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    • 16. 发明授权
    • System and method for analyzing chromosomal states based on gene expression
    • 基于基因表达分析染色体状态的系统和方法
    • US08594940B2
    • 2013-11-26
    • US10983405
    • 2004-11-08
    • Makoto KanoTetsuo Shibuya
    • Makoto KanoTetsuo Shibuya
    • G01N33/48
    • G06F19/20
    • Analyzes chromosomal states based on amounts of expression of genes. An example apparatus comprising: a unit for storing probability distribution of amounts of expression of genes for each chromosomal state, assuming any of the chromosomal states in which the distributions of amounts of expression are different; a unit for supplying state transition probability indicating probability in which when each of the genes arrayed on the chromosome assumes any one of the chromosomal states, a certain gene array assumes any one of the chromosomal states; an input unit for receiving an expression amount measurement value of the amount of expression for each of the genes on the chromosome; and a unit for detecting a combination of the chromosomal states maximizing a probability among those that can be assumed by the genes on the chromosome, based on the probability distribution and the state transition probability.
    • 基于基因表达量分析染色体状态。 一种示例性装置,包括:假设任何一种表达量分布不同的染色体状态,存储每种染色体状态的基因表达量概率分布的单元; 提供状态转移概率的单位,其指示当染色体上排列的每个基因呈现染色体状态中的任一种时的概率,某个基因阵列呈现染色体状态中的任何一种; 用于接收染色体上每个基因的表达量的表达量测量值的输入单元; 以及用于检测染色体状态的组合的单元,其基于概率分布和状态转移概率来检测可以由染色体上的基因假定的染色体状态之间的概率最大化。