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11. 发明申请

US20060246159A1 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
公开(公告)号：US20060246159A1
公开(公告)日：2006-11-02
申请号：US11406749
申请日：2006-04-19
申请人： Muraleedharan Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan Nair , Bolleddula Jayaprakasam
IPC分类号： A61K36/185
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source-of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.

12. 发明申请

US20060246158A1 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
标题翻译：环氧合酶-2抑制性脱脂素组合物及方法
公开(公告)号：US20060246158A1
公开(公告)日：2006-11-02
申请号：US11406630
申请日：2006-04-19
申请人： Muraleedharan Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan Nair , Bolleddula Jayaprakasam
IPC分类号： A61K36/185
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source-of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.
摘要翻译：描述了环加氧酶-2酶抑制卵磷脂。特别地，来自隐翅藻的化合物是去乙酸酯的优选来源，尽管它们可以来自其它植物来源。 COX-2抑制对COX-1具有选择性。

13. 发明申请

US20050267307A1 Novel anthraquinones and process for the preparation and method of use thereof 失效
标题翻译：新型蒽醌及其制备方法及其使用方法
公开(公告)号：US20050267307A1
公开(公告)日：2005-12-01
申请号：US11074227
申请日：2005-03-07
申请人： Muraleedharan Nair , Mugunthu Dhananjeyan , Michael Kron , Youli Milev
发明人： Muraleedharan Nair , Mugunthu Dhananjeyan , Michael Kron , Youli Milev
IPC分类号： C07C46/00 , C07C50/18 , C07C50/34
CPC分类号： C07C50/34 , C07C46/00
摘要： A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.
摘要翻译：描述了制备羟基取代的蒽醌的方法。该方法将邻苯二甲酸酐（取代或未取代的）与至少两个羟基取代的苯环部分结合。剩余的羟基在一些蒽醌中转化为甲氧基。该化合物特别可用于治疗寄生虫病。另外，使用蒽醌治疗或预防疟疾，丝虫病血吸虫病和其他寄生虫病的方法。

14. 发明申请

US20050037130A1 Method and compositions for producing berry derived products 审中-公开
标题翻译：用于生产浆果衍生产品的方法和组合物
公开(公告)号：US20050037130A1
公开(公告)日：2005-02-17
申请号：US10821581
申请日：2004-04-09
申请人： Muraleedharan Nair
发明人： Muraleedharan Nair
IPC分类号： A23L1/30 , A61K36/45 , A61K36/736 , B01D15/42 , A23L1/28
CPC分类号： A61K36/45 , A23L33/105 , A23L33/11 , A61K36/736 , A61K2300/00
摘要： A method for isolating a mixture of anthocyanins, bioflavonoids and phenolics from an edible berry using adsorbent resins which are regenerable for reuse is described. The mixture with a consumable carrier is particularly useful in foods and as a dietary supplement or nutraceutical product.
摘要翻译：描述了使用可再生再利用的吸附树脂从可食用浆果中分离花青素，生物类黄酮和酚类混合物的方法。与消耗性载体的混合物特别适用于食品和膳食补充剂或营养品。

15. 发明授权

US4803290A Nonanol/nonene antimicrobial compositions 失效
标题翻译：壬醇/壬烯抗菌组合物
公开(公告)号：US4803290A
公开(公告)日：1989-02-07
申请号：US55645
申请日：1987-05-29
申请人： Basil A. Burke , Muraleedharan Nair
发明人： Basil A. Burke , Muraleedharan Nair
IPC分类号： A01N43/30 , C07D317/50 , C07D317/54
CPC分类号： A01N43/30 , C07D317/50
摘要： Substituted 5'-nonanol/5'-nonene compounds which exhibit important antimicrobial and antifungal activity, compositions and methods of delivery against pathovars and pathogens, and methods of synthesis from commonly available reactants. The antimicrobial composition active ingredient is one or more substituted 1,2-alkylidenedioxybenzene compounds of the formula: ##STR1## where R.sub.3 is selected from 5'-nonanol and 5'-nonene, and R.sub.1 and R.sub.2 are selected from H and C.sub.1 -C.sub.5 alkyl, alkenyl and alkynyl groups. The preferred compounds are 5-(5'-hydroxy- 5'- nonanyl)-1,1-methylenedioxybenzene and 4-(5'-non-4'-enyl)-1,2-methylenedioxybenzene. Compositions including these compounds exhibit antimicrobial activity against a variety of pathogens and pathovars, e.g., Xanthomonas campestris spp. bacteria, antifungal activity against a variety of fungi and bacteria, and are highly specific, e.g., having antifungal activity against wheat powdery mildew and cucumber downy mildew, but do not affect seed germination or have appreciable herbicidal or insecticidal activity. Methods and compositions for delivery of these agents against such pathogens, and methods of chemical synthesis of the compounds are disclosed.
摘要翻译：表现出重要的抗微生物和抗真菌活性的替代的5'-壬醇/ 5'-壬烯化合物，对病原体和病原体递送的组合物和方法，以及通常可得到的反应物的合成方法。抗微生物组合物活性成分是一种或多种下式的取代的1,2-亚烷基二氧基苯化合物：其中R 3选自5'-壬醇和5'-壬烯，并且R 1和R 2选自H和C 1 -C 5 烷基，烯基和炔基。优选的化合物是5-（5'-羟基-5'-壬酰基）-1,1-亚甲二氧基苯和4-（5'-非-4'-烯基）-1,2-亚甲二氧基苯。包括这些化合物的组合物对各种病原体和病原体表现出抗菌活性，例如野油菜黄单胞菌（Xanthomonas campestris spp。）细菌，针对各种真菌和细菌的抗真菌活性，并且高度特异性，例如对小麦白粉病和黄瓜霜霉病具有抗真菌活性，但不影响种子萌发或具有明显的除草或杀虫活性。公开了用于递送这些试剂以抵抗这种病原体的方法和组合物，以及化合物的化学合成方法。

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