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11. 发明授权

US06764686B2 Modified immunogenic pneumolysin compositions as vaccines 失效
标题翻译：修饰的免疫原性肺炎溶蛋白组合物作为疫苗
公开(公告)号：US06764686B2
公开(公告)日：2004-07-20
申请号：US09120044
申请日：1998-07-21
申请人： Conceicao Minetti , Francis Michon , Jeffrey K. Pullen , Mary Ellen Polvino-Bodnar , Shu-Mei Liang , Joseph Y. Tai
发明人： Conceicao Minetti , Francis Michon , Jeffrey K. Pullen , Mary Ellen Polvino-Bodnar , Shu-Mei Liang , Joseph Y. Tai
IPC分类号： A61K3902
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/6037 , Y10S424/831 , Y10S530/825
摘要： This invention relates to modified pneumolysin polypeptides that retain the immunogenic nature of pneumolysin but have reduced or undetectable hemolytic activity compared to native pneumolysin. The invention also provides a method for generating novel pneumolysin variants with these desired characteristic properties. The invention also provides immunogenic compositions useful as pharmaceutical compositions including vaccines in which non-toxic, modified pneumolysin is used to stimulate protective immunity against Streptococcus pneumoniae. The vaccines may be compositions in which the modified pneumolysin is conjugated to bacterial polysaccharides or may be carried on an attenuated viral vector. In addition, the invention also provides a method of using the non-toxic, modified pneumolysin toxoid in order to stimulate antibodies against Streptococcus pneumoniae in a treated individual which are then isolated and transferred to a second individual, thereby conferring protection against Streptococcus pneumoniae in the second individual.
摘要翻译：本发明涉及与天然气溶素相比，保留免疫原性的气溶菌素的修饰的气溶胶素多肽，但具有降低的或不可检测的溶血活性。本发明还提供了一种产生具有这些所需特征性质的新型肺炎球菌变异体的方法。本发明还提供可用作药物组合物的免疫原性组合物，包括其中无毒的改良的肺炎溶血杆菌刺激对肺炎链球菌的保护性免疫的疫苗。疫苗可以是其中改性气溶胶与细菌多糖缀合或可以携带在减毒病毒载体上的组合物。此外，本发明还提供了一种使用无毒的改良型肺炎杆菌素类毒素以刺激处理的个体中针对肺炎链球菌的抗体的方法，然后将其分离并转移到第二个体中，从而在肺炎链球菌中得到保护第二个人。

12. 发明授权

US06372222B1 Antigenic group B Streptococcus type II and type III polysaccharide fragments having a 2, 5-anhydro-D-mannose terminal structure and conjugate vaccine thereof 失效
标题翻译：抗原组B型II型链球菌和具有2,5-脱水-D-甘露糖末端结构的III型多糖片段及其结合疫苗
公开(公告)号：US06372222B1
公开(公告)日：2002-04-16
申请号：US09025225
申请日：1998-02-18
申请人： Francis Michon , Catherine Uitz , Joseph Y. Tai
发明人： Francis Michon , Catherine Uitz , Joseph Y. Tai
IPC分类号： A61K39385
CPC分类号： A61K39/092 , A61K39/08 , A61K47/646 , C08B37/006 , Y10S424/831
摘要： The process for depolymerizing Group B Types II and III Streptococcal Polysaccharide is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to protein. Conjugate molecules, vaccines and their use to immunize mammals including humans are also disclosed.
摘要翻译：公开了B型II型和III型链球菌多糖的解聚方法，其导致具有适于与蛋白质缀合的还原末端的多糖片段。还公开了缀合物分子，疫苗及其用于免疫包括人在内的哺乳动物的用途。

13. 发明授权

US5425946A Vaccines against group C Neisseria meningitidis 失效
标题翻译：疫苗针对C组脑膜炎奈瑟氏球菌
公开(公告)号：US5425946A
公开(公告)日：1995-06-20
申请号：US938367
申请日：1992-08-31
申请人： Joseph Y. Tai , Lucjan J. J. Hronowski , Sharon Mates
发明人： Joseph Y. Tai , Lucjan J. J. Hronowski , Sharon Mates
IPC分类号： A61K39/095 , G01N33/68 , C07K1/10
CPC分类号： A61K39/095 , G01N33/6854 , A61K2039/6037 , Y10S530/807
摘要： An immunogenic conjugate comprising a modified group C meningococcal polysaccharide (GCMP) coupled to a carrier molecule. The GCMP is modified by O-deacetylation to a varying extent. This modified GCMP conjugate stimulates a strong immunogenic response. The antiserum, produced by immunization with this conjugate, is cross-reactive with the native polysaccharide. In addition, these antisera elicit a class of antibodies that have patent bactericidal activity.
摘要翻译：包含与载体分子偶联的修饰的C组脑膜炎球菌多糖（GCMP）的免疫原性缀合物。通过O-去乙酰化可以改变GCMP的程度。该修饰的GCMP缀合物刺激强的免疫原性反应。通过用该缀合物免疫产生的抗血清与天然多糖交叉反应。此外，这些抗血清引起一类具有专利杀菌活性的抗体。

14. 发明授权

US4459286A Coupled H. influenzae type B vaccine 失效
标题翻译： B型流感嗜血杆菌疫苗
公开(公告)号：US4459286A
公开(公告)日：1984-07-10
申请号：US462594
申请日：1983-01-31
申请人： Maurice R. Hilleman , Joseph Y. Tai , Richard L. Tolman , Philip P. Vella
发明人： Maurice R. Hilleman , Joseph Y. Tai , Richard L. Tolman , Philip P. Vella
IPC分类号： A61K39/095 , A61K39/102 , A61K39/40 , C07G7/00
CPC分类号： A61K39/095 , A61K39/102 , A61K2039/6068 , A61K2039/627 , Y10S530/806 , Y10S530/807 , Y10S530/825
摘要： Haemophilus influenzae type B polysaccharide is coupled through a spacer to a serotype outer membrane protein from Neisseria meningitidis. This conjugate has enhanced antigenicity and immunogenicity relative to the unconjugated polysaccharide.
摘要翻译：流感嗜血杆菌B型多糖通过间隔物与来自脑膜炎奈瑟球菌的血清型外膜蛋白偶联。该缀合物相对于非共轭多糖具有增强的抗原性和免疫原性。

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