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11. 发明申请

WO1992007551A1 PROCESS FOR PRODUCING FAT EMULSION 审中-公开
标题翻译：生产脂肪乳的方法
公开(公告)号：WO1992007551A1
公开(公告)日：1992-05-14
申请号：PCT/JP1991001510
申请日：1991-11-05
申请人： NIPPON SHINYAKU CO., LTD. , SEKI, Junzo , YAMAMOTO, Hirofumi , YAMANE, Shuji , TAKAHASHI, Yutaka , USHIMARU, Kouichi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K09/107
CPC分类号： A61K31/70 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A process for producing a fat emulsion wherein the emulsion particle has a mean diameter of 10 to 100 nm, characterized by shortening the emulsification time through the addition of sodium chloride as an emulsification aid in an amount of 0.01 to 0.2 % (w/v) based on the whole emulsion in an arbitrary stage of the production process. This process also serves to reduce the decomposition of the emulsion components as a result of shortening the emulsification time.
摘要翻译：一种脂肪乳液的制造方法，其中，乳剂粒子的平均直径为10〜100nm，其特征在于，以0.01〜0.2％（w / v）的量添加作为乳化助剂的氯化钠来缩短乳化时间，基于整个乳液在生产过程的任意阶段。该方法还用于减少乳化组分的分解，因为乳化时间缩短。

12. 发明申请

WO1992000277A1 PIPERIDINE DERIVATIVE 审中-公开
标题翻译：哌啶衍生物
公开(公告)号：WO1992000277A1
公开(公告)日：1992-01-09
申请号：PCT/JP1991000866
申请日：1991-06-27
申请人： NIPPON SHINYAKU CO., LTD. , EZURE, Yohji , MARUO, Shigeaki , MIYAZAKI, Katsunori , YAMADA, Naoyoshi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D211/46
CPC分类号： C07D211/46
摘要： A 3,4,5-trihydroxypiperidine derivative of general formula (I), having a β-galactosidase inhibitory action and therefore usable as a carcinostatic agent, wherein R represents a C1 to C18 saturated or unsaturated hydrocarbon group which may be substituted with a linear, branched or cyclic group.

13. 发明申请

WO1990002140A1 METHOD FOR PURIFYING TENEICINE 审中-公开
标题翻译：净化尼龙的方法
公开(公告)号：WO1990002140A1
公开(公告)日：1990-03-08
申请号：PCT/JP1989000839
申请日：1989-08-17
申请人： RIKAGAKU KENKYUSHO , JAPAN IMMUNORESEARCH LABORATORIES CO., LTD. , AMANO PHARMACEUTICAL CO., LTD. , NIPPON SHINYAKU CO., LTD. , SAKAKURA, Teruyo , OIKE, Yasuteru , HIRAIWA, Hideki , KAWAKATSU, Hisaaki
发明人： RIKAGAKU KENKYUSHO , JAPAN IMMUNORESEARCH LABORATORIES CO., LTD. , AMANO PHARMACEUTICAL CO., LTD. , NIPPON SHINYAKU CO., LTD.
IPC分类号： C07K15/14
CPC分类号： C07K14/47
摘要： According to the method of this invention, highly pure teneicine can be obtained in a high yield from an extract of an extracellular substance containing teneicine by flowing said extract through an affinity chromatograph containing gelatin bound thereto via covalent bonds to remove fibronectin to such an extent that its content is lowered to 1 % by weight or less of the solute and purifying the fraction thus treated by using a basic anion exchange resin.

14. 发明申请

WO1997028130A1 ISOQUINOLINE DERIVATIVES AND DRUGS 审中-公开
标题翻译：异喹啉衍生物和药物
公开(公告)号：WO1997028130A1
公开(公告)日：1997-08-07
申请号：PCT/JP1997000240
申请日：1997-01-31
申请人： NIPPON SHINYAKU CO., LTD. , HIDAKA, Hiroyoshi , MATSUURA, Akira , MATSUZAKI, Takushi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D217/02
CPC分类号： C07D401/12 , A61K31/495 , C07D217/02 , C07D217/04 , C07D217/22 , C07D471/08
摘要： Compounds represented by general formula (I), pharmacologically acceptable salts thereof, or solvates thereof, wherein R represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogeno; R represents hydrogen, hydroxy, or halogeno; R represents hydrogen, alkyl, or amidino; and A represents optionally substituted five- to eleven-membered cyclic amino, in which two arbitrary carbon atoms may form a bridge. The compounds are useful for the prevention and treatment of cerebral tissue disorders caused by vasoconstriction after cerebral hemorrhage.
摘要翻译：由通式（I）表示的化合物，其药理学上可接受的盐或其溶剂化物，其中R 1表示烷基，烯基，炔基，烷氧基，羟基，氰基或卤代; R 2表示氢，羟基或卤素; R 3表示氢，烷基或脒基; 并且A表示任选取代的五至十一元环状氨基，其中两个任意的碳原子可以形成桥。该化合物可用于预防和治疗由脑出血后血管收缩引起的脑组织疾病。

15. 发明申请

WO1997002278A1 SUGAR CHAIN DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：糖链衍生物及其生产方法
公开(公告)号：WO1997002278A1
公开(公告)日：1997-01-23
申请号：PCT/JP1996001810
申请日：1996-06-28
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , MORI, Kazuya , KYOTANI, Yohsuke , HASEGAWA, Akira
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： Moranoline derivatives represented by structural formula (I), wherein R1 represents hydrogen, linear or branched C1-30 alkyl, C3-30 alkenyl, C3-30 alkynyl, alkoxycarbonylalkyl, alkoxyalkoxyalkoxyamidoalkyl, 3-(fluoresceinthiocarbamylamino)propyl, aralkyl optionally mono- or di-substituted by hydroxy or C1-20 alkoxy, or a group represented by formula (a) wherein r is an integer of from 1 to 3; q is an integer of from 0 to 2; and n is an integer of from 1 to 5, provided that r + q is not more than 3. Because of having the activity of inhibiting cell adhesion and competitively inhibiting selectin, the compounds are useful in the prevention and treatment of inflammation, asthma, immunologic diseases, heart/brain ischemia, reflow disorders, etc..
摘要翻译：由结构式（I）表示的山梨醇衍生物，其中R 1表示氢，直链或支链C 1-30烷基，C 3-30烯基，C 3-30炔基，烷氧基羰基烷基，烷氧基烷氧基烷氧基氨基烷基，3-（荧光二硫代氨基甲酰基氨基）丙基，任选的单或二被羟基或C 1-20烷氧基取代，或由式（a）表示的基团，其中r为1至3的整数; q为0〜2的整数; 并且n为1〜5的整数，条件是r + q不大于3.由于具有抑制细胞粘附和竞争性抑制选择素的活性，所以该化合物可用于预防和治疗炎症，哮喘，免疫学疾病，心/脑缺血，回流障碍等。

16. 发明申请

WO1996034006A1 ANTIGENIC CARBOHYDRATE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：抗生素碳水化合物衍生物及其生产方法
公开(公告)号：WO1996034006A1
公开(公告)日：1996-10-31
申请号：PCT/JP1996001146
申请日：1996-04-26
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , MORI, Kazuya , OGAWA, Hirotsugu
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H17/02
CPC分类号： C07H17/02 , A61K31/70
摘要： Antigenic carbohydrates derivative of the Lewis type represented by structural formula (I), salts thereof or solvates thereof. In said formula, R1 represents linear or branched C1-30 alkyl, C3-30 alkenyl, C3-30 alkynyl, benzyl substituted by C1-20 alkoxy, 9-(lower)alkyl-3-carbazolyl(lower)alkyl, 3-(fluorescein-thiocarbamyl)aminopropyl or a group represented by structural formula (II), wherein r is an integer of from 1 to 3; q is an integer of from 0 to 2; and n is an integer of from 1 to 5, provided that r plus q is not more than 3; and A and B are different and each represents hydrogen, 1-D, L-fucopyranosyl, 3-O carboxymethyl- beta -D-1-galactopyranosyl or a salt of the same, provided that either A or B is 3-O-carboxymethyl- beta -D-1-galactopyranosyl or a salt of the same. The compounds have an excellent activity of inhibiting cell adhesion and thus are useful as a medicine.
摘要翻译：由结构式（I）表示的Lewis型抗原性碳水化合物衍生物，其盐或溶剂化物。在所述式中，R 1表示直链或支链C 1-30烷基，C 3-30烯基，C 3-30炔基，被C 1-20烷氧基取代的苄基，9-（低级）烷基-3-咔唑基（低级）烷基，3-（荧光素 - 硫代氨基甲酰基）氨基丙基或由结构式（II）表示的基团，其中r为1至3的整数; q是0〜2的整数; 并且n是1至5的整数，条件是r + q不大于3; A和B不同，各自表示氢，1-D，L-糠醛吡喃糖基，3-O羧甲基-β-D-1 - 吡喃半乳糖苷或其盐，条件是A或B为3-O-羧甲基 -β-D-1 - 吡喃半乳糖基或其盐。这些化合物具有优异的抑制细胞粘附的活性，因此可用作药物。

17. 发明申请

WO1995031899A1 PESTICIDE COMPOSITION, PESTICIDAL PREPARATION, AND PRODUCTION PROCESS 审中-公开
标题翻译：杀虫剂组合物，杀虫剂制备和生产过程
公开(公告)号：WO1995031899A1
公开(公告)日：1995-11-30
申请号：PCT/JP1995000986
申请日：1995-05-23
申请人： NIPPON SHINYAKU CO., LTD. , NAKAMICHI, Kouichi , IZUMI, Shougo , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A01N25/10
CPC分类号： A01N25/34
摘要： A waterborne pesticide composition which has a configuration entirely different from that of conventional waterborne pesticide compositions. It contains a macromolecular compound such as a cellulose derivative as the principal ingredient, further contains at least a pesticidally active ingredient and an expansion aid such as talc, is in the form of an expanded molding with a reticular cross section, and has an apparent density of 1 g/cm or less. It has a high buoyancy and is well developable on the water surface.
摘要翻译：具有与常规水性农药组成完全不同的配置的水性农药组合物。含有作为主要成分的纤维素衍生物的大分子化合物，还含有至少一种农药活性成分和膨胀助剂如滑石，是具有网状横截面的膨胀成形体，其表观密度为1g / cm 3以下。它具有很高的浮力，在水面上可以很好的显影。

18. 发明申请

WO1995026971A1 CYCLIC NUCLEOTIDE DERIVATIVE 审中-公开
标题翻译：循环核苷衍生物
公开(公告)号：WO1995026971A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000617
申请日：1995-03-31
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , SATO, Yoshitake , MAKITA, Yoshihiko , TATSUMI, Shigeru
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07H19/213
CPC分类号： A61K31/7076 , A61K31/708 , C07H19/20 , C07H19/24
摘要： A cyclic nucleotide derivative represented by general formula [I] and a pharmaceutically acceptable salt thereof, useful as a nootropic drug, antiarrhythmic agent, bronchial asthma remedy or anti-inflammatory, wherein R represents hydroxy, amino or -NR R (R and R being the same or different alkyls); R represents hydrogen, amino or hydroxy; R represents hydrogen, halogen, alkyl, hydroxy, mercapto, etc.; R represents hydrogen, hydroxy, acyloxy, alkoxy, etc.; R represents alkyl or aryl; and R represents hydrogen, halogen or alkyl.
摘要翻译：由通式[I]表示的环状核苷酸衍生物及其药学上可接受的盐，可用作益智药物，抗心律失常药，支气管哮喘药物或抗炎剂，其中R 1表示羟基，氨基或-NR 11 R 12（R 11和R 12是相同或不同的烷基）; R 2表示氢，氨基或羟基; R 3表示氢，卤素，烷基，羟基，巯基等; R 4表示氢，羟基，酰氧基，烷氧基等; R 5表示烷基或芳基; R 6表示氢，卤素或烷基。

19. 发明申请

WO1995015964A1 NUCLEOSIDE DERIVATIVE 审中-公开
标题翻译：核苷衍生物
公开(公告)号：WO1995015964A1
公开(公告)日：1995-06-15
申请号：PCT/JP1994002059
申请日：1994-12-08
申请人： NIPPON SHINYAKU CO., LTD. , OHGI, Tadaaki , YANO, Junichi
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： C07D405/04
CPC分类号： C07D473/00 , C07D405/06 , C07D473/18 , C07D473/30 , C07H19/04
摘要： A nucleoside derivative represented by general formula (I) and useful as an antiviral and a malignant tumor remedy, wherein R represents adenin-9-ylmethyl, guanine-9-ylmethyl, hypoxanthin-9-ylmethyl, thymin-1-ylmethyl, uracil-1-ylmethyl or cytosin-1-ylmethyl; and X and Y represent each independently hydrogen or hydroxy, provided the case where X is hydrogen and Y is hydroxy is excepted.
摘要翻译：由通式（I）表示的可用作抗病毒剂和恶性肿瘤治疗剂的核苷衍生物，其中R表示腺嘌呤-9-基甲基，鸟嘌呤-9-基甲基，次黄嘌呤-9-基甲基，甲氨宁-1-基甲基，尿嘧啶-9-基甲基， 1-甲基或细胞蛋白-1-基甲基; X和Y各自独立地表示氢或羟基，条件是X为氢且Y为羟基的情况除外。

20. 发明申请

WO1995005809A1 GASTRIC REMAINING PREPARATION, SWOLLEN MOLDING, AND PRODUCTION PROCESS 审中-公开
标题翻译：气体制备，卷筒成型和生产工艺
公开(公告)号：WO1995005809A1
公开(公告)日：1995-03-02
申请号：PCT/JP1994001367
申请日：1994-08-18
申请人： NIPPON SHINYAKU CO., LTD. , NAKAMICHI, Kouichi , IZUMI, Shougo , YASUURA, Hiroyuki
发明人： NIPPON SHINYAKU CO., LTD.
IPC分类号： A61K09/22
CPC分类号： A61K9/0065
摘要： A gastric remaining preparation having a configuration entirely different from that of the conventional ones. It comprises a swollen molding having an apparent density of less than 1, containing an acid-proof high-molecular compound as the chief ingredient and further at least a swelling aid and a drug, and having a reticular cross section. The molding can be produced by using a multi-screw extruder.
摘要翻译：具有与常规配置完全不同的配置的胃剩余制剂。其包含表观密度小于1的膨胀模制品，其含有耐酸性高分子化合物作为主要成分，并且还包括至少一种助溶剂和药物，并具有网状横截面。可以通过使用多螺杆挤出机来制造成型体。

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