific characteristics. By these processes, the recombinant nucleic acid that codes for the extrinsic protein having the objective specific characteristics is rapidly identified.

12. 发明专利

JP2005323620A Inducible alphaviral gene expression system 审中-公开
标题翻译：可诱导的ALPHAVIRAL基因表达系统
公开(公告)号：JP2005323620A
公开(公告)日：2005-11-24
申请号：JP2005233751
申请日：2005-08-11
申请人： Cytos Biotechnology Ag , サイトスバイオテクノロジーアーゲー
发明人： RENNER WOLFGANG A , NIEBA LARS , BOORSMA MARCO
IPC分类号： A01K67/027 , A61K48/00 , C07K14/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/04 , C12N9/12 , C12N15/09 , C12N15/86
CPC分类号： C07K14/005 , A01K2217/05 , A61K48/00 , C12N9/127 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2840/105
摘要： PROBLEM TO BE SOLVED: To provide compositions and methods for regulated expression of proteins or untranslated RNA molecules in recombinant host cells. SOLUTION: A DNA molecule comprising a polynucleotide which encodes an RNA molecule, the RNA molecule comprising: (a) at least one cis-acting sequence element, (b) a first open reading frame having a nucleotide sequence encoding a non-cytopathic, temperature-sensitive RNA-dependent RNA polymerase, and (c) at least one second nucleotide sequence selected from the group consisting of: (i) a second open reading frame encoding a protein or portion thereof; (ii) a sequence complementary to all or part of the second open reading frame of (i); and (iii) a sequence encoding an untranslated RNA molecule, or complement thereof. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于在重组宿主细胞中调节蛋白质或非翻译RNA分子表达的组合物和方法。解决方案：包含编码RNA分子的多核苷酸的DNA分子，所述RNA分子包含：（a）至少一种顺式作用序列元件，（b）第一开放阅读框，其具有编码非分子核苷酸序列的核苷酸序列，细胞病变，温度敏感的RNA依赖性RNA聚合酶，和（c）至少一种选自以下的第二核苷酸序列：（i）编码蛋白质或其部分的第二开放阅读框; （ii）与（i）的第二开放阅读框的全部或部分互补的序列; 和（iii）编码非翻译的RNA分子或其互补序列的序列。版权所有（C）2006，JPO＆NCIPI

13. 发明申请

WO0209751A3 COMPOSITIONS FOR INDUCING SELF-SPECIFIC ANTI-IgE ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：用于诱导自身抗IgE抗体的组合物及其用途
公开(公告)号：WO0209751A3
公开(公告)日：2002-09-26
申请号：PCT/IB0101353
申请日：2001-07-27
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN F , RENNER WOLFGANG A
发明人： BACHMANN MARTIN F , RENNER WOLFGANG A
IPC分类号： A61K39/00 , A61K39/385 , A61P37/02 , A61P37/08 , C07K16/00 , C12N15/62 , A61K31/7088 , A61K47/48 , A61K48/00 , C12N5/10 , C12N15/79
CPC分类号： C07K16/00 , A61K39/00 , A61K39/385 , A61K2039/5258 , A61K2039/57 , A61K2039/6075 , A61K2039/625 , C07K2317/52 , C07K2319/00 , C07K2319/30
摘要： The invention relates to compositions for the induction of anti-IgE antibodies in order to prevent or inhibit IgE-mediated disorders. The compositions contain carriers foreign to the immunized human or animal coupled to polypeptides containing fragments of the IgE molecule. The fragment of the IgE molecule includes the constant CH1 and/or the CH4 domain of the IgE molecule. The composition is administered to humans or animals in order to induce antibodies specific for endogenous IgE antibodies. These induced anti-IgE antibodies reduce or eliminate the pool of free IgE in the serum. Since many allergic diseases are mediated by IgE, IgE-mediated disorders are ameliorated in treated mammals.
摘要翻译：本发明涉及用于诱导抗IgE抗体以防止或抑制IgE介导的病症的组合物。该组合物含有与免疫的人或动物杂交的载体与含有IgE分子片段的多肽偶联。 IgE分子的片段包括IgE分子的恒定CH1和/或CH4结构域。将组合物施用于人或动物以诱导对内源性IgE抗体特异性的抗体。这些诱导的抗IgE抗体降低或消除血清中的游离IgE库。由于许多过敏性疾病是由IgE介导的，所以在被治疗的哺乳动物中改善了IgE介导的病症。

14. 发明申请

WO0209751A8 COMPOSITIONS FOR INDUCING SELF-SPECIFIC ANTI-IgE ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：用于诱导自身抗IgE抗体的组合物及其用途
公开(公告)号：WO0209751A8
公开(公告)日：2003-04-24
申请号：PCT/IB0101353
申请日：2001-07-27
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN F , RENNER WOLFGANG A
发明人： BACHMANN MARTIN F , RENNER WOLFGANG A
IPC分类号： A61K39/00 , A61K39/385 , A61P37/02 , A61P37/08 , C07K16/00 , C12N15/62 , A61K31/7088 , A61K47/48 , A61K48/00 , C12N5/10 , C12N15/79
CPC分类号： C07K16/00 , A61K39/00 , A61K39/385 , A61K2039/5258 , A61K2039/57 , A61K2039/6075 , A61K2039/625 , C07K2317/52 , C07K2319/00 , C07K2319/30
摘要： The invention relates to compositions for the induction of anti-IgE antibodies in order to prevent or inhibit IgE-mediated disorders. The compositions contain carriers foreign to the immunized human or animal coupled to polypeptides containing fragments of the IgE molecule. The fragment of the IgE molecule includes the constant CH1 and/or the CH4 domain of the IgE molecule. The composition is administered to humans or animals in order to induce antibodies specific for endogenous IgE antibodies. These induced anti-IgE antibodies reduce or eliminate the pool of free IgE in the serum. Since many allergic diseases are mediated by IgE, IgE-mediated disorders are ameliorated in treated mammals.
摘要翻译：本发明涉及用于诱导抗IgE抗体以防止或抑制IgE介导的病症的组合物。该组合物含有与免疫的人或动物杂交的载体与含有IgE分子片段的多肽偶联。 IgE分子的片段包括IgE分子的恒定CH1和/或CH4结构域。将组合物施用于人或动物以诱导对内源性IgE抗体特异性的抗体。这些诱导的抗IgE抗体降低或消除血清中的游离IgE库。由于许多过敏性疾病是由IgE介导的，所以在被治疗的哺乳动物中改善了IgE介导的病症。

15. 发明申请

WO0032227A3 ORDERED MOLECULAR PRESENTATION OF ANTIGENS, METHOD OF PREPARATION AND USE 审中-公开
标题翻译：有序分子抗原的呈递，制备和使用方法
公开(公告)号：WO0032227A3
公开(公告)日：2000-10-12
申请号：PCT/IB9901925
申请日：1999-11-30
申请人： CYTOS BIOTECHNOLOGY AG
发明人： RENNER WOLFGANG A , HENNECKE FRANK , NIEBA LARS , BACHMANN MARTIN
IPC分类号： A61K47/00 , A61K39/00 , A61P31/00 , A61P35/00 , A61P37/02 , C12N7/01 , C12N5/12
CPC分类号： A61K39/00 , A61K2039/5256 , A61K2039/5258
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a virus, virus-like particle, viral capsid particle, phage or recombinant form thereof coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions. In one specific embodiment, a versatile new technology based on a cassette-type system (Alpha Vaccine Technology) allows production of antigen coated viral particles. Other specific embodiments allow the production of antigen coated hepatitis B virus-like particles or antigen coated Measles virus-like particles.
摘要翻译：本发明提供了用于生产有序和重复的抗原或抗原决定簇阵列的组合物和方法。本发明的组合物可用于生产用于预防感染性疾病，治疗变态反应和治疗癌症的疫苗。作为特定相互作用的结果，本发明的各种实施方案提供了以高度有序且重复的方式涂覆有任何期望的抗原的病毒，病毒样颗粒，病毒衣壳颗粒，噬菌体或其重组形式。在一个具体实施方式中，基于盒式系统（Alpha疫苗技术）的多功能新技术允许生产抗原包被的病毒颗粒。其他具体实施方案允许产生抗原包被的乙型肝炎病毒样颗粒或抗原包被的麻疹病毒样颗粒。

16. 发明申请

WO2004018506A3 INDUCIBLE ALPHAVIRAL/ORIP BASED GENE EXPRESSION SYSTEM 审中-公开
标题翻译：可诱导的ALPHAVIRAL / ORIP基因表达系统
公开(公告)号：WO2004018506A3
公开(公告)日：2004-04-22
申请号：PCT/EP0309291
申请日：2003-08-21
申请人： CYTOS BIOTECHNOLOGY AG , IVANOVA LIDIA , RENNER WOLFGANG A , SAUDAN PHILIPPE
发明人： IVANOVA LIDIA , RENNER WOLFGANG A , SAUDAN PHILIPPE
IPC分类号： A61K48/00 , C12N15/86 , C12N15/869 , C07K14/18 , A01K67/027 , C12N5/10 , C12N7/04 , C12N9/12
CPC分类号： C12N15/86 , A61K48/00 , C12N15/85 , C12N2710/16243 , C12N2800/108 , C12N2840/20
摘要： The present invention relates to compositions and methods that allow the production of polypeptides and untranslated RNA molecules in host cells. More specifically, the invention provides nucleic acid molecules, expression systems, recombinant host cells, methods and kits, which enable the production and/or isolation and/or purification of polypeptides and untranslated RNA molecules. The compositions and methods of the invention can be applied in a regulatable expression system that is transiently transfected into mammalian host cells.
摘要翻译：本发明涉及允许在宿主细胞中产生多肽和非翻译的RNA分子的组合物和方法。更具体地，本发明提供能够产生和/或分离和/或纯化多肽和非翻译的RNA分子的核酸分子，表达系统，重组宿主细胞，方法和试剂盒。本发明的组合物和方法可以应用于瞬时转染入哺乳动物宿主细胞的可调节表达系统中。

17. 发明申请

WO02056905A3 MOLECULAR ANTIGEN ARRAY 审中-公开
标题翻译：分子抗体阵列
公开(公告)号：WO02056905A3
公开(公告)日：2003-10-09
申请号：PCT/IB0200166
申请日：2002-01-21
申请人： CYTOS BIOTECHNOLOGY AG , RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE
发明人： RENNER WOLFGANG A , BACHMANN MARTIN , TISSOT ALAIN , MAURER PATRICK , LECHNER FRANZISKA , SEBBEL PETER , PIOSSEK CHRISTINE
IPC分类号： A61K39/00 , A61K35/76 , A61K38/00 , A61K38/11 , A61K39/02 , A61K39/12 , A61K39/29 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/48 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/00 , C07K14/005 , C07K14/02 , C07K14/08 , C07K14/245 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/08 , C07K16/22 , C07K16/28 , C07K16/40 , C07K16/42 , C12N15/40 , A61K39/44
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供包含有序重复抗原或抗原决定簇的组合物。本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。有序的和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病的疫苗，用于预防或治愈癌症以及有效地诱导自身特异性免疫应答（特别是抗体应答）的过敏症药物和药物。

18. 发明申请

WO03059386A2 PRION PROTEIN CARRIER-CONJUGATES 审中-公开
标题翻译： PRION蛋白载体结合蛋白
公开(公告)号：WO03059386A2
公开(公告)日：2003-07-24
申请号：PCT/EP0300460
申请日：2003-01-17
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN , MAURER PATRICK , PELLICIOLI ERICA , RENNER WOLFGANG A
发明人： BACHMANN MARTIN , MAURER PATRICK , PELLICIOLI ERICA , RENNER WOLFGANG A
IPC分类号： A61K39/00 , A61P25/00 , C07K14/02 , C07K14/08 , C07K14/52 , C07K14/54 , A61K39/385
CPC分类号： C07K14/005 , A61K39/0007 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K2319/00 , C12N2730/10122
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a prion peptide or prion protein-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one prion protein PrP or a dimer thereof, or a PrP peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of prion diseases and as a pharmaccine to prevent or cure prion diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
摘要翻译：本发明涉及分子生物学，病毒学，免疫学和医学领域。本发明提供了包含有序和重复的抗原或抗原决定簇，特别是朊病毒肽或朊病毒蛋白-VLP阵列的组合物。更具体地，本发明提供包含病毒样颗粒和至少一种朊蛋白PrP或其二聚体或与其结合的PrP肽的组合物。本发明还提供了分别制备共轭物和有序和重复阵列的方法。本发明的组合物可用于生产用于治疗朊病毒疾病的疫苗和用于预防或治愈朊病毒疾病并有效诱导免疫应答，特别是抗体应答的药物。此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

19. 发明申请

WO2004000351A8 PACKAGED VIRUS-LIKE PARTICLES FOR USE AS ADJUVANTS: METHOD OF PREPARATION AND USE 审中-公开
标题翻译：用作ADJUVANTS的包装的病毒颗粒：制备和使用方法
公开(公告)号：WO2004000351A8
公开(公告)日：2005-02-03
申请号：PCT/EP0306541
申请日：2003-06-20
申请人： CYTOS BIOTECHNOLOGY AG , BACHMANN MARTIN F , RENNER WOLFGANG A
发明人： BACHMANN MARTIN F , RENNER WOLFGANG A
IPC分类号： A61K39/00 , A61K39/35 , A61K39/385 , A61K39/39 , A61P37/04 , C07K14/02 , C07K14/08 , C12N7/04
CPC分类号： C12N7/00 , A61K39/0011 , A61K39/35 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/55561 , A61K2039/55588 , A61K2039/57 , A61K2039/6075 , C07K14/005 , C12N2730/10122 , C12N2730/10123
摘要： The invention relates to the finding that virus like particles (VLPs) can be loaded and packaged, respectively, with DNA oligonucleotides rich in non methylated C and G (CpGs). If such CpG-VLPs are mixed with antigens, the immunogenicity of these antigens are dramatically enhanced. In addition, the T cell responses against the antigens are especially directed to the Thl type. Surprisingly, no covalent linkage of the antigen to the VLP is required; it is sufficient to simply mix the VLPs with the adjuvants for co-administration. In addition, it was found that VLPs did not enhance immune responses unless they were loaded and packaged, respectively, with CpGs. Antigens mixed with CpG-packaged VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self- molecules and chronic viral diseases.
摘要翻译：本发明涉及分别用富含非甲基化C和G（CpG）的DNA寡核苷酸负载和包装病毒样颗粒（VLPs）的发现。如果这种CpG-VLP与抗原混合，则这些抗原的免疫原性显着增强。此外，针对抗原的T细胞应答特别针对Th1型。令人惊讶的是，不需要抗原与VLP的共价连接; 简单地将VLP与用于共同给药的佐剂混合就足够了。此外，发现VLP除了分别用CpG装载和包装外，还没有增强免疫应答。因此，与CpG包装的VLP混合的抗原可能是针对过敏，肿瘤和其他自身分子和慢性病毒性疾病的预防性或治疗性接种疫苗的理想疫苗。

20. 发明申请

WO0142442A3 ACTIVATION OF ENDOGENOUS GENES BY GENOMIC INTRODUCTION OF A REPLICON 审中-公开
标题翻译：通过基因引物回报激活内源基因
公开(公告)号：WO0142442A3
公开(公告)日：2001-11-22
申请号：PCT/IB0001841
申请日：2000-12-08
申请人： CYTOS BIOTECHNOLOGY AG , HENNECKE FRANK , RENNER WOLFGANG A
发明人： HENNECKE FRANK , RENNER WOLFGANG A
IPC分类号： A61K48/00 , C07K14/505 , C12N15/85 , C12N15/86 , C12N15/90 , C07K14/18 , C12N5/10 , C12N7/04 , C12N9/12
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C07K14/505 , C12N15/86 , C12N15/907 , C12N2770/36143 , C12N2800/30 , C12N2830/008 , C12N2830/42 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to methods for the modification of genomes of eukaryotic cells to alter the expression of endogenous genes. The invention also relates to recombinant eukaryotic host cells and polypeptides produced by the practice of the disclosed methods. The invention further relates to vector systems useful for modifying the genomes of eukaryotic cells to alter the expression of endogenous genes.
摘要翻译：本发明涉及用于修饰真核细胞基因组以改变内源基因表达的方法。本发明还涉及通过实践所公开的方法产生的重组真核宿主细胞和多肽。本发明还涉及可用于修饰真核细胞基因组以改变内源基因表达的载体系统。

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