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11. 发明公开

EP1872811A4 HEMODIALYZER AND METHOD OF HEMODIALYSIS 有权
标题翻译： HÄMODIALYSATORUNDHÄMODIALYSE-VERFAHREN
公开(公告)号：EP1872811A4
公开(公告)日：2009-11-25
申请号：EP06714866
申请日：2006-02-28
申请人： NIKKISO CO LTD
发明人： MORI YOSHIHIRO , TOYODA MASAHIRO
IPC分类号： A61M1/14
CPC分类号： A61M1/16 , A61M1/1611 , A61M1/1613 , A61M1/341 , A61M2205/52 , A61M2230/207
摘要： A hemodialysis apparatus and method capable of performing an optimal ultrafiltration is provided to calculate a standardized parameter applicable to a large number of patients relating a predetermined blood benchmark to a body weight of a patient during a hemodialysis treatment in correlation with a dry-weight of the patient. There are provided a dialysis treatment means (ultrafiltration pump 8) for performing hemodialysis and ultrafiltration upon an extracorporeally-circulating blood of the patient to conduct a hemodialysis treatment, a measuring means 10 for measuring a variation rate of the body weight of the patient during the hemodialysis treatment by using the dialysis treatment means and a variation rate of a volume of an extracorporeally-circulating blood plasma obtained by a hematocrit sensor 5, and a calculation means 11 for calculating a parameter (PWI) relating the variation rate of the body weight obtained by the measuring means 10 to the variation rate ofthe extracorporeally-circulating blood plasma in correlation with the dry-weight of the patient.
摘要翻译：提供一种能够进行最佳超滤的血液透析装置和方法，用于计算适用于在血液透析治疗期间将预定血液基准与患者的体重相关联的大量患者的标准化参数与患者。提供了一种透析治疗装置（超滤泵8），用于对患者的体外循环血液进行血液透析和超滤以进行血液透析治疗;测量装置10，用于测量患者体内的体重变化率通过使用透析处理装置的血液透析处理和由血细胞比容传感器5获得的体外循环血浆的体积的变化率，以及计算装置11，用于计算与获得的体重的变化率有关的参数（PWI）通过测量装置10与体外循环血浆的变化率相关联，与患者的干重相关。

12. 发明公开

EP3238754A4 BLOOD PURIFICATION SYSTEM 有权
公开(公告)号：EP3238754A4
公开(公告)日：2018-07-04
申请号：EP15873120
申请日：2015-12-24
申请人： NIKKISO CO LTD
发明人： GOTO HITOSHI , MURAKAMI TOMOYA , TOYODA MASAHIRO
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/36 , A61L2/0011 , A61M1/14 , A61M1/34 , A61M1/3607 , A61M1/3639 , A61M2205/3561 , A61M2205/3576 , A61M2205/502 , A61M2205/52 , A61M2230/04
摘要： To provide a blood purification system that is capable of efficiently and assuredly notifying any changes in the patient's condition on the basis of noninvasive vital sings of the patient that are observed during the blood purification treatment, with a blood purification apparatus manufacturable at a reduced cost. An external information-processing apparatus 4 includes an external input device 11 into which a vital sign detected by a detecting device 2 is inputtable in real time; a checking device 12 capable of checking whether or not the vital sign inputted in real time into the external input device 11 satisfies a predetermined condition; and an external output device 13 capable of outputting, if it is determined by the checking device 12 that the vital sign satisfies the predetermined condition, a result of the checking or checked information including the vital sign leading to the result of the checking to a blood purification apparatus 1. The checked information outputted from the external output device 13 is displayable on a display 5 included in the blood purification apparatus 1.

13. 发明公开

EP2832384A4 BLOOD PURIFICATION DEVICE 有权
标题翻译： BLUTREINIGUNGSVORRICHTUNG
公开(公告)号：EP2832384A4
公开(公告)日：2015-11-18
申请号：EP13768746
申请日：2013-03-28
申请人： NIKKISO CO LTD
发明人： FURUHASHI TOMOHIRO , TAKEUCHI SATOSHI , SUGIOKA AKIRA , TOYODA MASAHIRO
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/1603 , A61M1/1615 , A61M1/342 , A61M1/3458 , A61M1/3626 , A61M1/3646 , A61M1/367 , A61M2202/0413 , A61M2205/3306 , A61M2205/331 , A61M2205/75
摘要： An object of the present invention is to provide a blood purification apparatus which can perform actions and operations according to the final stage of blood-return. According to the present invention, there is provided a blood purification apparatus comprising a blood circuit including an arterial blood circuit and a venous blood circuit for extracorporeally circulating blood of a patient from a tip end of the arterial blood circuit to a tip end of the venous blood circuit; a blood purification means arranged between the arterial blood circuit and the venous blood circuit of the blood circuit and purifying blood flowing through the blood circuit; a substitution solution supplying means for supplying substitution solution to the blood circuit; and performing blood-return by substituting the blood in the blood circuit with the substitution solution supplied from the substitution solution supplying means after the blood purification treatment characterized in that the blood purification apparatus further comprises a detecting means arranged at predetermined positions in the arterial blood circuit and the venous blood circuit and detecting presence or absence or blood concentration of the blood flowing in the arterial blood circuit and the venous blood circuit at said predetermined positions, and a recognition means for recognize a final stage of blood-return which is a condition near the end of the substitution of blood with the substitution solution based on the presence or absence of the blood or blood concentration detected by the detecting means.
摘要翻译：本发明的目的是提供一种能够根据血液回流的最后阶段进行动作和操作的血液净化装置。根据本发明，提供了一种血液净化装置，其包括：血液回路，其包括动脉血回路和静脉血回路，用于使患者的血液从动脉血回路的前端到静脉的前端体外循环血液回路; 血液净化装置，其布置在所述血液回路的动脉血液回路和静脉血液回路之间，并且净化血液循环中的血液; 用于向血液回路提供替代溶液的置换溶液供给装置; 通过在血液净化处理后由从取代溶液供给装置供给的替代溶液代入血液回路中进行血液回收，其特征在于，所述血液净化装置还具有配置在所述动脉血液回路中的规定位置的检测机构和所述静脉血回路，检测在所述预定位置处在动脉血回路和静脉血回路中流动的血液的存在或不存在或血液浓度，以及用于识别作为接近的状态的血液回流的最后阶段的识别装置基于由检测装置检测到的血液或血液浓度的存在或不存在，用取代溶液代替血液的结束。

14. 发明公开

EP2361643A4 BLOOD PURIFIER AND METHOD OF PRIMING SAME 有权
标题翻译：血液清洁器和出血及其方法
公开(公告)号：EP2361643A4
公开(公告)日：2015-05-20
申请号：EP09833194
申请日：2009-12-15
申请人： NIKKISO CO LTD
发明人： TOYODA MASAHIRO , TAKEUCHI SATOSHI
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/3643 , A61M1/3626 , A61M1/3644 , A61M1/3646 , A61M1/3649

15. 发明公开

EP2550984A4 BLOOD PURIFICATION DEVICE 有权
公开(公告)号：EP2550984A4
公开(公告)日：2015-03-18
申请号：EP11759506
申请日：2011-03-24
申请人： NIKKISO CO LTD
发明人： HASEGAWA SHINYA , TOYODA MASAHIRO
IPC分类号： A61M1/14 , A61M1/34
CPC分类号： A61M1/342 , A61M1/16 , A61M1/1601 , A61M1/1613 , A61M1/3431 , A61M1/3434 , A61M1/3441 , A61M1/3455 , A61M1/3462 , A61M1/3465 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M2205/3327 , A61M2205/3334 , A61M2205/3351 , A61M2230/207

16. 发明公开

EP1946782A4 BLOOD PURIFICATION APPARATUS AND METHOD OF COMPUTING RECIRCULATION RATIO THEREOF 有权
标题翻译：血液清洗装置和方法计算REZIRKULATIONSQUOTIENTEN
公开(公告)号：EP1946782A4
公开(公告)日：2010-10-06
申请号：EP06782381
申请日：2006-08-04
申请人： NIKKISO CO LTD
发明人： MURAKAMI TOMOYA , TOYODA MASAHIRO , MORI YOSHIHIRO
IPC分类号： A61M1/14
CPC分类号： A61M1/36 , A61M1/3612 , A61M1/3658 , A61M2230/207

17. 发明公开

EP1908486A4 APPARATUS FOR DIALYTIC THERAPY 有权
标题翻译： DIALYSETHERAPIEGERÄT
公开(公告)号：EP1908486A4
公开(公告)日：2010-05-19
申请号：EP06746616
申请日：2006-05-18
申请人： NIKKISO CO LTD
发明人： SUGIOKA AKIRA , MORI YOSHIHIRO , TOYODA MASAHIRO
IPC分类号： A61M1/14 , A61M1/16 , A61M1/36
CPC分类号： A61M1/16 , A61M1/1615 , A61M1/3663 , A61M2205/3306 , A61M2205/3331 , A61M2205/502 , A61M2205/52
摘要： [Problems] In a hemodialysis treatment, when there is a sudden decrease of a circulating blood volume variation rate (”BV) of a patient, the present invention is intended to provide a hemodialysis treatment apparatus capable of easily comparing ”BV with another vital sign different from ”BV, and easily determining whether or not ”BV is an omen of a shock symptom. [Means for solving problems] A hemodialysis treatment apparatus for carrying out a hemodialysis treatment by performing hemodialysis and ultrafiltration upon an extracorporeally-circulating blood of a patient comprising a circulating blood volume variation rate detecting means 10 for successively detecting a variation rate of a volume of circulating blood (”BV) of the patient as the hemodialysis treatment time passes, a vital sign detecting means 9 for successively detecting another vital sign different from the extracorporeally-circulating blood volume variation rate (”B.V) of the patient as the hemodialysis treatment time passes, and a display means 13 capable of displaying a value detected by the circulating blood volume variation rate detecting means 10 and a value detected by the vital sign detecting means 9 on a time basis on the identical screen 13a.

18. 发明专利

JP2010253130A Blood purifying apparatus and bubble removing method of the same 有权
标题翻译：血液净化装置及其相同的泡沫移除方法
公开(公告)号：JP2010253130A
公开(公告)日：2010-11-11
申请号：JP2009108581
申请日：2009-04-28
申请人： Nikkiso Co Ltd , 日機装株式会社
发明人： TOYODA MASAHIRO , TAKEUCHI SATOSHI
IPC分类号： A61M1/36 , A61M1/14 , B01D61/28 , B01D61/30
摘要： PROBLEM TO BE SOLVED: To provide a blood purifying apparatus capable of automatically removing bubbles stuck to the filtration net of a drip chamber and facilitating automation when shifting from priming to treatment, and its bubble removing method.
SOLUTION: At the end of priming, a control means 16 makes a pressure accumulation process of driving a blood pump 4 while closing a solenoid valve V6, supplying priming liquid from a priming liquid supply line Lc into a blood circuit, and turning the priming liquid to a pressure-accumulated state between the blood pump 4 and the solenoid valve V1 and a release process of opening the solenoid valve V6 and releasing the pressure-accumulated state of the priming liquid pressure-accumulated in the pressure accumulation process be performed, and bubbles stuck to the filtration net of the drip chamber 5 can be discharged from an overflow line 6.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：解决问题的方法：提供一种能够自动除去粘附在滴水室的过滤网上的气泡的血液净化装置，并且在从引发向处理转移时便于自动化，以及其除泡方法。解决方案：在起动结束时，控制装置16在关闭电磁阀V6的同时进行驱动血液泵4的压力累积过程，将起动液体从起动液体供给管线Lc供给到血液回路中，并且转动进入血液泵4与电磁阀V1之间的压力累积状态的启动液体和打开电磁阀V6的释放过程，释放在压力累积处理中累积的起动液体的压力累积状态，并且粘附到滴水室5的过滤网的气泡可以从溢流管线6排出。版权所有（C）2011，JPO＆INPIT

19. 发明专利

JP2010022701A Blood purifying apparatus 有权
标题翻译：血液净化装置
公开(公告)号：JP2010022701A
公开(公告)日：2010-02-04
申请号：JP2008189817
申请日：2008-07-23
申请人： Nikkiso Co Ltd , 日機装株式会社
发明人： AKITA KUNIHIKO , TOYODA MASAHIRO , MURAKAMI TOMOYA
IPC分类号： A61M1/14
摘要： PROBLEM TO BE SOLVED: To provide a blood purifying apparatus capable of precisely and easily calculating the real flow rate of blood extracorporeally circulating through blood circuits. SOLUTION: In the blood purifying apparatus including a blood circuit 1, a dialyzer 2 for purifying blood flowing through the blood circuit 1, change applying means for applying an artificial change (blood concentration) to the blood of a patient extracorporeally circulating through the blood circuit 1 and detection means including a first sensor 5a and a second sensor 5b both of which detect the applied blood concentration, the detection means includes a pair of the sensors provided so as to be separated from each other by a dimension L, measuring means 15 for measuring the time until the change of a blood index value detected by the first upstream sensor 5a is detected by the second downstream sensor 5b, and arithmetic means 16 for calculating the flow rate of the blood flowing through the blood circuit 1 by a predetermined arithmetic formula using the measured time (t), the spaced-apart dimension L of the sensors and the inner diameter D of the blood circuit 1 within the spaced-apart dimension L. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够精确且容易地计算通过血液回路体外循环的血液的实际流量的血液净化装置。解决方案：在包括血液回路1的血液净化装置中，用于净化血液循环1中流动的血液的透析器2，用于对体外循环通过的患者的血液进行人为改变（血液浓度）的改变施加装置血液回路1和检测装置包括检测所施加的血液浓度的第一传感器5a和第二传感器5b，所述检测装置包括一对传感器，所述一对传感器被设置成彼此分离尺寸L，用于测量由第二下游传感器5b检测到由第一上游传感器5a检测到的血液指标值的变化的时间的装置15以及用于计算通过血液回路1流过的血液的流量的算术装置16 使用测量时间（t）的预定算术公式，传感器的间隔尺寸L和血液回路1在间隔距离内的内径D 版权所有（C）2010，JPO＆INPIT

20. 发明专利

JP2009045307A Blood purifying apparatus 有权
标题翻译：血液净化装置
公开(公告)号：JP2009045307A
公开(公告)日：2009-03-05
申请号：JP2007215540
申请日：2007-08-22
申请人： Nikkiso Co Ltd , 日機装株式会社
发明人： MURAKAMI TOMOYA , TOYODA MASAHIRO , AGATA AKARI
IPC分类号： A61M1/14
CPC分类号： A61M1/3653 , A61M1/361 , A61M1/3612 , A61M1/3658
摘要： PROBLEM TO BE SOLVED: To provide a blood purifying apparatus capable of showing a clearer specific peak to be applied to blood, and surely detecting blood recirculation with good accuracy.
SOLUTION: The blood purifying apparatus includes a blood circuit 1, a blood pump 3, a dialyzer 2, a dialysate inducing line 7, a dialysate discharge line 8, a dual pump P, a pressure pump 11, blood concentration means, and detection means 5a, 5b to detect a specific peak applied by the blood concentration means. The blood concentration means is extended from between the pressure pump 11 in the dialysate discharge line 8 and the dual pump P, and has an air release line 13 whose end is to release the air and an electromagnetic valve 14 capable of opening/closing the air release line 13. Opening the air release line 13 by the electromagnetic valve 14 rapidly concentrates the blood running through the dialyzer 2 for a short time, and applies the specific peak to the blood.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够显示更清晰的比较峰值用于血液的血液净化装置，并且以高精度可靠地检测血液循环。解决方案：血液净化装置包括血液回路1，血液泵3，透析器2，透析液诱导线7，透析液排出管线8，双泵P，加压泵11，血液浓缩装置，以及检测装置5a，5b，以检测由血液浓度装置施加的特定峰值。血液浓度装置从透析液排出管线8中的压力泵11与双泵P之间延伸出来，并且具有一端释放空气的排气管13和能够打开/关闭空气的电磁阀14 释放线13.通过电磁阀14打开空气释放管线13快速浓缩通过透析器2的血液短时间，并将特定峰值应用于血液。版权所有（C）2009，JPO＆INPIT

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