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11. 发明授权

US5871515A Attachment apparatus and method for an implantable medical device employing ultrasonic energy 有权
公开(公告)号：US5871515A
公开(公告)日：1999-02-16
申请号：US140973
申请日：1998-08-27
申请人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
发明人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
IPC分类号： A61N1/375
CPC分类号： A61N1/3752 , Y10T29/49925
摘要： A method and apparatus for attaching a pre-formed header module, e.g. a connector header module or an electrode bearing header module, etc., to a hermetically sealed enclosure of the implantable medical device, typically including electronic integrated circuits, batteries, electromechanical pumps, or the like, are disclosed. A plurality of upstanding tabs that are fixed to the hermetically sealed enclosure, e.g. to the enclosure attachment surface, extend into a like plurality of tab channels formed in the header module housing. The upstanding tab(s) are inserted into the respective tab channel(s) during seating of the module and enclosure attachment surfaces and effects an initial alignment of the header module with the hermetically sealed enclosure. Each attachment tab has a retention feature formed on or in the tab that is designed to accommodate the flow of the thermoplastic material during the application of ultrasonic energy in the region of the tab channel and to cooperate with the solidified mass of thermoplastic material. During application of the ultrasonic energy, the thermoplastic material melts and flows into the remaining space of the tab channel and encapsulate the attachment tab including the retention feature. Upon termination of the ultrasonic energy, the thermoplastic housing material cools and solidifies and forms a continuous mass that encapsulates the surface of the attachment tab and the retention feature.

12. 发明授权

US5871514A Attachment apparatus for an implantable medical device employing ultrasonic energy 失效
标题翻译：用于使用超声波能量的可植入医疗装置的附件装置
公开(公告)号：US5871514A
公开(公告)日：1999-02-16
申请号：US904601
申请日：1997-08-01
申请人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
发明人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
IPC分类号： A61N1/375
CPC分类号： A61N1/3752 , Y10T29/49925
摘要： A method and apparatus for attaching a pre-formed header module to a hermetically sealed enclosure of an implantable medical device are described. A plurality of upstanding tabs attached to the hermetically sealed enclosure extend into a plurality of corresponding tab channels formed in the header module. The upstanding tabs are inserted into the respective tab channels during seating of the module and enclosure attachment surfaces and effect an initial alignment of the header module with the hermetically sealed enclosure. Each attachment tab has a retention feature such as a recess formed on or in the tab that is designed to receive molten thermoplastic material when ultrasonic energy is applied in the region of the tab channel.
摘要翻译：描述了一种用于将预成形头部模块附接到可植入医疗装置的密封外壳的方法和装置。附接到密封外壳的多个直立突出部延伸到形成在头部模块中的多个对应的突舌通道。在模块和外壳附接表面的座位期间，直立突出部插入到相应的突出部通道中，并实现头部模块与密封外壳的初始对准。每个附接凸片具有保持特征，例如形成在凸片上或凸片中的凹部，其设计成当超声波能量被施加在凸片通道的区域中时接收熔融的热塑性材料。

13. 发明授权

US5324769A Thermally stable blends of polyphenylene ether, diene based rubber and an antioxidant/metal deactivator 失效
标题翻译：聚苯醚，二烯基橡胶和抗氧化/金属钝化剂的热稳定共混物
公开(公告)号：US5324769A
公开(公告)日：1994-06-28
申请号：US140945
申请日：1993-10-25
申请人： William D. Richards , James F. Kelley
发明人： William D. Richards , James F. Kelley
IPC分类号： C08K5/00 , C08L21/00 , C08L53/02 , C08L71/00 , C08L71/12 , C08L77/00 , C08L25/10
CPC分类号： C08L53/02 , C08K5/005 , C08L21/00 , C08L71/123 , C08L9/00 , C08L71/00 , C08L77/00 , Y10S525/905
摘要： There are provided melt extruded blends of diene based rubber and preextruded polyphenylene ether, or blends thereof with an effective amount of a stabilizer such as a hindered phenol or metal deactivator/hindered phenol. The resulting polyphenylene ether composition can be further extruded with a polymeric organic matrix material, such as a polyamide or polyetherimide. When molded, the polyphenylene ether compositions have been found to resist loss of impact strength upon thermal aging and recycling.
摘要翻译：提供二烯基橡胶和预浸聚苯醚的熔融挤出共混物，或其与有效量的稳定剂如受阻酚或金属钝化剂/受阻酚的共混物。得到的聚苯醚组合物可以用聚合物有机基质材料如聚酰胺或聚醚酰亚胺进一步挤出。当模制时，发现聚苯醚组合物在热老化和再循环时抵抗冲击强度的损失。

14. 发明授权

US08180428B2 Methods and systems for use in selecting cardiac pacing sites 有权
标题翻译：用于选择心脏起搏部位的方法和系统
公开(公告)号：US08180428B2
公开(公告)日：2012-05-15
申请号：US12421176
申请日：2009-04-09
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas David Skadsberg , Kenneth C. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61B5/00
CPC分类号： A61B5/1107 , A61B5/1104 , A61B5/686 , A61B5/6882 , A61B2562/0209 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/368 , A61N1/3684 , A61N1/3686 , A61N2001/0585
摘要： A method and system for use in selecting a cardiac pacing site includes sensors for tracking wall motion (e.g., sensors coupled to the right and left ventricular heart wall). The wall motion of one or more non-paced cardiac cycles is compared to the wall motion of one or more paced cardiac cycles to determine the effectiveness of one or more pacing sites. For example, image data may be generated to notify the user as to the effectiveness of the one or more pacing sites.
摘要翻译：用于选择心脏起搏部位的方法和系统包括用于跟踪壁运动的传感器（例如耦合到右心室壁和左心室心壁的传感器）。将一个或多个非节奏心脏周期的壁运动与一个或多个节奏心动周期的壁运动进行比较，以确定一个或多个起搏部位的有效性。例如，可以生成图像数据以通知用户关于一个或多个起搏站点的有效性。

15. 发明授权

US08060185B2 Navigation system for cardiac therapies 有权
标题翻译：心脏治疗导航系统
公开(公告)号：US08060185B2
公开(公告)日：2011-11-15
申请号：US12573521
申请日：2009-10-05
申请人： Mark W. Hunter , Bradley A. Jascob , Laurent Verard , James F. Kelley
发明人： Mark W. Hunter , Bradley A. Jascob , Laurent Verard , James F. Kelley
IPC分类号： A61B5/055
CPC分类号： A61B1/00071 , A61B1/0058 , A61B1/012 , A61B5/0215 , A61B5/06 , A61B5/062 , A61B5/7285 , A61B6/12 , A61B6/463 , A61B6/541 , A61B17/3478 , A61B34/20 , A61B34/25 , A61B2017/00243 , A61B2017/00247 , A61B2018/00392 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2034/2072 , A61B2034/252 , A61B2034/254 , A61B2034/256 , A61B2090/365 , A61B2090/367 , A61M2005/14292
摘要： An image guided catheter navigation system for navigating a region of a patient includes an imaging device, a tracking device, a controller, and a display. The imaging device generates images of the region of the patient. The tracking device tracks the location of the catheter in the region of the patient. The controller superimposes an icon representing the catheter onto the images generated from the imaging device based upon the location of the catheter. The display displays the image of the region with the catheter superimposed onto the image at the current location of the catheter.
摘要翻译：用于导航患者区域的图像引导导管系统包括成像装置，跟踪装置，控制器和显示器。成像装置产生患者区域的图像。跟踪装置跟踪导管在患者区域中的位置。控制器基于导管的位置将表示导管的图标叠加到从成像装置产生的图像上。显示器将导管叠加在导管当前位置的图像上显示区域的图像。

16. 发明授权

US07818040B2 Deflectable medical therapy delivery device having common lumen profile 有权
标题翻译：具有共同流明特征的偏转药物治疗递送装置
公开(公告)号：US07818040B2
公开(公告)日：2010-10-19
申请号：US10655980
申请日：2003-09-05
申请人： Stanten C. Spear , James F. Kelley , Johnson E. Goode
发明人： Stanten C. Spear , James F. Kelley , Johnson E. Goode
IPC分类号： A61B8/14
CPC分类号： A61M25/0147 , A61M25/0141 , A61M2025/015
摘要： A method of locating a target site for delivering a therapy to a patient that includes advancing a delivery device having a steerable portion and a deflectable tip having a tapered portion to an area along a first site. A contrast media is delivered through a thru lumen and outward from a distal end of the delivery device in fluid communication with the thru lumen to position the contrast media along the first site and the delivery device is further advanced toward the first site and within the first site, or the delivery device is further advanced toward the first site and within the first site without the contrast. The contrast media is then delivered from the distal end of the delivery device within the first site to locate the target site.
摘要翻译：一种定位用于将治疗递送给患者的目标部位的方法，包括将具有可转向部分的输送装置和具有锥形部分的可偏转尖端推进到沿着第一部位的区域。造影剂通过内腔输送并且从输送装置的远端向外输送，其与穿过腔流体连通以沿着第一部位定位造影剂，并且输送装置进一步朝向第一部位前进，并且在第一部位内或者传送设备进一步向着第一站点和第一站点前进而没有对比。然后将造影剂从第一位点内的递送装置的远端递送以定位目标部位。

17. 发明申请

US20090125078A1 SELECTING CARDIAC PACING SITES 审中-公开
标题翻译：选择CARDIAC PACING SITES
公开(公告)号：US20090125078A1
公开(公告)日：2009-05-14
申请号：US12245570
申请日：2008-10-03
申请人： Daniel R. Kaiser , Michael R. Neidert , Nicholas D. Skadsberg , Kenneth G. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
发明人： Daniel R. Kaiser , Michael R. Neidert , Nicholas D. Skadsberg , Kenneth G. Gardeski , Lawrence J. Mulligan , James F. Kelley , Michael B. Shelton , Trent M. Fischer
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61B5/042 , A61B5/062 , A61B5/1104 , A61B5/1107 , A61B5/686 , A61B5/6882 , A61N1/0573 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： A method for selecting a cardiac pacing site includes steps of: securing first and second electromagnetic receiver coils at first and second positions, respectively, along a heart wall; collecting a set of non-paced heart wall motion data from each of the coils secured at the corresponding positions; applying cardiac pacing stimulation at at least one first pacing site; collecting a first set of paced heart wall motion data from each of the secured coils; comparing the non-paced heart wall motion data to the first set of paced heart wall motion data; and determining, based on the comparing, whether to maintain pacing at the at least one first cardiac pacing site or to apply pacing stimulation at a second pacing site for collection of a second set of paced heart wall motion data. The at least one first pacing site may include a right ventricular site and a left ventricular site.
摘要翻译：用于选择心脏起搏部位的方法包括以下步骤：分别沿心壁将第一和第二电磁接收线圈固定在第一和第二位置; 从固定在相应位置的每个线圈收集一组无节奏的心壁运动数据; 在至少一个第一起搏部位应用心脏起搏刺激; 从每个固定线圈收集第一组起搏心壁运动数据; 将不起搏的心脏壁运动数据与第一组起搏心脏壁运动数据进行比较; 以及基于所述比较确定是否在所述至少一个第一心脏起搏部位保持起搏，或者在第二起搏部位施加起搏刺激，以收集第二组起搏心脏壁运动数据。至少一个第一起搏部位可以包括右心室部位和左心室部位。

18. 发明授权

US07187974B2 Ultrasonically welded, staked or swaged components in an implantable medical device 有权
标题翻译：在植入式医疗设备中超声波焊接，固定或锻造组件
公开(公告)号：US07187974B2
公开(公告)日：2007-03-06
申请号：US10199601
申请日：2002-07-19
申请人： Daniel C. Haeg , Craig L. Wiklund , James F. Kelley
发明人： Daniel C. Haeg , Craig L. Wiklund , James F. Kelley
IPC分类号： A61N1/375
CPC分类号： A61N1/375
摘要： The present invention generally relates to an improved implantable medical device (IMD) and more particularly to an ultrasonically weld perforated lid for an IMD to form a hermetic seal between the IMD and the perforated lid. Appropriately configured perforated lids retain one or more components within a cavity or port formed in a part of an IMD. Such lids preferably secure a pierceable resilient grommet, septum or other resilient member in a cavity or port. When an adjustment instrument, a pull tool or a syringe is temporarily inserted therethrough and later extracted, the resilient member heals (i.e., seals and/or reseals). Preferably, the resilient member abuts a mechanical stop and is compressed slightly during assembly and ultrasonic welding of the lid. The resilient member preferably has a lateral dimension like the cavity or port so that when the lid compresses the resilient member it expands slightly and contacts the interior cavity surfaces thus improving the seal.
摘要翻译：本发明总体上涉及一种改进的可植入医疗装置（IMD），更具体地涉及用于IMD的超声波焊接多孔盖，以在IMD和多孔盖之间形成气密密封。适当配置的穿孔盖在IMD的一部分中形成的腔或端口内保留一个或多个部件。这种盖子优选地将可刺破的弹性垫圈，隔膜或其它弹性构件固定在空腔或端口中。当调节工具，拉动工具或注射器临时插入其中并随后抽出时，弹性部件愈合（即，密封和/或回收）。优选地，弹性构件邻接机械止动件并且在盖的组装和超声波焊接期间被稍微压缩。优选地，弹性构件具有类似于腔或端口的侧向尺寸，使得当盖子压缩弹性构件时，其稍微膨胀并与内腔表面接触，从而改善密封。

19. 发明授权

US5919215A Attachment apparatus for an implantable medical device employing ultrasonic energy 有权
标题翻译：用于使用超声波能量的可植入医疗装置的附件装置
公开(公告)号：US5919215A
公开(公告)日：1999-07-06
申请号：US140969
申请日：1998-08-27
申请人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
发明人： Craig L. Wiklund , Daniel C. Haeg , James F. Kelley
IPC分类号： A61N1/375
CPC分类号： A61N1/3752 , Y10T29/49925
摘要： A method and apparatus for attaching a pre-formed header module, e.g. a connector header module or an electrode bearing header module, etc., to a hermetically sealed enclosure of the implantable medical device, typically including electronic integrated circuits, batteries, electromechanical pumps, or the like, are disclosed. A plurality of upstanding tabs that are fixed to the hermetically sealed enclosure, e.g. to the enclosure attachment surface, extend into a like plurality of tab channels formed in the header module housing. The upstanding tab(s) are inserted into the respective tab channel(s) during seating of the module and enclosure attachment surfaces and effects an initial alignment of the header module with the hermetically sealed enclosure. Each attachment tab has a retention feature formed on or in the tab that is designed to accommodate the flow of the thermoplastic material during the application of ultrasonic energy in the region of the tab channel and to cooperate with the solidified mass of thermoplastic material. During application of the ultrasonic energy, the thermoplastic material melts and flows into the remaining space of the tab channel and encapsulate the attachment tab including the retention feature. Upon termination of the ultrasonic energy, the thermoplastic housing material cools and solidifies and forms a continuous mass that encapsulates the surface of the attachment tab and the retention feature.
摘要翻译：一种用于附接预成形头部模块的方法和装置，例如，公开了通常包括电子集成电路，电池，机电泵等的可植入医疗装置的气密密封外壳中的连接器插头模块或电极支承插头模块等。多个直立突出部，固定在密封的外壳上，例如。到壳体附接表面，延伸到形成在头部模块壳体中的相似的多个突片通道。在模块和机壳连接表面的座位期间，将直立的插片插入到相应的标签通道中，并且实现了头部模块与密封外壳的初始对准。每个附接翼片具有形成在翼片上或翼片中的保持特征，该保持特征被设计成在翼片通道的区域中施加超声波能量期间适应热塑性材料的流动并且与固化的热塑性材料块配合。在施加超声波能量期间，热塑性材料熔化并流入突片通道的剩余空间并且封装包括保持特征的连接片。在超声波能量终止时，热塑性外壳材料冷却并固化并形成包封附着突片的表面和保持特征的连续质量。

20. 发明授权

US08734397B2 System and method for positioning implantable medical devices within coronary veins 有权
标题翻译：将植入式医疗器械定位在冠状静脉内的系统和方法
公开(公告)号：US08734397B2
公开(公告)日：2014-05-27
申请号：US12357810
申请日：2009-01-22
申请人： Stanten C. Spear , James F. Kelley , Kenneth C. Gardeski , Mohmoud K. Seraj , Eric K. Y. Chan
发明人： Stanten C. Spear , James F. Kelley , Kenneth C. Gardeski , Mohmoud K. Seraj , Eric K. Y. Chan
IPC分类号： A61M5/178
CPC分类号： A61M25/0668 , A61B18/1492 , A61B2017/22038 , A61B2018/00386 , A61M25/005 , A61M25/0051 , A61M25/0054 , A61M25/008 , A61M25/0138 , A61M25/0141 , A61M25/0147 , A61M2025/0042 , A61M2025/0047 , A61M2025/0081 , A61M2025/0161 , A61M2025/0681 , A61M2025/1052 , A61M2025/1079 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An improved system and method for placing implantable medical devices (IMDs) such as leads within the coronary sinus and branch veins is disclosed. In one embodiment, a slittable delivery sheath and a method of using the sheath are provided. The sheath includes a slittable hub, and a substantially straight body defining an inner lumen. The body comprises a shaft section and a distal section that is distal to, and softer than, the shaft section. A slittable braid extends adjacent to at least a portion of one of the shaft section and the distal section. In one embodiment of the invention, the sheath further includes a transition section that is distal to the shaft section, and proximal to the distal section. The transition section is softer than the shaft section, but stiffer than the distal section.
摘要翻译：公开了用于在冠状窦和分支静脉内放置诸如引线的可植入医疗装置（IMD）的改进的系统和方法。在一个实施例中，提供了可切割的输送护套和使用护套的方法。护套包括可切割的毂，以及限定内腔的基本上直的身体。主体包括轴部分和远离轴部分的远端部分和远端部分。狭缝编织物相邻于轴部和远端部分中的一个的至少一部分延伸。在本发明的一个实施例中，护套还包括在轴部分的远侧并且靠近远端部分的过渡部分。过渡部分比轴部分软，但比远端部分更硬。

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