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11. 发明授权

US5635207A Methods for the preparation of blood substitutes for in vivo delivery 失效
标题翻译：用于制备用于体内递送的血液代用品的方法
公开(公告)号：US5635207A
公开(公告)日：1997-06-03
申请号：US480621
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译：根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。

12. 发明授权

US5362478A Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell 失效
标题翻译：用包含在交联聚合物壳中的碳氟化合物进行磁共振成像
公开(公告)号：US5362478A
公开(公告)日：1994-11-08
申请号：US35150
申请日：1993-03-26
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61K31/715
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising fluorine-containing magnetic resonance imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI). Fluorinated compounds in general are hydrophobic and as such have limited water solubility; thus the invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery. The shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, fluorocarbon filled polymeric shells of the invention can be used to measure and monitor local oxygen and temperature.
摘要翻译：根据本发明，提供了包含在聚合物壳内的含氟磁共振成像剂的组合物。本发明组合物可用作例如磁共振成像（MRI）的造影剂。氟化合物通常是疏水性的，因此具有有限的水溶性; 因此本发明的方法允许以适于准备输送的生物相容形式制备这些化合物。壳直径一般约为2微米。因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。此外，本发明的氟碳填充聚合物壳可用于测量和监测局部氧气和温度。

13. 发明授权

US5780653A Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers 失效
标题翻译：硝基苯基，10-脱乙酰基取代紫杉醇衍生物作为双功能细胞毒/放射增敏剂
公开(公告)号：US5780653A
公开(公告)日：1998-07-14
申请号：US485496
申请日：1995-06-07
申请人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford
发明人： Chunlin Tao , Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford
IPC分类号： A61K41/00 , C07D233/91 , C07D305/14 , C07D305/00 , A61K51/04 , C07D233/02 , C07D413/00
CPC分类号： C07D305/14 , A61K41/0038
摘要： In accordance with the present invention, there are provided derivatives of chemotherapeutic agents (e.g., paclitaxel), which serve as bifunctional agents. Invention derivatives retain the antitumor activity of the parent compound, and, coupled with the electron affinic substituents thereon, produce compounds which show a strong capability for radiosensitizing tumor cells growing in vitro. It is expected that a single drug which combines the properties of a radiosensitizer with chemotherapeutic activity will offer significant advantages not only to patients, but also to radiotherapists seeking improved modes of treatment. The combination of antitumor properties with electron-affinic function produces novel radiosensitizers, a second generation of drugs which are more powerful to fight cancers. Bifunctional agents with the dual properties of tubulin assembly and electron affinity will make the compounds useful not only as radiosensitizers, but also as cytotoxins.
摘要翻译：根据本发明，提供了用作双功能试剂的化学治疗剂（例如紫杉醇）的衍生物。本发明衍生物保留了母体化合物的抗肿瘤活性，并且与其上的电子亲和取代基一起产生显示出对体外生长的肿瘤细胞放射增敏的强大能力的化合物。预期将放射增敏剂的性质与化疗活性相结合的单一药物将不仅对患者具有显着的优点，而且还将提供寻求改善治疗方式的放射治疗师的显着优点。抗肿瘤性质与电子亲和功能的组合产生新型放射增敏剂，第二代更强大的抗癌药物。具有微管蛋白装配和电子亲和力的双重特性的双功能试剂将使得该化合物不仅用作放射增敏剂，而且用作细胞毒素。

14. 发明授权

US5550178A Process for encapsulating biologics using crosslinkable biocompatible encapsulation system 失效
标题翻译：使用可交联生物相容性封装系统封装生物制剂的方法
公开(公告)号：US5550178A
公开(公告)日：1996-08-27
申请号：US258769
申请日：1994-06-13
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and cross-linkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译：公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。提供了用交联和可交联的生物相容性组合物包封生物制剂的方法。此外，公开了用于封装微胶囊或生物制剂的可回收大囊。

15. 发明授权

US5846530A Macrocapsules prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor 失效
标题翻译：由可交联的多糖，聚阳离子和/或脂质制备的大胶囊并用于其中
公开(公告)号：US5846530A
公开(公告)日：1998-12-08
申请号：US475175
申请日：1995-06-07
申请人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
发明人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
IPC分类号： A61K9/50 , A61F13/00 , A61F13/02 , A61K9/127 , A61K9/16 , A61K47/30 , A61L15/00 , A61L15/58 , A61L24/04 , A61L24/08 , A61L26/00 , A61L27/38 , C08B37/00 , C08B37/08 , C08F2/50 , C08F290/00 , C08F290/08 , C08F290/10 , A61K9/62 , A61K9/56 , A61K9/64
CPC分类号： C08F290/00 , A61F13/02 , A61K9/1273 , A61K9/1635 , A61K9/1652 , A61L24/04 , A61L24/08 , A61L26/0009 , A61L26/0023 , A61L27/3804 , B82Y5/00 , C08B37/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/08 , C08F290/10 , A61F2013/00157 , A61F2013/00229 , A61F2013/00574 , A61F2013/00625 , A61F2013/00638 , A61F2013/0068 , A61F2013/00748 , A61F2013/00876 , A61F2013/00906 , A61F2013/0091 , Y10S514/866 , Y10S514/893 , Y10S514/962 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
摘要翻译：本发明涉及能够经历自由基聚合的新形式的生物相容性材料（例如脂质，聚阳离子，多糖），例如通过使用某些光源; 改变某些合成和天然存在的生物相容性材料以制备包含用所述可聚合材料涂覆的生物材料的可聚合微胶囊的方法，所述可聚合材料的复合材料，制备微胶囊的方法和包封生物材料的方法，以及用于制备含有生物细胞（特别是胰岛）的微胶囊的装置的朗格汉斯）涂覆有可聚合的藻酸盐或其复合物（例如藻酸盐和PEG）。本发明还涉及与上述相关的药物递送系统，以及利用上述技术制备的生物粘合剂和伤口敷料。

16. 发明授权

US5700848A Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor 失效
标题翻译：由交联性多糖，聚阳离子和/或脂质制备的凝胶组合物及其用途
公开(公告)号：US5700848A
公开(公告)日：1997-12-23
申请号：US472191
申请日：1995-06-07
申请人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
发明人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
IPC分类号： A61K9/50 , A61F13/00 , A61F13/02 , A61K9/127 , A61K9/16 , A61K47/30 , A61L15/00 , A61L15/58 , A61L24/04 , A61L24/08 , A61L26/00 , A61L27/38 , C08B37/00 , C08B37/08 , C08F2/50 , C08F290/00 , C08F290/08 , C08F290/10 , C12N11/04
CPC分类号： C08F290/00 , A61F13/02 , A61K9/1273 , A61K9/1635 , A61K9/1652 , A61L24/04 , A61L24/08 , A61L26/0009 , A61L26/0023 , A61L27/3804 , B82Y5/00 , C08B37/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/08 , C08F290/10 , A61F2013/00157 , A61F2013/00229 , A61F2013/00574 , A61F2013/00625 , A61F2013/00638 , A61F2013/0068 , A61F2013/00748 , A61F2013/00876 , A61F2013/00906 , A61F2013/0091 , Y10S514/866 , Y10S514/893 , Y10S514/962 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
摘要翻译：本发明涉及能够经历自由基聚合的新形式的生物相容性材料（例如脂质，聚阳离子，多糖），例如通过使用某些光源; 改变某些合成和天然存在的生物相容性材料以制备包含用所述可聚合材料涂覆的生物材料的可聚合微胶囊的方法，所述可聚合材料的复合材料，制备微胶囊的方法和包封生物材料的方法，以及用于制备含有生物细胞（特别是胰岛）的微胶囊的装置的朗格汉斯），其涂覆有可聚合的藻酸盐或其复合物（例如藻酸盐和PEG）。本发明还涉及与上述相关的药物递送系统，以及利用上述技术制备的生物粘合剂和伤口敷料。

17. 发明授权

US06565842B1 Crosslinkable polypeptide compositions 失效
标题翻译：可交联多肽组合物
公开(公告)号：US06565842B1
公开(公告)日：2003-05-20
申请号：US08484724
申请日：1995-06-07
申请人： Soebianto A. Sojomihardjo , Neil P. Desai , Paul A. Sandford , Patrick Soon-Shiong , Shubhi Nagrani
发明人： Soebianto A. Sojomihardjo , Neil P. Desai , Paul A. Sandford , Patrick Soon-Shiong , Shubhi Nagrani
IPC分类号： A61K4742
CPC分类号： C12N5/0677 , A61K9/1652 , A61K9/1658 , A61K38/28 , A61K47/42 , A61K2035/128 , C07K14/4732 , C07K14/76 , C07K14/78 , C08F290/14 , C08H1/00 , C12N5/0671 , C12N11/02
摘要： In accordance with the present invention, there are provided rapidly crosslinkable polypeptides which are obtained upon introduction of unsaturated group(s) into the polypeptide via linkage to amino acid residues on the polypeptide directly through one of three types of linkages, namely, an amide linkage, an ester linkage, or a thioester linkage. Each of these linkages are obtainable in a single step by use of a single derivatizing agent, acrylic anhydride. Also provided are methods for preparing such modified polypeptides and various uses therefor. It has unexpectedly been found that proteins with the above-described chemical modifications have the ability to rapidly crosslink to themselves under suitable conditions. This crosslinking occurs in the absence of any external crosslinking agents (indeed, in the absence of any extraneous agents), resulting in the formation of a solid gel material. Solid crosslinked gels are formed in seconds, starting from a freely flowing solution of polypeptide. Applications of such materials are broad ranging, including the encapsulation of living cells, the encapsulation of biologically active materials, the in situ formation of degradable gels, the formation of wound dressings, the prevention of post-surgical adhesions, gene delivery, drug targetting, as a microcarrier for culture of living cells, and the like.
摘要翻译：根据本发明，提供了快速可交联的多肽，其通过直接通过三种类型的连接之一连接到多肽上的氨基酸残基而将不饱和基团引入到多肽中，即三酰胺键，酯键或硫酯键。这些连接中的每一个可以通过使用单一衍生剂丙烯酸酐在一个步骤中获得。还提供了制备这种修饰的多肽及其各种用途的方法。意外地发现具有上述化学修饰的蛋白质具有在合适条件下快速与其自身交联的能力。这种交联发生在没有任何外部交联剂（实际上，在没有任何外来物质的情况下）的情况下，导致形成固体凝胶材料。固体交联凝胶在几秒钟内形成，自由流动的多肽溶液开始。这种材料的应用范围广泛，包括活细胞的包封，生物活性材料的包封，可降解凝胶的原位形成，伤口敷料的形成，预防手术后粘连，基因递送，药物靶向，作为活细胞培养的微载体等。

18. 发明授权

US5834556A Graft copolymer of polycationic species and water-soluble polymers, and uses therefor 失效
标题翻译：聚阳离子种类和水溶性聚合物的接枝共聚物，用途
公开(公告)号：US5834556A
公开(公告)日：1998-11-10
申请号：US697885
申请日：1996-08-29
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： A01N1/02 , A61K9/127 , A61K9/50 , A61K35/12 , C08G81/00 , C12N5/00 , C12N5/071 , C12N5/077 , C08G63/48 , C08G63/91
CPC分类号： C12N5/0677 , A01N1/021 , A61K9/1271 , A61K9/5031 , C08G81/00 , C12N5/0006 , C12N5/0012 , A61K2035/122 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40
摘要： In accordance with the present invention, there are provided methods to render cells non-adhesive and/or non-immunogenic with respect to macromolecules typically encountered in culture media or in physiological media.
摘要翻译：根据本发明，提供了相对于通常在培养基中或生理介质中遇到的大分子使细胞不粘合和/或非免疫原性的方法。

19. 发明授权

US5334640A Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods 失效
标题翻译：离子共价交联和可交联的生物相容性封装组合物和方法
公开(公告)号：US5334640A
公开(公告)日：1994-08-02
申请号：US866038
申请日：1992-04-08
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Roswitha E. Heintz
IPC分类号： C12N11/02 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/39 , C08F290/00 , C08F299/02 , C08G65/332 , C08K5/06 , C08L5/00 , C08L5/04 , C08L71/00 , C08L71/02 , C12N5/00 , C12N11/04 , C08K5/15 , A61K9/14
CPC分类号： C12N11/04 , A61K9/1652 , C08G65/332 , C08L5/04 , C08L71/02 , C12N5/0012 , C08L71/00 , C12N2533/30 , C12N2533/74
摘要： Crosslinked biocompatible compositions comprising an ionically crosslinked component and a covalently crosslinked component for encapsulating biologics are disclosed. In accordance with the present invention, also disclosed are crosslinkable biocompatible mixtures comprising an ionically crosslinkable component and a covalently crosslinkable component. Methods for encapsulating biologics with the crosslinked and crosslinkable biocompatible compositions are provided. Also, retrievable macrocapsules for encapsulating microcapsules or biologics are disclosed.
摘要翻译：公开了包含离子交联组分和用于封装生物制剂的共价交联组分的交联生物相容性组合物。根据本发明，还公开了包含可离子交联组分和共价可交联组分的可交联的生物相容性混合物。提供了用交联和可交联的生物相容组合物包封生物制剂的方法。此外，公开了用于封装微胶囊或生物制剂的可回收大囊。

20. 发明授权

US5837747A Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release 失效
标题翻译：可交联的多糖，聚阳离子和脂质可用于包封和药物释放
公开(公告)号：US5837747A
公开(公告)日：1998-11-17
申请号：US232054
申请日：1994-04-28
申请人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
发明人： Patrick Soon-Shiong , Neil P. Desai , Paul A. Sandford , Roswitha A. Heintz , Soebianto Sojomihardjo
IPC分类号： A61K9/50 , A61F13/00 , A61F13/02 , A61K9/127 , A61K9/16 , A61K47/30 , A61L15/00 , A61L15/58 , A61L24/04 , A61L24/08 , A61L26/00 , A61L27/38 , C08B37/00 , C08B37/08 , C08F2/50 , C08F290/00 , C08F290/08 , C08F290/10 , C08L5/00 , C08L5/04 , C08L5/08
CPC分类号： C08F290/00 , A61F13/02 , A61K9/1273 , A61K9/1635 , A61K9/1652 , A61L24/04 , A61L24/08 , A61L26/0009 , A61L26/0023 , A61L27/3804 , B82Y5/00 , C08B37/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/08 , C08F290/10 , A61F2013/00157 , A61F2013/00229 , A61F2013/00574 , A61F2013/00625 , A61F2013/00638 , A61F2013/0068 , A61F2013/00748 , A61F2013/00876 , A61F2013/00906 , A61F2013/0091 , Y10S514/866 , Y10S514/893 , Y10S514/962 , Y10S514/963 , Y10T428/2984
摘要： The present invention relates to a new form of biocompatible materials (e.g., lipids, polycations, polysaccharides) which are capable of undergoing free radical polymerization, e.g., by using certain sources of light; methods of modifying certain synthetic and naturally occurring biocompatible materials to make polymerizable microcapsules containing biological material coated with said polymerizable materials, composites of said polymerizable materials, methods of making microcapsules and encapsulating biological materials therein, and apparatus for making microcapsules containing biological cells (particularly islets of Langerhans) coated with polymerizable alginate or with a composite thereof (e.g., alginate and PEG). The present invention also relates to drug delivery systems relating to the foregoing, as well as bioadhesives and wound dressings made utilizing the foregoing technology.
摘要翻译： PCT No.PCT / US92 / 09364 Sec。 371日期1994年04月28日 102（e）日期1994年4月28日PCT提交1992年10月29日PCT公布。出版物WO93 / 09176 日期1993年5月13日本发明涉及能够进行自由基聚合的生物相容性材料（例如脂质，聚阳离子，多糖）的新形式，例如通过使用某些光源; 改变某些合成和天然存在的生物相容性材料以制备包含用所述可聚合材料涂覆的生物材料的可聚合微胶囊的方法，所述可聚合材料的复合材料，制备微胶囊的方法和包封生物材料的方法，以及用于制备含有生物细胞（特别是胰岛）的微胶囊的装置的朗格汉斯）涂覆有可聚合的藻酸盐或其复合物（例如藻酸盐和PEG）。本发明还涉及与上述相关的药物递送系统，以及利用上述技术制备的生物粘合剂和伤口敷料。

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