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11. 发明授权

US07935712B2 Spirochromanone derivatives as acetyl coenzyme A carboxylase (ACC) inhibitors 有权
标题翻译：螺吡色酮衍生物作为乙酰辅酶A羧化酶（ACC）抑制剂
公开(公告)号：US07935712B2
公开(公告)日：2011-05-03
申请号：US11988588
申请日：2006-07-14
申请人： Takeru Yamakawa , Hideki Jona , Kenji Niiyama , Koji Yamada , Tomoharu Iino , Mitsuru Ohkubo , Hideaki Imamura , Jun Shibata , Jun Kusunoki , Lihu Yang
发明人： Takeru Yamakawa , Hideki Jona , Kenji Niiyama , Koji Yamada , Tomoharu Iino , Mitsuru Ohkubo , Hideaki Imamura , Jun Shibata , Jun Kusunoki , Lihu Yang
IPC分类号： A01N43/42 , A61K31/44 , A61K31/535
CPC分类号： C07D491/10 , C07D495/10
摘要： The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.
摘要翻译：本发明涉及可用作各种ACC相关疾病的治疗剂的式（I）化合物或其药学上可接受的盐或酯。

12. 发明申请

US20070021453A1 Novel spirochromanone derivatives 有权
标题翻译：新型螺二色酮衍生物
公开(公告)号：US20070021453A1
公开(公告)日：2007-01-25
申请号：US11487029
申请日：2006-07-14
申请人： Takeru Yamakawa , Hideki Jona , Kenji Niiyama , Koji Yamada , Tomoharu Iino , Mitsuru Ohkubo , Hideaki Imamura , Jun Shibata , Jun Kusunoki , Lihu Yang
发明人： Takeru Yamakawa , Hideki Jona , Kenji Niiyama , Koji Yamada , Tomoharu Iino , Mitsuru Ohkubo , Hideaki Imamura , Jun Shibata , Jun Kusunoki , Lihu Yang
IPC分类号： A61K31/4747 , C07D471/14
CPC分类号： C07D491/10 , C07D495/10
摘要： The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.
摘要翻译：本发明涉及可用作各种ACC相关疾病的治疗剂的式（I）化合物或其药学上可接受的盐或酯。

13. 发明授权

US08524730B2 Spirochromanone carboxylic acids 有权
标题翻译：新型螺环酮羧酸
公开(公告)号：US08524730B2
公开(公告)日：2013-09-03
申请号：US12997263
申请日：2009-06-29
申请人： Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
发明人： Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
IPC分类号： C07D405/04 , A61K31/438
CPC分类号： C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4709
摘要： The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中A表示连接基团; Ar 1表示由芳香环形成的基团; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，卤代-C 1 -C 6烷氧基，环-C 3 -C 6烷氧基， C2-C7烷酰基，卤代-C2-C7烷酰基，C2-C7烷氧基羰基，卤代-C2-C7烷氧基羰基，环-C3-C6烷氧基羰基，芳烷氧基羰基，氨基甲酰基C1- C6烷氧基，羧基-C2-C6烯基或-Q1-N（Ra）-Q2-Rb的基团; 任选具有取代基的C1-C6烷基; 任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子，硫原子或亚氨基。本发明的化合物可用作各种ACC相关疾病的治疗剂。

14. 发明申请

US20110077262A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS 有权
标题翻译：新型螺环酮羧酸
公开(公告)号：US20110077262A1
公开(公告)日：2011-03-31
申请号：US12997263
申请日：2009-06-29
申请人： Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
发明人： Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
IPC分类号： A61K31/438 , C07D491/107 , A61P3/00 , A61P3/04 , A61P3/10 , A61P31/00
CPC分类号： C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/4709
摘要： The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
摘要翻译：本发明涉及通式（I）的化合物：其中A表示连接基团; Ar 1表示由芳香环形成的基团; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，卤代-C 1 -C 6烷氧基，环-C 3 -C 6烷氧基， C2-C7烷酰基，卤代-C2-C7烷酰基，C2-C7烷氧基羰基，卤代-C2-C7烷氧基羰基，环-C3-C6烷氧基羰基，芳烷氧基羰基，氨基甲酰基C1- C6烷氧基，羧基-C2-C6烯基或-Q1-N（Ra）-Q2-Rb的基团; 任选具有取代基的C1-C6烷基; 任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子，硫原子或亚氨基。本发明的化合物可用作各种ACC相关疾病的治疗剂。

15. 发明授权

US06251891B1 Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US06251891B1
公开(公告)日：2001-06-26
申请号：US09294091
申请日：1999-04-19
申请人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
发明人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
IPC分类号： C07D47720
CPC分类号： C07D477/20
摘要： A compound represented by the general formula wherein R1 either represents a hydrogen atom or a lower alkyl group, R2 represents a hydrogen atom, an ester residue, an alkali metal or negative charge, and R3 and R4 are the same or different, and each represent a hydrogen atom or a hydrocarbonic group optionally containing hetero atom(s) selected from the group consisting of oxygen atom(s), sulfur atom(s) and nitrogen atom(s), or they are combined together with the nitrogen atom to which they bound to form a heterocyclic group, and the use thereof as an antibacterial agent.
摘要翻译：由通式化合物R1表示的化合物表示氢原子或低级烷基，R2表示氢原子，酯残基，碱金属或负电荷，R3和R4相同或不同，分别表示氢原子或任选含有选自氧原子，硫原子和氮原子的杂原子的烃基，或它们与它们所结合的氮原子结合在一起形成杂环基，其用作抗菌剂。

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