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11. 发明申请

US20130240357A1 METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS 有权
标题翻译：用于单分子全基因组分析的方法和设备
公开(公告)号：US20130240357A1
公开(公告)日：2013-09-19
申请号：US13765353
申请日：2013-02-12
申请人： Ming Xiao , Han Cao
发明人： Ming Xiao , Han Cao
IPC分类号： G06F19/18
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g. determining structural variations and copy number variations between individuals.
摘要翻译：提供单分子基因组分析的方法和装置。在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。这些方法在例如，确定个体之间的结构变化和复制数量变化。

12. 发明申请

US20130072386A1 PHYSICAL MAP CONSTRUCTION OF WHOLE GENOME AND POOLED CLONE MAPPING IN NANOCHANNEL ARRAY 审中-公开
标题翻译： NANOCHANNEL ARRAY全基因组和重叠克隆映射的物理地图构建
公开(公告)号：US20130072386A1
公开(公告)日：2013-03-21
申请号：US13606819
申请日：2012-09-07
申请人： Ming Xiao , Alex Hastie
发明人： Ming Xiao , Alex Hastie
IPC分类号： C40B20/00 , C40B60/10
CPC分类号： G01N33/5302 , C12Q1/6869 , C12Q2563/157 , C12Q2565/133 , C12Q2565/631
摘要： Methods for generating physical maps for polynucleotides, such as genomic DNA, are disclosed herein. Also disclosed are methods for identifying the source of polynucleotides. The methods can, for example, be used in physical map construction of whole genome. In addition, methods and systems capable of performing high throughput characterization of macromolecules using nanofludic devices are enclosed.
摘要翻译：用于产生多核苷酸的物理图谱的方法，例如基因组DNA，在此公开。还公开了用于鉴定多核苷酸的来源的方法。该方法可以例如用于全基因组的物理图谱构建。另外，封装了能够使用纳米包装装置进行大分子高通量表征的方法和系统。

13. 发明授权

US07829278B2 Polynucleotide barcoding 有权
标题翻译：多核苷酸条形码
公开(公告)号：US07829278B2
公开(公告)日：2010-11-09
申请号：US10976546
申请日：2004-10-28
申请人： Paul R. Selvin , Matthew Gordon , Pui-Yan Kwok , Ming Xiao , Ting-Fung Chan
发明人： Paul R. Selvin , Matthew Gordon , Pui-Yan Kwok , Ming Xiao , Ting-Fung Chan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q1/6827
摘要： A polynucleotide is barcoded using a method whereby an isolated, individual polynucleotide is immobilized on a solid phase and stretched, targets are labeled using target-specific hybridization probes, and an individual label of an unamplified probe at each of the labeled targets is optically detected. The order of the labels is determined to form a barcode representation of the polynucleotide wherein the targets and their relative positions are represented.
摘要翻译：使用这样一种方法对多核苷酸进行条形码化，由此将分离的单个多核苷酸固定在固相上并拉伸，使用靶特异性杂交探针对靶进行标记，并光学检测每个标记靶上的未扩增探针的单个标记。确定标签的顺序以形成多核苷酸的条形码表示，其中表示靶标及其相对位置。

14. 发明申请

US20060163241A1 Scented wax heating device 审中-公开
标题翻译：香味蜡加热装置
公开(公告)号：US20060163241A1
公开(公告)日：2006-07-27
申请号：US11042728
申请日：2005-01-24
申请人： Ming Xiao
发明人： Ming Xiao
IPC分类号： F27D11/00
CPC分类号： A61L9/03
摘要： The present invention discloses a scented wax heating device, which includes a heating cylinder, an electric wire, and a ceramic heating piece installed at the bottom of the heating cylinder. The heating cylinder is installed in an insulating cylinder for an insulating effect, so that a user can freely move the heating device. The heating cylinder is filled with appropriate amount of water, and the scented wax is put into the heating cylinder. The heating cylinder is heated by the ceramic heating piece, so that the temperature of water in the heating cylinder rises to evenly vaporize the scented wax. The invention features a simple structure and a useful function.
摘要翻译：本发明公开了一种香味蜡加热装置，其包括加热缸，电线和安装在加热缸底部的陶瓷加热片。加热缸安装在绝缘筒中，用于隔热效果，使得使用者可以自由地移动加热装置。加热缸内装满适量的水，将香味蜡放入加热缸内。加热缸被陶瓷加热片加热，使得加热缸内的水温上升，从而使香味蜡均匀蒸发。本发明具有简单的结构和有用的功能。

15. 发明授权

US11923463B2 Power Schottky barrier diodes with high breakdown voltage and low leakage current 有权
公开(公告)号：US11923463B2
公开(公告)日：2024-03-05
申请号：US17244394
申请日：2021-04-29
申请人： Yuhao Zhang , Ming Xiao
发明人： Yuhao Zhang , Ming Xiao
IPC分类号： H01L29/872 , H01L29/06 , H01L29/20 , H01L29/205 , H01L29/417 , H01L29/66
CPC分类号： H01L29/872 , H01L29/0688 , H01L29/2003 , H01L29/205 , H01L29/417 , H01L29/66212
摘要： This disclosure provides a diode including a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type. The diode also includes a plurality of sidewalls exposed in the semiconductor region defining at least one trench extending through the at least one two-dimensional carrier channel and a material of a second conductivity type, the second conductivity type being the other of the n-type and the p-type conductivity, disposed on the plurality of sidewalls and in contact with the at least one two-dimensional carrier channel. The diode also includes an anode material in contact with at least a portion of the semiconductor region and in contact with at least a portion of the material of the second conductivity type, and a cathode material in contact with the at least one two-dimensional carrier channel.

16. 发明申请

US20120237936A1 METHODS AND RELATED DEVICES FOR SINGLE MOLECULE WHOLE GENOME ANALYSIS 审中-公开
标题翻译：用于单分子全基因组分析的方法和相关设备
公开(公告)号：US20120237936A1
公开(公告)日：2012-09-20
申请号：US13503307
申请日：2010-10-21
申请人： Ming Xiao , Someskumar Das
发明人： Ming Xiao , Someskumar Das
IPC分类号： G01N21/64 , C12M1/34
CPC分类号： C12Q1/683 , G01N21/6486 , C12Q2563/107 , C12Q2561/109 , C12Q2537/137 , C12Q2563/185 , C12Q2535/131
摘要： Provided are methods of labeling and analyzing features along at least one macro molecule such as a linear biopolymer, including methods of mapping the distribution and frequency of specific sequence motifs or the chemical or proteomic modification state of such sequence motifs along individual unfolded nucleic acid molecules. The present invention also provides methods of identifying signature patterns of sequence or epigenetic variations along such labeled macro molecules for direct massive parallel single molecule level analysis. The present invention also provides systems suitable for high throughput analysis of such labeled macro mo lecules.
摘要翻译：提供了沿着沿着至少一个宏观分子（例如线性生物聚合物）标记和分析特征的方法，包括将特定序列基序的分布和频率或沿着各个未折叠核酸分子的这种序列基序的化学或蛋白质组修饰状态映射的方法。本发明还提供了鉴定用于直接大规模并行单分子水平分析的沿着这种标记的宏分子的序列或表观遗传变异的特征图案的方法。本发明还提供了适用于这种标记的宏观移动体的高通量分析的系统。

17. 发明申请

US20110306504A1 POLYNUCLEOTIDE MAPPING AND SEQUENCING 有权
标题翻译：多核苷酸映射和测序
公开(公告)号：US20110306504A1
公开(公告)日：2011-12-15
申请号：US13129634
申请日：2009-11-18
申请人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
发明人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
IPC分类号： C40B20/08 , C40B40/06 , C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6874 , C12Q1/68 , C12Q1/6806 , C12Q1/6869 , C12Q2565/133 , C12Q2565/1025 , C12Q2521/301 , C12Q2563/107 , C12Q2535/101
摘要： The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
摘要翻译：本发明提供获得关于生物聚合物样品的结构信息的方法。所述方法包括在一些情况下标记生物聚合物（例如DNA或RNA）的部分线性化生物聚合物，并确定标签之间的距离。然后，用户可以比较不同样品的标记间距离，以定性比较不同的样品，并测定给定的样品，用于在标签侧翼的区域中添加或缺失核苷酸。该方法还允许对生物聚合物进行测序。

18. 发明申请

US20070108691A1 Accumulation system for processing media items of various sizes and types 审中-公开
标题翻译：用于处理各种尺寸和类型的介质物品的累积系统
公开(公告)号：US20070108691A1
公开(公告)日：2007-05-17
申请号：US11274794
申请日：2005-11-15
申请人： Thomas Lyga , Ming Xiao , Joseph Gelb , Michael Chen , James Fairweather , James Salomon
发明人： Thomas Lyga , Ming Xiao , Joseph Gelb , Michael Chen , James Fairweather , James Salomon
IPC分类号： B65H5/22
CPC分类号： B65H39/10 , B65H31/20 , B65H31/3027 , B65H31/3081 , B65H2301/4213 , B65H2301/42262 , B65H2301/42266 , B65H2511/10 , B65H2220/01 , B65H2220/04
摘要： An accumulator system and method for collating a plurality of media items wherein the media items enter in seriatim at an media item entry point and become at least partially overlapped with each other at a media item exit point. A media item transport path connects the media item entry point and the media item exit point. A moveable member is mounted along the media item transport path between the entry point and the exit point. The moveable member forms part of a pocket into which media items are moved to create a collation of media items. The moveable member is moveable to change the size of the pocket. A protective member may be mounted to the moveable member and positioned to protect the trailing edge of media items in the pocket from the leading edge of media items to thereafter be moved into the pocket. The media item may be aligned in the collation position when moving the protective member to a media item trailing edge protective position. The transport means for media items can be controlled to partially move a media item along an exit path beyond the collation position. Media items of different lengths can be formed as part of the collation at the collation position with the trailing edge of the media items aligned.
摘要翻译：一种用于整理多个媒体项目的累加器系统和方法，其中媒体项目在媒体项目入口点处串行进入，并且在媒体项目出口点处彼此至少部分地重叠。媒体项目传输路径连接媒体项目入口点和媒体项目出口点。可移动构件沿入口点和出口点之间的介质物品传送路径安装。可移动构件形成口袋的一部分，媒体物品移动到该口袋中以创建媒体项目的整理。可移动构件可移动以改变口袋的尺寸。保护构件可以安装到可移动构件并且被定位成保护袋中的介质物品的后缘与介质物品的前缘之间，然后移动到袋中。当将保护构件移动到介质物品后缘保护位置时，介质物品可以对准排列位置。可以控制用于媒体物品的传送装置，以便沿着出口路径部分移动媒体物品超过整理位置。不同长度的媒体项目可以形成为对照位置处的对照的一部分，其中媒体物品的后缘对齐。

19. 发明申请

US20050170949A1 Polyethylene catalyst and a process for preparing the same 有权
标题翻译：聚乙烯催化剂及其制备方法
公开(公告)号：US20050170949A1
公开(公告)日：2005-08-04
申请号：US11003236
申请日：2004-12-03
申请人： Ming Xiao , Shijiong Yu , Xiaofeng Ye
发明人： Ming Xiao , Shijiong Yu , Xiaofeng Ye
IPC分类号： B01J31/00 , B01J31/02 , B01J31/12 , B01J31/14 , C08F4/645 , C08F10/00 , C08F110/02
CPC分类号： B01J31/0211 , B01J31/068 , B01J31/122 , B01J31/128 , B01J31/143 , B01J2231/122 , B01J2531/22 , B01J2531/31 , B01J2531/46 , C08F10/00 , C08F110/02 , C08F4/6555 , C08F2500/18 , C08F2500/12
摘要： The present invention discloses a polyethylene catalyst and a process for preparing the same, said catalyst being composed of a main component of catalyst and a cocatalyst, wherein the main component of catalyst is prepared by reacting: (1) a magnesium-alcohol complex, (2) an alkyl aluminum compound having a formula R3nAlCl3-n supported on silica, and (3) a titanium compound having a formula Ti(OR2)mCl4-m, and the cocatalyst is an organic aluminum compound. The catalyst of the present invention has advantages including high polymerization activity, less difference between the polymerization activities at low hydrogen level condition and at high hydrogen level condition, stable polymerization reaction, good particle morphology of catalyst, and less fine powder of polymer product.
摘要翻译：本发明公开了一种聚乙烯催化剂及其制备方法，所述催化剂由催化剂的主要成分和助催化剂组成，其中催化剂的主要成分是通过使（1）镁 - 醇络合物，（ 2）负载在二氧化硅上的具有式R 3 3 AlCl 3-n N的烷基铝化合物，和（3）具有配方Ti（OR 2）3 Cl 4-m，助催化剂是有机铝化合物。本发明的催化剂具有聚合活性高，氢气低条件下的聚合活性与高氢水平条件下的差异小，聚合反应稳定，催化剂粒子形态好，聚合物产品细微粉末等优点。

20. 发明授权

US06441892B2 Compact spectrofluorometer 有权
标题翻译：紧凑型荧光分光光度计
公开(公告)号：US06441892B2
公开(公告)日：2002-08-27
申请号：US09813325
申请日：2001-03-19
申请人： Ming Xiao
发明人： Ming Xiao
IPC分类号： G01N2164
CPC分类号： G01J3/26 , G01J3/02 , G01J3/0294 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423
摘要： Spectrofluorometer employing a pair of linear variable spectral filters to produce a three dimensional data output is disclosed. A collimated white light source is used that first passes through a first linear variable spectral filter, then through a sample where fluorescence occurs, then the resultant light passes through a second linear variable spectral light filter that is oriented at ninety degrees from the first filter. The light is then detected by a CCD sensor for conversion into data. This arrangement provides a very simple, rugged and compact instrument that can be used almost anywhere, such as at the scene of a contamination accident.
摘要翻译：公开了使用一对线性可变光谱滤波器产生三维数据输出的分光荧光计。使用准直的白光源，其首先通过第一线性可变光谱滤光器，然后通过荧光发生的样品，然后所得光通过从第一滤光器定向成90度的第二线性可变光谱滤光器。然后由CCD传感器检测光转换成数据。这种安排提供了一种非常简单，坚固耐用的紧凑型仪器，可以在几乎任何地方使用，例如在污染事故现场。

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