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11. 发明申请

WO2019241658A2 DELIVERY OF CARDIAC PACING THERAPY FOR CARDIAC REMODELING 审中-公开
公开(公告)号：WO2019241658A2
公开(公告)日：2019-12-19
申请号：PCT/US2019/037229
申请日：2019-06-14
申请人： MEDTRONIC, INC.
发明人： SHARMA, Vinod , WHITMAN, Teresa A. , JACKSON, Troy E.
IPC分类号： A61N1/362 , A61B5/026 , A61N1/37
摘要： A method and device apparatus to deliver a pacing therapy capable of remodeling a patient's heart over a period of time that includes monitoring one or more parameters in response to a delivered cardiac remodeling pacing, determining whether the cardiac remodeling pacing has an effect on cardiac normalization in response to the monitoring, and adjusting the cardiac remodeling pacing in response to the determined effect on cardiac normalization. The method and device may also perform short-term monitoring of one or more parameters in response to the delivered cardiac remodeling pacing, monitor one or more long-term parameter indicative of a long-term effect of the delivered cardiac remodeling pacing, determine the long-term effect of the delivered cardiac remodeling pacing on cardiac normalization in response to the monitoring, and adjust the cardiac remodeling pacing in response to one or both of the short-term monitoring and the determined long-term effect on cardiac normalization.

12. 发明申请

WO2017160507A1 SYNCHRONIZATION OF ANTI-TACHYCARDIA PACING IN AN EXTRA-CARDIOVASCULAR IMPLANTABLE SYSTEM 审中-公开
标题翻译：抗心律失常药物在心血管外可植入系统中的同步化
公开(公告)号：WO2017160507A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/020413
申请日：2017-03-02
申请人： MEDTRONIC, INC.
发明人： JACKSON, Troy E.
IPC分类号： A61N1/39 , A61N1/362 , A61B5/046 , A61B5/0464 , A61N1/05
摘要： An extra-cardiovascular implantable cardioverter defibrillator (ICD) system receives a cardiac electrical signal by an electrical sensing circuit via an extra-cardiovascular sensing electrode vector and senses cardiac events from the cardiac electrical signal. The ICD system detects tachycardia from the cardiac electrical signal and determines a tachycardia cycle length from the cardiac electrical signal. The ICD system determines an ATP interval based on the tachycardia cycle length and sets an extended ATP interval that is longer than the ATP interval. The ICD delivers ATP pulses to a patient's heart via an extra-cardiovascular pacing electrode vector different than the sensing electrode vector. The ATP pulses include a leading ATP pulse delivered at the extended ATP interval after a cardiac event is sensed from the cardiac electrical signal and a second ATP pulse delivered at the ATP interval following the leading ATP pulse.
摘要翻译：额外心血管植入式心脏复律除颤器（ICD）系统经由心外电极感测电极向量通过电感测电路接收心电信号并且感测来自心电信号的心脏事件。 ICD系统检测来自心电信号的心动过速并根据心电信号确定心动过速周期长度。 ICD系统根据心动过速周期长度确定ATP间隔，并设置比ATP间隔更长的延长ATP间隔。 ICD通过与感测电极矢量不同的额外心血管起搏电极矢量向患者心脏递送ATP脉冲。 ATP脉冲包括在心脏电信号感测到心脏事件之后以延长的ATP间隔递送的前导ATP脉冲，以及在ATP前导脉冲之后以ATP间隔递送的第二个ATP脉冲。

13. 发明申请

WO2014149806A1 A SYSTEM FOR AVOIDING UNDERSENSING OF VENTRICULAR FIBRILLATION 审中-公开
标题翻译：用于避免心脏纤维化不全的系统
公开(公告)号：WO2014149806A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/020998
申请日：2014-03-06
申请人： MEDTRONIC, INC.
发明人： ZHANG, Xusheng , BROWN, Mark L. , DEGROOT, Paul J. , GREENHUT, Saul E. , JACKSON, Troy E.
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/39 , A61N1/362 , A61B5/0452 , A61B5/00
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/046 , A61B5/6869 , A61B5/7264 , A61N1/3621 , A61N1/395 , A61N1/3956
摘要： A medical device for detecting and treating tachyarrhythmias acquires a cardiac signal using electrodes coupled to a sensing module. Cardiac events are sensed from the cardiac signal and a first processing module computes a first morphology metric for each sensed cardiac event occurring during a time segment of the cardiac signal. The first morphology metrics corresponding to an event originating in a ventricular chamber are counted. The first processing module computes a second morphology metric for the time segment of the cardiac signal in response to the count of the first morphology metrics meeting a threshold number of events. The time segment is classified as a shockable segment in response to the second morphology metric meeting a detection criterion.
摘要翻译：用于检测和治疗快速性心律失常的医疗装置使用耦合到感测模块的电极获取心脏信号。从心脏信号感测心脏事件，并且第一处理模块计算在心脏信号的时间段期间发生的每个感测的心脏事件的第一形态度量。计算对应于起始于心室的事件的第一形态学指标。第一处理模块响应于满足阈值数量事件的第一形态学量度的计数，计算心脏信号的时间段的第二形态度量。响应于符合检测标准的第二形态度量，该时间段被分类为可震击段。

14. 发明申请

WO2014120769A1 SYSTEMS AND METHODS FOR LEADLESS PACING AND SHOCK THERAPY 审中-公开
标题翻译：无铅和防震治疗的系统和方法
公开(公告)号：WO2014120769A1
公开(公告)日：2014-08-07
申请号：PCT/US2014/013601
申请日：2014-01-29
申请人： MEDTRONIC, INC.
发明人： GREENHUT, Saul E. , NEHLS, Robert J. , OLSON, Walter H. , ZHANG, Xusheng , DEMMER, Wade M. , JACKSON, Troy E.
IPC分类号： A61N1/372 , A61N1/362 , A61N1/39 , A61N1/375
CPC分类号： A61N1/3962 , A61N1/056 , A61N1/3621 , A61N1/36585 , A61N1/37288 , A61N1/3756 , A61N1/3987
摘要： Techniques and systems for monitoring cardiac arrhythmias and delivering electrical stimulation therapy using a subcutaneous implantable cardioverter defibrillator (SICD) and a leadless pacing device (LPD) are described. For example, the SICD may detect a tachyarrhythmia within a first electrical signal from a heart and determine, based on the tachyarrhythmia, to deliver anti-tachyarrhythmia shock therapy to the patient to treat the detected arrhythmia. The LPD may receive communication from the SICD requesting the LPD deliver anti-tachycardia pacing to the heart and determine, based on a second electrical signal from the heart sensed by the LPD, whether to deliver anti-tachycardia pacing (ATP) to the heart. In this manner, the SICD and LPD may communicate to coordinate ATP and/or cardioversion/defibrillation therapy. In another example, the LPD may be configured to deliver post-shock pacing after detecting delivery of anti-tachyarrhythmia shock therapy.
摘要翻译：描述了使用皮下植入式心律转复除颤器（SICD）和无引线起搏装置（LPD）监测心律不齐和递送电刺激治疗的技术和系统。例如，SICD可以检测来自心脏的第一电信号内的快速性心律失常，并且基于快速性心律失常确定将抗心律失常休克疗法递送给患者以治疗所检测到的心律失常。 LPD可以接收来自SICD的通信，请求LPD向心脏提供抗心动过速起搏，并且基于由LPD感测到的心脏的第二电信号确定是否将心动过速（ATP）提供给心脏。以这种方式，SICD和LPD可以通信以协调ATP和/或心脏复律/除颤疗法。在另一个示例中，LPD可以被配置为在检测到抗快速性心律失常性休克疗法的递送之后递送后冲击起搏。

15. 发明申请

WO2023023545A2 HVAD ADVERSE EVENT DETECTION FROM CARDIAC COMPASS DATA 审中-公开
公开(公告)号：WO2023023545A2
公开(公告)日：2023-02-23
申请号：PCT/US2022/075063
申请日：2022-08-17
申请人： MEDTRONIC, INC.
发明人： KADROLKAR, Abhijit , JACKSON, Troy E.
IPC分类号： A61B5/00 , A61B5/024 , A61B5/361 , A61B5/363
摘要： An example system includes an implantable medical device configured to obtain measurement values of one or more patient metrics; and processing circuitry configured to: determine a baseline value for each of the respective one or more patient metrics based on measurement values of the one or more patient metrics over a first period of time; determine a short-term value for each of the one or more patient metrics based on measurement values of the one or more patient metrics over a second period of time, determine a difference between each of the short-term values and the respective baseline value for each of the one or more patient metrics; determine that a risk of an adverse event occurring in the patient is high in response to the determined difference meeting a respective adverse event risk threshold; and generate for output an adverse event high risk alert.

16. 发明申请

WO2021154423A1 VENTRICULAR GEOMETRIC AND HEMODYNAMIC CONTROL BY HEART RATE MODULATION IN LVAD THERAPY 审中-公开
公开(公告)号：WO2021154423A1
公开(公告)日：2021-08-05
申请号：PCT/US2020/066295
申请日：2020-12-21
申请人： MEDTRONIC, INC.
发明人： JACKSON, Troy E.
IPC分类号： A61N1/365 , A61M60/122
摘要： A method of operating an implantable blood pump and a pacing device, the method includes determining an end diastolic volume (EDV) and ejection fraction of one from the group consisting of the right ventricle and the left ventricle at a predetermined pump set speed. An average flow rate based on the predetermined pump set speed is determined. A target heart rate based at least in part on the determined EDV, ejection fraction, and average flow rate is determined. A lower rate for the pacing device is determined, the pacing device being in electrical communication with a chamber of the heart. The chamber of the heart is paced when a measured heart rate drops below the lower rate.

17. 发明申请

WO2021072019A1 CARDIAC PACING DEVICE WITH MECHANICAL MODE SWITCHING 审中-公开
公开(公告)号：WO2021072019A1
公开(公告)日：2021-04-15
申请号：PCT/US2020/054697
申请日：2020-10-08
申请人： MEDTRONIC, INC.
发明人： RIES, Andrew J. , DEMMER, Wade M. , JACKSON, Troy E.
IPC分类号： A61N1/375 , A61N1/365 , A61N1/05
摘要： An implantable medical device includes an electrically conductive first housing, a conductive feedthrough extending through the first housing, electronic circuitry positioned within the first housing, a device electrode, and a second housing. The electronic circuitry is electrically coupled to the first housing and the feedthrough, and senses electrical signals of a patient and/or delivers electrical stimulation therapy to the patient via the first housing and the feedthrough. The device electrode is configured to electrically connect with tissue and/or a fluid at a target site in the patient. A lead connector is configured to connect to a proximal end of an implantable medical lead. The lead connector includes a first connector contact electrically coupled to the feedthrough and a second connector contact electrically coupled to the first housing.

18. 发明申请

WO2019241673A1 DELIVERY OF CARDIAC PACING THERAPY FOR CARDIAC REMODELING 审中-公开
公开(公告)号：WO2019241673A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/037253
申请日：2019-06-14
申请人： MEDTRONIC, INC.
发明人： SHARMA, Vinod , WHITMAN, Teresa A. , JACKSON, Troy E.
IPC分类号： A61N1/362 , A61N1/365
摘要： A method and device apparatus to deliver a pacing therapy capable of remodeling a patient's heart over a period of time that includes delivering remodeling pacing during a first interval, the first interval comprising a first rate and a first duration, determining whether to adjust one or both of the first rate and the first duration during delivery of remodeling pacing during a next interval subsequent to the first interval, and delivering remodeling pacing during the next interval in response to the determining, wherein the next interval comprises one of the first rate and the first duration of the first interval and the adjusted one or both of the first rate and the first duration.

19. 发明申请

WO2019241658A3 DELIVERY OF CARDIAC PACING THERAPY FOR CARDIAC REMODELING 审中-公开
公开(公告)号：WO2019241658A3
公开(公告)日：2019-12-19
申请号：PCT/US2019/037229
申请日：2019-06-14
申请人： MEDTRONIC, INC.
发明人： SHARMA, Vinod , WHITMAN, Teresa A. , JACKSON, Troy E.
IPC分类号： A61N1/362 , A61B5/026 , A61N1/37
摘要： A method and device apparatus to deliver a pacing therapy capable of remodeling a patient's heart over a period of time that includes monitoring one or more parameters in response to a delivered cardiac remodeling pacing, determining whether the cardiac remodeling pacing has an effect on cardiac normalization in response to the monitoring, and adjusting the cardiac remodeling pacing in response to the determined effect on cardiac normalization. The method and device may also perform short-term monitoring of one or more parameters in response to the delivered cardiac remodeling pacing, monitor one or more long-term parameter indicative of a long-term effect of the delivered cardiac remodeling pacing, determine the long-term effect of the delivered cardiac remodeling pacing on cardiac normalization in response to the monitoring, and adjust the cardiac remodeling pacing in response to one or both of the short-term monitoring and the determined long-term effect on cardiac normalization.

20. 发明申请

WO2023057843A1 MEDICAL DEVICE AND METHOD FOR CARDIAC PACING AND SENSING 审中-公开
公开(公告)号：WO2023057843A1
公开(公告)日：2023-04-13
申请号：PCT/IB2022/058659
申请日：2022-09-14
申请人： MEDTRONIC, INC.
发明人： GREENHUT, Saul E. , ARANDA HERNANDEZ, Alfonso , EBELING, Timothy A. , HEINKS, Michael W. , HUDSON, Jean E. , JACKSON, Troy E. , LIU, Yuanzhen , SANCHEZ, Irving J. , VANDER HEYDEN, James A. , ZHANG, Xusheng
IPC分类号： A61N1/37 , A61N1/3706
摘要： A medical device is configured to receive cardiac electrical signals and sense ventricular event signals from the cardiac electrical signals. The medical device may start a validation window in response to sensing a ventricular event signal and determine if the ventricular event signal is a valid event signal or an invalid event signal based on processing of a different cardiac electrical signal than the cardiac electrical signal from which the ventricular event signal was sensed.

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