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11. 发明申请

WO2013171501A2 ORTHOGONAL ACCELERATION COAXIAL CYLINDER TIME OF FLIGHT MASS ANALYSER 审中-公开
标题翻译：飞行质量分析仪的正交加速同轴气缸时间
公开(公告)号：WO2013171501A2
公开(公告)日：2013-11-21
申请号：PCT/GB2013/051271
申请日：2013-05-16
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , G01N2223/506 , H01J49/0031 , H01J49/405 , H01J49/406 , H01J49/408
摘要： A Time of Flight mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. The ions are then orthogonally accelerated ions from the first annular ion guide section into the second annular ion guide section. An ion detector is disposed within the annular ion guide and has an ion detecting surface arranged in a plane which is substantially perpendicular to the longitudinal axis.
摘要翻译：公开了一种飞行时间质量分析器，其包括具有纵向轴线的环形离子引导件，并且包括第一环形离子引导部分和第二环形离子引导部分。离子被引入到第一环形离子引导部分中，使得离子在第一环形离子引导部分内围绕纵向轴线形成基本上稳定的圆周轨道。然后离子是从第一环形离子引导部分到第二环形离子引导部分的正交加速离子。离子检测器设置在环形离子引导件内，并且具有布置在基本上垂直于纵向轴线的平面中的离子检测表面。

12. 发明申请

WO2020188236A1 MULTIPLEXED TIME OF FLIGHT MASS SPECTROMETER 审中-公开
公开(公告)号：WO2020188236A1
公开(公告)日：2020-09-24
申请号：PCT/GB2020/050471
申请日：2020-02-27
申请人： MICROMASS UK LIMITED
发明人： WILDGOOSE, Jason Lee , HOYES, John Brian , DENNY, Richard
IPC分类号： H01J49/00 , H01J49/40
摘要： A method of time of flight (ToF) mass spectrometry comprising: pushing ions into a ToF mass analyser in a plurality of pushes, wherein the time spacing between adjacent pushes is shorter than either the longest flight time, or the range of flight times, of the ions; detecting the ions so as to obtain spectral data; decoding the spectral data to determine first mass spectral data relating to ions pushed into the ToF mass analyser by a first plurality of the pushes (P1-P4), and allocating this first mass spectral data to a first time stamp (t1); and decoding the spectral data to determine second mass spectral data relating to ions pushed into the ToF mass analyser by a second plurality of the pushes (P5-P8), and allocating this second mass spectral data to a second time-stamp (t2); wherein the first and second time-stamps have a time difference therebetween that is shorter than said longest flight time, or said range of flight times (4), in the ToF mass analyser.

13. 发明申请

WO2016178029A1 OVERSAMPLED TIME OF FLIGHT MASS SPECTROMETRY 审中-公开
标题翻译：超大型飞行时间
公开(公告)号：WO2016178029A1
公开(公告)日：2016-11-10
申请号：PCT/GB2016/051304
申请日：2016-05-06
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , DENNY, Richard , WILDGOOSE, Jason Lee , NIXON, Peter
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/40 , H01J49/0031 , H01J49/004
摘要： A method of mass spectrometry is disclosed comprising passing ions to an oversampled Time of Flight mass analyser (4) and sequentially recording ion signals on a plurality of different channels (51, 52) to obtain a plurality of first oversampled mass spectral data sets of reduced complexity. An upstream separation device (3) may be provided to further reduce the complexity of each of the mass spectral data sets.
摘要翻译：公开了一种质谱法，其包括使离子进入过取样的飞行时间质量分析器（4）并在多个不同通道（51,52）上依次记录离子信号，以获得多个第一过采样质谱数据集复杂。可以提供上游分离装置（3）以进一步降低每个质谱数据集的复杂度。

14. 发明申请

WO2014184570A1 METHOD OF GENERATING ELECTRIC FIELD FOR MANIPULATING CHARGED PARTICLES 审中-公开
标题翻译：用于操作充电颗粒的电场生成方法
公开(公告)号：WO2014184570A1
公开(公告)日：2014-11-20
申请号：PCT/GB2014/051501
申请日：2014-05-16
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/062 , H01J49/401 , H01J49/405 , H01J49/421
摘要： A method of manufacturing a device for manipulating charged particles using an axial electric field as they travel along a longitudinal axis of the device is disclosed. The method comprises providing first electrodes of different lengths, supplying different voltages to these electrodes and arranging grounded electrodes between the first electrodes in order to form the desired axial potential profile.
摘要翻译：公开了一种制造用于在沿着装置的纵向轴线行进时使用轴向电场来操纵带电粒子的装置的方法。该方法包括提供不同长度的第一电极，向这些电极提供不同的电压并在第一电极之间布置接地电极，以便形成期望的轴向电位分布。

15. 发明申请

WO2013171499A2 ORTHOGONAL ACCELERATION COAXIAL CYLINDER TIME OF FLIGHT MASS ANALYSER 审中-公开
标题翻译：飞行质量分析仪的正交加速同轴气缸时间
公开(公告)号：WO2013171499A2
公开(公告)日：2013-11-21
申请号：PCT/GB2013/051269
申请日：2013-05-16
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , G01N2223/506 , H01J49/0031 , H01J49/405 , H01J49/406 , H01J49/408
摘要： A Time of Flight mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.
摘要翻译：公开了一种飞行时间质量分析器，其包括具有纵向轴线的环形离子引导件，并且包括第一环形离子引导部分和第二环形离子引导部分。离子被引入到第一环形离子引导部分中，使得离子在第一环形离子引导部分内围绕纵向轴线形成基本上稳定的圆周轨道。离子检测器设置在环形离子导向器内。离子在从第一环形离子引导部分到第二环形离子引导部分的第一轴向方向上正交加速。沿着第二环形离子引导部分的至少一部分保持轴向DC电位，使得离子在基本上与第一轴向方向相对的第二轴向反射。在被离子检测器检测到之前，离子经过多个轴向通过第二环形离子引导部分。

16. 发明申请

WO2013045947A1 MULTIPLE CHANNEL DETECTION FOR TIME OF FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：飞行时间质谱仪的多通道检测
公开(公告)号：WO2013045947A1
公开(公告)日：2013-04-04
申请号：PCT/GB2012/052415
申请日：2012-09-28
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , GILBERT, Anthony James , SUYAMA, Motohiro
IPC分类号： H01J49/40 , H01J49/02
CPC分类号： H01J49/025 , H01J49/0031 , H01J49/40
摘要： An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate (1) which is arranged to receive ions (2) and output electrons (3). The electrons (3) are directed onto an array of photodiodes (4) which directly detects the electrons (3). The output from each photodiode (4) is connected to a separate Time to Digital Converter provided on an ASIC (5).
摘要翻译：公开了一种用于飞行时间质谱仪的离子检测器，其包括布置成接收离子（2）和输出电子（3）的单个微通道板（1）。电子（3）被引导到直接检测电子（3）的光电二极管阵列（4）上。来自每个光电二极管（4）的输出连接到ASIC（5）上提供的单独的时间到数字转换器。

17. 发明申请

WO2018215737A1 TIME OF FLIGHT MASS ANALYSER WITH SPATIAL FOCUSSING 审中-公开
公开(公告)号：WO2018215737A1
公开(公告)日：2018-11-29
申请号：PCT/GB2018/051320
申请日：2018-05-16
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , KOZLOV, Boris
IPC分类号： H01J49/00 , H01J49/06 , H01J49/40
摘要： A Time of Flight mass analyser is disclosed comprising: at least one ion mirror ((34) for reflecting ions; an ion detector (36) arranged for detecting the reflected ions; a first pulsed ion accelerator (30) for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector (36) so that the ion packet spatially converges in the first dimension as it travels to the detector (36); and a pulsed orthogonal accelerator (32) for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors (34).

18. 发明申请

WO2018203082A1 MULTI-REFLECTING TIME-OF-FLIGHT MASS SPECTROMETERS 审中-公开
公开(公告)号：WO2018203082A1
公开(公告)日：2018-11-08
申请号：PCT/GB2018/051206
申请日：2018-05-04
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , VERENCHIKOV, Anatoly
IPC分类号： H01J49/40
摘要： A multi-reflecting time of flight mass analyser is disclosed in which the ion flight path is maintained relatively small and the duty cycle is made relatively high. Spatial focussing of the ions in the dimension (z-dimension) in which the mirrors (36) are elongated can be eliminated whilst maintaining a reasonably high sensitivity and resolution.

19. 发明申请

WO2016174462A1 MULTI-REFLECTING TOF MASS SPECTROMETER 审中-公开
标题翻译：多反射TOF质谱仪
公开(公告)号：WO2016174462A1
公开(公告)日：2016-11-03
申请号：PCT/GB2016/051238
申请日：2016-04-29
申请人： MICROMASS UK LIMITED , LECO CORPORATION
发明人： HOYES, John Brian , RICHARDSON, Keith , VERENCHIKOV, Anatoly , YAVOR, Mikhail
IPC分类号： H01J49/40 , H01J49/06
CPC分类号： H01J49/405 , H01J49/061 , H01J49/406 , H01J49/426
摘要： A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).
摘要翻译：公开了一种飞行时间质谱法的方法，其包括：提供在第一维度（X维）上间隔开的两个离子镜（42），并且每个离子镜在与第二维度（X维）正交的第二维度第一维度使用离子引入机构（43）将离子束（47）引入到反射镜之间的空间中，使得当它们漂移通过所述空间中的所述空间时，离子在反射镜（42）之间的第一维度（X维）中重复地振荡第二维（Z维）; 当离子漂移通过第二维度（Z维）中的所述空间时，使垂直于第一和第二维度的第三维（Y-维）中的离子振荡; 以及在所述离子在所述第一维度（X维度）中多次振荡之后，接收离子接收机构（44）中或其上的离子; 其中所述离子引入机构（43）的至少一部分和/或所述离子接收机构（44）的至少一部分配置在所述反射镜（42）之间。

20. 发明申请

WO2015082939A2 MICROWAVE CAVITY RESONATOR DETECTOR 审中-公开
标题翻译：微波腔谐振探测器
公开(公告)号：WO2015082939A2
公开(公告)日：2015-06-11
申请号：PCT/GB2014/053627
申请日：2014-12-05
申请人： MICROMASS UK LIMITED
发明人： HOYES, John Brian , RICHARDSON, Keith
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , G01N30/72 , G01T1/20 , H01J40/00 , H01J43/02 , H01J49/0031 , H01J49/401
摘要： An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.
摘要翻译：公开了一种用于质谱仪的离子检测器系统，其包括布置并且适于接收离子并发射或输出第一电子的第一器件和布置并且适于将第一电子偏转到第一电子上的第一电子检测器。

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