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    • 11. 发明申请
    • Multiphoton-excitation-type examination apparatus
    • 多光子激发型检查仪
    • US20070120070A1
    • 2007-05-31
    • US11647031
    • 2006-12-27
    • Yoshihiro KawanoTadashi HirataTatsuo NakataHiroshi Sasaki
    • Yoshihiro KawanoTadashi HirataTatsuo NakataHiroshi Sasaki
    • G01J1/58
    • G01N21/6486G01N21/6456
    • The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
    • 本发明提供了一种多光子激发型检查装置,其有效地产生使得测量头紧凑,并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括:振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上,以便可上下移动一定角度,并且具有光学系统,该光学系统用由光纤透射的超短脉冲激光照射样本,该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
    • 13. 发明授权
    • Scanning microscope device
    • 扫描显微镜装置
    • US08445865B2
    • 2013-05-21
    • US12784643
    • 2010-05-21
    • Hiroshi SasakiTatsuo Nakata
    • Hiroshi SasakiTatsuo Nakata
    • G01J1/58
    • G02B21/0076
    • A scanning microscope device includes a light source that emits laser light; an X-Y galvanometer mirror that scans the laser light on a sample; an objective lens that irradiates the sample with the scanned laser light and collects fluorescence generated at an irradiated position; a non-descan-detection excitation DM that is disposed between the X-Y galvanometer mirror and the objective lens and separates the laser light and the fluorescence from each other; a fiber that receives the separated fluorescence through an entrance end thereof and emits the fluorescence from an exit end thereof that is formed in a substantially linear shape; a diffraction grating that disperses the fluorescence emitted from the exit end of the fiber in a direction orthogonal to a longitudinal direction of the exit end; and a multi-anode PMT having plural cells arrayed in the dispersing direction of the dispersed fluorescence.
    • 扫描显微镜装置包括发射激光的光源; 用于扫描样品上的激光的X-Y电流计镜; 物镜,用扫描的激光照射样品并收集在照射位置产生的荧光; 设置在X-Y电流计反射镜和物镜之间并将激光和荧光彼此分离的非除数检测激励DM; 通过其入口端接收分离的荧光并从其出口端发射形成大致线状的荧光的光纤; 衍射光栅,其在与所述出射端的长度方向正交的方向上分散从所述光纤的出射端发射的荧光; 以及具有沿分散荧光的分散方向排列的多个单元的多阳极PMT。
    • 14. 发明申请
    • Scanning laser microscope apparatus
    • 扫描激光显微镜装置
    • US20060278530A1
    • 2006-12-14
    • US11447761
    • 2006-06-06
    • Kunihiko SasakiYasunari MatsukawaHiroshi SasakiTatsuo Nakata
    • Kunihiko SasakiYasunari MatsukawaHiroshi SasakiTatsuo Nakata
    • B01D57/02B01D59/42B01D59/50
    • G02B21/008G01N21/6458
    • A scanning laser microscope that can quantitatively display a laser irradiation power on a display unit and that can suppress fluctuations in the laser irradiation power is provided. The scanning laser microscope includes a light source configured to emit laser light, a scanning unit configured to scan the laser light emitted from the light source on a sample, a photodetector configured to detect light from the sample, a processing unit configured to convert a signal from the photodetector into an image signal of the sample and to output the image signal, a reference light detector configured to detect part of the laser light emitted from the light source as a reference light signal, a laser light control unit configured to control the power of the laser light emitted from the light source, an irradiation-power calculation unit configured to calculate an irradiation power value at the sample on the basis of the reference light signal detected by the reference light detector, and a display unit configured to display the calculated irradiation power value at the sample.
    • 提供了一种可以在显示单元上定量显示激光照射功率并且可以抑制激光照射功率的波动的扫描激光显微镜。 该扫描激光显微镜包括配置为发射激光的光源,被配置为扫描从样品上的光源发射的激光的扫描单元,被配置为检测来自样品的光的光电检测器,被配置为将信号 从光电检测器到样品的图像信号并输出​​图像信号;参考光检测器,被配置为检测从光源发射的激光的一部分作为参考光信号;激光控制单元,被配置为控制功率 照射功率计算单元,被配置为基于由参考光检测器检测的参考光信号计算样本处的照射功率值;以及显示单元,被配置为显示所计算的 样品照射功率值。
    • 16. 发明申请
    • Multiphoton-excitation-type examination apparatus
    • 多光子激发型检查仪
    • US20050279950A1
    • 2005-12-22
    • US11070191
    • 2005-03-03
    • Yoshihiro KawanoTadashi HirataTatsuo NakataHiroshi Sasaki
    • Yoshihiro KawanoTadashi HirataTatsuo NakataHiroshi Sasaki
    • G01N21/64G01T1/10
    • G01N21/6486G01N21/6456
    • The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-excitation-type examination apparatus comprises a laser light source that oscillates ultrashort pulsed laser light; an optical fiber that transmits the ultrashort pulsed laser light from the laser light source; a support member; a measurement head supported on the support member so as to be movable upwards and downwards and at an angle, and having an optical system that irradiates a specimen with the ultrashort pulsed laser light transmitted by the optical fiber that measures fluorescence or reflected light coming from the specimen; and a dispersion-compensating member, in the measurement head, that compensates for group velocity dispersion of the ultrashort pulsed laser light irradiated onto the specimen.
    • 本发明提供了一种多光子激发型检查装置,其有效地产生使得测量头紧凑,并且在更换测量头时可以容易地调节的多光子激发效果。 多光子激发型检查装置包括:振荡超短脉冲激光的激光光源; 从激光光源发射超短脉冲激光的光纤; 支撑构件; 测量头支撑在支撑构件上,以便可上下移动一定角度,并且具有光学系统,该光学系统用由光纤透射的超短脉冲激光照射样本,该光纤测量荧光或来自 标本; 以及在测量头中补偿照射到样本上的超短脉冲激光的组速度色散的色散补偿部件。
    • 19. 发明授权
    • Endoscope system, imaging apparatus, and control method
    • 内窥镜系统,成像装置和控制方法
    • US08723937B2
    • 2014-05-13
    • US13049055
    • 2011-03-16
    • Hiroshi Sasaki
    • Hiroshi Sasaki
    • H04N7/18A62B1/04
    • A61B1/00096A61B1/00009A61B1/00188A61B1/05G02B23/2407
    • An endoscope system includes an imaging section that includes an optical system and an imaging element, an observation mode setting section that sets an object observation mode, a diaphragm control section that selects a diaphragm state based on the observation mode, and an image processing section that processes an image acquired by the imaging section. The diaphragm control section selecting a first diaphragm state when the observation mode is a first observation mode. The first diaphragm state being a state in which a resolution determined by a diffraction limit based on a diaphragm of the optical system is lower than a resolution determined by the imaging element. The diaphragm control section selecting a second diaphragm state when the observation mode is a second observation mode. The second diaphragm state being a state in which the resolution determined by the diffraction limit based on the diaphragm of the optical system is equal to or higher than the resolution determined by the imaging element.
    • 一种内窥镜系统,包括:摄像部,其具备光学系统和摄像元件,设定被摄体观察模式的观察模式设定部,基于观察模式选择光阑状态的光圈控制部;以及图像处理部, 处理由成像部获取的图像。 当观察模式是第一观察模式时,光圈控制部分选择第一光阑状态。 第一光阑状态是其中由基于光学系统的光阑的衍射极限决定的分辨率低于由成像元件确定的分辨率的状态。 当观察模式是第二观察模式时,光圈控制部分选择第二光阑状态。 第二光阑状态是基于光学系统的光阑的由衍射极限决定的分辨率等于或高于由成像元件确定的分辨率的状态。