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11. 发明申请

US20060094743A1 Isoquinoline compounds and medicinal use thereof 有权
公开(公告)号：US20060094743A1
公开(公告)日：2006-05-04
申请号：US10536173
申请日：2003-11-21
申请人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
发明人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi , Taichi Takahashi
IPC分类号： A61K31/4745 , A61K31/4709 , C07D471/02 , C07D403/02
CPC分类号： C07D471/04 , A61K31/472 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5377 , C07D217/24 , C07D401/04 , C07D401/06 , C07D513/04
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.

12. 发明授权

US06468998B1 Pyrrolidine compounds and medicinal utilization thereof 失效
标题翻译：吡咯烷化合物及其药用
公开(公告)号：US06468998B1
公开(公告)日：2002-10-22
申请号：US09830718
申请日：2001-05-01
申请人： Takanobu Kuroita , Masakazu Fujio , Haruto Nakagawa
发明人： Takanobu Kuroita , Masakazu Fujio , Haruto Nakagawa
IPC分类号： C07D20714
CPC分类号： C07D451/02 , C07D207/14 , C07D453/02
摘要： The present invention provides a pyrrolidine compound of the formula (I) wherein each symbol is as defined in the specification, an optically active compound thereof and a pharmaceutically acceptable salt thereof. The present invention further provides a pharmaceutical composition containing a compound of the formula (I), an optically active compound thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable additive. The compound of the present invention has a serotonin 2 receptor antagonistic action along with a platelet aggregation suppressive action, a peripheral circulation improving action and a lacrimation promoting action. Therefore, the compound of the present invention can be a useful medicine showing effect against thrombotic embolism, dry eye and the like.
摘要翻译：本发明提供式（I）的吡咯烷化合物，其中各符号如说明书中所定义，其光学活性化合物及其药学上可接受的盐。本发明还提供含有式（I）化合物，其光学活性化合物或其药学上可接受的盐和药学上可接受的添加剂的药物组合物。本发明的化合物具有5-羟色胺2受体拮抗作用以及血小板聚集抑制作用，周围循环改善作用和流泪促进作用。因此，本发明的化合物可以是显示对血栓栓塞，干眼症等的效果的有用的药物。

13. 发明申请

US20120221324A1 Document Processing Apparatus 审中-公开
标题翻译：文件处理装置
公开(公告)号：US20120221324A1
公开(公告)日：2012-08-30
申请号：US13397497
申请日：2012-02-15
申请人： Kimiyoshi Machii , Kaoru Kawabata , Takeshi Yokota , Yoshiyuki Kobayashi , Masakazu Fujio
发明人： Kimiyoshi Machii , Kaoru Kawabata , Takeshi Yokota , Yoshiyuki Kobayashi , Masakazu Fujio
IPC分类号： G06F17/27
CPC分类号： G06F17/2785 , G06F16/3344
摘要： In a text document processing apparatus, there is provided standard knowledge network data composed of networked phrases having strong mutual relation to each other, the phrases being selected from a knowledge field including contents of a text document to be examined. In addition, there is provided a document knowledge preparing function that prepares knowledge network data of the document to be examined, the knowledge network data being composed of networked phrases having strong mutual relation to each other, the phrases being selected from the text document. Further, a processing unit that checks a specified word constituting the knowledge network data of the document to be examined and a standard knowledge network data, and in a case when information of phrases which are networked to the specified word are different from each other, outputs difference information including information of the specified word.
摘要翻译：在文本文档处理装置中，提供由彼此之间具有强相互关系的网络短语组成的标准知识网络数据，该短语从包括要检查的文本文档的内容的知识字段中选择。此外，提供了一种准备要检查的文档的知识网络数据的文档知识准备功能，知识网络数据由彼此之间具有强相互关系的网络短语组成，短语从文本文档中选择。此外，检查构成待检查文档的知识网络数据的特定单词和标准知识网络数据的处理单元，并且在与指定单词联网的短语的信息彼此不同的情况下，输出差异信息包括指定字的信息。

14. 发明授权

US07812178B2 Isoquinoline compound and pharmaceutical use thereof 有权
标题翻译：异喹啉化合物及其药物用途
公开(公告)号：US07812178B2
公开(公告)日：2010-10-12
申请号：US12263963
申请日：2008-11-03
申请人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi
发明人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi
IPC分类号： C07D405/00 , C07D207/00 , C07D207/40
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译：本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。其中符号与描述中定义的相同。

15. 发明授权

US07459465B2 Isoquinoline compound and pharmaceutical use thereof 有权
标题翻译：异喹啉化合物及其药物用途
公开(公告)号：US07459465B2
公开(公告)日：2008-12-02
申请号：US11688103
申请日：2007-03-19
申请人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi
发明人： Masakazu Fujio , Hiroyuki Satoh , Shinya Inoue , Toshifumi Matsumoto , Yasuhiro Egi
IPC分类号： C07D403/02 , A61K31/47
CPC分类号： C07D401/04 , A61K31/4725 , C07D207/12 , C07D401/06 , C07D405/06
摘要： The present invention relates to an isoquinoline compound represented by the following formula (I), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. Furthermore, this compound is useful as a prophylactic and/or therapeutic agent that improves neurological symptoms associated with cerebral infarction, particularly acute cerebral infarction. wherein the symbols are the same as defined in the description.
摘要翻译：本发明涉及由下式（I）表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和溶剂化物，以及预防药物和/或治疗由含有该化合物的聚（ADP-核糖）聚合酶和含该化合物的聚（ADP-核糖）聚合酶抑制剂）的高反应性引起的疾病。此外，该化合物可用作预防和/或治疗脑梗塞的药剂，特别是作为预防和/或治疗急性脑梗死的药物。此外，该化合物可用作改善与脑梗死特别是急性脑梗死相关的神经症状的预防和/或治疗剂。其中符号与描述中定义的相同。

16. 发明授权

US08774705B2 Learning support system and learning support method 有权
标题翻译：学习支持系统和学习支持方法
公开(公告)号：US08774705B2
公开(公告)日：2014-07-08
申请号：US13523324
申请日：2012-06-14
申请人： Ryuji Mine , Takeshi Nagasaki , Masakazu Fujio
发明人： Ryuji Mine , Takeshi Nagasaki , Masakazu Fujio
IPC分类号： G09B9/00 , G06F17/30
CPC分类号： G09B7/02
摘要： In order to provide questions suited to skill levels of a learner, it is provided a learning support system which consists of a computer including a processor and a memory, comprising: a question database; a question generator; an answer acquisition module; a scoring module and an achievement degree estimator. The achievement degree estimator compares a number of types of perturbation within the questions to which a correct answer has been given with a predetermined second threshold value. The question generator generates a word changed in accordance with the perturbation of a different type in a case where the number of types of perturbation within the questions to which the correct answer has been given is smaller than the predetermined second threshold value, and sets a question relating to the generated word as a candidate for the question.
摘要翻译：为了提供适合于学习者的技能水平的问题，提供了一种由包括处理器和存储器的计算机组成的学习支持系统，包括：问题数据库; 问题生成器答案采集模块; 评分模块和成就度量估计器。成就度估计器将已经给出正确答案的问题中的扰动类型的数量与预定的第二阈值进行比较。在已经给出正确答案的问题中的扰动类型的数量小于预定的第二阈值的情况下，问题生成器生成根据不同类型的扰动而改变的单词，并且设置问题将所生成的词作为该问题的候选者。

17. 发明授权

US08309573B2 Salt of isoquinoline compound and crystal thereof 有权
标题翻译：异喹啉化合物的盐及其结晶
公开(公告)号：US08309573B2
公开(公告)日：2012-11-13
申请号：US12672784
申请日：2008-08-08
申请人： Masakazu Fujio , Toshihiko Tanaka , Hisao Takayanagi , Hiroyuki Satoh , Takanori Ito
发明人： Masakazu Fujio , Toshihiko Tanaka , Hisao Takayanagi , Hiroyuki Satoh , Takanori Ito
IPC分类号： A61K31/47 , C07D217/22
CPC分类号： C07D403/06 , C07D401/06
摘要： The invention provides a salt of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one and a crystal thereof. (R)-3-[2-(2-Hydroxymethylpyrrolidin-1-ypethyl]-5-methyl-2H-1-isoquinolin-1-one monophosphate is a compound which is chemically stable, has high solubility, and shows less weight change due to humidity as compared to a free form and monohydrochloride dihydrate, and is superior as a bulk drug for pharmaceutical products.
摘要翻译：本发明提供（R）-3- [2-（2-羟甲基吡咯烷-1-基）乙基] -5-甲基-2H-异喹啉-1-酮及其结晶的盐。（R）-3- [2-（2-羟甲基吡咯烷-1-基乙基）-5-甲基-2H-1-异喹啉-1-酮单磷酸酯是一种化学稳定的化合物，溶解度高，重量变化较小由于与游离形式和单盐酸盐二水合物相比的湿度，并且作为药物的主要药物是优异的。

18. 发明授权

US07590651B2 Search apparatus 有权
标题翻译：搜索装置
公开(公告)号：US07590651B2
公开(公告)日：2009-09-15
申请号：US11501117
申请日：2006-08-09
申请人： Masakazu Fujio , Yoshiki Niwa , Shigeo Sumino
发明人： Masakazu Fujio , Yoshiki Niwa , Shigeo Sumino
IPC分类号： G06F17/30
CPC分类号： G06F17/30398 , G06F17/30392 , G06F17/30395 , Y10S707/99933 , Y10S707/99934 , Y10S707/99935 , Y10S707/99936 , Y10S707/99943 , Y10S707/99945
摘要： The setting of a search condition is supported. Databases 130 and 140 store use frequency information about search conditions, co-occurrence frequency information between search conditions, relationship information unique to a particular field, use history information for each search condition, and simultaneous use history information. Based on a search condition that is already set, the database are referred to so as to calculate the recommendation level of other search conditions, and search conditions that have high recommendation levels and that are likely to be used simultaneously with the already-set search condition are arranged at conspicuous positions. The recommendation level is calculated based on the value of a co-occurrence frequency between search conditions, the history of simultaneous setting, or the estimated number of search results, for example.
摘要翻译：支持搜索条件的设置。数据库130和140存储关于搜索条件的使用频率信息，搜索条件之间的共现频率信息，特定字段唯一的关系信息，每个搜索条件的使用历史信息和同时使用历史信息。基于已经设置的搜索条件，参考数据库来计算其他搜索条件的推荐级别，以及具有高推荐级别并且可能与已经设置的搜索条件同时使用的搜索条件被安排在显眼位置。例如，基于搜索条件，同时设置的历史或估计的搜索结果的数量之间的同现频率的值来计算推荐级别。

19. 发明申请

US20130052630A1 LEARNING SUPPORT SYSTEM AND LEARNING SUPPORT METHOD 有权
标题翻译：学习支持系统和学习支持方法
公开(公告)号：US20130052630A1
公开(公告)日：2013-02-28
申请号：US13523324
申请日：2012-06-14
申请人： Ryuji MINE , Takeshi Nagasaki , Masakazu Fujio
发明人： Ryuji MINE , Takeshi Nagasaki , Masakazu Fujio
IPC分类号： G09B9/00 , G06F17/30
CPC分类号： G09B7/02
摘要： In order to provide questions suited to skill levels of a learner, it is provided a learning support system which consists of a computer including a processor and a memory, comprising: a question database; a question generator; an answer acquisition module; a scoring module and an achievement degree estimator. The achievement degree estimator compares a number of types of perturbation within the questions to which a correct answer has been given with a predetermined second threshold value. The question generator generates a word changed in accordance with the perturbation of a different type in a case where the number of types of perturbation within the questions to which the correct answer has been given is smaller than the predetermined second threshold value, and sets a question relating to the generated word as a candidate for the question.
摘要翻译：为了提供适合于学习者的技能水平的问题，提供了一种由包括处理器和存储器的计算机组成的学习支持系统，包括：问题数据库; 问题生成器答案采集模块; 评分模块和成就度量估计器。成就度估计器将已经给出正确答案的问题中的扰动类型的数量与预定的第二阈值进行比较。在已经给出正确答案的问题中的扰动类型的数量小于预定的第二阈值的情况下，问题生成器生成根据不同类型的扰动而改变的单词，并且设置问题将所生成的词作为该问题的候选者。

20. 发明申请

US20070276857A1 Search apparatus 有权
标题翻译：搜索装置
公开(公告)号：US20070276857A1
公开(公告)日：2007-11-29
申请号：US11501117
申请日：2006-08-09
申请人： Masakazu Fujio , Yoshiki Niwa , Shigeo Sumino
发明人： Masakazu Fujio , Yoshiki Niwa , Shigeo Sumino
IPC分类号： G06F7/00
CPC分类号： G06F17/30398 , G06F17/30392 , G06F17/30395 , Y10S707/99933 , Y10S707/99934 , Y10S707/99935 , Y10S707/99936 , Y10S707/99943 , Y10S707/99945
摘要： The setting of a search condition is supported. Databases 130 and 140 store use frequency information about search conditions, co-occurrence frequency information between search conditions, relationship information unique to a particular field, use history information for each search condition, and simultaneous use history information. Based on a search condition that is already set, the database are referred to so as to calculate the recommendation level of other search conditions, and search conditions that have high recommendation levels and that are likely to be used simultaneously with the already-set search condition are arranged at conspicuous positions. The recommendation level is calculated based on the value of a co-occurrence frequency between search conditions, the history of simultaneous setting, or the estimated number of search results, for example.
摘要翻译：支持搜索条件的设置。数据库130和140存储关于搜索条件的使用频率信息，搜索条件之间的共现频率信息，特定字段唯一的关系信息，每个搜索条件的使用历史信息和同时使用历史信息。基于已经设置的搜索条件，参考数据库来计算其他搜索条件的推荐级别，以及具有高推荐级别并且可能与已经设置的搜索条件同时使用的搜索条件被安排在显眼位置。例如，基于搜索条件，同时设置的历史或估计的搜索结果的数量之间的同现频率的值来计算推荐级别。

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