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11. 发明申请

US20060183797A1 Fatty alcohols and fatty acid esters useful for treatment of inflammation 审中-公开
标题翻译：用于治疗炎症的脂肪醇和脂肪酸酯
公开(公告)号：US20060183797A1
公开(公告)日：2006-08-17
申请号：US10474447
申请日：2002-04-11
申请人： Irun Cohen , Meir Shinitzky , Raanan Margalit
发明人： Irun Cohen , Meir Shinitzky , Raanan Margalit
IPC分类号： A61K31/22 , A61K31/045
CPC分类号： A61K31/225 , A61K31/20 , A61K31/22
摘要： Immunomodulators selected from: (a) a saturated or cis-unsaturated C10-C20 fatty alcohol or an ester thereof with a C1-C6 alkanoic acid; (b) a monoester of a C2-C8 alkanediol or of Glycerol with a saturated or cis-unsaturated C10-C20 fatty acid; and (c) a diester of glycerol with a saturated or cis-unsaturated C10-C20 fatty acid, are useful for treatment of inflammation, particularly immunologically-mediated inflammation such as it occurs in autoimmune diseases.
摘要翻译：选自以下的免疫调节剂：（a）饱和或顺式不饱和的C 10 -C 20脂肪醇或其具有C 1〜 C 6链烷酸; （b）C 2 -C 12烷基二醇或具有饱和或顺式不饱和C 10 -C 13的甘油的单酯 > 20脂肪酸; 和（c）具有饱和或顺式不饱和C 10 -C 20脂肪酸的甘油二酯可用于治疗炎症，特别是免疫介导的炎症，例如因为它发生在自身免疫性疾病中。

12. 发明申请

US20060089302A1 Hsp70-derived peptides and uses thereof in the diagnosis and treatment of autoimmune diseases 审中-公开
标题翻译： Hsp70衍生肽及其在自身免疫疾病诊断和治疗中的应用
公开(公告)号：US20060089302A1
公开(公告)日：2006-04-27
申请号：US10505848
申请日：2003-02-24
申请人： Rivkn Abulafia-Lapid , Henri Atlan , Irun Cohen
发明人： Rivkn Abulafia-Lapid , Henri Atlan , Irun Cohen
IPC分类号： A61K39/00 , C07K14/47 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4713 , C07K16/18
摘要： The invention relates to specific peptides derived from hsp70, and to pharmaceutical compositions comprising the same. The peptides and compositions of the invention are particularly suitable for the prevention or treatment of an autoimmune disease such as Type 1 Diabetes, Systemic Lupus Erithematosus, Multiple Sclerosis or Rheumatoid Arthritis. The invention further relates to a method for diagnosing the occurrence or incipience of an autoimmune disease in a patient by use of the peptides of the invention, by testing a blood or urine sample of a patient for the presence of antibodies or T-cells which are immunologically reactive to human hsp70. The invention also relates to a kit for the diagnosis of an autoimmune disease by testing for the presence of anti-hsp70 antibodies by aid of the peptides of the invention.
摘要翻译：本发明涉及来源于hsp70的特异性肽以及包含其的药物组合物。本发明的肽和组合物特别适用于预防或治疗自身免疫性疾病，例如1型糖尿病，系统性狼疮，多发性硬化或类风湿性关节炎。本发明还涉及一种通过使用本发明的肽来诊断患者自身免疫性疾病的发生或发病的方法，通过测试患者的血液或尿液样品中是否存在抗体或T细胞对人hsp70具有免疫反应性。本发明还涉及一种用于诊断自身免疫性疾病的试剂盒，其通过借助本发明的肽测试抗hsp70抗体的存在来进行。

13. 发明申请

US20050260770A1 Antigen array and diagnostic uses thereof 审中-公开
标题翻译：抗原阵列及其诊断用途
公开(公告)号：US20050260770A1
公开(公告)日：2005-11-24
申请号：US11094142
申请日：2005-03-31
申请人： Irun Cohen , Francisco Quintana , Eytan Domany , Gad Elizur , Peter Hagedorn
发明人： Irun Cohen , Francisco Quintana , Eytan Domany , Gad Elizur , Peter Hagedorn
IPC分类号： G01N33/543 , G01N33/564
CPC分类号： G01N33/564
摘要： A method of diagnosing an immune disease, or a predisposition thereto, in a subject is disclosed. The method comprises determining a capacity of immunoglobulins of the subject to specifically bind each antigen probe of an antigen probe set, wherein the antigen probe set comprises a plurality of antigen probes selected from the group consisting of at least a portion of a cell/tissue structure molecule, at least a portion of a heat shock protein, at least a portion of an immune system molecule, at least a portion of a homopolymeric polypeptide, at least a portion of a hormone, at least a portion of a metabolic enzyme, at least a portion of a microbial antigen, at least a portion of a molluscan antigen, at least a portion of a nucleic acid, at least a portion of a plant antigen, at least a portion of plasma molecule, and at least a portion of a tissue antigen, wherein the capacity is indicative of the immune disease or the predisposition thereto, thereby diagnosing the immune disease, or the predisposition thereto, in the subject.
摘要翻译：公开了一种在受试者中诊断免疫疾病或其倾向的方法。该方法包括确定受试者的免疫球蛋白的能力以特异性结合抗原探针组的每个抗原探针，其中所述抗原探针组包含多个选自下组的抗原探针：至少一部分细胞/组织结构分子，至少一部分热休克蛋白，至少一部分免疫系统分子，至少一部分均聚多肽，至少一部分激素，代谢酶的至少一部分，至少一部分微生物抗原，至少一部分软体动物素抗原，至少一部分核酸，至少一部分植物抗原，至少一部分血浆分子和至少一部分组织抗原，其中所述能力指示免疫疾病或其易感性，从而诊断受试者的免疫疾病或其易感性。

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