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11. 发明公开

EP1470240A4 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747,1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165,2 审中-公开
标题翻译：方法和用于治疗心血管疾病的处理组合使用1682，6169，6193，7771，14395，29002，33216，43726，69292，21656，32427，2402，7747.1720，9151，60491，1371，7077，33207，1419 ，18036，16105，38650，14245，58848，1870年，25856，32394，3484，345，9252，9135，10532，18610，8165.2
公开(公告)号：EP1470240A4
公开(公告)日：2006-08-30
申请号：EP03708889
申请日：2003-01-29
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG , GALVIN KATHERINE M , HEALY AILEEN , ACTON SUSAN L , DONAGHUE MARY , STAGLIANO NANCY , PERODIN JACQUELINE , RODRIGUE-WAY AMELIE
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , C12N5/06 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68 , C12Q1/00
CPC分类号： G01N33/5067 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5064 , G01N33/6893 , G01N2333/914 , G01N2500/04 , G01N2800/32

12. 发明公开

EP1435975A4 METHODS OF USING 279, A HUMAN G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：利用279的方法中，人G蛋白偶联受体
公开(公告)号：EP1435975A4
公开(公告)日：2005-06-15
申请号：EP02780469
申请日：2002-10-16
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , A61K31/70 , A61K38/16 , A61K38/43 , A61K39/395 , A61K48/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/723
摘要： The invention provides isolated nucleic acids molecules, designated 279 nucleic acid molecules, which encode human G protein-coupled receptor (GPCR) family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 279 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 279 gene bas been introduced or disrupted. The invention still further provides isolated 279 proteins, fusion proteins, antigenic peptides and anti-279 antibodies. Methods utilizing compositions of the invention to treat, prevent or diagnose angiogenic disorders, e.g., cardiovascular and cancerous disorders, are also provided.

13. 发明专利

AU2002343523A1 Methods of using 279, a human g protein-coupled receptor 未知
公开(公告)号：AU2002343523A1
公开(公告)日：2003-04-28
申请号：AU2002343523
申请日：2002-10-16
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , GALVIN KATHERINE M
IPC分类号： A61K38/00 , C07K14/705 , C07K14/72 , A61K31/70 , A61K38/16 , A61K39/395 , A61K38/43 , A61K48/00
摘要： The invention provides isolated nucleic acids molecules, designated 279 nucleic acid molecules, which encode human G protein-coupled receptor (GPCR) family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 279 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 279 gene has been introduced or disrupted. The invention still further provides isolated 279 proteins, fusion proteins, antigenic peptides and anti-279 antibodies. Methods utilizing compositions of the invention to treat, prevent or diagnose angiogenic disorders, e.g., cardiovascular and cancerous disorders, are also provided.

14. 发明专利

AU2003212850A1 METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747,1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165,2 未知
公开(公告)号：AU2003212850A1
公开(公告)日：2003-09-02
申请号：AU2003212850
申请日：2003-01-29
申请人： MILLENNIUM PHARM INC
发明人： CHUN MIYOUNG , GALVIN KATHERINE M , HEALY AILEEN , ACTON SUSAN L , DONAGHUE MARY , STAGLIANO NANCY , PERODIN JACQUELINE , RODRIGUE-WAY AMELIE , LOGAN THOMAS JOSEPH
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , C12N5/06 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, heart failure, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 and 6585 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

15. 发明专利

AU2002360531A1 METHODS AND COMPOSITIONS TO TREAT CARDIOVASCULAR DISEASE USING 1419, 58765 AND 2201 未知
公开(公告)号：AU2002360531A1
公开(公告)日：2003-06-23
申请号：AU2002360531
申请日：2002-12-10
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , CHUN MIYOUNG
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/68
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1419, 58765 or 2210 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

16. 发明专利

AU2002360343A1 Methods and compositions to treat cardiovascular disease using 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 or 93804 未知
公开(公告)号：AU2002360343A1
公开(公告)日：2003-05-19
申请号：AU2002360343
申请日：2002-11-05
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH , GALVIN KATHERINE M , CHUN MIYOUNG
IPC分类号： A61K45/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P43/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/566 , G01N33/68 , A01N25/00
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 139, 258, 1261, 1486, 2398, 2414, 7660, 8587, 10183, 10550, 12680, 17921, 32248, 60489 or 93804 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

17. 发明专利

AU2002336551A1 Mid 4460, a human tyrosine phosphatase family member and uses therefor 未知
公开(公告)号：AU2002336551A1
公开(公告)日：2003-04-01
申请号：AU2002336551
申请日：2002-09-17
申请人： MILLENNIUM PHARM INC
发明人： LOGAN THOMAS JOSEPH
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/12 , A61P1/14 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P5/14 , A61P5/16 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P27/02 , A61P27/16 , A61P29/00 , A61P29/02 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/20 , A61P31/22 , A61P33/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C12N9/16 , C12N15/09 , C12Q1/42 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/573
摘要： The invention provides isolated nucleic acids molecules, designated MID 4460 nucleic acid molecules, which encode novel tyrosine phosphatase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MID 4460 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MID 4460 gene has been introduced or disrupted. The invention still further provides isolated MID 4460 proteins, fusion proteins, antigenic peptides and anti-MID 4460 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

18. 发明专利

AU8520401A Atcr-1, a novel human acyltransferase and uses thereof 未知
公开(公告)号：AU8520401A
公开(公告)日：2002-03-04
申请号：AU8520401
申请日：2001-08-21
申请人： MILLENNIUM PHARM INC
发明人： KAPELLER-LIBERMANN ROSANNA , LOGAN THOMAS JOSEPH
IPC分类号： A61K38/00 , C12N9/10 , C12N15/20 , C12N15/00

19. 发明专利

ES2317929T3 ATCR-1, UNA ACILTRANSFERASA HUMANA Y SUS USOS. 未知
公开(公告)号：ES2317929T3
公开(公告)日：2009-05-01
申请号：ES01964339
申请日：2001-08-21
申请人： MILLENNIUM PHARM INC
发明人： KAPELLER-LIBERMANN ROSANNA , LOGAN THOMAS JOSEPH
IPC分类号： C12N15/00 , A61K38/00 , C12N9/10 , C12N15/20
摘要： Método para identificar un sujeto que tiene un tumor de mama o que corre el riesgo de desarrollar un tumor de mama, que comprende: a) poner en contacto una primera muestra de un sujeto que tiene un tumor de mama o que corre el riesgo de desarrollar un tumor de mama que comprende moléculas de ácido nucleico con una sonda de hibridación que comprende al menos 25 nucleótidos contiguos de la SEQ ID NO:1 ó 3. b) detectar la presencia de una molécula de ácido nucleico en la muestra que se hibrida con la sonda; c) poner en contacto una segunda muestra de un sujeto de control que comprende moléculas de ácido nucleico con una sonda de hibridación que comprende al menos 25 nucleótidos contiguos de la SEQ ID NO:1 ó 3; d) detectar la presencia de una molécula de ácido nucleico en la muestra que se hibrida con la sonda; e) comparar el nivel de los ácidos nucleicos que se hibridan con la sonda en la primera muestra con el nivel de los ácidos nucleicos que se hibridan con la sonda en la segunda muestra, en el que una disminución del nivel de los ácidos nucleicos que se hibridan en la primera muestra respecto a la segunda muestra identifica un sujeto que tiene un tumor de mama o que corre el riesgo de desarrollar un tumor de mama.

20. 发明专利

AU2003212850A8 Methods and compositions for treating cardiovascular disease 未知
公开(公告)号：AU2003212850A8
公开(公告)日：2003-09-02
申请号：AU2003212850
申请日：2003-01-29
申请人： MILLENNIUM PHARM INC
发明人： DONAGHUE MARY , LOGAN THOMAS JOSEPH , CHUN MIYOUNG , HEALY AILEEN , RODRIGUE-WAY AMELIE , STAGLIANO NANCY , GALVIN KATHERINE M , ACTON SUSAN L , PERODIN JACQUELINE
IPC分类号： A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , C12N5/06 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68 , C12Q1/00
摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, heart failure, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1682, 6169, 6193, 7771, 14395, 29002, 33216, 43726, 69292, 21656, 32427, 2402, 7747, 1720, 9151, 60491, 1371, 7077, 33207, 1419, 18036, 16105, 38650, 14245, 58848, 1870, 25856, 32394, 3484, 345, 9252, 9135, 10532, 18610, 8165, 2448, 2445, 64624, 84237, 8912, 2868, 283, 2554, 9464, 17799, 26686, 43848, 32135, 12208, 2914, 51130, 19489, 21833, 2917, 59590, 15992, 2094, 2252, 3474, 9792, 15400, 1452 and 6585 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

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