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11. 发明授权

US07715919B2 Control of treatment therapy during start-up and during operation of a medical device system 有权
标题翻译：在医疗器械系统启动和运行过程中控制治疗
公开(公告)号：US07715919B2
公开(公告)日：2010-05-11
申请号：US10687290
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , David L. Carlson
发明人： Ivan Osorio , Mark G. Frei , David L. Carlson
IPC分类号： A61N1/32
CPC分类号： A61N1/37235 , A61B5/4094 , A61B5/725 , A61N1/36014 , A61N1/36025 , A61N1/36082 , A61N1/36135 , A61N1/37229
摘要： A method and medical device system for controlling treatment therapy delivered to treat a nervous system disorder. During start-up, the medical device system prevents the therapy device from delivering therapy to the patient for a predetermined time period after the therapy device has been activated. During operation, before the therapy device is programmed, the system performs a check on the programming information to ensure that the programming information will result in treatment therapy being within of an acceptable range of one or more therapy parameters.
摘要翻译：一种用于治疗输送治疗神经系统疾病的治疗疗法的方法和医疗装置系统。在启动期间，医疗装置系统防止治疗装置在治疗装置被激活之后的预定时间段内向患者递送治疗。在操作期间，在治疗装置被编程之前，系统对编程信息进行检查，以确保编程信息将导致治疗疗法在一个或多个治疗参数的可接受范围内。

12. 发明授权

US09050469B1 Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals 有权
标题翻译：记录定量癫痫发作信息的方法和系统，并使用心脏信号评估治疗效果
公开(公告)号：US09050469B1
公开(公告)日：2015-06-09
申请号：US10997540
申请日：2004-11-24
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/04 , A61N1/36
CPC分类号： A61N1/36064 , A61B5/04012 , A61B5/0452 , A61B5/0456 , A61B5/4094 , A61B5/4836 , A61B5/7282 , G06F19/3481 , G16H50/20
摘要： A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or the brain state change.
摘要翻译：一种用于基于所述至少一个心脏信号来分析和记录受试者脑部状态变化以对受试者进行治疗的系统和方法，其中所述系统和方法包括以下步骤：将所述受试者的至少一个心脏信号接收到处理器分析心脏信号以检测指示脑状态改变的至少一个心脏信号变化，以及记录检测到的信号改变或脑状态改变的至少一个特征。

13. 发明授权

US08515538B1 Medical device failure detection and warning system 有权
标题翻译：医疗器械故障检测和警告系统
公开(公告)号：US08515538B1
公开(公告)日：2013-08-20
申请号：US12157955
申请日：2008-06-13
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/08
CPC分类号： A61B5/7221 , A61B5/0022 , A61B5/01 , A61B5/04005 , A61B5/4094 , A61B5/686 , A61B5/746 , A61B7/00 , A61N1/36142 , A61N1/3706 , A61N1/37258 , G16H40/63
摘要： A failure detection and warning system for monitoring a medical device wherein the system includes means structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
摘要翻译：一种用于监测医疗装置的故障检测和警告系统，其中所述系统包括构造成被动地或主动地检测正被监视的医疗装置中发生的故障的装置，并且其中所述故障包括被监视的医疗装置的未编程和/或不期望的切断或者由系统监视的未编程和/或非期望的关闭医疗设备的输出。

14. 发明授权

US08024032B1 Method and system for the prediction, rapid detection, warning, prevention, or control of changes in the brain states of a subject using hurst parameter estimation 有权
标题翻译：使用赫斯特参数估计预测，快速检测，警告，预防或控制受试者脑状态变化的方法和系统
公开(公告)号：US08024032B1
公开(公告)日：2011-09-20
申请号：US11604407
申请日：2006-11-27
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/04
CPC分类号： A61B5/0476 , A61B5/16 , A61B5/165 , A61B5/4094 , A61B5/6814
摘要： A system for analyzing signals representative of a subject's brain activity in a signal processor for information indicating the subject's current activity state and for detecting or predicting a change in the activity state. One preferred embodiment uses a method for estimating the Hurst parameter to perform real-time analysis of the electroencephalogram (EEG) or electrocorticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.
摘要翻译：一种用于分析表示受试者在脑部活动信号的信号的系统，用于指示受试者的当前活动状态的信息，以及用于检测或预测活动状态的变化。一个优选实施例使用用于估计Hurst参数的方法来执行来自对象患者的脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成所需的分析至少在临床发作发作前。优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

15. 发明授权

US07966156B1 Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale 有权
标题翻译：方法，计算机程序和系统，用于任意原点或时间尺度信号的固有时间尺度分解，滤波和自动分析
公开(公告)号：US07966156B1
公开(公告)日：2011-06-21
申请号：US12217893
申请日：2008-07-09
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： G06F17/00 , G06F19/00
CPC分类号： G06K9/00503 , G06F17/14 , G06K9/00523
摘要： A method and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale including receiving an input signal, determining a baseline segment and a monotonic residual segment with strictly negative minimum and strictly positive maximum between two successive extrema of the input signal, and producing a baseline output signal and a residual output signal. The method and system also includes determining at least one instantaneous frequency estimate from a proper rotation signal, determining a zero-crossing and a local extremum of the proper rotation signal, and applying interpolation thereto to determine an instantaneous frequency estimate thereof. The method and system further includes determining at least one instantaneous frequency estimate from a proper rotation signal, extracting an amplitude-normalized half wave therefrom and applying an arcsine function to the amplitude-normalized half wave to determine an instantaneous frequency estimate of the proper rotation signal.
摘要翻译：用于固有时间尺度分解，过滤和任意来源或时间尺度信号的自动分析的方法和系统，包括接收输入信号，确定基线段和具有严格为负的最小值和严格正的最大值的两个连续极值之间的单调残差段输入信号，并产生基线输出信号和残留输出信号。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，确定适当旋转信号的过零点和局部极值，以及对其进行插值以确定其瞬时频率估计。所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，从其中提取幅度归一化的半波，并对所述幅度归一化的半波应用反正弦函数，以确定适当旋转信号的瞬时频率估计。

16. 发明授权

US07917206B2 Signal quality monitoring and control for a medical device system 有权
标题翻译：医疗器械系统的信号质量监测和控制
公开(公告)号：US07917206B2
公开(公告)日：2011-03-29
申请号：US11557433
申请日：2006-11-07
申请人： Mark G. Frei , Ivan Osorio
发明人： Mark G. Frei , Ivan Osorio
IPC分类号： A61N1/00
CPC分类号： A61B5/04012 , A61B5/048 , A61B5/4094 , A61B5/7203 , A61B5/7217 , A61B5/7221 , A61N1/36014 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/3702 , A61N1/37229 , A61N1/37252
摘要： Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.
摘要翻译：用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

17. 发明授权

US07856272B2 Implantable interface for a medical device system 有权
标题翻译：用于医疗设备系统的可植入界面
公开(公告)号：US07856272B2
公开(公告)日：2010-12-21
申请号：US11414736
申请日：2006-04-28
申请人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Alexei V. Nikitin , Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/375
CPC分类号： A61N1/0529 , A61M5/14276 , A61M5/16827 , A61M5/16881 , A61M2205/054 , A61M2205/3507 , A61M2210/0693 , A61N1/36082
摘要： An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.
摘要翻译：一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗，多余的治疗元素，而不需要额外的主要外科手术。

18. 发明授权

US07389144B1 Medical device failure detection and warning system 有权
标题翻译：医疗器械故障检测和警告系统
公开(公告)号：US07389144B1
公开(公告)日：2008-06-17
申请号：US10982748
申请日：2004-11-05
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju
IPC分类号： A61N1/00
CPC分类号： A61B5/7221 , A61B5/0022 , A61B5/01 , A61B5/04005 , A61B5/4094 , A61B5/686 , A61B5/746 , A61B7/00 , A61N1/36142 , A61N1/3706 , A61N1/37258 , G16H40/63
摘要： A failure detection and warning system for monitoring a medical device wherein the system includes means structured to passively or actively detect faults occurring in the medical device being monitored, and wherein the fault includes an unprogrammed and/or undesired shut off of the medical device being monitored or an unprogrammed and/or undesired shut-off of the output of the medical device being monitored by the system.
摘要翻译：一种用于监测医疗设备的故障检测和警告系统，其中所述系统包括构造成被动地或主动地检测正被监视的医疗设备中发生的故障的装置，并且其中所述故障包括被监视的所述医疗设备的未编程和/或不期望的切断或者由系统监视的未编程和/或非期望的关闭医疗设备的输出。

19. 发明授权

US06920357B2 Vagal nerve stimulation techniques for treatment of epileptic seizures 有权
标题翻译：迷走神经刺激技术治疗癫痫发作
公开(公告)号：US06920357B2
公开(公告)日：2005-07-19
申请号：US10435832
申请日：2003-05-12
申请人： Ivan Osorio , Mark G. Frei
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61B5/4094 , A61B5/02405 , A61B5/02455 , A61B5/0452 , A61B5/0456 , A61B5/686 , A61B5/7282 , A61B2560/0475 , A61N1/36053 , A61N1/36064 , A61N1/36114 , A61N1/36135
摘要： The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, the invention may include a modified pacemaker to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.
摘要翻译：本发明使用迷走神经的电刺激来治疗癫痫，对心脏具有最小化或不起作用。治疗由可植入信号发生器，用于电刺激迷走神经的预定刺激部位的一个或多个可植入电极以及用于感测心脏特征的传感器例如心率进行。来自传感器的心率信息可用于确定迷走神经刺激是否对心脏有不利影响。一旦达到阈值参数，就可以停止或调整迷走神经刺激。在替代实施例中，本发明可以包括修改的起搏器，以在迷走神经刺激期间将心脏保持在期望的状态。在另一个实施例中，本发明可以简单地是具有确定是否正在刺激迷走神经的电路的改进的起搏器。在迷走神经被刺激的情况下，修改的起搏器可以控制心脏在迷走神经刺激期间将其保持在期望的条件下。

20. 发明授权

US06768969B1 Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes 有权
标题翻译：方法，计算机程序和用于信号变化的检测，量化和预测的自动化实时信号分析系统
公开(公告)号：US06768969B1
公开(公告)日：2004-07-27
申请号：US09824946
申请日：2001-04-03
申请人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio
发明人： Alexei V. Nikitin , Mark G. Frei , Naresh C. Bhavaraju , Ivan Osorio
IPC分类号： G01L2100
CPC分类号： G06K9/00536 , G06F17/10 , G06F17/18 , G06F19/24 , G16H50/20 , G16H50/50
摘要： A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.
摘要翻译：一种用于实时信号分析的方法，计算机程序和系统，通过跟踪顺序统计滤波器的输出（也称为百分位数，分位数）来提供移动时间窗口中的任意类型信号的时间演化密度和信号特征分布的表征或等级阶滤波器）。给定任意类型，原点或尺度的原始输入信号，本发明能够自动量化和检测该信号随时间发生的任何一组可量化特征的分布变化。此外，本发明快速准确地检测输入信号的某些特征的变化的能力还可以在与未来信号的可能性增加相关联的检测到的变化的情况下进行预测。

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