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11. 发明申请

US20080119904A1 METHOD AND DEVICE FOR TREATING MYOCARDIAL ISCHEMIA 有权
标题翻译：用于治疗心肌梗塞的方法和装置
公开(公告)号：US20080119904A1
公开(公告)日：2008-05-22
申请号：US11561049
申请日：2006-11-17
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

12. 发明授权

US07941216B2 Method and device for treating myocardial ischemia 有权
标题翻译：治疗心肌缺血的方法和装置
公开(公告)号：US07941216B2
公开(公告)日：2011-05-10
申请号：US11561049
申请日：2006-11-17
申请人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
发明人： Rodney W. Salo , Allan C. Shuros , Tamara Colette Baynham
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译：描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。

13. 发明授权

US07778707B2 Method and device for myocardial stress redistribution 有权
标题翻译：心肌应激再分配的方法和装置
公开(公告)号：US07778707B2
公开(公告)日：2010-08-17
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/368
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such as the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可以用于故意地减压可能预期会发生有害重建的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或者故意强迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

14. 发明授权

US07953485B2 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US07953485B2
公开(公告)日：2011-05-31
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

15. 发明申请

US20100274306A1 METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效
标题翻译：用于设备控制的基因表达用于心脏保护的方法和装置
公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61M37/00 , A61N1/00
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

16. 发明申请

US20100145401A1 MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION 有权
公开(公告)号：US20100145401A1
公开(公告)日：2010-06-10
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适用于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

17. 发明申请

US20090143835A1 Method and apparatus for delivering pacing pulses using a coronary stent 审中-公开
标题翻译：使用冠状动脉支架输送起搏脉冲的方法和装置
公开(公告)号：US20090143835A1
公开(公告)日：2009-06-04
申请号：US12322382
申请日：2009-02-02
申请人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/365
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
摘要翻译：可植入心脏保护起搏系统提供起搏脉冲，以保护心脏免受与缺血和心肌梗塞相关的损伤。该系统包括输送起搏脉冲的可植入脉冲发生器（PG）和电连接到可植入PG的冠状动脉支架，起到起搏电极的作用，起搏电极通过该起搏电极被输送。在一个实施例中，血管内引线提供冠状支架和可植入PG之间的电连接，以允许将可植入PG植入股骨区域。在另一个实施例中，冠状动脉支架和可植入PG集成到血管内脉冲发生器 - 支架中。

18. 发明申请

US20080249583A1 THERAPY CONTROL BASED ON THE RATE OF CHANGE OF INTRACARDIAC IMPEDANCE 有权
标题翻译：基于内皮抑素变化率的治疗控制
公开(公告)号：US20080249583A1
公开(公告)日：2008-10-09
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

19. 发明授权

US07366567B2 Method for treating myocardial infarction 有权
公开(公告)号：US07366567B2
公开(公告)日：2008-04-29
申请号：US11088231
申请日：2005-03-23
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

20. 发明授权

US08731677B2 Myocardium conditioning using myocardial and parasympathetic stimulation 有权
标题翻译：心肌调理使用心肌和副交感神经刺激
公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

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