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11. 发明专利

AU2015368496B2 Cell death-inducing agent, cell growth-inhibiting agent, and pharmaceutical composition for treatment of disease caused by abnormal cell growth 未知
公开(公告)号：AU2015368496B2
公开(公告)日：2021-07-01
申请号：AU2015368496
申请日：2015-12-24
申请人： NITTO DENKO CORP
发明人： TANAKA HIROYUKI , MINOMI KENJIROU , NIITSU YOSHIRO
IPC分类号： A61K45/06 , A61K31/7105 , A61K31/711 , A61P35/00 , A61P43/00 , C12N15/113 , C12Q1/02
摘要： The present invention induces cell death, and suppresses cell growth, in cancer cells. The invention includes as active ingredients a drug for suppressing GST-π and a drug for suppressing both GST-π and suppressing homeostasis- and maintenance-related proteins exhibiting synthetic lethality.

12. 发明专利

AU2016371624B2 siRNA structures for high activity and reduced off target 未知
公开(公告)号：AU2016371624B2
公开(公告)日：2020-08-27
申请号：AU2016371624
申请日：2016-12-12
申请人： NITTO DENKO CORP
发明人： YING WENBIN , MINOMI KENJIROU , HARBORTH JENS , CINA CIMA , ZHENG JANE , VAISH NARENDRA
IPC分类号： A61K31/713 , C07H21/02 , C12N15/11 , C12N15/113
摘要： This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2'-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.

13. 发明专利

RU2719185C2 ПРЕПАРАТЫ, ОСУЩЕСТВЛЯЮЩИЕ РНК-ИНТЕРФЕРЕНЦИЮ, ДЛЯ МОДУЛЯЦИИ ГЕНА GST-PI 未知
公开(公告)号：RU2719185C2
公开(公告)日：2020-04-17
申请号：RU2017126613
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： TERADA ERIKA , TAKAHASHI HIROKAZU , MINOMI KENJIROU , YING WENBIN , AHMADIAN MOHAMMAD , ZHANG JUN , HARBORTH JENS
IPC分类号： A61K31/52 , A61K31/713
摘要： Изобретениеотноситсяк биотехнологии. Описана siRNA дляингибированияэкспрессии GST-π, содержащаясмысловуюцепьи антисмысловуюцепь, гдецепиобразуютдуплекснуюобласть, игдеантисмысловаяцепьпредставляетсобой SEQ ID NO:157, исмысловаяцепьпредставляетсобой SEQ ID NO:131, гдедлинакаждойцеписоставляет 30 нуклеотидовилименее. Такжеописанакомпозиция, содержащаяуказанную siRNA. Раскрытспособлечениязаболевания, связанногос экспрессией GST-π. Такжераскрыта siRNA дляингибированияэкспрессии GST-π, содержащаясмысловуюцепьи антисмысловуюцепь, гдецепиобразуютдуплекснуюобласть, игдеантисмысловаяцепьпредставляетсобой SEQ ID NO:195, исмысловаяцепьпредставляетсобой SEQ ID NO:183, гдедлинакаждойцеписоставляет 30 нуклеотидовилименее. Раскрытысоответствующиефармацевтическиекомпозиции. Изобретениеможноиспользоватьв способахдляпредотвращенияилилечениязаболевания, такогокакзлокачественнаяопухоль. 16 н. и 49 з.п. ф-лы, 14 ил., 14 табл., 17 пр.

14. 发明专利

HK1245674A1 用於GST-PI基因調節的RNA干擾劑未知
公开(公告)号：HK1245674A1
公开(公告)日：2018-08-31
申请号：HK18105480
申请日：2018-04-27
申请人： NITTO DENKO CORP
发明人： YING WENBIN , MINOMI KENJIROU , HARBORTH JENS , TAKAHASHI HIROKAZU , TERADA ERIKA , ZHANG JUN , AHMADIAN MOHAMMAD
IPC分类号： A61K20060101

15. 发明专利

AU2015369595A1 Therapeutic compositions and methods for malignant tumors with RNAi molecules targeted to Hsp47 and p21 未知
公开(公告)号：AU2015369595A1
公开(公告)日：2017-07-27
申请号：AU2015369595
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , YONEDA AKIHIRO , TAMURA YASUAKI , MINOMI KENJIROU , MAJETI BHARAT , LIU JIHUA
IPC分类号： A61K9/127 , A61K31/7088 , A61K31/713
摘要： This invention provides compositions and methods for preventing or treating a malignant tumor in a mammal in need thereof, by administering to the mammal a therapeutically effective amount of a composition comprising RNAi molecules, which RNAi molecules can be active in reducing expression of Hsp47, or a combination of RNAi molecules active for Hsp47 and p21

16. 发明专利

ES2843654T3 Composiciones de interferencia por ARN y métodos para tumores malignos 未知
公开(公告)号：ES2843654T3
公开(公告)日：2021-07-20
申请号：ES15874366
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , NIITSU YOSHIRO , MINOMI KENJIROU , MAJETI BHARAT , WANG LI , LIU JIHUA , ADAMI ROGER
IPC分类号： C12N15/113 , A61K31/713
摘要： Composición que comprende moléculas de iARN dirigidas a una GST-p humana, moléculas de iARN dirigidas a una p21 humana codificada por un gen CDKN1A, y un portador farmacéuticamente aceptable.

17. 发明专利

AU2015369592A1 RNA interference agents for GST-pi gene modulation 未知
公开(公告)号：AU2015369592A1
公开(公告)日：2017-08-10
申请号：AU2015369592
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , MINOMI KENJIROU , HARBORTH JENS , TAKAHASHI HIROKAZU , TERADA ERIKA , ZHANG JUN , AHMADIAN MOHAMMAD
IPC分类号： A61K31/713 , A61K31/52
摘要： This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications

18. 发明专利

AU2015369598A1 RNA agents for GST-pi gene modulation 未知
公开(公告)号：AU2015369598A1
公开(公告)日：2017-07-27
申请号：AU2015369598
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , MINOMI KENJIROU , HARBORTH JENS , TAKAHASHI HIROKAZU , TERADA ERIKA , ZHANG JUN , AHMADIAN MOHAMMAD
IPC分类号： A61K31/7088 , A61K31/713 , A61K48/00 , C12N15/113
摘要： This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-π; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.

19. 发明专利

CA2972270A1 METHODS AND COMPOSITIONS FOR TREATING MALIGNANT TUMORS ASSOCIATED WITH KRAS MUTATION 未知
公开(公告)号：CA2972270A1
公开(公告)日：2016-06-30
申请号：CA2972270
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , MINOMI KENJIROU , MAJETI BHARAT , WANG LI , LIU JIHUA , ADAMI ROGER
IPC分类号： A61K31/52 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/45
摘要： This invention provides methods and compositions for preventing, treating or ameliorating one or more symptoms of a malignant tumor associated with KRAS mutation in a mammal in need thereof, by identifying a tumor cell in the mammal, the tumor cell comprising at least one of: (i) a mutation of the KRAS gene, and (ii) an aberrant expression level of KRAS protein; and administering to the mammal a therapeutically effective amount of a composition comprising one or more RNAi molecules that are active in reducing expression of GST-p.

20. 发明专利

CA2972268A1 THERAPEUTIC COMPOSITIONS AND METHODS FOR MALIGNANT TUMORS WITH RNAI MOLECULES TARGETED TO HSP47 AND P21 未知
公开(公告)号：CA2972268A1
公开(公告)日：2016-06-30
申请号：CA2972268
申请日：2015-12-28
申请人： NITTO DENKO CORP
发明人： YING WENBIN , YONEDA AKIHIRO , TAMURA YASUAKI , MINOMI KENJIROU , MAJETI BHARAT , LIU JIHUA
IPC分类号： A61K9/127 , A61K31/7088 , A61K31/713
摘要： This invention provides compositions and methods for preventing or treating a malignant tumor in a mammal in need thereof, by administering to the mammal a therapeutically effective amount of a composition comprising RNAi molecules, which RNAi molecules can be active in reducing expression of Hsp47, or a combination of RNAi molecules active for Hsp47 and p21

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