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11. 发明授权

US08614083B2 Method and device for the concentration of multiple microorganisms and toxins from large liquid toxins 有权
标题翻译：用于浓缩大量液体毒素的多种微生物和毒素的方法和装置
公开(公告)号：US08614083B2
公开(公告)日：2013-12-24
申请号：US12602819
申请日：2008-06-13
申请人： Saul Tzipori , Udi Zukerman , Gary Stacey
发明人： Saul Tzipori , Udi Zukerman , Gary Stacey
IPC分类号： C12N3/00
CPC分类号： B01D21/262 , B01D21/302 , B01D2221/10 , B03C3/15 , B03C5/02 , B03C2201/26 , B04B5/10 , G01N1/4077
摘要： A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of protozoa, bacteria, bacterial spores, and toxins is delivered to the centrifuge bowl. A centrifugal force is applied to the separation bowl. The water sample is concentrated to remove large particles of the toxins in the bowl due to the centrifugal forces. The concentrated water sample is passes through the positively charged inner core to capture any remaining concentrated targets by electrostatic forces and the concentrated targets are eluted.
摘要翻译：从大量水中同时浓缩多种毒素的方法。该方法包括提供一次性分离离心机碗的步骤，离心机碗在其内核处包含带正电荷的材料。从原生动物，细菌，细菌孢子和毒素组成的组中被毒素污染的大量水样品被输送到离心机碗中。离心力被施加到分离碗。由于离心力，将水样品浓缩以除去碗中的大量毒素。浓缩水样品通过带正电荷的内核，通过静电力捕获任何剩余的浓缩靶，并且浓缩的靶被洗脱。

12. 发明申请

US20120198587A1 SOYBEAN TRANSCRIPTION FACTORS AND OTHER GENES AND METHODS OF THEIR USE 审中-公开
标题翻译：大豆转录因子及其使用的基因及方法
公开(公告)号：US20120198587A1
公开(公告)日：2012-08-02
申请号：US13381448
申请日：2010-06-30
申请人： Henry T. Nguyen , Gary Stacey , Dong Xu , Jianlin Cheng , Trupti Joshi , Marc Libault , Babu Valliyodan
发明人： Henry T. Nguyen , Gary Stacey , Dong Xu , Jianlin Cheng , Trupti Joshi , Marc Libault , Babu Valliyodan
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C07K14/415
摘要： Gene expression is controlled at the transcriptional level by very diverse group of proteins called transcription factors (TFs). 5671 soybean (Glycine max) genes have been identified and disclosed as putative transcription factors through mining of soybean genome sequences. Distinct classes of the TFs are also disclosed which may be expressed and or function in a manner that is tissue specific, developmental stage specific, biotic and/or abiotic stress specific. Manipulation and/or genetic engineering of specific transcription factors may improve the agronomic performance or nutritional quality of plants. Transgenic plants expressing a select number of these TFs are disclosed. These transgenic plants show some promising traits, such as improving the capability of the plant to grow and reproduce under drought conditions.
摘要翻译：基因表达通过称为转录因子（TF）的非常多样化的蛋白质组在转录水平下控制。已经通过大豆基因组序列的开采，鉴定了5671个大豆（Glycine max）基因并将其公开为推定的转录因子。还公开了TF的不同类别，其可以以组织特异性，发育阶段特异性，生物和/或非生物胁迫特异性的方式表达和/或起作用。特定转录因子的操作和/或遗传工程可以改善植物的农艺性能或营养品质。公开了表达选择数目的这些TF的转基因植物。这些转基因植物显示出一些有希望的性状，例如提高植物在干旱条件下生长和繁殖的能力。

13. 发明授权

US08169600B2 Surface mapping by optical manipulation of particles in relation to a functionalized surface 有权
标题翻译：通过相对于功能化表面的颗粒的光学操作的表面映射
公开(公告)号：US08169600B2
公开(公告)日：2012-05-01
申请号：US12440949
申请日：2007-09-14
申请人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
发明人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
IPC分类号： G01N33/48
CPC分类号： G01N33/48 , G01N33/54373 , G01N33/80
摘要： Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.
摘要翻译：提供了分析颗粒表面性质的方法和装置。用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区缔合，向第一颗粒施加光学力，感测第一颗粒对第一颗粒的响应并且使用感测到的响应来确定第一颗粒表面上的第一化学物质的存在，不存在或数量。该过程可以并行重复以测试多个颗粒。除了直接测试颗粒的表面性质之外，该方法可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。提供了一种具有捕获区域的流体盒，其具有被调整以用于光学力的空间。还提供了用于执行该方法的软件程序。

14. 发明授权

US08100875B2 Ostomy coupling 有权
标题翻译：造口耦合
公开(公告)号：US08100875B2
公开(公告)日：2012-01-24
申请号：US11548553
申请日：2006-10-11
申请人： John Cline , John L. Blum , Gary Stacey , Phillip Davies , Trevor Beckett
发明人： John Cline , John L. Blum , Gary Stacey , Phillip Davies , Trevor Beckett
IPC分类号： A61F5/44
CPC分类号： A61F5/448 , A61F5/445 , A61F2005/4402 , A61F2005/4486
摘要： A single-use ostomy appliance is described including an ostomy coupling for releasable coupling first and second portions at a stomal orifice. The two portions may be separable body-side and non-body-side parts, or the two portions may be portions of a unitary ostomy device such as a controlled evacuation device. The coupling includes a mechanical fastener configured such that the coupling is rendered substantially not resecurable after the fastener is released.
摘要翻译：描述了一种一次性造口术装置，其包括用于在口咽口处可释放地联接第一和第二部分的造口术联接器。两个部分可以是可分离的身体侧部分和非体侧部分，或者两个部分可以是诸如受控排泄装置的整体造口术装置的部分。联接器包括机械紧固件，其被配置为使得在紧固件被释放之后，联接器基本上不可再生。

15. 发明授权

US08097771B2 LysM receptor-like kinases to improve plant defense response against fungal pathogens 有权
标题翻译： LysM受体样激酶，以改善植物对真菌病原体的防御反应
公开(公告)号：US08097771B2
公开(公告)日：2012-01-17
申请号：US11835328
申请日：2007-08-07
申请人： Jinrong Wan , Gary Stacey , Minviluz Stacey , Xuecheng Zhang
发明人： Jinrong Wan , Gary Stacey , Minviluz Stacey , Xuecheng Zhang
IPC分类号： A01H5/00 , A01H1/00 , C12N15/09 , C12N15/82
CPC分类号： C12N15/8282 , C12N9/12
摘要： Perception of chitin fragments (chitooligosaccharides) is an important first step in plant defense response against fungal pathogen. LysM receptor-like kinases (LysM RLKs) are instrumental in this perception process. LysM RLKs also play a role in activating transcription of chitin-responsive genes (CRGs) in plants. Mutations in the LysM kinase receptor genes or the downstream CRGs may affect the fungal susceptibility of a plant. Mutations in LysM RLKs or transgenes carrying the same may be beneficial in imparting resistance against fungal pathogens.
摘要翻译：几丁质片段（壳寡糖）的感知是植物对真菌病原体防御反应的重要第一步。 LysM受体样激酶（LysM RLKs）在此感知过程中起了重要作用。 LysM RLKs也在植物中激活壳多糖应答基因（CRG）的转录中发挥作用。 LysM激酶受体基因或下游CRG中的突变可能影响植物的真菌易感性。 LysM RLK中的突变或携带其的转基因可能有益于赋予对真菌病原体的抗性。

16. 发明申请

US20100216215A1 METHOD AND DEVICE FOR THE CONCENTRATION OF MULTIPLE MICROORGANISMS AND TOXINS FROM LARGE LIQUID TOXINS 有权
标题翻译：用于浓缩大量液体毒素的多种微生物和毒素的方法和装置
公开(公告)号：US20100216215A1
公开(公告)日：2010-08-26
申请号：US12602819
申请日：2008-06-13
申请人： Udi Zukerman , Saul Tzipori , Gary Stacey
发明人： Udi Zukerman , Saul Tzipori , Gary Stacey
IPC分类号： C12N3/00 , C12N1/02 , C12N1/20 , C12M1/00 , B01D21/24
CPC分类号： B01D21/262 , B01D21/302 , B01D2221/10 , B03C3/15 , B03C5/02 , B03C2201/26 , B04B5/10 , G01N1/4077
摘要： A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of protozoa, bacteria, bacterial spores, and toxins is delivered to the centrifuge bowl. A centrifugal force is applied to the separation bowl. The water sample is concentrated to remove large particles of the toxins in the bowl due to the centrifugal forces. The concentrated water sample is passes through the positively charged inner core to capture any remaining concentrated targets by electrostatic forces and the concentrated targets are eluted.
摘要翻译：从大量水中同时浓缩多种毒素的方法。该方法包括提供一次性分离离心机碗的步骤，离心机碗在其内核处包含带正电荷的材料。从原生动物，细菌，细菌孢子和毒素组成的组中被毒素污染的大量水样品被输送到离心机碗中。离心力被施加到分离碗。由于离心力，将水样品浓缩以除去碗中的大量毒素。浓缩水样品通过带正电荷的内核，通过静电力捕获任何剩余的浓缩靶，并且浓缩的靶被洗脱。

17. 发明授权

US08764717B2 Seal for an ostomy appliance 有权
标题翻译：造口器具的密封
公开(公告)号：US08764717B2
公开(公告)日：2014-07-01
申请号：US13505459
申请日：2010-11-02
申请人： Alastair Willoughby , Thomas Bates Jackson , Gary Stacey
发明人： Alastair Willoughby , Thomas Bates Jackson , Gary Stacey
IPC分类号： A61F5/445 , A61F5/448 , A61F5/449 , A61F5/44
CPC分类号： A61F5/445 , A61F5/44 , A61F5/4408 , A61F5/448 , A61F5/449 , A61F2210/0057
摘要： The present invention relates to a sealing wafer (1) adapted to be arranged in a stoma receiving hole (5) of a base plate (2) comprising an attachment platform extending from an outer edge adapted to be attached to the base plate towards an inner edge defining a through-going hole (17) for receiving a stoma, the sealing wafer further comprising at least a first urging part extending transversely from the proximal surface facing towards the user during use of the attachment platform and wherein the first urging part is resilient in the direction transverse to the proximal surface. This provides a sealing wafer which is particularly suitable for use with a stoma around which the skin has an uneven curvature, such as a retracted stoma wherein the stoma has pulled back resulting in a crater-like area.
摘要翻译：本发明涉及一种适于布置在基板（2）的造口接纳孔（5）中的密封晶片（1），包括从适于附接到基板的外边缘朝向内部边缘限定用于接收造口的穿孔（17），所述密封晶片还包括至少第一推动部分，所述第一推动部分在所述附接平台的使用期间从近侧表面朝向使用者横向延伸，并且其中所述第一推动部分是弹性的在横向于近端表面的方向上。这提供了一种密封晶片，其特别适合于与皮肤周围具有不均匀曲率的造口一起使用，例如缩回的造口，其中造口已经拉回，导致火山口状区域。

18. 发明授权

US08512303B2 Negative drawstring seal for an ostomy bag 有权
标题翻译：用于造口袋的负束带密封
公开(公告)号：US08512303B2
公开(公告)日：2013-08-20
申请号：US13697014
申请日：2011-05-10
申请人： Alastair Willoughby , Mark Rogers , Gary Stacey , Wai Chan
发明人： Alastair Willoughby , Mark Rogers , Gary Stacey , Wai Chan
IPC分类号： A61F5/44
CPC分类号： A61F5/445 , A61F5/448
摘要： An ostomy body side member with a sealing member is provided. The sealing member has a fixed base member defining an opening having a first diameter and a resilient sealing element comprising a stoma receiving orifice defining an inner boundary. The inner boundary of the stoma receiving orifice has a second diameter that is smaller than the first diameter of the frame. The sealing member is also provided with at least one adjustment member coupled between the fixed base member and the resilient sealing element. Furthermore, an alignment member for adjusting the tension of the at least one adjustment member is provided thereby allowing the diametrical dimension of the stoma sealing orifice to be adjusted from a first diameter to a second diameter.
摘要翻译：提供具有密封构件的造口体侧构件。密封构件具有限定具有第一直径的开口的固定基部构件和包括限定内部边界的造口接收孔的弹性密封元件。造口接收孔的内边界具有小于框架的第一直径的第二直径。密封构件还设置有联接在固定基部构件和弹性密封元件之间的至少一个调节构件。此外，提供了用于调节至少一个调节构件的张力的对准构件，从而允许气孔密封孔的直径尺寸从第一直径调节到第二直径。

19. 发明申请

US20130129870A1 METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES 有权
标题翻译：用于基于罐装碳酸饮料的方法和装置
公开(公告)号：US20130129870A1
公开(公告)日：2013-05-23
申请号：US13565214
申请日：2012-08-02
申请人： Thomas J. Novak , Ross Packard , Peter Peterson , Shawn Gulla , Jennifer Caitlin Huot Carlson , Camilla Schmitt , Mark Joseph Cohen , Ross Peter Jones , Nicolas Alejandro Martinez , Milles William Noel Hember , Fabien Yannick Schmitt , Gary Stacey , Niall Allan Mottram , Neil Lester Campbell , Cormac O'Prey , Wai Ting Chan , Nicholas David Rollings , Charles Frazer Kilby , Christopher Paul Richardson , Thomas Bates Jackson , Scott Grubb , Chris Covey , Barry Dobson , Paul Wilkins , Chris Roach , Peter Cauwood , Keith Thompson
发明人： Thomas J. Novak , Ross Packard , Peter Peterson , Shawn Gulla , Jennifer Caitlin Huot Carlson , Camilla Schmitt , Mark Joseph Cohen , Ross Peter Jones , Nicolas Alejandro Martinez , Milles William Noel Hember , Fabien Yannick Schmitt , Gary Stacey , Niall Allan Mottram , Neil Lester Campbell , Cormac O'Prey , Wai Ting Chan , Nicholas David Rollings , Charles Frazer Kilby , Christopher Paul Richardson , Thomas Bates Jackson , Scott Grubb , Chris Covey , Barry Dobson , Paul Wilkins , Chris Roach , Peter Cauwood , Keith Thompson
IPC分类号： B65D85/73
CPC分类号： A47J31/407 , A23L2/54 , A47J31/41 , B01F3/04248 , B01F3/0446 , B01F3/04758 , B01F3/04787 , B01F3/04808 , B01F3/04815 , B01F5/0606 , B01F5/10 , B01F15/0205 , B01F15/0206 , B01F2215/0022 , B65D85/73 , B65D85/8043 , F17C11/00
摘要： Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage. A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid. A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage. The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home.
摘要翻译：将气体碳酸化或以其他方式溶解在前体液体如水中的系统，方法和筒，以形成饮料。气体源可以设置在用于产生溶解在前体液体中的气体的盒中。饮料介质，例如粉末状饮料混合物或液体糖浆可以设置在其中，或作为气体源的单独的筒中，并与前体液体混合以形成饮料。用于气源和/或饮料介质的一个或多个墨盒的使用可以使得易于使用和无混乱的系统用于制造起泡饮料，例如在消费者的家中。

20. 发明申请

US20130078678A1 Protozoan Glycosidases and Related Methods 审中-公开
标题翻译：原生动物糖苷酶及相关方法
公开(公告)号：US20130078678A1
公开(公告)日：2013-03-28
申请号：US13619376
申请日：2012-09-14
申请人： Gary Stacey , Seth D. Findley , Melanie Mormile
发明人： Gary Stacey , Seth D. Findley , Melanie Mormile
IPC分类号： C12N9/42
CPC分类号： C12N9/2434 , C12N9/2437 , C12N9/248
摘要： Nucleic acids encoding glycosidases useful for the hydrolysis of cellulose and hemicellulose obtained from ciliates residing in a bovine rumen are provided. Also provided recombinant nucleic acids encoding the glycosidases, transformed cells comprising the same and related methods of using the transformed cells and glycosidases to degrade cellulose and/or hemicellulose.
摘要翻译：提供了编码糖苷酶的核酸，其可用于从驻留在牛瘤胃中的纤毛虫获得的纤维素和半纤维素的水解。还提供了编码糖苷酶的重组核酸，转化细胞，其包含使用转化细胞和糖苷酶的相同方法和相关方法降解纤维素和/或半纤维素。

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