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11. 发明申请

US20090215794A1 SEROTONERGIC AGENTS 失效
标题翻译： SEROTONERGIC代理
公开(公告)号：US20090215794A1
公开(公告)日：2009-08-27
申请号：US12435862
申请日：2009-05-05
申请人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
发明人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
IPC分类号： A61K31/496
CPC分类号： A61K31/496
摘要： Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.
摘要翻译：提供具有下式的新型哌嗪衍生物其中R 1是氰基，硝基，三氟甲基或卤素，或其药学上可接受的酸加成盐，其可用作5-HT 1A受体拮抗剂。

12. 发明授权

US07049330B2 Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents 失效
标题翻译：环烷基取代的芳基哌嗪，哌啶和四氢吡啶作为血清素能药
公开(公告)号：US07049330B2
公开(公告)日：2006-05-23
申请号：US10340087
申请日：2003-01-10
申请人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
发明人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
IPC分类号： A61K31/445 , C07D211/26
CPC分类号： C07D239/42 , C07D209/08 , C07D211/22 , C07D213/74 , C07D217/22 , C07D277/82 , C07D295/125 , C07D295/13 , C07D319/20
摘要： This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; R1 is optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is H or alkyl; R3 is H, COR5, COOR5, and CONR5R6; R4 is H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; R5 and R6 are H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or R5 and R6 taken together may form a 5–7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR4; when R5 or R6 are chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C1–C3 alkyl group; or an optical isomer; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有下式的化合物，其具有作为5-HT 1A激动剂和拮抗剂的活性，其可用于治疗焦虑，抑郁，认知缺陷和前列腺癌，其中：X为选自以下的基团：n选自整数1至5; R 1是任选取代的芳基或单或双环杂芳基，条件是杂芳基不是噻二唑; R 2是H或烷基; R 3是H，COR 5，COOR 5和CONR 5 R 6 O / >; R 4是H，烷基，烯基，炔基，芳基，单或双环杂芳基，芳烷基和单或双环杂芳烷基，其中芳基或杂芳基任选被取代; R 5和R 6是H，烷基，烯基，炔基，环烷基，环烯基，金刚烷基和去月桂外基或R 5和R 共同组合可以形成5-7元的氮杂环，任选地含有选自O，S或NR 4的另外的杂原子。当R 5或R 6选自环烷基或环烯基时，环状基团可以任选地在1位被C 1〜 -C 3烷基; 或光学异构体; 或其药学上可接受的盐。

13. 发明授权

US07026320B2 Serotonergic agents 失效
公开(公告)号：US07026320B2
公开(公告)日：2006-04-11
申请号：US10441536
申请日：2003-05-20
申请人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
发明人： Wayne E. Childers , Michael G. Kelly , Sharon J. Rosenzweig-Lipson
IPC分类号： A61K31/496
CPC分类号： C07D405/12
摘要： Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.

14. 发明授权

US06239134B1 Diazole derivatives as serotonergic agents 失效
标题翻译：二唑衍生物作为血清素能药剂
公开(公告)号：US06239134B1
公开(公告)日：2001-05-29
申请号：US09515049
申请日：2000-02-25
申请人： Annmarie L. Sabb , Robert L. Vogel , Michael G. Kelly , Yvette L. Palmer , Wayne E. Childers
发明人： Annmarie L. Sabb , Robert L. Vogel , Michael G. Kelly , Yvette L. Palmer , Wayne E. Childers
IPC分类号： A61K31496
CPC分类号： C07D285/10 , C07D417/12
摘要： The present invention provides compounds of the general formula (1): wherein: two atoms of X, Y, or Z are nitrogen and the third atom is sulfur or oxygen; R is H, halogen, OH, SH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 thioalkyl, phenoxy, thiophenoxy, phenyl or substituted phenyl; A is C, CH, or N; R1 is aryl, heteroaryl, or cycloalkyl groups, optionally substituted by from 1 to 3 substituents selected from C1-C6 alkyl, C1-C6 alkoxy; CF3, Cl, Br, F, CN, or CO2CH3; R2is H or alkyl R3 is C1-C6 alkyl, optionally substituted aryl, optionally substituted 5- or 6-membered heteroaryl, C3 to C8 cycloalkyl optionally substituted by C1-C6 alkyl, or a 3 to 8-membered heterocyclic ring containing one or more heteroatoms selected from O, S or N; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of treating central nervous system disorders using these compounds.
摘要翻译：本发明提供通式（1）的化合物：其中X，Y或Z的两个原子是氮，第三个原子是硫或氧; R是H，卤素，OH，SH，C 1 -C 6烷基， C 1 -C 6烷氧基，C 1 -C 6硫代烷基，苯氧基，硫代苯氧基，苯基或取代的苯基; A是C，CH或N; R 1是芳基，杂芳基或环烷基，任选地被1至3个选自C1- C6烷基，C1-C6烷氧基; CF 3，Cl，Br，F，CN或CO 2 CH 3; R 2为H或烷基R 3为C 1 -C 6烷基，任选取代的芳基，任选取代的5或6元杂芳基，任选被C 1 -C 6烷基取代的C 3至C 8环烷基，含有一个或多个选自O，S或N的杂原子的3至8元杂环; 或其药学上可接受的盐，以及使用这些化合物治疗中枢神经系统疾病的药物组合物和方法。

15. 发明授权

US06376494B1 Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents 失效
标题翻译：环烷基取代的芳基哌嗪，哌啶和四氢吡啶作为血清素能药
公开(公告)号：US06376494B1
公开(公告)日：2002-04-23
申请号：US09723478
申请日：2000-11-28
申请人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
发明人： Wayne E. Childers , Michael G. Kelly , Yvette L. Palmer , Edward J. Podlesny
IPC分类号： A61K31496
CPC分类号： C07D239/42 , C07D209/08 , C07D211/22 , C07D213/74 , C07D217/22 , C07D277/82 , C07D295/125 , C07D295/13 , C07D319/20
摘要： This invention relates to compounds which have activity as 5-HT1A agonists and antagonists which may be useful for the treatment of anxiety, depression, cognitive deficits, and prostate cancer, having the formula wherein: X is a moiety selected from the group of: n is selected from the integers 1 through 5; R1 is optionally substituted aryl or mono or bicyclic heteroaryl, with a proviso that heteroaryl is not thiadiazole; R2 is H or alkyl; R3 is H, COR5, COOR5, and CONR5R6; R4 is H, alkyl, alkenyl, alkynyl, aryl, mono or bicyclic heteroaryl, aralkyl, and mono or bicyclic heteroaralkyl, wherein the aryl or heteroaryl groups are optionally substituted; R5 and R6 are H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, adamantyl, and noradamantyl or R5 and R6 taken together may form a 5-7 membered azacyclic ring, optionally containing an additional heteroatom selected from O, S, or NR4; when R5 or R6 are chosen from cycloalkyl or cycloalkenyl, the cyclic group may optionally be substituted at the 1-position with a C1-C3 alkyl group; or an optical isomer; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及具有作为5-HT 1A激动剂和拮抗剂的活性的化合物，其可用于治疗具有下列基团的焦虑，抑郁，认知缺陷和前列腺癌：X是选自以下的部分：n是从整数1到5中选择; R1是任选取代的芳基或单或双环杂芳基，条件是杂芳基不是噻二唑; R2是H或烷基; R3是H，COR5，COOR5和CONR5R6; R 4是H，烷基，烯基，炔基，芳基，单或双环杂芳基，芳烷基和单或双环杂芳烷基，其中芳基或杂芳基任选被取代; R5和R6是H，烷基，烯基，炔基，环烷基，环烯基，金刚烷基和去月桂烷基或R5和R6一起可以形成5-7元的氮杂环，任选地含有选自O，S或NR4的另外的杂原子; 当R5或R6选自环烷基或环烯基时，环状基团可以任选在1-位被C1-C3烷基取代;或光学异构体; 或其药学上可接受的盐。

16. 发明授权

US06239126B1 Arylpiperidine and aryl-1,2,5,6-tetra-hydropyridine urea derivatives 失效
标题翻译：芳基哌啶和芳基-1,2,5,6-四氢吡啶脲衍生物
公开(公告)号：US06239126B1
公开(公告)日：2001-05-29
申请号：US09459791
申请日：1999-12-13
申请人： Michael G. Kelly , Gan Zhang
发明人： Michael G. Kelly , Gan Zhang
IPC分类号： A01N4300
CPC分类号： C07D211/22 , C07D211/70
摘要： Compounds of the formula are useful for the treatment of disorder of the central nervous system including anxiety, depression, panic, alcohol and drug addiction, sexual dysfunction, sleep disorders, migraine, obesity, cognitive disorders and neurodegenerative diseases.
摘要翻译：该化合物可用于治疗中枢神经系统疾病，包括焦虑，抑郁，恐慌，酒精和药物成瘾，性功能障碍，睡眠障碍，偏头痛，肥胖症，认知障碍和神经变性疾病。

17. 发明授权

US08859545B2 Tetrahydronaphthyridine and tetrahydropyrido[4,3-D]pyrimidine compounds and compositions thereof useful for the treatment of inflammatory and respiratory diseases 有权
标题翻译：四氢吡啶和四氢吡啶并[4,3-D]嘧啶化合物及其组合物可用于治疗炎性和呼吸系统疾病
公开(公告)号：US08859545B2
公开(公告)日：2014-10-14
申请号：US12660588
申请日：2010-03-01
申请人： Michael G. Kelly , John Kincaid , Carl J. Kaub
发明人： Michael G. Kelly , John Kincaid , Carl J. Kaub
IPC分类号： C07D471/04 , C07D413/12 , A61K31/5355 , A61K31/519 , A61P19/02 , A61P25/16 , A61P25/28 , A61P25/18 , A61P25/22 , A61P11/06 , A61P9/10 , A61P25/24
CPC分类号： C07D471/04
摘要： Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, respiratory conditions, and others.
摘要翻译：公开了具有式1的四氢萘并吡啶和四氢吡啶并[4,3-d]嘧啶化合物：其中A，B，L，N，R 1，R 3，R 4'，Y和Z如本文所定义。其化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，疼痛，炎症，呼吸病症等。

18. 发明申请

US20140134804A1 Method And System For A Semiconductor For Device Package With A Die-To-Packaging Substrate First Bond 有权
标题翻译：用于器件封装的半导体的方法和系统具有封装到封装的基板第一键
公开(公告)号：US20140134804A1
公开(公告)日：2014-05-15
申请号：US13678058
申请日：2012-11-15
申请人： Michael G. Kelly , Ronald Patrick Huemoeller , Won Chul Do , David Jon Hiner
发明人： Michael G. Kelly , Ronald Patrick Huemoeller , Won Chul Do , David Jon Hiner
IPC分类号： H01L21/762
CPC分类号： H01L21/76251 , H01L21/486 , H01L21/50 , H01L21/563 , H01L21/67288 , H01L21/6836 , H01L21/6838 , H01L21/68735 , H01L23/147 , H01L23/3107 , H01L23/3128 , H01L23/3142 , H01L23/3675 , H01L23/481 , H01L23/49816 , H01L23/49827 , H01L23/49833 , H01L23/5386 , H01L23/544 , H01L24/13 , H01L24/16 , H01L24/27 , H01L24/29 , H01L24/32 , H01L24/81 , H01L24/83 , H01L24/95 , H01L24/97 , H01L25/0652 , H01L25/0655 , H01L25/0657 , H01L25/50 , H01L2221/68322 , H01L2223/54486 , H01L2224/13147 , H01L2224/16145 , H01L2224/16146 , H01L2224/16225 , H01L2224/16227 , H01L2224/17181 , H01L2224/27622 , H01L2224/2763 , H01L2224/29011 , H01L2224/2919 , H01L2224/32145 , H01L2224/32225 , H01L2224/32245 , H01L2224/73204 , H01L2224/73253 , H01L2224/81001 , H01L2224/81005 , H01L2224/81011 , H01L2224/81024 , H01L2224/81191 , H01L2224/81203 , H01L2224/81815 , H01L2224/83101 , H01L2224/83104 , H01L2224/83192 , H01L2224/83203 , H01L2224/83855 , H01L2224/92125 , H01L2224/92225 , H01L2224/97 , H01L2225/06513 , H01L2225/06517 , H01L2225/06541 , H01L2225/06568 , H01L2225/06589 , H01L2924/12042 , H01L2924/15311 , H01L2924/16152 , H01L2924/1616 , H01L2924/16235 , H01L2924/16251 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/19105 , H01L2924/3511 , H01L2924/00014 , H01L2924/00 , H01L2224/81
摘要： Methods and systems for a semiconductor device package with a die-to-packing substrate first bond are disclosed and may include bonding a first semiconductor die to a packaging substrate, applying an underfill material between the first semiconductor die and the packaging substrate, and bonding one or more additional die to the first semiconductor die. The additional die may comprise electronic devices. The first semiconductor die may comprise an interposer die or may comprise electronic devices. The first semiconductor die may be bonded to the packaging substrate utilizing a mass reflow process or a thermal compression process. The additional die may be bonded to the first die utilizing a mass reflow process or a thermal compression process. The bonded die may be encapsulated in a mold material, which may comprise a polymer. The one or more additional die may comprise micro-bumps for coupling to the first semiconductor die.
摘要翻译：公开了具有管芯到基板的第一接合的半导体器件封装的方法和系统，并且可以包括将第一半导体管芯接合到封装基板，在第一半导体管芯和封装基板之间施加底部填充材料，或更多的额外管芯到第一半导体管芯。附加的管芯可以包括电子器件。第一半导体管芯可以包括插入器管芯，或者可以包括电子器件。第一半导体管芯可以利用质量回流工艺或热压缩工艺结合到封装衬底上。可以使用质量回流工艺或热压缩工艺将附加模具结合到第一模具。粘合的模具可以包封在可以包含聚合物的模具材料中。一个或多个附加管芯可以包括用于耦合到第一半导体管芯的微突起。

19. 发明授权

US07745451B2 Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions 有权
标题翻译：四氢吡啶并四氢吡啶并[4,3-d]嘧啶化合物及其组合物可用于治疗与神经系统疾病和炎症疾病和功能障碍有关的病症
公开(公告)号：US07745451B2
公开(公告)日：2010-06-29
申请号：US11429026
申请日：2006-05-04
申请人： Michael G. Kelly , John Kincaid , Carl J. Kaub
发明人： Michael G. Kelly , John Kincaid , Carl J. Kaub
IPC分类号： C07D471/04 , C07D487/04 , C07D413/04 , C07D413/06 , C07D295/13 , C07D209/04 , C07D209/34
CPC分类号： C07D471/04
摘要： Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
摘要翻译：公开了具有式1的稠合杂环化合物：其中A，B，L，N，R 1，R 3，R 4'，Y和Z如本文所定义。其化合物及其药物组合物可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括非限制性实例，疼痛，炎症，认知障碍，焦虑，抑郁等。

20. 发明申请

US20100004222A1 Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same 审中-公开
标题翻译：酰胺衍生物作为离子通道配体和药物组合物及其使用方法
公开(公告)号：US20100004222A1
公开(公告)日：2010-01-07
申请号：US12224357
申请日：2007-02-22
申请人： Michael G. Kelly , Carl J. Kaub , John Kincaid , Satyanarayana Janagani , Guoxian Wu , Zhi-Liang Wei , Kiran Sahasrabudhe , Matthew Duncton , Ravindra B. Upasani , Yunfeng Fang , Matthew Cox , Jianhua He
发明人： Michael G. Kelly , Carl J. Kaub , John Kincaid , Satyanarayana Janagani , Guoxian Wu , Zhi-Liang Wei , Kiran Sahasrabudhe , Matthew Duncton , Ravindra B. Upasani , Yunfeng Fang , Matthew Cox , Jianhua He
IPC分类号： A61K31/47 , C07D215/38 , C07D513/04 , C07D471/04 , C07D217/02 , C07D265/36 , C07D413/12 , C07D319/16 , C07D277/62 , C07D267/14 , C07D498/04 , A61K31/436 , A61K31/4375 , A61K31/498 , A61K31/404 , A61K31/428 , A61K31/437 , A61K31/553 , A61P25/00 , A61P11/00
CPC分类号： C07D209/08 , C07D209/48 , C07D215/06 , C07D217/02 , C07D217/22 , C07D231/56 , C07D235/08 , C07D237/28 , C07D241/42 , C07D263/58 , C07D265/36 , C07D267/14 , C07D277/64 , C07D295/088 , C07D295/13 , C07D317/52 , C07D317/58 , C07D319/18 , C07D333/54 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D498/04 , C07D513/04
摘要： Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
摘要翻译：公开了具有由下式表示的式的化合物：式（I）。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的各种病症，包括作为非限制性实例，疼痛，炎症，创伤性损伤等。

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