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11. 发明授权

US07852490B2 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US07852490B2
公开(公告)日：2010-12-14
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

12. 发明授权

US07456953B2 Method and apparatus for improved light distribution in an anti-resonant waveguide sensor 有权
标题翻译：用于改善反谐振波导传感器中的光分布的方法和装置
公开(公告)号：US07456953B2
公开(公告)日：2008-11-25
申请号：US11777976
申请日：2007-07-13
申请人： Oliver Schmidt , Michael Bassler , Peter Kiesel , Patrick Y Maeda , Noble M Johnson
发明人： Oliver Schmidt , Michael Bassler , Peter Kiesel , Patrick Y Maeda , Noble M Johnson
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G02B6/10 , G01N21/03 , G01N21/0303 , G01N21/33 , G01N21/35 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/651 , G02B6/032 , G02B6/34
摘要： An improved method of analyzing target analytes in a sample is described. The method is based on creating an approximately homogeneous distribution of light in an anti-resonant guided optical waveguide to improve light-target interaction in a target-containing medium. The light-target interaction can be monitored by many different means to determine characteristics of the target analyte.
摘要翻译：描述了一种分析样品中目标分析物的改进方法。该方法基于在反谐振引导光波导中产生大致均匀的光分布，以改善含靶介质中的光 - 目标相互作用。光靶相互作用可以通过许多不同的手段来监测，以确定目标分析物的特征。

13. 发明申请

US20080186483A1 Implanting optical cavity structures 有权
标题翻译：植入光腔结构
公开(公告)号：US20080186483A1
公开(公告)日：2008-08-07
申请号：US11702329
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Richard H. Bruce , Noble M. Johnson
IPC分类号： G01N1/10
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译：可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。第二部分包括封闭的容器并且包含参考流体。可植入产品还可以包括光源组件和感光组件中的一个或两个。可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

14. 发明授权

US09164037B2 Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances 有权
标题翻译：用于评估从空间调制的激发和发射接收的信号的方法和系统，以准确地确定粒子位置和距离
公开(公告)号：US09164037B2
公开(公告)日：2015-10-20
申请号：US11698338
申请日：2007-01-26
申请人： Michael Bassler , Peter Kiesel , Oliver Schmidt
发明人： Michael Bassler , Peter Kiesel , Oliver Schmidt
IPC分类号： G01N33/48 , G01N21/64 , G06F19/00 , G06F19/12 , G01N31/00 , G06G7/58 , G01N15/10 , G01N15/14
CPC分类号： G01N21/6408 , G01N21/6458 , G01N2015/1075 , G01N2015/1486 , G06F19/12 , G06F2217/16 , G16H50/20
摘要： A method is provided for extracting the position of a particle, e.g., a moving or stationary particle that is excited or is emitting light. The method includes, among other steps, detecting and recording a signal based on, for example, the movement of the particle, a correlation step to eliminate noise and to create a transformed signal, a matching or fitting step to match the transformed signal to a fit function and an extracting or determining step to determine the position of the particle from the fit function. In one form, at least two particle positions are detected so that the distance between the subject particles can be determined.
摘要翻译：提供了用于提取颗粒的位置的方法，例如被激发或正在发光的移动或静止的颗粒。除了其他步骤之外，该方法包括基于例如粒子的移动来检测和记录信号，消除噪声并产生变换信号的相关步骤，匹配或拟合步骤，以将变换后的信号与拟合函数和提取或确定步骤以从拟合函数确定粒子的位置。在一种形式中，检测至少两个颗粒位置，使得可以确定主体颗粒之间的距离。

15. 发明授权

US08120782B2 Processes for producing tunable optical cavities 有权
标题翻译：用于生产可调谐光腔的工艺
公开(公告)号：US08120782B2
公开(公告)日：2012-02-21
申请号：US12603627
申请日：2009-10-22
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Uma Srinivasan
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Uma Srinivasan
IPC分类号： G01B9/02
CPC分类号： G01J3/26 , G01N21/45 , G01N2021/451 , G02B26/001
摘要： A tunable optical cavity can be tuned by relative movement between two reflection surfaces, such as by deforming elastomer spacers connected between mirrors or other light-reflective components that include the reflection surfaces. The optical cavity structure includes an analyte region in its light-transmissive region, and presence of analyte in the analyte region affects output light when the optical cavity is tuned to a set of positions. Electrodes that cause deformation of the spacers can also be used to capacitively sense the distance between them. Control circuitry that provides tuning signals can cause continuous movement across a range of positions, allowing continuous photosensing of analyte-affected output light by a detector.
摘要翻译：可调光学腔可以通过两个反射表面之间的相对运动进行调节，例如通过变形连接在反射镜之间的弹性体隔离物或包括反射表面的其它光反射部件。光腔结构包括其透光区域中的分析物区域，并且当光学腔被调谐到一组位置时，分析物区域中的分析物的存在影响输出光。导致间隔物变形的电极也可用于电容地感测它们之间的距离。提供调谐信号的控制电路可以在一定范围的位置上引起连续的运动，从而允许由检测器对被分析物影响的输出光进行持续的光敏。

16. 发明授权

US07936463B2 Containing analyte in optical cavity structures 有权
标题翻译：含有光学腔结构中的分析物
公开(公告)号：US07936463B2
公开(公告)日：2011-05-03
申请号：US11702325
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler
IPC分类号： G01B9/02
CPC分类号： G01N21/0303 , G01N21/05 , G01N21/253 , G01N2021/0346
摘要： A device can include both a photosensing component and an optical cavity structure, with the optical cavity structure including a part that can operate as an optical cavity in response to input light, providing laterally varying output light. For example, the optical cavity can be a graded linearly varying filter (LVF) or other inhomogeneous optical cavity, and the photosensing component can have a photosensitive surface that receives its output light without it passing through another optical component, thus avoiding loss of information. The optical cavity part can include a region that can contain analyte. Presence of the analyte affects the optical cavity part's output light, and the photosensing component can respond to the output light, providing sensing results indicating the analyte's optical characteristics.
摘要翻译：设备可以包括光敏元件和光学腔结构，其中光学腔结构包括响应于输入光可以作为光腔工作的部件，提供横向变化的输出光。例如，光学腔可以是渐变的线性变化的滤光器（LVF）或其他不均匀的光学腔，并且光敏元件可以具有接收其输出光而不通过另一个光学部件的感光表面，从而避免信息的丢失。光腔部分可以包括可以含有分析物的区域。分析物的存在影响光腔部分的输出光，并且光敏元件可以对输出光进行响应，提供指示分析物的光学特性的感测结果。

17. 发明授权

US07817281B2 Tuning optical cavities 有权
标题翻译：调谐光腔
公开(公告)号：US07817281B2
公开(公告)日：2010-10-19
申请号：US11702320
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Uma Srinivasan
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler , Uma Srinivasan
IPC分类号： G01B9/02
CPC分类号： H01S3/08081 , G01J3/26 , H01S3/105
摘要： An inhomogeneous optical cavity is tuned by changing its shape, such as by changing reflection surface positions to change tilt angle, thickness, or both. Deformable components such as elastomer spacers can be connected so that, when deformed, they change relative positions of structures with light-reflective components such as mirrors, changing cavity shape. Electrodes can cause deformation, such as electrostatically, electromagnetically, or piezoelectrically, and can also be used to measure thicknesses of the cavity. The cavity can be tuned, for example, across a continuous spectrum, to a specific wavelength band, to a shape that increases or decreases the number of modes it has, to a series of transmission ranges each suitable for a respective light source, with a modulation that allows lock-in with photosensing for greater sensitivity, and so forth. The optical cavity can be a linear variable filter fabricated on the photosensitive surface of a photosensing component such as a photosensor array or a position-sensitive detector.
摘要翻译：通过改变其形状来调整不均匀的光学腔，例如通过改变反射面位置来改变倾斜角，厚度或两者。变形部件如弹性体间隔件可以连接，使得当变形时，它们改变结构与诸如反射镜的光反射部件的相对位置，改变腔体形状。电极可能导致变形，例如静电，电磁或压电，也可用于测量腔的厚度。空腔可以例如通过连续光谱被调谐到特定波长带，以使其具有的模式数量增加或减少的形状调整到各自适用于相应光源的一系列传输范围，其中允许通过光敏锁定来实现更高灵敏度的调制，等等。光腔可以是制造在诸如光电传感器阵列或位置敏感检测器的感光部件的感光表面上的线性可变滤波器。

18. 发明授权

US07718948B2 Monitoring light pulses 有权
标题翻译：监控光脉冲
公开(公告)号：US07718948B2
公开(公告)日：2010-05-18
申请号：US11633323
申请日：2006-12-04
申请人： Peter Kiesel , Oliver Schmidt
发明人： Peter Kiesel , Oliver Schmidt
IPC分类号： H01J40/14
CPC分类号： H01L31/02165 , G01J3/02 , G01J3/0259 , G01J3/26 , G01J9/0246 , H01S3/0014 , H01S3/1305
摘要： To monitor light pulses from a light source, such as a laser, sense signals are provided to a photosensing component or array, causing photosensing during a series of one or more sense periods for the light pulse. Each light pulse can be provided through a transmission structure, such as a layered structure, that provides output light with an energy-dependent position on the photosensing component. A pulse's sensing results can be used to obtain a set of one or more differential quantities; for example, with a photosensing array, two cells of the array can be read out and compared. For a narrow band light pulse, a transmission structure can provide a spot on the photosensing component, and the light spot position can be sensed.
摘要翻译：为了监测来自光源（例如激光器）的光脉冲，感测信号被提供给光敏元件或阵列，在光脉冲的一个或多个感测周期的系列期间引起光敏。每个光脉冲可以通过诸如分层结构的传输结构提供，其提供光敏部件上的能量相关位置的输出光。可以使用脉冲的感测结果来获得一个或多个差分量的集合; 例如，使用光敏阵列，可以读出并比较阵列的两个单元。对于窄带光脉冲，透射结构可以在光敏元件上提供光点，并且可以感测光点位置。

19. 发明授权

US07554673B2 Obtaining information about analytes using optical cavity output light 有权
标题翻译：使用光学腔输出光获取有关分析物的信息
公开(公告)号：US07554673B2
公开(公告)日：2009-06-30
申请号：US11702470
申请日：2007-02-05
申请人： Peter Kiesel , Oliver Schmidt , Michael Bassler
发明人： Peter Kiesel , Oliver Schmidt , Michael Bassler
IPC分类号： G01B9/02
CPC分类号： G01N21/031 , B01L3/5085 , B01L2200/10 , B01L2300/168 , G01J3/26 , G01N2021/391
摘要： While two or more analytes within an optical cavity move relative to an array of photosensing elements, the cavity provides output light that has a position/time varying intensity function that depends on optical characteristics of the analytes and on the relative movement. The output light is photosensed to obtain sensing results that depend on the position/time varying intensity function. The sensing results are used to obtain information about at least one of the analytes. The relative movement can, for example, be caused by moving analytes within channels within the cavity, such as by causing flow of a medium that carries the analytes through the channels. Or the analytes can be in wells of a biochip, with the cavity defined by reflective slides on opposite surfaces of the biochip, and the slides and biochip can be caused to move together relative to the array.
摘要翻译：虽然光学腔内的两个或更多个分析物相对于光敏元件阵列移动，但腔提供具有取决于分析物的光学特性和相对运动的位置/时间变化强度函数的输出光。输出光被光照以获得取决于位置/时变强度函数的感测结果。感测结果用于获得关于至少一种分析物的信息。例如，相对运动可以通过在腔内的通道内移动分析物，例如通过使携带分析物的介质流过通道而引起。或者分析物可以在生物芯片的孔中，其中空腔由生物芯片的相对表面上的反射片限定，并且可以使载片和生物芯片相对于阵列一起移动。

20. 发明授权

US07522786B2 Transmitting light with photon energy information 有权
标题翻译：用光子能量信息传输光
公开(公告)号：US07522786B2
公开(公告)日：2009-04-21
申请号：US11316241
申请日：2005-12-22
申请人： Peter Kiesel , Oliver Schmidt
发明人： Peter Kiesel , Oliver Schmidt
IPC分类号： G02B6/00 , G01J3/45 , G02F1/35
CPC分类号： G02B6/4215 , G01J3/02 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/024 , G01J3/0256 , G01J3/26 , G01J3/2803 , G02B6/29358 , G02B6/4298
摘要： In detection and sensing, light is transmitted through layers or structures that vary laterally, such as with a constant gradient or a step-like gradient. After transmission, a position of a transmitted portion of the light or of output photons can be used to determine wavelength change or to obtain other photon energy information. The light can be received, for example, from a stimulus-wavelength converter such as an optical fiber sensor or another optical sensor. A component that propagates the light from the converter to a transmission structure can spread the light across the transmission structure's entry surface. At the exit surface of the transmission structure, photosensor components can sense or detect transmitted light or output photons, such as with a photosensor array or a position sensor. A photosensed quantity can be compared, such as with another photosensed quantity or with a calibration quantity. A differential quantity can be obtained using photosensed quantities.
摘要翻译：在检测和感测中，光通过横向变化的层或结构透射，例如以恒定的梯度或阶梯状梯度。在传输之后，可以使用光或输出光子的透射部分的位置来确定波长变化或获得其它光子能量信息。光可以例如从诸如光纤传感器或另一光学传感器的刺激 - 波长转换器接收。将来自转换器的光传播到透射结构的部件可以将光传播穿过透射结构的入射表面。在透射结构的出射表面处，光电传感器部件可以感测或检测透射光或输出光子，例如用光电传感器阵列或位置传感器。可以比较光照数量，例如与另一张照片数量或校准数量。使用光照量可以获得差分量。

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